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A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.

Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP.

J Mol Biol. 2018 Oct 19;430(21):4102-4118. doi: 10.1016/j.jmb.2018.08.009. Epub 2018 Aug 16.


Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE.

Nature. 2018 Sep;561(7724):E44. doi: 10.1038/s41586-018-0302-0.


Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE.

Nature. 2018 Jun;558(7711):553-558. doi: 10.1038/s41586-018-0215-y. Epub 2018 Jun 13. Erratum in: Nature. 2018 Jun 21;:.


Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.

Ye L, Neale C, Sljoka A, Lyda B, Pichugin D, Tsuchimura N, Larda ST, Pomès R, García AE, Ernst OP, Sunahara RK, Prosser RS.

Nat Commun. 2018 Apr 10;9(1):1372. doi: 10.1038/s41467-018-03314-9.


Gi- and Gs-coupled GPCRs show different modes of G-protein binding.

Van Eps N, Altenbach C, Caro LN, Latorraca NR, Hollingsworth SA, Dror RO, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2383-2388. doi: 10.1073/pnas.1721896115. Epub 2018 Feb 20.


High-throughput in situ X-ray screening of and data collection from protein crystals at room temperature and under cryogenic conditions.

Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP.

Nat Protoc. 2018 Feb;13(2):260-292. doi: 10.1038/nprot.2017.135. Epub 2018 Jan 4.


Structure of the glucagon receptor in complex with a glucagon analogue.

Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, Hanson MA, Stevens RC, Wang MW, Reedtz-Runge S, Jiang H, Zhao Q, Wu B.

Nature. 2018 Jan 3;553(7686):106-110. doi: 10.1038/nature25153.


Accessible virtual reality of biomolecular structural models using the Autodesk Molecule Viewer.

Balo AR, Wang M, Ernst OP.

Nat Methods. 2017 Nov 30;14(12):1122-1123. doi: 10.1038/nmeth.4506. No abstract available.


Utilizing tagged paramagnetic shift reagents to monitor protein dynamics by NMR.

Ye L, Van Eps N, Li X, Ernst OP, Prosser RS.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1555-1563. doi: 10.1016/j.bbapap.2017.09.011. Epub 2017 Sep 22.


Recent advances in biophysical studies of rhodopsins - Oligomerization, folding, and structure.

Brown LS, Ernst OP.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1512-1521. doi: 10.1016/j.bbapap.2017.08.007. Epub 2017 Aug 24. Review.


Light-independent phospholipid scramblase activity of bacteriorhodopsin from Halobacterium salinarum.

Verchère A, Ou WL, Ploier B, Morizumi T, Goren MA, Bütikofer P, Ernst OP, Khelashvili G, Menon AK.

Sci Rep. 2017 Aug 25;7(1):9522. doi: 10.1038/s41598-017-09835-5.


Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE.

Cell. 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.


Molecular assembly of rhodopsin with G protein-coupled receptor kinases.

He Y, Gao X, Goswami D, Hou L, Pal K, Yin Y, Zhao G, Ernst OP, Griffin P, Melcher K, Xu HE.

Cell Res. 2017 Jun;27(6):728-747. doi: 10.1038/cr.2017.72. Epub 2017 May 19.


X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization.

Schieferstein JM, Pawate AS, Sun C, Wan F, Sheraden PN, Broecker J, Ernst OP, Gennis RB, Kenis PJA.

Biomicrofluidics. 2017 Apr 24;11(2):024118. doi: 10.1063/1.4981818. eCollection 2017 Mar.


Low-dose fixed-target serial synchrotron crystallography.

Owen RL, Axford D, Sherrell DA, Kuo A, Ernst OP, Schulz EC, Miller RJ, Mueller-Werkmeister HM.

Acta Crystallogr D Struct Biol. 2017 Apr 1;73(Pt 4):373-378. doi: 10.1107/S2059798317002996. Epub 2017 Mar 31.


Conformational equilibria of light-activated rhodopsin in nanodiscs.

Van Eps N, Caro LN, Morizumi T, Kusnetzow AK, Szczepek M, Hofmann KP, Bayburt TH, Sligar SG, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3268-E3275. doi: 10.1073/pnas.1620405114. Epub 2017 Apr 3.


The Primary Photochemistry of Vision Occurs at the Molecular Speed Limit.

Johnson PJM, Farag MH, Halpin A, Morizumi T, Prokhorenko VI, Knoester J, Jansen TLC, Ernst OP, Miller RJD.

J Phys Chem B. 2017 Apr 27;121(16):4040-4047. doi: 10.1021/acs.jpcb.7b02329. Epub 2017 Apr 13.


A Versatile System for High-Throughput In Situ X-ray Screening and Data Collection of Soluble and Membrane-Protein Crystals.

Broecker J, Klingel V, Ou WL, Balo AR, Kissick DJ, Ogata CM, Kuo A, Ernst OP.

Cryst Growth Des. 2016 Nov 2;16(11):6318-6326. doi: 10.1021/acs.cgd.6b00950. Epub 2016 Oct 3.


Erratum to: 7TM Domain Structure of Adhesion GPCRs.

Nijmeijer S, Wolf S, Ernst OP, de Graaf C.

Handb Exp Pharmacol. 2016;234:E1. doi: 10.1007/978-3-319-41523-9_18. No abstract available.


Crystallogenesis of Membrane Proteins Mediated by Polymer-Bounded Lipid Nanodiscs.

Broecker J, Eger BT, Ernst OP.

Structure. 2017 Feb 7;25(2):384-392. doi: 10.1016/j.str.2016.12.004. Epub 2017 Jan 12.


7TM Domain Structure of Adhesion GPCRs.

de Graaf C, Nijmeijer S, Wolf S, Ernst OP.

Handb Exp Pharmacol. 2016;234:43-66. Review.


Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK.

Nat Commun. 2016 Oct 3;7:12832. doi: 10.1038/ncomms12832.


Toward Precise Interpretation of DEER-Based Distance Distributions: Insights from Structural Characterization of V1 Spin-Labeled Side Chains.

Balo AR, Feyrer H, Ernst OP.

Biochemistry. 2016 Sep 20;55(37):5256-63. doi: 10.1021/acs.biochem.6b00608. Epub 2016 Sep 2.


TakeTwo: an indexing algorithm suited to still images with known crystal parameters.

Ginn HM, Roedig P, Kuo A, Evans G, Sauter NK, Ernst OP, Meents A, Mueller-Werkmeister H, Miller RJ, Stuart DI.

Acta Crystallogr D Struct Biol. 2016 Aug;72(Pt 8):956-65. doi: 10.1107/S2059798316010706. Epub 2016 Jul 28.


Fixed target combined with spectral mapping: approaching 100% hit rates for serial crystallography.

Oghbaey S, Sarracini A, Ginn HM, Pare-Labrosse O, Kuo A, Marx A, Epp SW, Sherrell DA, Eger BT, Zhong Y, Loch R, Mariani V, Alonso-Mori R, Nelson S, Lemke HT, Owen RL, Pearson AR, Stuart DI, Ernst OP, Mueller-Werkmeister HM, Miller RJ.

Acta Crystallogr D Struct Biol. 2016 Aug;72(Pt 8):944-55. doi: 10.1107/S2059798316010834. Epub 2016 Jul 27.


Activation of the A2A adenosine G-protein-coupled receptor by conformational selection.

Ye L, Van Eps N, Zimmer M, Ernst OP, Prosser RS.

Nature. 2016 May 12;533(7602):265-8. doi: 10.1038/nature17668. Epub 2016 May 4.


Fixed target matrix for femtosecond time-resolved and in situ serial micro-crystallography.

Mueller C, Marx A, Epp SW, Zhong Y, Kuo A, Balo AR, Soman J, Schotte F, Lemke HT, Owen RL, Pai EF, Pearson AR, Olson JS, Anfinrud PA, Ernst OP, Dwayne Miller RJ.

Struct Dyn. 2015 Aug 18;2(5):054302. doi: 10.1063/1.4928706. eCollection 2015 Sep.


Local vibrational coherences drive the primary photochemistry of vision.

Johnson PJ, Halpin A, Morizumi T, Prokhorenko VI, Ernst OP, Miller RJ.

Nat Chem. 2015 Dec;7(12):980-6. doi: 10.1038/nchem.2398. Epub 2015 Nov 16.


The effect of phosphorylation on arrestin-rhodopsin interaction in the squid visual system.

Robinson KA, Ou WL, Guan X, Sugamori KS, Bandyopadhyay A, Ernst OP, Mitchell J.

J Neurochem. 2015 Dec;135(6):1129-39. doi: 10.1111/jnc.13366. Epub 2015 Oct 28.


Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE.

Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.


Phospholipid scrambling by rhodopsin.

Ernst OP, Menon AK.

Photochem Photobiol Sci. 2015 Nov;14(11):1922-31. doi: 10.1039/c5pp00195a. Review.


Characterizing rhodopsin signaling by EPR spectroscopy: from structure to dynamics.

Van Eps N, Caro LN, Morizumi T, Ernst OP.

Photochem Photobiol Sci. 2015 Sep 26;14(9):1586-97. doi: 10.1039/c5pp00191a. Epub 2015 Jul 3. Review.


Rapid and facile recombinant expression of bovine rhodopsin in HEK293S GnTI(-) cells using a PiggyBac inducible system.

Caro LN, Li Z, Balo AR, Van Eps N, Rini JM, Ernst OP.

Methods Enzymol. 2015;556:307-30. doi: 10.1016/bs.mie.2015.01.005. Epub 2015 Mar 21.


Does ketamine target olfactory receptors in the brain?

Wolf S, Hatt H, Ernst OP.

Sci Signal. 2015 Mar 31;8(370):fs6. doi: 10.1126/scisignal.aab0600.


Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

Goren MA, Morizumi T, Menon I, Joseph JS, Dittman JS, Cherezov V, Stevens RC, Ernst OP, Menon AK.

Nat Commun. 2014 Oct 8;5:5115. doi: 10.1038/ncomms6115.


The photocycle and ultrafast vibrational dynamics of bacteriorhodopsin in lipid nanodiscs.

Johnson PJ, Halpin A, Morizumi T, Brown LS, Prokhorenko VI, Ernst OP, Dwayne Miller RJ.

Phys Chem Chem Phys. 2014 Oct 21;16(39):21310-20. doi: 10.1039/c4cp01826e. Epub 2014 Sep 1.


Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor.

Redka DS, Morizumi T, Elmslie G, Paranthaman P, Shivnaraine RV, Ellis J, Ernst OP, Wells JW.

J Biol Chem. 2014 Aug 29;289(35):24347-65. doi: 10.1074/jbc.M114.559294. Epub 2014 Jul 14.


Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.

Ernst OP, Lodowski DT, Elstner M, Hegemann P, Brown LS, Kandori H.

Chem Rev. 2014 Jan 8;114(1):126-63. doi: 10.1021/cr4003769. Epub 2013 Dec 23. Review. No abstract available.


Opsin, a structural model for olfactory receptors?

Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP.

Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. Epub 2013 Aug 26.


Crystal structure of pre-activated arrestin p44.

Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME.

Nature. 2013 May 2;497(7447):142-6. doi: 10.1038/nature12133. Epub 2013 Apr 21.


Conformation of receptor-bound visual arrestin.

Kim M, Vishnivetskiy SA, Van Eps N, Alexander NS, Cleghorn WM, Zhan X, Hanson SM, Morizumi T, Ernst OP, Meiler J, Gurevich VV, Hubbell WL.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18407-12. doi: 10.1073/pnas.1216304109. Epub 2012 Oct 22.


Engineering of an artificial light-modulated potassium channel.

Caro LN, Moreau CJ, Estrada-Mondragón A, Ernst OP, Vivaudou M.

PLoS One. 2012;7(8):e43766. doi: 10.1371/journal.pone.0043766. Epub 2012 Aug 22.


Effect of channel mutations on the uptake and release of the retinal ligand in opsin.

Piechnick R, Ritter E, Hildebrand PW, Ernst OP, Scheerer P, Hofmann KP, Heck M.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5247-52. doi: 10.1073/pnas.1117268109. Epub 2012 Mar 19.


Structural biology: Ion channel in the spotlight.

Ernst OP, Sakmar TP.

Nature. 2012 Feb 15;482(7385):318-9. doi: 10.1038/482318a. No abstract available.


G protein-coupled receptor modulation with pepducins: moving closer to the clinic.

Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SW 3rd.

Ann N Y Acad Sci. 2011 May;1226:34-49. doi: 10.1111/j.1749-6632.2011.06039.x.


Conserved Tyr223(5.58) plays different roles in the activation and G-protein interaction of rhodopsin.

Elgeti M, Kazmin R, Heck M, Morizumi T, Ritter E, Scheerer P, Ernst OP, Siebert F, Hofmann KP, Bartl FJ.

J Am Chem Soc. 2011 May 11;133(18):7159-65. doi: 10.1021/ja200545n. Epub 2011 Apr 20.


Crystal structure of metarhodopsin II.

Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP.

Nature. 2011 Mar 31;471(7340):651-5. doi: 10.1038/nature09789. Epub 2011 Mar 9.


Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding.

Bayburt TH, Vishnivetskiy SA, McLean MA, Morizumi T, Huang CC, Tesmer JJ, Ernst OP, Sligar SG, Gurevich VV.

J Biol Chem. 2011 Jan 14;286(2):1420-8. doi: 10.1074/jbc.M110.151043. Epub 2010 Oct 21.


Transmembrane signaling by GPCRs: insight from rhodopsin and opsin structures.

Choe HW, Park JH, Kim YJ, Ernst OP.

Neuropharmacology. 2011 Jan;60(1):52-7. doi: 10.1016/j.neuropharm.2010.07.018. Epub 2010 Aug 12. Review.


A photo-cross-linking strategy to map sites of protein-protein interactions.

Chen Y, Wu Y, Henklein P, Li X, Hofmann KP, Nakanishi K, Ernst OP.

Chemistry. 2010 Jul 5;16(25):7389-94. doi: 10.1002/chem.201000441. No abstract available.


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