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Items: 1 to 50 of 218

1.

Erratum: The impact of PI 5-phosphatases on phosphoinositides in cell function and human disease.

Ramos AR, Ghosh S, Erneux C.

J Lipid Res. 2019 May;60(5):1065. doi: 10.1194/jlr.R087908ERR. No abstract available.

2.

Potentiation of imatinib by cilostazol in sensitive and resistant gastrointestinal stromal tumor cell lines involves YAP inhibition.

Vandenberghe P, Delvaux M, Hagué P, Erneux C, Vanderwinden JM.

Oncotarget. 2019 Mar 5;10(19):1798-1811. doi: 10.18632/oncotarget.26734. eCollection 2019 Mar 5.

3.

Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma.

Ramos AR, Ghosh S, Dedobbeleer M, Robe PA, Rogister B, Erneux C.

FEBS J. 2019 Mar;286(6):1120-1135. doi: 10.1111/febs.14769. Epub 2019 Feb 16.

PMID:
30695232
4.

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.

Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P.

Sci Signal. 2018 Sep 18;11(548). pii: eaap8608. doi: 10.1126/scisignal.aap8608.

PMID:
30228226
5.

The impact of phosphoinositide 5-phosphatases on phosphoinositides in cell function and human disease.

Ramos AR, Ghosh S, Erneux C.

J Lipid Res. 2019 Feb;60(2):276-286. doi: 10.1194/jlr.R087908. Epub 2018 Sep 7. Erratum in: J Lipid Res. 2019 May;60(5):1065.

PMID:
30194087
6.

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells.

Ghosh S, Scozzaro S, Ramos AR, Delcambre S, Chevalier C, Krejci P, Erneux C.

J Cell Sci. 2018 Aug 16;131(16). pii: jcs216408. doi: 10.1242/jcs.216408.

7.

Phosphoinositide 5-phosphatase activities control cell motility in glioblastoma: Two phosphoinositides PI(4,5)P2 and PI(3,4)P2 are involved.

Ramos AR, Elong Edimo W, Erneux C.

Adv Biol Regul. 2018 Jan;67:40-48. doi: 10.1016/j.jbior.2017.09.001. Epub 2017 Sep 5. Review.

PMID:
28916189
8.

Fibroblasts derived from patients with opsismodysplasia display SHIP2-specific cell migration and adhesion defects.

Ghosh S, Huber C, Siour Q, Sousa SB, Wright M, Cormier-Daire V, Erneux C.

Hum Mutat. 2017 Dec;38(12):1731-1739. doi: 10.1002/humu.23321. Epub 2017 Sep 21.

PMID:
28869677
9.

The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells.

Sun CH, Wacquier B, Aguilar DI, Carayol N, Denis K, Boucherie S, Valencia-Gallardo C, Simsek C, Erneux C, Lehman A, Enninga J, Arbibe L, Sansonetti P, Dupont G, Combettes L, Tran Van Nhieu G.

EMBO J. 2017 Sep 1;36(17):2567-2580. doi: 10.15252/embj.201696272. Epub 2017 Jul 12.

10.

Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST).

Vandenberghe P, Hagué P, Hockman SC, Manganiello VC, Demetter P, Erneux C, Vanderwinden JM.

Oncotarget. 2017 Jun 20;8(25):41026-41043. doi: 10.18632/oncotarget.17010.

11.

Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep.

Foley J, Blutstein T, Lee S, Erneux C, Halassa MM, Haydon P.

Front Neural Circuits. 2017 Jan 23;11:3. doi: 10.3389/fncir.2017.00003. eCollection 2017.

12.

SHIP2: Structure, Function and Inhibition.

Thomas MP, Erneux C, Potter BV.

Chembiochem. 2017 Feb 1;18(3):233-247. doi: 10.1002/cbic.201600541. Epub 2017 Jan 10. Review.

PMID:
27907247
13.

IPMK and β-catenin mediate PLC-β1-dependent signaling in myogenic differentiation.

Ramazzotti G, Billi AM, Manzoli L, Mazzetti C, Ruggeri A, Erneux C, Kim S, Suh PG, Cocco L, Faenza I.

Oncotarget. 2016 Dec 20;7(51):84118-84127. doi: 10.18632/oncotarget.11527.

14.

The SHIP2 interactor Myo1c is required for cell migration in 1321 N1 glioblastoma cells.

Edimo WE, Ramos AR, Ghosh S, Vanderwinden JM, Erneux C.

Biochem Biophys Res Commun. 2016 Aug 5;476(4):508-514. doi: 10.1016/j.bbrc.2016.05.154. Epub 2016 May 28.

PMID:
27246739
15.

Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice.

Scoumanne A, Molina-Ortiz P, Monteyne D, Perez-Morga D, Erneux C, Schurmans S.

Adv Biol Regul. 2016 Sep;62:1-10. doi: 10.1016/j.jbior.2016.03.001. Epub 2016 Mar 22.

16.

New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer.

Erneux C, Ghosh S, Ramos AR, Edimo WE.

Curr Pharm Des. 2016;22(16):2309-14. Review.

PMID:
26916021
17.

SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells.

Elong Edimo W, Ghosh S, Derua R, Janssens V, Waelkens E, Vanderwinden JM, Robe P, Erneux C.

J Cell Sci. 2016 Mar 15;129(6):1101-14. doi: 10.1242/jcs.179663. Epub 2016 Jan 29.

18.

Inositol(1,4,5)P3 3-kinase isoenzymes: Catalytic properties and importance of targeting to F-actin to understand function.

Erneux C, Ghosh S, Koenig S.

Adv Biol Regul. 2016 Jan;60:135-143. doi: 10.1016/j.jbior.2015.09.004. Epub 2015 Sep 26. Review.

PMID:
26446452
19.

Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice.

Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM.

PLoS One. 2015 Apr 29;10(4):e0124861. doi: 10.1371/journal.pone.0124861. eCollection 2015.

20.

Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells.

Koenig S, Moreau C, Dupont G, Scoumanne A, Erneux C.

FEBS J. 2015 Jul;282(13):2553-69. doi: 10.1111/febs.13300. Epub 2015 May 7.

21.

Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines.

Deneubourg L, Elong Edimo W, Moreau C, Vanderwinden JM, Erneux C.

Cell Signal. 2014 Jun;26(6):1193-203. doi: 10.1016/j.cellsig.2014.02.005. Epub 2014 Feb 19.

PMID:
24561238
22.

Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology.

Stygelbout V, Leroy K, Pouillon V, Ando K, D'Amico E, Jia Y, Luo HR, Duyckaerts C, Erneux C, Schurmans S, Brion JP.

Brain. 2014 Feb;137(Pt 2):537-52. doi: 10.1093/brain/awt344. Epub 2014 Jan 8.

PMID:
24401760
23.

SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.

Elong Edimo W, Schurmans S, Roger PP, Erneux C.

Adv Biol Regul. 2014 Jan;54:142-51. doi: 10.1016/j.jbior.2013.09.002. Epub 2013 Sep 15. Review.

PMID:
24091101
24.

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.

Liu Y, Lai YC, Hill EV, Tyteca D, Carpentier S, Ingvaldsen A, Vertommen D, Lantier L, Foretz M, Dequiedt F, Courtoy PJ, Erneux C, Viollet B, Shepherd PR, Tavaré JM, Jensen J, Rider MH.

Biochem J. 2013 Oct 15;455(2):195-206. doi: 10.1042/BJ20130644.

PMID:
23905686
25.

When worlds collide: inositol pyrophosphates and phosphoinositides intersect at the plasma membrane.

Erneux C, Elong Edimo W.

Biochem J. 2013 Aug 1;453(3):e3-4. doi: 10.1042/BJ20130785.

PMID:
23849059
26.

SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein.

Awad A, Sar S, Barré R, Cariven C, Marin M, Salles JP, Erneux C, Samuel D, Gassama-Diagne A.

Mol Biol Cell. 2013 Jul;24(14):2171-85. doi: 10.1091/mbc.E12-08-0626. Epub 2013 May 22.

27.

How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity?

Xie J, Erneux C, Pirson I.

Bioessays. 2013 Aug;35(8):733-43. doi: 10.1002/bies.201200168. Epub 2013 May 7.

PMID:
23650141
28.

Actin-based confinement of calcium responses during Shigella invasion.

Tran Van Nhieu G, Kai Liu B, Zhang J, Pierre F, Prigent S, Sansonetti P, Erneux C, Kuk Kim J, Suh PG, Dupont G, Combettes L.

Nat Commun. 2013;4:1567. doi: 10.1038/ncomms2561.

PMID:
23463010
29.

Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.

Mills SJ, Luyten T, Erneux C, Parys JB, Potter BV.

Messenger (Los Angel). 2012 Dec 1;1(2):167-181.

30.

SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts.

Elong Edimo W, Vanderwinden JM, Erneux C.

Adv Biol Regul. 2013 Jan;53(1):28-37. doi: 10.1016/j.jbior.2012.09.003. Epub 2012 Sep 13. Review.

PMID:
23040614
31.

Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells.

Pouillon V, Maréchal Y, Frippiat C, Erneux C, Schurmans S.

Adv Biol Regul. 2013 Jan;53(1):39-50. doi: 10.1016/j.jbior.2012.08.001. Epub 2012 Sep 5.

PMID:
22981169
32.

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

Dubois E, Jacoby M, Blockmans M, Pernot E, Schiffmann SN, Foukas LC, Henquin JC, Vanhaesebroeck B, Erneux C, Schurmans S.

Cell Signal. 2012 Nov;24(11):1971-80. doi: 10.1016/j.cellsig.2012.06.012. Epub 2012 Jun 30.

PMID:
22750293
33.

Reversible Ser/Thr SHIP phosphorylation: a new paradigm in phosphoinositide signalling?: Targeting of SHIP1/2 phosphatases may be controlled by phosphorylation on Ser and Thr residues.

Edimo WE, Janssens V, Waelkens E, Erneux C.

Bioessays. 2012 Aug;34(8):634-42. doi: 10.1002/bies.201100195. Epub 2012 May 29.

PMID:
22641604
34.

A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells.

Hoofd C, Devreker F, Deneubourg L, Deleu S, Nguyen TM, Sermon K, Englert Y, Erneux C.

Cell Signal. 2012 Jul;24(7):1461-70. doi: 10.1016/j.cellsig.2012.03.006. Epub 2012 Mar 13.

PMID:
22446005
35.

A synthetic polyphosphoinositide headgroup surrogate in complex with SHIP2 provides a rationale for drug discovery.

Mills SJ, Persson C, Cozier G, Thomas MP, Trésaugues L, Erneux C, Riley AM, Nordlund P, Potter BV.

ACS Chem Biol. 2012 May 18;7(5):822-8. doi: 10.1021/cb200494d. Epub 2012 Feb 27.

36.

Transfer of IP₃ through gap junctions is critical, but not sufficient, for the spread of apoptosis.

Decrock E, Krysko DV, Vinken M, Kaczmarek A, Crispino G, Bol M, Wang N, De Bock M, De Vuyst E, Naus CC, Rogiers V, Vandenabeele P, Erneux C, Mammano F, Bultynck G, Leybaert L.

Cell Death Differ. 2012 Jun;19(6):947-57. doi: 10.1038/cdd.2011.176. Epub 2011 Nov 25.

37.

The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.

Pernot E, Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S.

Pflugers Arch. 2011 Dec;462(6):871-83. doi: 10.1007/s00424-011-1028-0. Epub 2011 Sep 22.

38.

Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability.

Elong Edimo W, Derua R, Janssens V, Nakamura T, Vanderwinden JM, Waelkens E, Erneux C.

Biochem J. 2011 Nov 1;439(3):391-401. doi: 10.1042/BJ20110173.

PMID:
21770892
39.

Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).

Deneubourg L, Ralea S, Gromova P, Parsons R, Vanderwinden JM, Erneux C.

Cell Signal. 2011 Nov;23(11):1857-68. doi: 10.1016/j.cellsig.2011.06.023. Epub 2011 Jul 3.

PMID:
21757001
40.

The host phosphoinositide 5-phosphatase SHIP2 regulates dissemination of vaccinia virus.

McNulty S, Powell K, Erneux C, Kalman D.

J Virol. 2011 Jul;85(14):7402-10. doi: 10.1128/JVI.02391-10. Epub 2011 May 4.

41.

SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.

Erneux C, Edimo WE, Deneubourg L, Pirson I.

J Cell Biochem. 2011 Sep;112(9):2203-9. doi: 10.1002/jcb.23146. Review.

PMID:
21503961
42.

ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours.

Gromova P, Rubin BP, Thys A, Cullus P, Erneux C, Vanderwinden JM.

J Cell Mol Med. 2012 Feb;16(2):306-17. doi: 10.1111/j.1582-4934.2011.01315.x.

43.

Neurotensin receptor 1 is expressed in gastrointestinal stromal tumors but not in interstitial cells of Cajal.

Gromova P, Rubin BP, Thys A, Erneux C, Vanderwinden JM.

PLoS One. 2011 Feb 18;6(2):e14710. doi: 10.1371/journal.pone.0014710.

44.

SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.

Charlier E, Condé C, Zhang J, Deneubourg L, Di Valentin E, Rahmouni S, Chariot A, Agostinis P, Pang PC, Haslam SM, Dell A, Penninger J, Erneux C, Piette J, Gloire G.

Leukemia. 2010 Apr;24(4):821-32. doi: 10.1038/leu.2010.9. Epub 2010 Feb 11.

45.

5-Stabilized phosphatidylinositol 3,4,5-trisphosphate analogues bind Grp1 PH, inhibit phosphoinositide phosphatases, and block neutrophil migration.

Zhang H, He J, Kutateladze TG, Sakai T, Sasaki T, Markadieu N, Erneux C, Prestwich GD.

Chembiochem. 2010 Feb 15;11(3):388-95. doi: 10.1002/cbic.200900545.

46.

Regulation of SHIP2 function through plasma membrane interaction.

Deneubourg L, Vanderwinden JM, Erneux C.

Adv Enzyme Regul. 2010;50(1):262-71. doi: 10.1016/j.advenzreg.2009.10.009. Epub 2009 Nov 4. No abstract available.

PMID:
19895833
47.

SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.

De Schutter J, Guillabert A, Imbault V, Degraef C, Erneux C, Communi D, Pirson I.

J Biol Chem. 2009 Dec 25;284(52):36062-76. doi: 10.1074/jbc.M109.064923. Epub 2009 Oct 30.

48.
49.

Insulin increase in MAP kinase phosphorylation is shifted to early time-points by overexpressing APS, while Akt phosphorylation is not influenced.

Onnockx S, Xie J, Degraef C, Erneux C, Pirson I.

Exp Cell Res. 2009 Sep 10;315(15):2479-86. doi: 10.1016/j.yexcr.2009.06.006. Epub 2009 Jun 13.

PMID:
19527711
50.

Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.

Gromova P, Ralea S, Lefort A, Libert F, Rubin BP, Erneux C, Vanderwinden JM.

J Cell Mol Med. 2009 Aug;13(8A):1536-48. doi: 10.1111/j.1582-4934.2009.00768.x. Epub 2009 May 19.

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