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Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacterium tuberculosis in Macaques.

Foreman TW, Bucşan AN, Mehra S, Peloquin C, Doyle LA, Russell-Lodrigue K, Gandhi NR, Altman J, Day CL, Ernst JD, Blumberg HM, Rengarajan J, Kaushal D; TBRU-ASTRa Study Group.

Am J Respir Crit Care Med. 2019 Oct 24. doi: 10.1164/rccm.201903-0646OC. [Epub ahead of print]


Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil.

Rivera-Correa J, de Siqueira IC, Mota S, do Rosário MS, Pereira de Jesus PA, Alcantara LCJ, Ernst JD, Rodriguez A.

PLoS Negl Trop Dis. 2019 Sep 17;13(9):e0007695. doi: 10.1371/journal.pntd.0007695. eCollection 2019 Sep.


Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay.

Ernst JD, Cornelius A, Bolz M.

mBio. 2019 Apr 23;10(2). pii: e00611-19. doi: 10.1128/mBio.00611-19.


Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention.

Norris BA, Ernst JD.

PLoS Pathog. 2018 Oct 26;14(10):e1007154. doi: 10.1371/journal.ppat.1007154. eCollection 2018 Oct.


Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design.

Ernst JD.

Cell Host Microbe. 2018 Jul 11;24(1):34-42. doi: 10.1016/j.chom.2018.06.004. Review.


Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation.

Ernst JD, Cornelius A, Desvignes L, Tavs J, Norris BA.

J Infect Dis. 2018 Oct 5;218(10):1653-1662. doi: 10.1093/infdis/jiy142.


A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.

Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL; TBRU-ASTRa Study Group.

J Immunol. 2018 Apr 15;200(8):3008-3019. doi: 10.4049/jimmunol.1701737. Epub 2018 Mar 14.


Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis.

Ernst JD.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):706-707. doi: 10.1164/rccm.201712-2368ED. No abstract available.


Antigenic Variation and Immune Escape in the MTBC.

Ernst JD.

Adv Exp Med Biol. 2017;1019:171-190. doi: 10.1007/978-3-319-64371-7_9. Review.


Fishing for Answers in Human Mycobacterial Infections.

Bolz M, Ernst JD.

Immunity. 2017 Sep 19;47(3):395-397. doi: 10.1016/j.immuni.2017.09.005.


"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report.

Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H.

Vaccine. 2017 Jun 14;35(27):3433-3440. doi: 10.1016/j.vaccine.2017.04.007. Epub 2017 May 2.


Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.

Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst JD; TBRU-ASTRa Study Team.

Hum Immunol. 2017 Apr;78(4):325-326. doi: 10.1016/j.humimm.2017.03.007. Epub 2017 Mar 16.


Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity.

Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst JD.

PLoS Pathog. 2016 Dec 14;12(12):e1006111. doi: 10.1371/journal.ppat.1006111. eCollection 2016 Dec.


Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation.

Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR Jr, Philips JA.

Nat Microbiol. 2016 Dec 5;2:16232. doi: 10.1038/nmicrobiol.2016.232.


Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection.

Wiens KE, Ernst JD.

J Infect Dis. 2016 Dec 15;214(12):1893-1896. Epub 2016 Oct 31.


The Challenge of Latent TB Infection.

Blumberg HM, Ernst JD.

JAMA. 2016 Sep 6;316(9):931-3. doi: 10.1001/jama.2016.11021. No abstract available.


The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.

Wiens KE, Ernst JD.

PLoS Pathog. 2016 Aug 8;12(8):e1005809. doi: 10.1371/journal.ppat.1005809. eCollection 2016 Aug.


A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A.

PLoS Pathog. 2016 Jul 13;12(7):e1005760. doi: 10.1371/journal.ppat.1005760. eCollection 2016 Jul.


Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.

Srivastava S, Grace PS, Ernst JD.

Cell Host Microbe. 2016 Jan 13;19(1):44-54. doi: 10.1016/j.chom.2015.12.003.


Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N.

PLoS Pathog. 2015 Dec 9;11(12):e1005336. doi: 10.1371/journal.ppat.1005336. eCollection 2015 Dec.


M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.

Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S.

Cell Host Microbe. 2015 Nov 11;18(5):538-48.


Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo.

Grace PS, Ernst JD.

J Immunol. 2016 Jan 1;196(1):357-64. doi: 10.4049/jimmunol.1501494. Epub 2015 Nov 16.


STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.

Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S.

J Clin Invest. 2015 Jun;125(6):2347-62. doi: 10.1172/JCI80273. Epub 2015 May 4.


In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.

Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB.

Chem Biol. 2015 Apr 23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.


Beyond macrophages: the diversity of mononuclear cells in tuberculosis.

Srivastava S, Ernst JD, Desvignes L.

Immunol Rev. 2014 Nov;262(1):179-92. doi: 10.1111/imr.12217. Review.


LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.

Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N.

PLoS Pathog. 2014 Sep 18;10(9):e1004376. doi: 10.1371/journal.ppat.1004376. eCollection 2014 Sep. Erratum in: PLoS Pathog. 2014 Oct;10(10):e1004489. PLoS Pathog. 2014 Oct;10(10):e1004494. Gibbs, Sara [corrected to González-Nilo, Fernando D]. PLoS Pathog. 2015 Dec 9;11(12):e1005336.


Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG).

Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst JD.

Vaccine. 2014 Oct 14;32(45):5998-6004. doi: 10.1016/j.vaccine.2014.07.113. Epub 2014 Sep 6.


Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming.

Srivastava S, Ernst JD.

Cell Host Microbe. 2014 Jun 11;15(6):741-52. doi: 10.1016/j.chom.2014.05.007.


Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.

Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst JD.

mBio. 2014 Jan 14;5(1):e00960-13. doi: 10.1128/mBio.00960-13.


Equivalent T cell epitope promiscuity in ecologically diverse human pathogens.

Wiens KE, Swaminathan H, Copin R, Lun DS, Ernst JD.

PLoS One. 2013 Aug 9;8(8):e73124. doi: 10.1371/journal.pone.0073124. eCollection 2013.


Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo.

Srivastava S, Ernst JD.

J Immunol. 2013 Aug 1;191(3):1016-20. doi: 10.4049/jimmunol.1301236. Epub 2013 Jul 1.


Taking sides: interferons in leprosy.

Desvignes LP, Ernst JD.

Cell Host Microbe. 2013 Apr 17;13(4):377-8. doi: 10.1016/j.chom.2013.04.001.


Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects.

Fan L, Xiao HP, Hu ZY, Ernst JD.

PLoS One. 2012;7(8):e42716. doi: 10.1371/journal.pone.0042716. Epub 2012 Aug 6.


CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.

Bold TD, Ernst JD.

J Immunol. 2012 Sep 1;189(5):2530-6. doi: 10.4049/jimmunol.1200994. Epub 2012 Jul 25.


The immunological life cycle of tuberculosis.

Ernst JD.

Nat Rev Immunol. 2012 Jul 13;12(8):581-91. doi: 10.1038/nri3259. Review.


Meeting report: The International Conference on Human Immunity to Tuberculosis.

Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J.

Tuberculosis (Edinb). 2012 Sep;92(5):440-4. doi: 10.1016/ Epub 2012 Jun 2.


Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis.

Desvignes L, Wolf AJ, Ernst JD.

J Immunol. 2012 Jun 15;188(12):6205-15. doi: 10.4049/jimmunol.1200255. Epub 2012 May 7.


Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6.

Bold TD, Davis DC, Penberthy KK, Cox LM, Ernst JD, de Jong BC.

J Infect Dis. 2012 Mar 15;205(6):984-90. doi: 10.1093/infdis/jir883. Epub 2012 Feb 1.


Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells.

Blomgran R, Desvignes L, Briken V, Ernst JD.

Cell Host Microbe. 2012 Jan 19;11(1):81-90. doi: 10.1016/j.chom.2011.11.012.


Tuberculosis pathogenesis and immunity.

Philips JA, Ernst JD.

Annu Rev Pathol. 2012;7:353-84. doi: 10.1146/annurev-pathol-011811-132458. Epub 2011 Oct 31. Review.


Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo.

Bold TD, Banaei N, Wolf AJ, Ernst JD.

PLoS Pathog. 2011 May;7(5):e1002063. doi: 10.1371/journal.ppat.1002063. Epub 2011 May 26.


Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection.

Blomgran R, Ernst JD.

J Immunol. 2011 Jun 15;186(12):7110-9. doi: 10.4049/jimmunol.1100001. Epub 2011 May 9.


HIV and tuberculosis: a deadly human syndemic.

Kwan CK, Ernst JD.

Clin Microbiol Rev. 2011 Apr;24(2):351-76. doi: 10.1128/CMR.00042-10. Review.


Directly observing therapy: a new view of drug tolerance in tuberculosis.

Philips JA, Ernst JD.

Cell. 2011 Apr 1;145(1):13-4. doi: 10.1016/j.cell.2011.02.041.


Initiation and regulation of T-cell responses in tuberculosis.

Urdahl KB, Shafiani S, Ernst JD.

Mucosal Immunol. 2011 May;4(3):288-93. doi: 10.1038/mi.2011.10. Epub 2011 Mar 30. Review.


Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.

Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S.

Nat Genet. 2010 Jun;42(6):498-503. doi: 10.1038/ng.590. Epub 2010 May 23.


Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis.

Desvignes L, Ernst JD.

Immunity. 2009 Dec 18;31(6):974-85. doi: 10.1016/j.immuni.2009.10.007.


Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice.

Olmos S, Stukes S, Ernst JD.

J Immunol. 2010 Jan 15;184(2):895-901. doi: 10.4049/jimmunol.0901230. Epub 2009 Dec 9.


TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms.

Benson SA, Ernst JD.

PLoS One. 2009 Jul 24;4(7):e6329. doi: 10.1371/journal.pone.0006329.


Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green.

Banaei N, Kincaid EZ, Lin SY, Desmond E, Jacobs WR Jr, Ernst JD.

Antimicrob Agents Chemother. 2009 Sep;53(9):3799-802. doi: 10.1128/AAC.00647-09. Epub 2009 Jul 13.

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