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Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.

Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J.

Inflamm Bowel Dis. 2018 Jun 8. doi: 10.1093/ibd/izy214. [Epub ahead of print]


Judgements about double-embedded relative clauses differ between languages.

Frank SL, Ernst P.

Psychol Res. 2018 Apr 23. doi: 10.1007/s00426-018-1014-7. [Epub ahead of print]


Observational Studies of Inhaled Corticosteroid Effectiveness in COPD: Lessons Learned.

Suissa S, Ernst P.

Chest. 2018 Apr 19. pii: S0012-3692(18)30574-9. doi: 10.1016/j.chest.2018.04.006. [Epub ahead of print]


Of mice, men and immunity: a case for evolutionary systems biology.

Ernst PB, Carvunis AR.

Nat Immunol. 2018 May;19(5):421-425. doi: 10.1038/s41590-018-0084-4. No abstract available.


Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.

Schmid M, Ernst P, Honegger A, Suomalainen M, Zimmermann M, Braun L, Stauffer S, Thom C, Dreier B, Eibauer M, Kipar A, Vogel V, Greber UF, Medalia O, Plückthun A.

Nat Commun. 2018 Jan 31;9(1):450. doi: 10.1038/s41467-017-02707-6.


MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.

Gan T, Li BE, Mishra BP, Jones KL, Ernst P.

J Immunol. 2018 Mar 1;200(5):1682-1691. doi: 10.4049/jimmunol.1701572. Epub 2018 Jan 19.


Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H.

Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.


Design and applications of a clamp for Green Fluorescent Protein with picomolar affinity.

Hansen S, Stüber JC, Ernst P, Koch A, Bojar D, Batyuk A, Plückthun A.

Sci Rep. 2017 Nov 24;7(1):16292. doi: 10.1038/s41598-017-15711-z.


Lung cancer care trajectory at a Canadian centre: an evaluation of how wait times affect clinical outcomes.

Kasymjanova G, Small D, Cohen V, Jagoe RT, Batist G, Sateren W, Ernst P, Pepe C, Sakr L, Agulnik J.

Curr Oncol. 2017 Oct;24(5):302-309. doi: 10.3747/co.24.3611. Epub 2017 Oct 25.


Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study.

Jun M, Lix LM, Durand M, Dahl M, Paterson JM, Dormuth CR, Ernst P, Yao S, Renoux C, Tamim H, Wu C, Mahmud SM, Hemmelgarn BR; Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.

BMJ. 2017 Oct 17;359:j4323. doi: 10.1136/bmj.j4323.


ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.

Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S.

J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528.


Only SETBP1 hotspot mutations are associated with refractory disease in myeloid malignancies.

Winkelmann N, Schäfer V, Rinke J, Kaiser A, Ernst P, Scholl S, Hochhaus A, Ernst T.

J Cancer Res Clin Oncol. 2017 Dec;143(12):2511-2519. doi: 10.1007/s00432-017-2518-z. Epub 2017 Sep 14.


Applying the Care Group model to tuberculosis control: findings from a community-based project in Mozambique.

Brown A, Ernst P, Cambule A, Morrow M, Dortzbach D, Golub JE, Perry HB.

Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1086-1093. doi: 10.5588/ijtld.17.0179.


Curvature of designed armadillo repeat proteins allows modular peptide binding.

Hansen S, Ernst P, König SLB, Reichen C, Ewald C, Nettels D, Mittl PRE, Schuler B, Plückthun A.

J Struct Biol. 2018 Feb;201(2):108-117. doi: 10.1016/j.jsb.2017.08.009. Epub 2017 Aug 31.


Neuropsychiatric adverse effects of montelukast in children.

Ernst P, Ernst G.

Eur Respir J. 2017 Aug 17;50(2). pii: 1701020. doi: 10.1183/13993003.01020-2017. Print 2017 Aug. No abstract available.


Precision Medicine Urgency: The Case of Inhaled Corticosteroids in COPD.

Suissa S, Ernst P.

Chest. 2017 Aug;152(2):227-231. doi: 10.1016/j.chest.2017.05.020. No abstract available.


Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture.

Gonzalez AV, Coulombe J, Ernst P, Suissa S.

Chest. 2018 Feb;153(2):321-328. doi: 10.1016/j.chest.2017.07.002. Epub 2017 Jul 14.


Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.

Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LAB, Laferriere F, Maniecka Z, Plückthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M.

Nat Commun. 2017 Jun 29;8(1):45. doi: 10.1038/s41467-017-00062-0.


MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P.

Cancer Cell. 2017 Jun 12;31(6):755-770.e6. doi: 10.1016/j.ccell.2017.05.002.


Concurrent use of long-acting bronchodilators in COPD and the risk of adverse cardiovascular events.

Suissa S, Dell'Aniello S, Ernst P.

Eur Respir J. 2017 May 23;49(5). pii: 1602245. doi: 10.1183/13993003.02245-2016. Print 2017 May.


Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis.

Butcher LD, den Hartog G, Ernst PB, Crowe SE.

Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):316-322. doi: 10.1016/j.jcmgh.2017.02.002. eCollection 2017 May. Review.


Pneumonia risk in asthma patients using inhaled corticosteroids: a quasi-cohort study.

Qian CJ, Coulombe J, Suissa S, Ernst P.

Br J Clin Pharmacol. 2017 Sep;83(9):2077-2086. doi: 10.1111/bcp.13295. Epub 2017 May 7.


Distinct functions of histone H3, lysine 4 methyltransferases in normal and malignant hematopoiesis.

Yang W, Ernst P.

Curr Opin Hematol. 2017 Jul;24(4):322-328. doi: 10.1097/MOH.0000000000000346. Review.


Enablers and determinants of the provision of written action plans to patients with asthma: a stratified survey of Canadian physicians.

Djandji F, Lamontagne AJ, Blais L, Bacon SL, Ernst P, Grad R, Lavoie KL, McKinney ML, Desplats E, Ducharme FM.

NPJ Prim Care Respir Med. 2017 Mar 31;27(1):21. doi: 10.1038/s41533-017-0012-3.


Our New President- Sheila E. Crowe, MD.

Ernst PB.

Gastroenterology. 2017 May;152(6):1599-1604. doi: 10.1053/j.gastro.2017.03.028. Epub 2017 Mar 29. No abstract available.


The Risk of Sepsis with Inhaled and Oral Corticosteroids in Patients with COPD.

Ernst P, Coulombe J, Brassard P, Suissa S.

COPD. 2017 Apr;14(2):137-142. doi: 10.1080/15412555.2016.1238450. Epub 2016 Dec 23.


Androgen deprivation therapy for prostate cancer and the risk of hospitalisation for community-acquired pneumonia.

Hicks BM, Yin H, Bladou F, Ernst P, Azoulay L.

Thorax. 2017 Jul;72(7):596-597. doi: 10.1136/thoraxjnl-2016-209512. Epub 2016 Dec 16.


Statin potency and the risk of hospitalization for community-acquired pneumonia.

Shin JY, Eberg M, Ernst P, Filion KB.

Br J Clin Pharmacol. 2017 Jun;83(6):1319-1327. doi: 10.1111/bcp.13208. Epub 2017 Jan 29.


The Effectiveness of Web-Based Asthma Self-Management System, My Asthma Portal (MAP): A Pilot Randomized Controlled Trial.

Ahmed S, Ernst P, Bartlett SJ, Valois MF, Zaihra T, Paré G, Grad R, Eilayyan O, Perreault R, Tamblyn R.

J Med Internet Res. 2016 Dec 1;18(12):e313.


NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.

Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA.

Cancer Cell. 2016 Dec 12;30(6):863-878. doi: 10.1016/j.ccell.2016.10.019. Epub 2016 Nov 23.


Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.

Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, Meyerson M.

Cancer Biol Ther. 2016 Dec;17(12):1274-1281. doi: 10.1080/15384047.2016.1250986. Epub 2016 Nov 1.


SET/MLL family proteins in hematopoiesis and leukemia.

Yang W, Ernst P.

Int J Hematol. 2017 Jan;105(1):7-16. doi: 10.1007/s12185-016-2118-8. Epub 2016 Oct 31. Review.


Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.

Reichen C, Hansen S, Forzani C, Honegger A, Fleishman SJ, Zhou T, Parmeggiani F, Ernst P, Madhurantakam C, Ewald C, Mittl PRE, Zerbe O, Baker D, Caflisch A, Plückthun A.

J Mol Biol. 2016 Nov 6;428(22):4467-4489. doi: 10.1016/j.jmb.2016.09.012. Epub 2016 Sep 21.


Physician agreement regarding the expansion of pharmacist professional activities in the management of patients with asthma.

Tilly-Gratton A, Lamontagne A, Blais L, Bacon SL, Ernst P, Grad R, Lavoie KL, McKinney ML, Desplats E, Ducharme FM.

Int J Pharm Pract. 2017 Oct;25(5):335-342. doi: 10.1111/ijpp.12320. Epub 2016 Oct 24.


The effect of statins on influenza-like illness morbidity and mortality.

Brassard P, Wu JW, Ernst P, Dell'Aniello S, Smiechowski B, Suissa S.

Pharmacoepidemiol Drug Saf. 2017 Jan;26(1):63-70. doi: 10.1002/pds.4112. Epub 2016 Sep 30.


Advances in the design and engineering of peptide-binding repeat proteins.

Ernst P, Plückthun A.

Biol Chem. 2017 Jan 1;398(1):23-29. doi: 10.1515/hsz-2016-0233. Review.


Long-Acting Bronchodilator Initiation in COPD and the Risk of Adverse Cardiopulmonary Events: A Population-Based Comparative Safety Study.

Suissa S, Dell'Aniello S, Ernst P.

Chest. 2017 Jan;151(1):60-67. doi: 10.1016/j.chest.2016.08.001. Epub 2016 Aug 20.


Neuronal Deletion of Kmt2a/Mll1 Histone Methyltransferase in Ventral Striatum is Associated with Defective Spike-Timing-Dependent Striatal Synaptic Plasticity, Altered Response to Dopaminergic Drugs, and Increased Anxiety.

Shen EY, Jiang Y, Javidfar B, Kassim B, Loh YE, Ma Q, Mitchell AC, Pothula V, Stewart AF, Ernst P, Yao WD, Martin G, Shen L, Jakovcevski M, Akbarian S.

Neuropsychopharmacology. 2016 Dec;41(13):3103-3113. doi: 10.1038/npp.2016.144. Epub 2016 Aug 3.


Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis.

Azoulay L, Filion KB, Platt RW, Dahl M, Dormuth CR, Clemens KK, Durand M, Hu N, Juurlink DN, Paterson JM, Targownik LE, Turin TC, Ernst P; and the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators, Suissa S, Dormuth CR, Hemmelgarn BR, Teare GF, Caetano P, Chateau D, Henry DA, Paterson JM, LeLorier J, Levy AR, Ernst P, Platt RW, Sketris IS.

JAMA Intern Med. 2016 Oct 1;176(10):1464-1473. doi: 10.1001/jamainternmed.2016.1522.


Enablers of Physician Prescription of a Long-Term Asthma Controller in Patients with Persistent Asthma.

Ducharme FM, Lamontagne AJ, Blais L, Grad R, Lavoie KL, Bacon SL, McKinney ML, Desplats E, Ernst P.

Can Respir J. 2016;2016:4169010. doi: 10.1155/2016/4169010. Epub 2016 Jun 15.


Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.

Watanabe T, Ernst P.

Cancer Cell. 2016 Jul 11;30(1):3-5. doi: 10.1016/j.ccell.2016.06.011.


Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK.

Science. 2016 May 27;352(6289):1116-20. doi: 10.1126/science.aad9948. Epub 2016 May 5.


Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.

Renoux C, Dell'Aniello S, Khairy P, Marras C, Bugden S, Turin TC, Blais L, Tamim H, Evans C, Steele R, Dormuth C, Ernst P; Canadian Network for Observational Drug Effect Studies (CNODES) investigators.

Br J Clin Pharmacol. 2016 Aug;82(2):461-72. doi: 10.1111/bcp.12964. Epub 2016 May 19.


A Multicenter Observational Study of Incretin-based Drugs and Heart Failure.

Filion KB, Azoulay L, Platt RW, Dahl M, Dormuth CR, Clemens KK, Hu N, Paterson JM, Targownik L, Turin TC, Udell JA, Ernst P; CNODES Investigators.

N Engl J Med. 2016 Mar 24;374(12):1145-54. doi: 10.1056/NEJMoa1506115.


Splenic irradiation before hematopoietic stem cell transplantation for chronic myeloid leukemia: long-term follow-up of a prospective randomized study.

Gratwohl A, Iacobelli S, Bootsman N, van Biezen A, Baldomero H, Arcese W, Arnold R, Bron D, Cordonnier C, Ernst P, Ferrant A, Frassoni F, Gahrton G, Richard C, Kolb HJ, Link H, Niederwieser D, Ruutu T, Schattenberg A, Schmitz N, Torres-Gomez A, Zwaan F, Apperley J, Olavarria E, Kröger N; Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation EBMT.

Ann Hematol. 2016 May;95(6):967-72. doi: 10.1007/s00277-016-2638-6. Epub 2016 Mar 19.


MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.

Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM.

J Clin Invest. 2016 Apr 1;126(4):1438-50. doi: 10.1172/JCI80825. Epub 2016 Feb 29.


Incretin based drugs and the risk of pancreatic cancer: international multicentre cohort study.

Azoulay L, Filion KB, Platt RW, Dahl M, Dormuth CR, Clemens KK, Durand M, Juurlink DN, Targownik LE, Turin TC, Paterson JM, Ernst P; Canadian Network for Observational Drug Effect Studies Investigators.

BMJ. 2016 Feb 17;352:i581. doi: 10.1136/bmj.i581.


ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome.

Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB.

Cell Mol Gastroenterol Hepatol. 2015 Apr 1;1(3):311-324.


Inflammatory bowel disease and risk of mortality in COPD.

Vutcovici M, Bitton A, Ernst P, Kezouh A, Suissa S, Brassard P.

Eur Respir J. 2016 May;47(5):1357-64. doi: 10.1183/13993003.01945-2015. Epub 2016 Feb 11.


Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia.

den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE.

PLoS Pathog. 2016 Jan 13;12(1):e1005382. doi: 10.1371/journal.ppat.1005382. eCollection 2016 Jan.

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