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Beta 2 agonists and the incidence of Parkinson's disease.

Giorgianni F, Ernst P, Dell'Aniello S, Suissa S, Renoux C.

Am J Epidemiol. 2020 Feb 4. pii: kwaa012. doi: 10.1093/aje/kwaa012. [Epub ahead of print]


MitoQ regulates redox-related non-coding RNAs to preserve mitochondrial network integrity in pressure overload heart failure.

Kim S, Song J, Ernst P, Latimer MN, Ha CM, Goh KY, Ma W, Rajasekaran NS, Zhang J, Liu XM, Prabhu S, Qin G, Wende AR, Young ME, Zhou L.

Am J Physiol Heart Circ Physiol. 2020 Jan 31. doi: 10.1152/ajpheart.00617.2019. [Epub ahead of print]


Structure-Guided Design of a Peptide Lock for Modular Peptide Binders.

Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A.

ACS Chem Biol. 2020 Feb 13. doi: 10.1021/acschembio.9b00928. [Epub ahead of print]


Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis.

Yang W, Trahan GD, Howell ED, Speck NA, Jones KL, Gillen AE, Riemondy K, Hesselberth J, Bryder D, Ernst P.

Stem Cell Reports. 2020 Feb 11;14(2):285-299. doi: 10.1016/j.stemcr.2019.12.009. Epub 2020 Jan 16.


Chaperone-assisted structure elucidation with DARPins.

Mittl PR, Ernst P, Plückthun A.

Curr Opin Struct Biol. 2020 Jan 6;60:93-100. doi: 10.1016/ [Epub ahead of print] Review.


Comparative Effectiveness Of Fluoroquinolone Antibiotic Use In Uncomplicated Acute Exacerbations Of COPD: A Multi-Cohort Study.

Ernst P, Dahl M, Chateau D, Daneman N, Quail J, Sketris IS, Fisher A, Zhang J, Bugden S; Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.

Int J Chron Obstruct Pulmon Dis. 2019 Dec 18;14:2939-2946. doi: 10.2147/COPD.S226324. eCollection 2019.


Zwitterionic Stealth Dye-Loaded Polymer Nanoparticles for Intracellular Imaging.

Runser A, Dujardin D, Ernst P, Klymchenko AS, Reisch A.

ACS Appl Mater Interfaces. 2020 Jan 8;12(1):117-125. doi: 10.1021/acsami.9b15396. Epub 2019 Dec 24.


Comparative Effects of LAMA-LABA-ICS vs LAMA-LABA for COPD: Cohort Study in Real-World Clinical Practice.

Suissa S, Dell'Aniello S, Ernst P.

Chest. 2019 Nov 22. pii: S0012-3692(19)34225-4. doi: 10.1016/j.chest.2019.11.007. [Epub ahead of print]


Inhaled corticosteroid use and the incidence of lung cancer in COPD.

Suissa S, Dell'Aniello S, Gonzalez AV, Ernst P.

Eur Respir J. 2019 Nov 19. pii: 1901720. doi: 10.1183/13993003.01720-2019. [Epub ahead of print]


Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.

Ernst P, Honegger A, van der Valk F, Ewald C, Mittl PRE, Plückthun A.

Sci Rep. 2019 Nov 7;9(1):16162. doi: 10.1038/s41598-019-52121-9.


Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins.

Dunne M, Rupf B, Tala M, Qabrati X, Ernst P, Shen Y, Sumrall E, Heeb L, Plückthun A, Loessner MJ, Kilcher S.

Cell Rep. 2019 Oct 29;29(5):1336-1350.e4. doi: 10.1016/j.celrep.2019.09.062.


Fluoroquinolone use for uncomplicated urinary tract infections in women: a retrospective cohort study.

Daneman N, Chateau D, Dahl M, Zhang J, Fisher A, Sketris IS, Quail J, Marra F, Ernst P, Bugden S; Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.

Clin Microbiol Infect. 2019 Oct 23. pii: S1198-743X(19)30552-X. doi: 10.1016/j.cmi.2019.10.016. [Epub ahead of print]


Structural analysis of biological targets by host:guest crystal lattice engineering.

Ernst P, Plückthun A, Mittl PRE.

Sci Rep. 2019 Oct 23;9(1):15199. doi: 10.1038/s41598-019-51017-y.


MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

Addicks GC, Brun CE, Sincennes MC, Saber J, Porter CJ, Francis Stewart A, Ernst P, Rudnicki MA.

Nat Commun. 2019 Sep 18;10(1):4256. doi: 10.1038/s41467-019-12086-9.


Comparative safety of biologic versus conventional synthetic DMARDs in rheumatoid arthritis with COPD: a real-world population study.

Hudson M, Dell'Aniello S, Shen S, Simon TA, Ernst P, Suissa S.

Rheumatology (Oxford). 2019 Sep 3. pii: kez359. doi: 10.1093/rheumatology/kez359. [Epub ahead of print]


Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases.

Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S.

Gastroenterology. 2019 Dec;157(6):1530-1543.e4. doi: 10.1053/j.gastro.2019.08.021. Epub 2019 Aug 21.


Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision.

Ernst P, Xu N, Qu J, Chen H, Goldberg MS, Darley-Usmar V, Zhang JJ, O'Rourke B, Liu X, Zhou L.

Biophys J. 2019 Aug 20;117(4):631-645. doi: 10.1016/j.bpj.2019.06.038. Epub 2019 Jul 26.


Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M.

Genes Dev. 2019 Sep 1;33(17-18):1265-1279. doi: 10.1101/gad.327593.119. Epub 2019 Aug 8.



Suissa S, Ernst P.

Chest. 2019 Aug;156(2):416-417. doi: 10.1016/j.chest.2019.04.097. No abstract available.


Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity.

Zhao M, Tang Y, Ernst PJ, Kahn-Krell A, Fan C, Pretorius D, Zhu H, Lou X, Zhou L, Zhang J, Zhu W.

J Vis Exp. 2019 Jul 10;(149). doi: 10.3791/59452.


Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.

Chen Y, Ernst P.

Cell Cycle. 2019 Jul;18(14):1525-1531. doi: 10.1080/15384101.2019.1618642. Epub 2019 Jun 4.


Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?

Dulai PS, Singh S, Vande Casteele N, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ.

Clin Gastroenterol Hepatol. 2019 Dec;17(13):2634-2643. doi: 10.1016/j.cgh.2019.04.040. Epub 2019 Apr 19. Review.


Comparative safety of abatacept in rheumatoid arthritis with COPD: A real-world population-based observational study.

Suissa S, Hudson M, Dell'Aniello S, Shen S, Simon TA, Ernst P.

Semin Arthritis Rheum. 2019 Dec;49(3):366-372. doi: 10.1016/j.semarthrit.2019.03.007. Epub 2019 Mar 16.


Comparative Effectiveness and Safety of LABA-LAMA vs LABA-ICS Treatment of COPD in Real-World Clinical Practice.

Suissa S, Dell'Aniello S, Ernst P.

Chest. 2019 Jun;155(6):1158-1165. doi: 10.1016/j.chest.2019.03.005. Epub 2019 Mar 26.


Beta-Blockers in COPD: A Methodological Review of the Observational Studies.

Suissa S, Ernst P.

COPD. 2018 Oct;15(5):520-525. doi: 10.1080/15412555.2018.1554637. Review.


Highly active single-layer MoS2 catalysts synthesized by swift heavy ion irradiation.

Madauß L, Zegkinoglou I, Vázquez Muiños H, Choi YW, Kunze S, Zhao MQ, Naylor CH, Ernst P, Pollmann E, Ochedowski O, Lebius H, Benyagoub A, Ban-d'Etat B, Johnson ATC, Djurabekova F, Roldan Cuenya B, Schleberger M.

Nanoscale. 2018 Dec 13;10(48):22908-22916. doi: 10.1039/c8nr04696d.


Mitochondrial-Mediated Oxidative Ca2+/Calmodulin-Dependent Kinase II Activation Induces Early Afterdepolarizations in Guinea Pig Cardiomyocytes: An In Silico Study.

Yang R, Ernst P, Song J, Liu XM, Huke S, Wang S, Zhang JJ, Zhou L.

J Am Heart Assoc. 2018 Aug 7;7(15):e008939. doi: 10.1161/JAHA.118.008939.


A comprehensive understanding of the gut mucosal immune system in allergic inflammation.

Tokuhara D, Kurashima Y, Kamioka M, Nakayama T, Ernst P, Kiyono H.

Allergol Int. 2019 Jan;68(1):17-25. doi: 10.1016/j.alit.2018.09.004. Epub 2018 Oct 23. Review.


Comparative effectiveness of LABA-ICS versus LAMA as initial treatment in COPD targeted by blood eosinophils: a population-based cohort study.

Suissa S, Dell'Aniello S, Ernst P.

Lancet Respir Med. 2018 Nov;6(11):855-862. doi: 10.1016/S2213-2600(18)30368-0. Epub 2018 Oct 18.


Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P.

Exp Hematol. 2019 Jan;69:37-42. doi: 10.1016/j.exphem.2018.10.001. Epub 2018 Oct 10.


Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12.


Sequential rerandomization.

Zhou Q, Ernst PA, Morgan KL, Rubin DB, Zhang A.

Biometrika. 2018 Sep;105(3):745-752. doi: 10.1093/biomet/asy031. Epub 2018 Jun 24.


An Interface-Driven Design Strategy Yields a Novel, Corrugated Protein Architecture.

ElGamacy M, Coles M, Ernst P, Zhu H, Hartmann MD, Plückthun A, Lupas AN.

ACS Synth Biol. 2018 Sep 21;7(9):2226-2235. doi: 10.1021/acssynbio.8b00224. Epub 2018 Sep 4.


Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.

Zhao M, Fan C, Ernst PJ, Tang Y, Zhu H, Mattapally S, Oduk Y, Borovjagin AV, Zhou L, Zhang J, Zhu W.

Cardiovasc Res. 2019 Feb 1;115(2):343-356. doi: 10.1093/cvr/cvy207.


Blood eosinophils in COPD and the future risk of pneumonia.

Ernst P.

Eur Respir J. 2018 Jul 27;52(1). pii: 1800981. doi: 10.1183/13993003.00981-2018. Print 2018 Jul. No abstract available.


Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.

Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J.

Inflamm Bowel Dis. 2018 Oct 12;24(11):2366-2376. doi: 10.1093/ibd/izy214.


Judgements about double-embedded relative clauses differ between languages.

Frank SL, Ernst P.

Psychol Res. 2019 Oct;83(7):1581-1593. doi: 10.1007/s00426-018-1014-7. Epub 2018 Apr 23.


Observational Studies of Inhaled Corticosteroid Effectiveness in COPD: Lessons Learned.

Suissa S, Ernst P.

Chest. 2018 Aug;154(2):257-265. doi: 10.1016/j.chest.2018.04.006. Epub 2018 Apr 19. Review.


Of mice, men and immunity: a case for evolutionary systems biology.

Ernst PB, Carvunis AR.

Nat Immunol. 2018 May;19(5):421-425. doi: 10.1038/s41590-018-0084-4. No abstract available.


Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.

Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A.

Nat Commun. 2018 Jan 31;9(1):450. doi: 10.1038/s41467-017-02707-6.


MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.

Gan T, Li BE, Mishra BP, Jones KL, Ernst P.

J Immunol. 2018 Mar 1;200(5):1682-1691. doi: 10.4049/jimmunol.1701572. Epub 2018 Jan 19.


Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H.

Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.


Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity.

Hansen S, Stüber JC, Ernst P, Koch A, Bojar D, Batyuk A, Plückthun A.

Sci Rep. 2017 Nov 24;7(1):16292. doi: 10.1038/s41598-017-15711-z.


Lung cancer care trajectory at a Canadian centre: an evaluation of how wait times affect clinical outcomes.

Kasymjanova G, Small D, Cohen V, Jagoe RT, Batist G, Sateren W, Ernst P, Pepe C, Sakr L, Agulnik J.

Curr Oncol. 2017 Oct;24(5):302-309. doi: 10.3747/co.24.3611. Epub 2017 Oct 25.


Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study.

Jun M, Lix LM, Durand M, Dahl M, Paterson JM, Dormuth CR, Ernst P, Yao S, Renoux C, Tamim H, Wu C, Mahmud SM, Hemmelgarn BR; Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.

BMJ. 2017 Oct 17;359:j4323. doi: 10.1136/bmj.j4323.


ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.

Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S.

J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528.


Only SETBP1 hotspot mutations are associated with refractory disease in myeloid malignancies.

Winkelmann N, Schäfer V, Rinke J, Kaiser A, Ernst P, Scholl S, Hochhaus A, Ernst T.

J Cancer Res Clin Oncol. 2017 Dec;143(12):2511-2519. doi: 10.1007/s00432-017-2518-z. Epub 2017 Sep 14.


Applying the Care Group model to tuberculosis control: findings from a community-based project in Mozambique.

Brown A, Ernst P, Cambule A, Morrow M, Dortzbach D, Golub JE, Perry HB.

Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1086-1093. doi: 10.5588/ijtld.17.0179.


Curvature of designed armadillo repeat proteins allows modular peptide binding.

Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, Mittl PRE, Schuler B, Plückthun A.

J Struct Biol. 2018 Feb;201(2):108-117. doi: 10.1016/j.jsb.2017.08.009. Epub 2017 Aug 31.


Neuropsychiatric adverse effects of montelukast in children.

Ernst P, Ernst G.

Eur Respir J. 2017 Aug 17;50(2). pii: 1701020. doi: 10.1183/13993003.01020-2017. Print 2017 Aug. No abstract available.

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