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Items: 1 to 50 of 126

1.

Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism.

Brünle S, Eisinger ML, Poppe J, Mills DJ, Langer JD, Vonck J, Ermler U.

Proc Natl Acad Sci U S A. 2019 Dec 6. pii: 201913031. doi: 10.1073/pnas.1913031116. [Epub ahead of print]

PMID:
31811022
2.

Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors.

Willistein M, Bechtel DF, Müller CS, Demmer U, Heimann L, Kayastha K, Schünemann V, Pierik AJ, Ullmann GM, Ermler U, Boll M.

Nat Commun. 2019 May 6;10(1):2074. doi: 10.1038/s41467-019-10078-3.

3.

The Bacterial [Fe]-Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates.

Watanabe T, Wagner T, Huang G, Kahnt J, Ataka K, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2019 Mar 11;58(11):3506-3510. doi: 10.1002/anie.201813465. Epub 2019 Jan 25.

PMID:
30600878
4.

The Molybdenum Storage Protein: A soluble ATP hydrolysis-dependent molybdate pump.

Poppe J, Brünle S, Hail R, Wiesemann K, Schneider K, Ermler U.

FEBS J. 2018 Dec;285(24):4602-4616. doi: 10.1111/febs.14684. Epub 2018 Nov 12.

5.

The molybdenum storage protein - A bionanolab for creating experimentally alterable polyoxomolybdate clusters.

Brünle S, Poppe J, Hail R, Demmer U, Ermler U.

J Inorg Biochem. 2018 Dec;189:172-179. doi: 10.1016/j.jinorgbio.2018.09.011. Epub 2018 Sep 21. No abstract available.

PMID:
30278367
6.

How [Fe]-Hydrogenase from Methanothermobacter is Protected Against Light and Oxidative Stress.

Wagner T, Huang G, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15056-15059. doi: 10.1002/anie.201807203. Epub 2018 Oct 19.

PMID:
30207625
7.

Dioxygen Sensitivity of [Fe]-Hydrogenase in the Presence of Reducing Substrates.

Huang G, Wagner T, Ermler U, Bill E, Ataka K, Shima S.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4917-4920. doi: 10.1002/anie.201712293. Epub 2018 Mar 23.

PMID:
29462510
8.

Molecular basis of the flavin-based electron-bifurcating caffeyl-CoA reductase reaction.

Demmer JK, Bertsch J, Öppinger C, Wohlers H, Kayastha K, Demmer U, Ermler U, Müller V.

FEBS Lett. 2018 Feb;592(3):332-342. doi: 10.1002/1873-3468.12971. Epub 2018 Feb 1.

9.

The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile.

Demmer JK, Pal Chowdhury N, Selmer T, Ermler U, Buckel W.

Nat Commun. 2017 Nov 17;8(1):1577. doi: 10.1038/s41467-017-01746-3.

10.

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons.

Weinert T, Olieric N, Cheng R, Brünle S, James D, Ozerov D, Gashi D, Vera L, Marsh M, Jaeger K, Dworkowski F, Panepucci E, Basu S, Skopintsev P, Doré AS, Geng T, Cooke RM, Liang M, Prota AE, Panneels V, Nogly P, Ermler U, Schertler G, Hennig M, Steinmetz MO, Wang M, Standfuss J.

Nat Commun. 2017 Sep 14;8(1):542. doi: 10.1038/s41467-017-00630-4.

11.

Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction.

Wagner T, Koch J, Ermler U, Shima S.

Science. 2017 Aug 18;357(6352):699-703. doi: 10.1126/science.aan0425.

PMID:
28818947
12.

A rare polyglycine type II-like helix motif in naturally occurring proteins.

Warkentin E, Weidenweber S, Schühle K, Demmer U, Heider J, Ermler U.

Proteins. 2017 Nov;85(11):2017-2023. doi: 10.1002/prot.25355. Epub 2017 Aug 4.

PMID:
28722183
13.

A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC.

Bai L, Wagner T, Xu T, Hu X, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2017 Aug 28;56(36):10806-10809. doi: 10.1002/anie.201705605. Epub 2017 Aug 2.

PMID:
28682478
14.

Phylogenetic and Structural Comparisons of the Three Types of Methyl Coenzyme M Reductase from Methanococcales and Methanobacteriales.

Wagner T, Wegner CE, Kahnt J, Ermler U, Shima S.

J Bacteriol. 2017 Jul 25;199(16). pii: e00197-17. doi: 10.1128/JB.00197-17. Print 2017 Aug 15.

15.

Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase.

Bai L, Fujishiro T, Huang G, Koch J, Takabayashi A, Yokono M, Tanaka A, Xu T, Hu X, Ermler U, Shima S.

Faraday Discuss. 2017 Jun 2;198:37-58. doi: 10.1039/c6fd00209a.

PMID:
28294213
16.

Structure of the acetophenone carboxylase core complex: prototype of a new class of ATP-dependent carboxylases/hydrolases.

Weidenweber S, Schühle K, Demmer U, Warkentin E, Ermler U, Heider J.

Sci Rep. 2017 Jan 5;7:39674. doi: 10.1038/srep39674.

17.

The Crystal Structure of RosB: Insights into the Reaction Mechanism of the First Member of a Family of Flavodoxin-like Enzymes.

Konjik V, Brünle S, Demmer U, Vanselow A, Sandhoff R, Ermler U, Mack M.

Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1146-1151. doi: 10.1002/anie.201610292. Epub 2016 Dec 16.

PMID:
27981706
18.

Ligand binding and conformational dynamics in a flavin-based electron-bifurcating enzyme complex revealed by Hydrogen-Deuterium Exchange Mass Spectrometry.

Demmer JK, Rupprecht FA, Eisinger ML, Ermler U, Langer JD.

FEBS Lett. 2016 Dec;590(24):4472-4479. doi: 10.1002/1873-3468.12489. Epub 2016 Dec 16.

19.

The methanogenic CO2 reducing-and-fixing enzyme is bifunctional and contains 46 [4Fe-4S] clusters.

Wagner T, Ermler U, Shima S.

Science. 2016 Oct 7;354(6308):114-117.

PMID:
27846502
20.

Didehydroaspartate Modification in Methyl-Coenzyme M Reductase Catalyzing Methane Formation.

Wagner T, Kahnt J, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10630-3. doi: 10.1002/anie.201603882. Epub 2016 Jul 28.

PMID:
27467699
21.

Identification of HcgC as a SAM-Dependent Pyridinol Methyltransferase in [Fe]-Hydrogenase Cofactor Biosynthesis.

Fujishiro T, Bai L, Xu T, Xie X, Schick M, Kahnt J, Rother M, Hu X, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9648-51. doi: 10.1002/anie.201604352. Epub 2016 Jul 8.

PMID:
27391308
22.

Molecular characterization of methanogenic N(5)-methyl-tetrahydromethanopterin: Coenzyme M methyltransferase.

Upadhyay V, Ceh K, Tumulka F, Abele R, Hoffmann J, Langer J, Shima S, Ermler U.

Biochim Biophys Acta. 2016 Sep;1858(9):2140-2144. doi: 10.1016/j.bbamem.2016.06.011. Epub 2016 Jun 21.

23.

MtrA of the sodium ion pumping methyltransferase binds cobalamin in a unique mode.

Wagner T, Ermler U, Shima S.

Sci Rep. 2016 Jun 21;6:28226. doi: 10.1038/srep28226.

24.

X-ray structure of linalool dehydratase/isomerase from Castellaniella defragrans reveals enzymatic alkene synthesis.

Weidenweber S, Marmulla R, Ermler U, Harder J.

FEBS Lett. 2016 May;590(9):1375-83. doi: 10.1002/1873-3468.12165. Epub 2016 Apr 18.

25.

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment.

Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PM, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H.

J Mol Microbiol Biotechnol. 2016;26(1-3):5-28. doi: 10.1159/000443997. Epub 2016 Mar 10. Review.

26.

Fermentative Cyclohexane Carboxylate Formation in Syntrophus aciditrophicus.

Boll M, Kung JW, Ermler U, Martins BM, Buckel W.

J Mol Microbiol Biotechnol. 2016;26(1-3):165-79. doi: 10.1159/000440881. Epub 2016 Mar 10. Review.

PMID:
26959729
27.

Structure and Function of the Unusual Tungsten Enzymes Acetylene Hydratase and Class II Benzoyl-Coenzyme A Reductase.

Boll M, Einsle O, Ermler U, Kroneck PM, Ullmann GM.

J Mol Microbiol Biotechnol. 2016;26(1-3):119-37. doi: 10.1159/000440805. Epub 2016 Mar 10. Review.

PMID:
26959374
28.

Corrigendum: Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Oct;11(10):815. doi: 10.1038/nchembio1015-815a. No abstract available.

PMID:
26379025
29.

Erratum: Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Sep;11(9):741. doi: 10.1038/nchembio0915-741d. No abstract available.

PMID:
26284679
30.

Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure.

Demmer JK, Huang H, Wang S, Demmer U, Thauer RK, Ermler U.

J Biol Chem. 2015 Sep 4;290(36):21985-95. doi: 10.1074/jbc.M115.656520. Epub 2015 Jul 2.

31.

Structural basis of enzymatic benzene ring reduction.

Weinert T, Huwiler SG, Kung JW, Weidenweber S, Hellwig P, Stärk HJ, Biskup T, Weber S, Cotelesage JJ, George GN, Ermler U, Boll M.

Nat Chem Biol. 2015 Aug;11(8):586-91. doi: 10.1038/nchembio.1849. Epub 2015 Jun 29. Erratum in: Nat Chem Biol. 2015 Sep;11(9):741. Nat Chem Biol. 2015 Oct;11(10):815.

PMID:
26120796
32.

Towards a functional identification of catalytically inactive [Fe]-hydrogenase paralogs.

Fujishiro T, Ataka K, Ermler U, Shima S.

FEBS J. 2015 Sep;282(17):3412-23. doi: 10.1111/febs.13351. Epub 2015 Jul 14.

33.

Protein-pyridinol thioester precursor for biosynthesis of the organometallic acyl-iron ligand in [Fe]-hydrogenase cofactor.

Fujishiro T, Kahnt J, Ermler U, Shima S.

Nat Commun. 2015 Apr 17;6:6895. doi: 10.1038/ncomms7895.

PMID:
25882909
34.

Structure of the GcpE-HMBPP complex from Thermus thermophilius.

Rekittke I, Warkentin E, Jomaa H, Ermler U.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):246-50. doi: 10.1016/j.bbrc.2015.01.088. Epub 2015 Feb 7.

PMID:
25660452
35.

Structural diversity of polyoxomolybdate clusters along the three-fold axis of the molybdenum storage protein.

Poppe J, Warkentin E, Demmer U, Kowalewski B, Dierks T, Schneider K, Ermler U.

J Inorg Biochem. 2014 Sep;138:122-128. doi: 10.1016/j.jinorgbio.2014.05.009. Epub 2014 May 28.

PMID:
24945101
36.

A possible iron delivery function of the dinuclear iron center of HcgD in [Fe]-hydrogenase cofactor biosynthesis.

Fujishiro T, Ermler U, Shima S.

FEBS Lett. 2014 Aug 25;588(17):2789-93. doi: 10.1016/j.febslet.2014.05.059. Epub 2014 Jun 12.

37.

The F₄₂₀-reducing [NiFe]-hydrogenase complex from Methanothermobacter marburgensis, the first X-ray structure of a group 3 family member.

Vitt S, Ma K, Warkentin E, Moll J, Pierik AJ, Shima S, Ermler U.

J Mol Biol. 2014 Jul 29;426(15):2813-26. doi: 10.1016/j.jmb.2014.05.024. Epub 2014 Jun 2.

PMID:
24887099
38.

A decade of crystallization drops: crystallization of the cbb3 cytochrome c oxidase from Pseudomonas stutzeri.

Buschmann S, Richers S, Ermler U, Michel H.

Protein Sci. 2014 Apr;23(4):411-22. doi: 10.1002/pro.2423. Epub 2014 Feb 4.

39.

Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans.

Chowdhury NP, Mowafy AM, Demmer JK, Upadhyay V, Koelzer S, Jayamani E, Kahnt J, Hornung M, Demmer U, Ermler U, Buckel W.

J Biol Chem. 2014 Feb 21;289(8):5145-57. doi: 10.1074/jbc.M113.521013. Epub 2013 Dec 30.

40.

Identification of the HcgB enzyme in [Fe]-hydrogenase-cofactor biosynthesis.

Fujishiro T, Tamura H, Schick M, Kahnt J, Xie X, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12555-8. doi: 10.1002/anie.201306745. Epub 2013 Nov 7. No abstract available.

PMID:
24249552
41.

Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum.

Rekittke I, Olkhova E, Wiesner J, Demmer U, Warkentin E, Jomaa H, Ermler U.

FEBS Lett. 2013 Dec 11;587(24):3968-72. doi: 10.1016/j.febslet.2013.10.029. Epub 2013 Nov 1.

42.

Structural, biochemical and genetic characterization of dissimilatory ATP sulfurylase from Allochromatium vinosum.

Parey K, Demmer U, Warkentin E, Wynen A, Ermler U, Dahl C.

PLoS One. 2013 Sep 20;8(9):e74707. doi: 10.1371/journal.pone.0074707. eCollection 2013.

43.

Advanced electron paramagnetic resonance on the catalytic iron-sulfur cluster bound to the CCG domain of heterodisulfide reductase and succinate: quinone reductase.

Fielding AJ, Parey K, Ermler U, Scheller S, Jaun B, Bennati M.

J Biol Inorg Chem. 2013 Dec;18(8):905-15. doi: 10.1007/s00775-013-1037-x. Epub 2013 Sep 14.

PMID:
24037219
44.

Crystal structures of [Fe]-hydrogenase in complex with inhibitory isocyanides: implications for the H2-activation site.

Tamura H, Salomone-Stagni M, Fujishiro T, Warkentin E, Meyer-Klaucke W, Ermler U, Shima S.

Angew Chem Int Ed Engl. 2013 Sep 9;52(37):9656-9. doi: 10.1002/anie.201305089. Epub 2013 Jul 22. No abstract available.

PMID:
23873755
45.

Structural basis for a bispecific NADP+ and CoA binding site in an archaeal malonyl-coenzyme A reductase.

Demmer U, Warkentin E, Srivastava A, Kockelkorn D, Pötter M, Marx A, Fuchs G, Ermler U.

J Biol Chem. 2013 Mar 1;288(9):6363-70. doi: 10.1074/jbc.M112.421263. Epub 2013 Jan 16.

46.

Conserving energy with sulfate around 100 °C--structure and mechanism of key metal enzymes in hyperthermophilic Archaeoglobus fulgidus.

Parey K, Fritz G, Ermler U, Kroneck PM.

Metallomics. 2013 Apr;5(4):302-17. doi: 10.1039/c2mt20225e. Review.

PMID:
23324858
47.

Active site analysis of yeast flavohemoglobin based on its structure with a small ligand or econazole.

El Hammi E, Warkentin E, Demmer U, Marzouki NM, Ermler U, Baciou L.

FEBS J. 2012 Dec;279(24):4565-75. doi: 10.1111/febs.12043. Epub 2012 Nov 21.

48.

Structure and catalytic mechanism of N(5),N(10)-methenyl-tetrahydromethanopterin cyclohydrolase.

Upadhyay V, Demmer U, Warkentin E, Moll J, Shima S, Ermler U.

Biochemistry. 2012 Oct 23;51(42):8435-43. doi: 10.1021/bi300777k. Epub 2012 Oct 8.

PMID:
23013430
49.

Structure of the GcpE (IspG)-MEcPP complex from Thermus thermophilus.

Rekittke I, Jomaa H, Ermler U.

FEBS Lett. 2012 Sep 21;586(19):3452-7. doi: 10.1016/j.febslet.2012.07.070. Epub 2012 Aug 9.

50.

Nature's polyoxometalate chemistry: X-ray structure of the Mo storage protein loaded with discrete polynuclear Mo-O clusters.

Kowalewski B, Poppe J, Demmer U, Warkentin E, Dierks T, Ermler U, Schneider K.

J Am Chem Soc. 2012 Jun 13;134(23):9768-74. doi: 10.1021/ja303084n. Epub 2012 May 31. Erratum in: J Am Chem Soc. 2013 Mar 6;135(9):3729.

PMID:
22612644

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