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Efficient RNP-Directed Human Gene Targeting Reveals SPDEF is Required for IL-13-Induced Mucostasis.

Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ.

Am J Respir Cell Mol Biol. 2019 Oct 9. doi: 10.1165/rcmb.2019-0266OC. [Epub ahead of print]


The airway epithelium in asthma.

Bonser LR, Erle DJ.

Adv Immunol. 2019;142:1-34. doi: 10.1016/ Epub 2019 Jul 1.


The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.

Sin JH, Zuckerman C, Cortez JT, Eckalbar WL, Erle DJ, Anderson MS, Waterfield MR.

J Exp Med. 2019 Sep 2;216(9):2024-2037. doi: 10.1084/jem.20182316. Epub 2019 Jun 19.


A massively parallel 3' UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization.

Litterman AJ, Kageyama R, Le Tonqueze O, Zhao W, Gagnon JD, Goodarzi H, Erle DJ, Ansel KM.

Genome Res. 2019 Jun;29(6):896-906. doi: 10.1101/gr.242552.118. Epub 2019 May 31.


Singling out Th2 cells in eosinophilic esophagitis.

Eckalbar WL, Erle DJ.

J Clin Invest. 2019 Apr 8;129(5):1830-1832. doi: 10.1172/JCI128479. eCollection 2019 Apr 8.


An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.


Large Differences in Small RNA Composition Between Human Biofluids.

Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ.

Cell Rep. 2018 Oct 30;25(5):1346-1358. doi: 10.1016/j.celrep.2018.10.014.


Putting Mucins on the Map.

Bonser LR, Erle DJ.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):681-682. doi: 10.1164/rccm.201809-1818ED. No abstract available.


Integrative approach identifies corticosteroid response variant in diverse populations with asthma.

Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK.

J Allergy Clin Immunol. 2019 May;143(5):1791-1802. doi: 10.1016/j.jaci.2018.09.034. Epub 2018 Oct 24.


Tissue signals imprint ILC2 identity with anticipatory function.

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM.

Nat Immunol. 2018 Oct;19(10):1093-1099. doi: 10.1038/s41590-018-0201-4. Epub 2018 Sep 10.


Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M.

Nat Biotechnol. 2018 Sep 6;36(9):899. doi: 10.1038/nbt0918-899b. No abstract available.


Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.

Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, Locksley RM, Anderson MS.

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.


Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.

Nadjsombati MS, McGinty JW, Lyons-Cohen MR, Jaffe JB, DiPeso L, Schneider C, Miller CN, Pollack JL, Nagana Gowda GA, Fontana MF, Erle DJ, Anderson MS, Locksley RM, Raftery D, von Moltke J.

Immunity. 2018 Jul 17;49(1):33-41.e7. doi: 10.1016/j.immuni.2018.06.016.


Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling.

Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M.

Nat Biotechnol. 2018 Sep;36(8):746-757. doi: 10.1038/nbt.4183. Epub 2018 Jul 16.


Widespread Effects of Chemokine 3' Untranslated Regions on mRNA Degradation and Protein Production in Human Cells.

Zhao W, Erle DJ.

J Immunol. 2018 Aug 1;201(3):1053-1061. doi: 10.4049/jimmunol.1800114. Epub 2018 Jun 15.


CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.

Oh J, Wu N, Barczak AJ, Barbeau R, Erle DJ, Shin JS.

J Immunol. 2018 Feb 15;200(4):1399-1412. doi: 10.4049/jimmunol.1700768. Epub 2018 Jan 10.


Airway Mucus and Asthma: The Role of MUC5AC and MUC5B.

Bonser LR, Erle DJ.

J Clin Med. 2017 Nov 29;6(12). pii: E112. doi: 10.3390/jcm6120112. Review.


IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):313-324. doi: 10.1164/rccm.201706-1070OC.


CRISPR-Cas9-mediated functional dissection of 3'-UTRs.

Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ.

Nucleic Acids Res. 2017 Oct 13;45(18):10800-10810. doi: 10.1093/nar/gkx675.


Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD.

Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2017 Jun 22;49(6). pii: 1602322. doi: 10.1183/13993003.02322-2016. Print 2017 Jun.


Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP.

Cell Rep. 2017 May 23;19(8):1558-1571. doi: 10.1016/j.celrep.2017.04.076.


Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM.

Cell. 2017 Apr 20;169(3):497-509.e13. doi: 10.1016/j.cell.2017.03.044.


Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.

Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H, Di H, Zou Y, Zhang H, Zhao J, Xu Y, Erle DJ, Zhen G.

Mucosal Immunol. 2017 Nov;10(6):1491-1503. doi: 10.1038/mi.2017.10. Epub 2017 Feb 22.


A tissue checkpoint regulates type 2 immunity.

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM.

Nat Immunol. 2016 Dec;17(12):1381-1387. doi: 10.1038/ni.3582. Epub 2016 Oct 17.


Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol.

Khosravi AR, Erle DJ.

PLoS One. 2016 Jul 27;11(7):e0159459. doi: 10.1371/journal.pone.0159459. eCollection 2016.


miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis.

Disayabutr S, Kim EK, Cha SI, Green G, Naikawadi RP, Jones KD, Golden JA, Schroeder A, Matthay MA, Kukreja J, Erle DJ, Collard HR, Wolters PJ.

PLoS One. 2016 Jun 30;11(6):e0158367. doi: 10.1371/journal.pone.0158367. eCollection 2016.


Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

Bonser LR, Zlock L, Finkbeiner W, Erle DJ.

J Clin Invest. 2016 Jun 1;126(6):2367-71. doi: 10.1172/JCI84910. Epub 2016 May 16.


Massively Parallel Identification of Regulatory Variants in Asthma.

Biton A, Torgerson D, Letonqueze O, Zhao W, Zaitlen N, Erle DJ.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S104. doi: 10.1513/AnnalsATS.201508-523MG. No abstract available.


Linoleic acid-derived lipid mediators increase in a female-dominated subphenotype of COPD.

Balgoma D, Yang M, Sjödin M, Snowden S, Karimi R, Levänen B, Merikallio H, Kaarteenaho R, Palmberg L, Larsson K, Erle DJ, Dahlén SE, Dahlén B, Sköld CM, Wheelock ÅM, Wheelock CE.

Eur Respir J. 2016 Jun;47(6):1645-56. doi: 10.1183/13993003.01080-2015. Epub 2016 Mar 10.


MicroRNAs 24 and 27 Suppress Allergic Inflammation and Target a Network of Regulators of T Helper 2 Cell-Associated Cytokine Production.

Pua HH, Steiner DF, Patel S, Gonzalez JR, Ortiz-Carpena JF, Kageyama R, Chiou NT, Gallman A, de Kouchkovsky D, Jeker LT, McManus MT, Erle DJ, Ansel KM.

Immunity. 2016 Apr 19;44(4):821-32. doi: 10.1016/j.immuni.2016.01.003. Epub 2016 Feb 2.


Identification of MiR-205 As a MicroRNA That Is Highly Expressed in Medullary Thymic Epithelial Cells.

Khan IS, Park CY, Mavropoulos A, Shariat N, Pollack JL, Barczak AJ, Erle DJ, McManus MT, Anderson MS, Jeker LT.

PLoS One. 2015 Aug 13;10(8):e0135440. doi: 10.1371/journal.pone.0135440. eCollection 2015.


Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1102-13. doi: 10.1152/ajplung.00380.2014. Epub 2015 Mar 20.


The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.

Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):536-43. doi: 10.1165/rcmb.2014-0318OC.


Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Dec 8;26(6):938. doi: 10.1016/j.ccell.2014.11.010. Epub 2014 Dec 8. No abstract available.


Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF.

Cancer Cell. 2014 Nov 10;26(5):638-52. doi: 10.1016/j.ccell.2014.09.007. Epub 2014 Oct 16.


IL-17 and "TH2-high" asthma: Adding fuel to the fire?

Bhakta NR, Erle DJ.

J Allergy Clin Immunol. 2014 Nov;134(5):1187-8. doi: 10.1016/j.jaci.2014.07.034. Epub 2014 Aug 28. No abstract available.


Epithelial interleukin-25 is a key mediator in Th2-high, corticosteroid-responsive asthma.

Cheng D, Xue Z, Yi L, Shi H, Zhang K, Huo X, Bonser LR, Zhao J, Xu Y, Erle DJ, Zhen G.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):639-48. doi: 10.1164/rccm.201403-0505OC.


Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL.

Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074.


The cell biology of asthma.

Erle DJ, Sheppard D.

J Cell Biol. 2014 Jun 9;205(5):621-31. doi: 10.1083/jcb.201401050. Review.


Massively parallel functional annotation of 3' untranslated regions.

Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ.

Nat Biotechnol. 2014 Apr;32(4):387-91. doi: 10.1038/nbt.2851. Epub 2014 Mar 16.


The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

Waterfield M, Khan IS, Cortez JT, Fan U, Metzger T, Greer A, Fasano K, Martinez-Llordella M, Pollack JL, Erle DJ, Su M, Anderson MS.

Nat Immunol. 2014 Mar;15(3):258-65. doi: 10.1038/ni.2820. Epub 2014 Jan 26. Erratum in: Nat Immunol. 2014 Sep;15(9):894.


Asthmatics with exacerbation during acute respiratory illness exhibit unique transcriptional signatures within the nasal mucosa.

McErlean P, Berdnikovs S, Favoreto S Jr, Shen J, Biyasheva A, Barbeau R, Eisley C, Barczak A, Ward T, Schleimer RP, Erle DJ, Boushey HA, Avila PC.

Genome Med. 2014 Jan 17;6(1):1. doi: 10.1186/gm520. eCollection 2014.


Hands-on workshops as an effective means of learning advanced technologies including genomics, proteomics and bioinformatics.

Reisdorph N, Stearman R, Kechris K, Phang TL, Reisdorph R, Prenni J, Erle DJ, Coldren C, Schey K, Nesvizhskii A, Geraci M.

Genomics Proteomics Bioinformatics. 2013 Dec;11(6):368-77. doi: 10.1016/j.gpb.2013.10.002. Epub 2013 Dec 6.


Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.

Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL.

J Clin Invest. 2013 Sep;123(9):3728-39. doi: 10.1172/JCI68182. Epub 2013 Aug 8.


Apolipoprotein A1 potentiates lipoxin A4 synthesis and recovery of allergen-induced disrupted tight junctions in the airway epithelium.

Park SW, Lee EH, Lee EJ, Kim HJ, Bae DJ, Han S, Kim D, Jang AS, Uh ST, Kim YH, Erle DJ, Park CS.

Clin Exp Allergy. 2013 Aug;43(8):914-27. doi: 10.1111/cea.12143.


Molecular basis of selective atrial fibrosis due to overexpression of transforming growth factor-β1.

Rahmutula D, Marcus GM, Wilson EE, Ding CH, Xiao Y, Paquet AC, Barbeau R, Barczak AJ, Erle DJ, Olgin JE.

Cardiovasc Res. 2013 Sep 1;99(4):769-79. doi: 10.1093/cvr/cvt074. Epub 2013 Apr 23.


T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire.

Bronevetsky Y, Villarino AV, Eisley CJ, Barbeau R, Barczak AJ, Heinz GA, Kremmer E, Heissmeyer V, McManus MT, Erle DJ, Rao A, Ansel KM.

J Exp Med. 2013 Feb 11;210(2):417-32. doi: 10.1084/jem.20111717. Epub 2013 Feb 4.


Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients.

Levänen B, Bhakta NR, Torregrosa Paredes P, Barbeau R, Hiltbrunner S, Pollack JL, Sköld CM, Svartengren M, Grunewald J, Gabrielsson S, Eklund A, Larsson BM, Woodruff PG, Erle DJ, Wheelock ÅM.

J Allergy Clin Immunol. 2013 Mar;131(3):894-903. doi: 10.1016/j.jaci.2012.11.039. Epub 2013 Jan 16.


An integrated nano-scale approach to profile miRNAs in limited clinical samples.

Seumois G, Vijayanand P, Eisley CJ, Omran N, Kalinke L, North M, Ganesan AP, Simpson LJ, Hunkapiller N, Moltzahn F, Woodruff PG, Fahy JV, Erle DJ, Djukanovic R, Blelloch R, Ansel KM.

Am J Clin Exp Immunol. 2012 Nov 30;1(2):70-89.


Airway epithelial miRNA expression is altered in asthma.

Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):965-74. doi: 10.1164/rccm.201201-0027OC. Epub 2012 Sep 6.

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