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Items: 29


Assembly, Release, and Transport of Airway Mucins in Pigs and Humans.

Ermund A, Trillo-Muyo S, Hansson GC.

Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S159-S163. doi: 10.1513/AnnalsATS.201804-238AW.


Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.

Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC.

JCI Insight. 2018 Sep 6;3(17). pii: 120994. doi: 10.1172/jci.insight.120994. eCollection 2018 Sep 6.


The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation.

Ermund A, Meiss LN, Dolan B, Bähr A, Klymiuk N, Hansson GC.

Eur Respir J. 2018 Aug 30;52(2). pii: 1800457. doi: 10.1183/13993003.00457-2018. Print 2018 Aug.


Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.

J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. Epub 2018 Feb 13.


Extracellular ATP activates store-operated Ca2+ entry in white adipocytes: functional evidence for STIM1 and ORAI1.

El Hachmane MF, Ermund A, Brännmark C, Olofsson CS.

Biochem J. 2018 Feb 14;475(3):691-704. doi: 10.1042/BCJ20170484.


Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB.

Wichert R, Ermund A, Schmidt S, Schweinlin M, Ksiazek M, Arnold P, Knittler K, Wilkens F, Potempa B, Rabe B, Stirnberg M, Lucius R, Bartsch JW, Nikolaus S, Falk-Paulsen M, Rosenstiel P, Metzger M, Rose-John S, Potempa J, Hansson GC, Dempsey PJ, Becker-Pauly C.

Cell Rep. 2017 Nov 21;21(8):2090-2103. doi: 10.1016/j.celrep.2017.10.087.


Progress in understanding mucus abnormalities in cystic fibrosis airways.

Wine JJ, Hansson GC, König P, Joo NS, Ermund A, Pieper M.

J Cyst Fibros. 2018 Mar;17(2S):S35-S39. doi: 10.1016/j.jcf.2017.09.003. Epub 2017 Sep 23. Review.


The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC.

Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. Epub 2017 Aug 30.


OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium.

Ermund A, Recktenwald CV, Skjåk-Braek G, Meiss LN, Onsøyen E, Rye PD, Dessen A, Myrset AH, Hansson GC.

Clin Exp Pharmacol Physiol. 2017 Jun;44(6):639-647. doi: 10.1111/1440-1681.12744.


Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14.


Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization.

Johansson ME, Jakobsson HE, Holmén-Larsson J, Schütte A, Ermund A, Rodríguez-Piñeiro AM, Arike L, Wising C, Svensson F, Bäckhed F, Hansson GC.

Cell Host Microbe. 2015 Nov 11;18(5):582-92. doi: 10.1016/j.chom.2015.10.007. Epub 2015 Oct 29.


Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.

Ermund A, Meiss LN, Gustafsson JK, Hansson GC.

Eur J Pharmacol. 2015 Oct 5;764:109-17. doi: 10.1016/j.ejphar.2015.06.051. Epub 2015 Jun 30.


The composition of the gut microbiota shapes the colon mucus barrier.

Jakobsson HE, Rodríguez-Piñeiro AM, Schütte A, Ermund A, Boysen P, Bemark M, Sommer F, Bäckhed F, Hansson GC, Johansson ME.

EMBO Rep. 2015 Feb;16(2):164-77. doi: 10.15252/embr.201439263. Epub 2014 Dec 18.


Hypertonic saline releases the attached small intestinal cystic fibrosis mucus.

Ermund A, Meiss LN, Scholte BJ, Hansson GC.

Clin Exp Pharmacol Physiol. 2015 Jan;42(1):69-75. doi: 10.1111/1440-1681.12322.


Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.

Schütte A, Ermund A, Becker-Pauly C, Johansson ME, Rodriguez-Pineiro AM, Bäckhed F, Müller S, Lottaz D, Bond JS, Hansson GC.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12396-401. doi: 10.1073/pnas.1407597111. Epub 2014 Aug 11.


The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.

Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC.

Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Review.


Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches.

Ermund A, Gustafsson JK, Hansson GC, Keita AV.

PLoS One. 2013 Dec 16;8(12):e83688. doi: 10.1371/journal.pone.0083688. eCollection 2013.


Monoacylglycerols activate TRPV1--a link between phospholipase C and TRPV1.

Zygmunt PM, Ermund A, Movahed P, Andersson DA, Simonsen C, Jönsson BA, Blomgren A, Birnir B, Bevan S, Eschalier A, Mallet C, Gomis A, Högestätt ED.

PLoS One. 2013 Dec 2;8(12):e81618. doi: 10.1371/journal.pone.0081618. eCollection 2013.


Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches.

Ermund A, Schütte A, Johansson ME, Gustafsson JK, Hansson GC.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G341-7. doi: 10.1152/ajpgi.00046.2013. Epub 2013 Jul 5.


Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.

Rodríguez-Piñeiro AM, Bergström JH, Ermund A, Gustafsson JK, Schütte A, Johansson ME, Hansson GC.

Am J Physiol Gastrointest Liver Physiol. 2013 Sep 1;305(5):G348-56. doi: 10.1152/ajpgi.00047.2013. Epub 2013 Jul 5.


Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.

Pelaseyed T, Gustafsson JK, Gustafsson IJ, Ermund A, Hansson GC.

Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C457-67. doi: 10.1152/ajpcell.00141.2013. Epub 2013 Jun 19.


Perspectives on mucus properties and formation--lessons from the biochemical world.

Ambort D, Johansson ME, Gustafsson JK, Ermund A, Hansson GC.

Cold Spring Harb Perspect Med. 2012 Nov 1;2(11). pii: a014159. doi: 10.1101/cshperspect.a014159. Review.


Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

Gustafsson JK, Ermund A, Ambort D, Johansson ME, Nilsson HE, Thorell K, Hebert H, Sjövall H, Hansson GC.

J Exp Med. 2012 Jul 2;209(7):1263-72. doi: 10.1084/jem.20120562. Epub 2012 Jun 18.


Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin.

Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJ, Hebert H, Hansson GC.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5645-50. doi: 10.1073/pnas.1120269109. Epub 2012 Mar 26.


An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants.

Gustafsson JK, Ermund A, Johansson ME, Schütte A, Hansson GC, Sjövall H.

Am J Physiol Gastrointest Liver Physiol. 2012 Feb 15;302(4):G430-8. doi: 10.1152/ajpgi.00405.2011.. Epub 2011 Dec 8.


Composition and functional role of the mucus layers in the intestine.

Johansson ME, Ambort D, Pelaseyed T, Schütte A, Gustafsson JK, Ermund A, Subramani DB, Holmén-Larsson JM, Thomsson KA, Bergström JH, van der Post S, Rodriguez-Piñeiro AM, Sjövall H, Bäckström M, Hansson GC.

Cell Mol Life Sci. 2011 Nov;68(22):3635-41. doi: 10.1007/s00018-011-0822-3. Epub 2011 Sep 25. Review.


TRPV1 in brain is involved in acetaminophen-induced antinociception.

Mallet C, Barrière DA, Ermund A, Jönsson BA, Eschalier A, Zygmunt PM, Högestätt ED.

PLoS One. 2010 Sep 17;5(9). pii: e12748. doi: 10.1371/journal.pone.0012748.


Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists.

Movahed P, Jönsson BA, Birnir B, Wingstrand JA, Jørgensen TD, Ermund A, Sterner O, Zygmunt PM, Högestätt ED.

J Biol Chem. 2005 Nov 18;280(46):38496-504. Epub 2005 Aug 4.


Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.

Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM.

J Biol Chem. 2005 Sep 9;280(36):31405-12. Epub 2005 Jun 29.

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