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Items: 1 to 50 of 67

1.

Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate.

Blache U, Vallmajo-Martin Q, Horton ER, Guerrero J, Djonov V, Scherberich A, Erler JT, Martin I, Snedeker JG, Milleret V, Ehrbar M.

EMBO Rep. 2018 Jul 2. pii: e45964. doi: 10.15252/embr.201845964. [Epub ahead of print]

PMID:
29967223
2.

Hypoxic Signalling in Tumour Stroma.

Laitala A, Erler JT.

Front Oncol. 2018 May 29;8:189. doi: 10.3389/fonc.2018.00189. eCollection 2018. Review.

3.

Proteomic Characterization of Caenorhabditis elegans Larval Development.

Xia T, Horton ER, Salcini AE, Pocock R, Cox TR, Erler JT.

Proteomics. 2018 Jan;18(2). doi: 10.1002/pmic.201700238. Epub 2017 Dec 27.

PMID:
29178193
4.

Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease.

Cox TR, Erler JT, Rumney RMH.

Calcif Tissue Int. 2018 Feb;102(2):163-173. doi: 10.1007/s00223-017-0352-6. Epub 2017 Nov 2. Review.

5.

Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments.

Koplev S, Longden J, Ferkinghoff-Borg J, Blicher Bjerregård M, Cox TR, Erler JT, Pedersen JT, Voellmy F, Sommer MOA, Linding R.

Cell Rep. 2017 Sep 19;20(12):2784-2791. doi: 10.1016/j.celrep.2017.08.095.

6.

Fibrosis and Cancer: Partners in Crime or Opposing Forces?

Cox TR, Erler JT.

Trends Cancer. 2016 Jun;2(6):279-282. doi: 10.1016/j.trecan.2016.05.004. Epub 2016 May 30.

PMID:
28741525
7.

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix.

Mayorca-Guiliani AE, Madsen CD, Cox TR, Horton ER, Venning FA, Erler JT.

Nat Med. 2017 Jul;23(7):890-898. doi: 10.1038/nm.4352. Epub 2017 Jun 12.

PMID:
28604702
8.

Pre-metastatic niches: organ-specific homes for metastases.

Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D.

Nat Rev Cancer. 2017 May;17(5):302-317. doi: 10.1038/nrc.2017.6. Epub 2017 Mar 17. Review.

PMID:
28303905
9.

Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour Model.

Elyas E, Papaevangelou E, Alles EJ, Erler JT, Cox TR, Robinson SP, Bamber JC.

Sci Rep. 2017 Mar 13;7(1):165. doi: 10.1038/s41598-017-00144-5.

10.

Dynamics of cancerous tissue correlates with invasiveness.

West AV, Wullkopf L, Christensen A, Leijnse N, Tarp JM, Mathiesen J, Erler JT, Oddershede LB.

Sci Rep. 2017 Mar 6;7:43800. doi: 10.1038/srep43800.

11.

Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.

Chang J, Lucas MC, Leonte LE, Garcia-Montolio M, Singh LB, Findlay AD, Deodhar M, Foot JS, Jarolimek W, Timpson P, Erler JT, Cox TR.

Oncotarget. 2017 Apr 18;8(16):26066-26078. doi: 10.18632/oncotarget.15257.

12.

Multi-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of Flight.

Elyas E, Grimwood A, Erler JT, Robinson SP, Cox TR, Woods D, Clowes P, De Luca R, Marinozzi F, Fromageau J, Bamber JC.

PLoS One. 2017 Jan 20;12(1):e0169664. doi: 10.1371/journal.pone.0169664. eCollection 2017.

13.

The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.

Gartland A, Erler JT, Cox TR.

J Bone Oncol. 2016 Jul 1;5(3):100-103. eCollection 2016 Sep.

14.

Quantification of Lung Metastases from In Vivo Mouse Models.

Chang J, Erler JT.

Adv Exp Med Biol. 2016;899:245-51. doi: 10.1007/978-3-319-26666-4_14.

PMID:
27325271
15.

Nuclear expression of lysyl oxidase enzyme is an independent prognostic factor in rectal cancer patients.

Liu N, Cox TR, Cui W, Adell G, Holmlund B, Ping J, Jarlsfelt I, Erler JT, Sun XF.

Oncotarget. 2016 May 26;8(36):60015-60024. doi: 10.18632/oncotarget.9623. eCollection 2017 Sep 1.

16.

Structural ECM components in the premetastatic and metastatic niche.

Høye AM, Erler JT.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C955-67. doi: 10.1152/ajpcell.00326.2015. Epub 2016 Apr 6. Review.

17.

Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.

Cox TR, Gartland A, Erler JT.

Cancer Res. 2016 Jan 15;76(2):188-92. doi: 10.1158/0008-5472.CAN-15-2306. Epub 2016 Jan 5. Review.

18.

Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.

Cox TR, Schoof EM, Gartland A, Erler JT, Linding R.

Data Brief. 2015 Oct 23;5:621-5. doi: 10.1016/j.dib.2015.09.039. eCollection 2015 Dec.

19.

Targeting ECM Disrupts Cancer Progression.

Venning FA, Wullkopf L, Erler JT.

Front Oncol. 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015. Review.

20.

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Creixell P, Schoof EM, Simpson CD, Longden J, Miller CJ, Lou HJ, Perryman L, Cox TR, Zivanovic N, Palmeri A, Wesolowska-Andersen A, Helmer-Citterich M, Ferkinghoff-Borg J, Itamochi H, Bodenmiller B, Erler JT, Turk BE, Linding R.

Cell. 2015 Sep 24;163(1):202-17. doi: 10.1016/j.cell.2015.08.056. Epub 2015 Sep 17.

21.

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT.

EMBO Rep. 2015 Oct;16(10):1394-408. doi: 10.15252/embr.201540107. Epub 2015 Aug 31.

22.

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction.

González-Santamaría J, Villalba M, Busnadiego O, López-Olañeta MM, Sandoval P, Snabel J, López-Cabrera M, Erler JT, Hanemaaijer R, Lara-Pezzi E, Rodríguez-Pascual F.

Cardiovasc Res. 2016 Jan 1;109(1):67-78. doi: 10.1093/cvr/cvv214. Epub 2015 Aug 10.

PMID:
26260798
23.

Stimulating translational research: several European life science institutions put their heads together.

Bentires-Alj M, Rajan A, van Harten W, van Luenen HG, Kubicek S, Andersen JB, Saarela J, Cook SJ, Van Minnebruggen G, Roman-Roman S, Maurer C, Erler JT, Bertero MG.

Trends Mol Med. 2015 Sep;21(9):525-7. doi: 10.1016/j.molmed.2015.07.002. Epub 2015 Aug 5.

PMID:
26254816
24.

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ.

EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827.

25.

Pten Regulates Epithelial Cytodifferentiation during Prostate Development.

Lokody IB, Francis JC, Gardiner JR, Erler JT, Swain A.

PLoS One. 2015 Jun 15;10(6):e0129470. doi: 10.1371/journal.pone.0129470. eCollection 2015.

26.

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.

Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT.

Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27.

27.

Interdisciplinary research: Bold alliances aid translational work.

Erler JT.

Nature. 2015 Jan 22;517(7535):438. doi: 10.1038/517438e. No abstract available.

PMID:
25612042
28.

STRIPAK components determine mode of cancer cell migration and metastasis.

Madsen CD, Hooper S, Tozluoglu M, Bruckbauer A, Fletcher G, Erler JT, Bates PA, Thompson B, Sahai E.

Nat Cell Biol. 2015 Jan;17(1):68-80. doi: 10.1038/ncb3083. Epub 2014 Dec 22.

29.

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.

Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J, Sturge J.

J Pathol. 2015 Mar;235(4):581-92. doi: 10.1002/path.4485. Epub 2014 Dec 24.

PMID:
25408555
30.

Lysyl oxidase in cancer research.

Perryman L, Erler JT.

Future Oncol. 2014;10(9):1709-17. doi: 10.2217/fon.14.39. Review.

PMID:
25145437
31.

Brain cancer spreads.

Perryman L, Erler JT.

Sci Transl Med. 2014 Jul 30;6(247):247fs28. doi: 10.1126/scitranslmed.3009920.

PMID:
25080473
32.

Ionizing radiation induces tumor cell lysyl oxidase secretion.

Shen CJ, Sharma A, Vuong DV, Erler JT, Pruschy M, Broggini-Tenzer A.

BMC Cancer. 2014 Jul 22;14:532. doi: 10.1186/1471-2407-14-532.

33.

Molecular pathways: connecting fibrosis and solid tumor metastasis.

Cox TR, Erler JT.

Clin Cancer Res. 2014 Jul 15;20(14):3637-43. doi: 10.1158/1078-0432.CCR-13-1059.

34.

Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics.

Djidja MC, Chang J, Hadjiprocopis A, Schmich F, Sinclair J, Mršnik M, Schoof EM, Barker HE, Linding R, Jørgensen C, Erler JT.

J Proteome Res. 2014 May 2;13(5):2297-313. doi: 10.1021/pr401056c. Epub 2014 Apr 24.

PMID:
24702160
35.

Cancer: Disabling defences in the brain.

Erler JT.

Nature. 2014 Apr 3;508(7494):46-7. doi: 10.1038/508046a. No abstract available.

PMID:
24695307
36.

The potential for targeting extracellular LOX proteins in human malignancy.

Mayorca-Guiliani A, Erler JT.

Onco Targets Ther. 2013 Nov 25;6:1729-35. doi: 10.2147/OTT.S38110. Review.

37.

Tumor-secreted LOXL2 activates fibroblasts through FAK signaling.

Barker HE, Bird D, Lang G, Erler JT.

Mol Cancer Res. 2013 Nov;11(11):1425-36. doi: 10.1158/1541-7786.MCR-13-0033-T. Epub 2013 Sep 5.

38.

Lysyl oxidase in colorectal cancer.

Cox TR, Erler JT.

Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G659-66. doi: 10.1152/ajpgi.00425.2012. Epub 2013 Sep 5. Review.

39.

LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.

Chang J, Nicolau MM, Cox TR, Wetterskog D, Martens JW, Barker HE, Erler JT.

Breast Cancer Res. 2013;15(4):R67.

40.

LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis.

Cox TR, Bird D, Baker AM, Barker HE, Ho MW, Lang G, Erler JT.

Cancer Res. 2013 Mar 15;73(6):1721-32. doi: 10.1158/0008-5472.CAN-12-2233. Epub 2013 Jan 23.

41.

Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis.

Baker AM, Bird D, Welti JC, Gourlaouen M, Lang G, Murray GI, Reynolds AR, Cox TR, Erler JT.

Cancer Res. 2013 Jan 15;73(2):583-94. doi: 10.1158/0008-5472.CAN-12-2447. Epub 2012 Nov 27.

42.

Navigating cancer network attractors for tumor-specific therapy.

Creixell P, Schoof EM, Erler JT, Linding R.

Nat Biotechnol. 2012 Sep;30(9):842-8. doi: 10.1038/nbt.2345.

PMID:
22965061
43.

Contrasting effects of sunitinib within in vivo models of metastasis.

Welti JC, Powles T, Foo S, Gourlaouen M, Preece N, Foster J, Frentzas S, Bird D, Sharpe K, van Weverwijk A, Robertson D, Soffe J, Erler JT, Pili R, Springer CJ, Mather SJ, Reynolds AR.

Angiogenesis. 2012 Dec;15(4):623-41. doi: 10.1007/s10456-012-9291-z. Epub 2012 Jul 28.

44.

The rationale for targeting the LOX family in cancer.

Barker HE, Cox TR, Erler JT.

Nat Rev Cancer. 2012 Jul 19;12(8):540-52. doi: 10.1038/nrc3319. Review.

PMID:
22810810
45.

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK.

Baker AM, Bird D, Lang G, Cox TR, Erler JT.

Oncogene. 2013 Apr 4;32(14):1863-8. doi: 10.1038/onc.2012.202. Epub 2012 May 28.

PMID:
22641216
46.

Network medicine strikes a blow against breast cancer.

Erler JT, Linding R.

Cell. 2012 May 11;149(4):731-3. doi: 10.1016/j.cell.2012.04.014.

47.

The pre-metastatic niche: is metastasis random?

Cox TR, Gartland A, Erler JT.

Bonekey Rep. 2012 May 2;1:80. doi: 10.1038/bonekey.2012.80. eCollection 2012. Review.

48.

The potential for LOXL2 as a target for future cancer treatment.

Barker HE, Erler JT.

Future Oncol. 2011 Jun;7(6):707-10. doi: 10.2217/fon.11.46. No abstract available.

PMID:
21675833
49.

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer.

Cox TR, Erler JT.

Dis Model Mech. 2011 Mar;4(2):165-78. doi: 10.1242/dmm.004077. Epub 2011 Feb 14.

50.

The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer.

Baker AM, Cox TR, Bird D, Lang G, Murray GI, Sun XF, Southall SM, Wilson JR, Erler JT.

J Natl Cancer Inst. 2011 Mar 2;103(5):407-24. doi: 10.1093/jnci/djq569. Epub 2011 Jan 31.

PMID:
21282564

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