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Framing cancer progression: influence of the organ- and tumour-specific matrisome.

Rafaeva M, Erler JT.

FEBS J. 2020 Jan 23. doi: 10.1111/febs.15223. [Epub ahead of print] Review.


Decellularization and antibody staining of mouse tissues to map native extracellular matrix structures in 3D.

Mayorca-Guiliani AE, Willacy O, Madsen CD, Rafaeva M, Elisabeth Heumüller S, Bock F, Sengle G, Koch M, Imhof T, Zaucke F, Wagener R, Sasaki T, Erler JT, Reuten R.

Nat Protoc. 2019 Dec;14(12):3395-3425. doi: 10.1038/s41596-019-0225-8. Epub 2019 Nov 8.


Editor's Note: LOX-Mediated Collagen Cross-linking Is Responsible for Fibrosis-Enhanced Metastasis.

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT.

Cancer Res. 2019 Oct 1;79(19):5124. doi: 10.1158/0008-5472.CAN-19-2419. No abstract available.


Correction: LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution.

Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A, Erler JT.

Cancer Res. 2019 Oct 1;79(19):5123. doi: 10.1158/0008-5472.CAN-19-2420. No abstract available.


Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments.

Blache U, Horton ER, Xia T, Schoof EM, Blicher LH, Schönenberger A, Snedeker JG, Martin I, Erler JT, Ehrbar M.

Life Sci Alliance. 2019 Jun 3;2(3). pii: e201900304. doi: 10.26508/lsa.201900304. Print 2019 Jun.


Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment.

Amendola PG, Reuten R, Erler JT.

Cancers (Basel). 2019 May 26;11(5). pii: E729. doi: 10.3390/cancers11050729. Review.


Cancer cells' ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential.

Wullkopf L, West AV, Leijnse N, Cox TR, Madsen CD, Oddershede LB, Erler JT.

Mol Biol Cell. 2018 Oct 1;29(20):2378-2385. doi: 10.1091/mbc.E18-05-0319. Epub 2018 Aug 9.


Tumor endothelial marker 8 promotes cancer progression and metastasis.

Høye AM, Tolstrup SD, Horton ER, Nicolau M, Frost H, Woo JH, Mauldin JP, Frankel AE, Cox TR, Erler JT.

Oncotarget. 2018 Jul 10;9(53):30173-30188. doi: 10.18632/oncotarget.25734. eCollection 2018 Jul 10.


Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate.

Blache U, Vallmajo-Martin Q, Horton ER, Guerrero J, Djonov V, Scherberich A, Erler JT, Martin I, Snedeker JG, Milleret V, Ehrbar M.

EMBO Rep. 2018 Aug;19(8). pii: e45964. doi: 10.15252/embr.201845964. Epub 2018 Jul 2.


Hypoxic Signalling in Tumour Stroma.

Laitala A, Erler JT.

Front Oncol. 2018 May 29;8:189. doi: 10.3389/fonc.2018.00189. eCollection 2018. Review.


Proteomic Characterization of Caenorhabditis elegans Larval Development.

Xia T, Horton ER, Salcini AE, Pocock R, Cox TR, Erler JT.

Proteomics. 2018 Jan;18(2). doi: 10.1002/pmic.201700238. Epub 2017 Dec 27.


Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease.

Cox TR, Erler JT, Rumney RMH.

Calcif Tissue Int. 2018 Feb;102(2):163-173. doi: 10.1007/s00223-017-0352-6. Epub 2017 Nov 2. Review.


Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments.

Koplev S, Longden J, Ferkinghoff-Borg J, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R.

Cell Rep. 2017 Sep 19;20(12):2784-2791. doi: 10.1016/j.celrep.2017.08.095.


Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Cox TR, Erler JT.

Trends Cancer. 2016 Jun;2(6):279-282. doi: 10.1016/j.trecan.2016.05.004. Epub 2016 May 30.


ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix.

Mayorca-Guiliani AE, Madsen CD, Cox TR, Horton ER, Venning FA, Erler JT.

Nat Med. 2017 Jul;23(7):890-898. doi: 10.1038/nm.4352. Epub 2017 Jun 12.


Pre-metastatic niches: organ-specific homes for metastases.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.

Nat Rev Cancer. 2017 May;17(5):302-317. doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17. Review.


Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model.

Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC.

Sci Rep. 2017 Mar 13;7(1):165. doi: 10.1038/s41598-017-00144-5.


Dynamics of cancerous tissue correlates with invasiveness.

West AV, Wullkopf L, Christensen A, Leijnse N, Tarp JM, Mathiesen J, Erler JT, Oddershede LB.

Sci Rep. 2017 Mar 6;7:43800. doi: 10.1038/srep43800.


Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.

Chang J, Lucas MC, Leonte LE, Garcia-Montolio M, Singh LB, Findlay AD, Deodhar M, Foot JS, Jarolimek W, Timpson P, Erler JT, Cox TR.

Oncotarget. 2017 Apr 18;8(16):26066-26078. doi: 10.18632/oncotarget.15257.


Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight.

Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC.

PLoS One. 2017 Jan 20;12(1):e0169664. doi: 10.1371/journal.pone.0169664. eCollection 2017.


The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.

Gartland A, Erler JT, Cox TR.

J Bone Oncol. 2016 Jul 1;5(3):100-103. eCollection 2016 Sep.


Quantification of Lung Metastases from In Vivo Mouse Models.

Chang J, Erler JT.

Adv Exp Med Biol. 2016;899:245-51. doi: 10.1007/978-3-319-26666-4_14.


Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.

Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF.

Oncotarget. 2016 May 26;8(36):60015-60024. doi: 10.18632/oncotarget.9623. eCollection 2017 Sep 1.


Structural ECM components in the premetastatic and metastatic niche.

Høye AM, Erler JT.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C955-67. doi: 10.1152/ajpcell.00326.2015. Epub 2016 Apr 6. Review.


Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.

Cox TR, Gartland A, Erler JT.

Cancer Res. 2016 Jan 15;76(2):188-92. doi: 10.1158/0008-5472.CAN-15-2306. Epub 2016 Jan 5. Review.


Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.

Cox TR, Schoof EM, Gartland A, Erler JT, Linding R.

Data Brief. 2015 Oct 23;5:621-5. doi: 10.1016/j.dib.2015.09.039. eCollection 2015 Dec.


Targeting ECM Disrupts Cancer Progression.

Venning FA, Wullkopf L, Erler JT.

Front Oncol. 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015. Review.


Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.


Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.

EMBO Rep. 2015 Oct;16(10):1394-408. doi: 10.15252/embr.201540107. Epub 2015 Aug 31.


Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction.

González-Santamaría J, Villalba M, Busnadiego O, López-Olañeta MM, Sandoval P, Snabel J, López-Cabrera M, Erler JT, Hanemaaijer R, Lara-Pezzi E, Rodríguez-Pascual F.

Cardiovasc Res. 2016 Jan 1;109(1):67-78. doi: 10.1093/cvr/cvv214. Epub 2015 Aug 10.


Stimulating translational research: several European life science institutions put their heads together.

Bentires-Alj M, Rajan A, van Harten W, van Luenen HG, Kubicek S, Andersen JB, Saarela J, Cook SJ, Van Minnebruggen G, Roman-Roman S, Maurer C, Erler JT, Bertero MG.

Trends Mol Med. 2015 Sep;21(9):525-7. doi: 10.1016/j.molmed.2015.07.002. Epub 2015 Aug 5.


Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ.

EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827.


Pten Regulates Epithelial Cytodifferentiation during Prostate Development.

Lokody IB, Francis JC, Gardiner JR, Erler JT, Swain A.

PLoS One. 2015 Jun 15;10(6):e0129470. doi: 10.1371/journal.pone.0129470. eCollection 2015.


The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.

Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27.


Interdisciplinary research: Bold alliances aid translational work.

Erler JT.

Nature. 2015 Jan 22;517(7535):438. doi: 10.1038/517438e. No abstract available.


STRIPAK components determine mode of cancer cell migration and metastasis.

Madsen CD, Hooper S, Tozluoglu M, Bruckbauer A, Fletcher G, Erler JT, Bates PA, Thompson B, Sahai E.

Nat Cell Biol. 2015 Jan;17(1):68-80. doi: 10.1038/ncb3083. Epub 2014 Dec 22.


AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.

Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J.

J Pathol. 2015 Mar;235(4):581-92. doi: 10.1002/path.4485. Epub 2014 Dec 24.


Lysyl oxidase in cancer research.

Perryman L, Erler JT.

Future Oncol. 2014;10(9):1709-17. doi: 10.2217/fon.14.39. Review.


Brain cancer spreads.

Perryman L, Erler JT.

Sci Transl Med. 2014 Jul 30;6(247):247fs28. doi: 10.1126/scitranslmed.3009920.


Ionizing radiation induces tumor cell lysyl oxidase secretion.

Shen CJ, Sharma A, Vuong DV, Erler JT, Pruschy M, Broggini-Tenzer A.

BMC Cancer. 2014 Jul 22;14:532. doi: 10.1186/1471-2407-14-532.


Molecular pathways: connecting fibrosis and solid tumor metastasis.

Cox TR, Erler JT.

Clin Cancer Res. 2014 Jul 15;20(14):3637-43. doi: 10.1158/1078-0432.CCR-13-1059.


Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics.

Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, Erler JT.

J Proteome Res. 2014 May 2;13(5):2297-313. doi: 10.1021/pr401056c. Epub 2014 Apr 24.


Cancer: Disabling defences in the brain.

Erler JT.

Nature. 2014 Apr 3;508(7494):46-7. doi: 10.1038/508046a. No abstract available.


The potential for targeting extracellular LOX proteins in human malignancy.

Mayorca-Guiliani A, Erler JT.

Onco Targets Ther. 2013 Nov 25;6:1729-35. doi: 10.2147/OTT.S38110. Review.


Tumor-secreted LOXL2 activates fibroblasts through FAK signaling.

Barker HE, Bird D, Lang G, Erler JT.

Mol Cancer Res. 2013 Nov;11(11):1425-36. doi: 10.1158/1541-7786.MCR-13-0033-T. Epub 2013 Sep 5. Erratum in: Mol Cancer Res. 2019 Oct;17(10):2141.


Lysyl oxidase in colorectal cancer.

Cox TR, Erler JT.

Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G659-66. doi: 10.1152/ajpgi.00425.2012. Epub 2013 Sep 5. Review.


LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.

Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT.

Breast Cancer Res. 2013;15(4):R67.


LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis.

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT.

Cancer Res. 2013 Mar 15;73(6):1721-32. doi: 10.1158/0008-5472.CAN-12-2233. Epub 2013 Jan 23.


Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis.

Baker AM, Bird D, Welti JC, Gourlaouen M, Lang G, Murray GI, Reynolds AR, Cox TR, Erler JT.

Cancer Res. 2013 Jan 15;73(2):583-94. doi: 10.1158/0008-5472.CAN-12-2447. Epub 2012 Nov 27.


Navigating cancer network attractors for tumor-specific therapy.

Creixell P, Schoof EM, Erler JT, Linding R.

Nat Biotechnol. 2012 Sep;30(9):842-8. doi: 10.1038/nbt.2345.


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