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Items: 49

1.

The fungal metabolite cyclonerodiol inhibits IL-4/IL-13 induced Stat6-signaling through blocking the association of Stat6 with p38, ERK1/2 and p300.

Rudolph AK, Walter T, Erkel G.

Int Immunopharmacol. 2018 Dec;65:392-401. doi: 10.1016/j.intimp.2018.10.033. Epub 2018 Oct 27.

PMID:
30380514
2.

Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitro Models.

Schreiber D, Marx L, Felix S, Clasohm J, Weyland M, Schäfer M, Klotz M, Lilischkis R, Erkel G, Schäfer KH.

Front Physiol. 2017 Aug 7;8:566. doi: 10.3389/fphys.2017.00566. eCollection 2017.

3.

Anti-inflammatory tetraquinane diterpenoids from a Crinipellis species.

Rohr M, Oleinikov K, Jung M, Sandjo LP, Opatz T, Erkel G.

Bioorg Med Chem. 2017 Jan 15;25(2):514-522. doi: 10.1016/j.bmc.2016.11.016. Epub 2016 Nov 12.

PMID:
27887964
4.

A surprising switch in absolute configuration of anti-inflammatory macrolactones.

Tauber J, Rohr M, Walter T, Schollmeyer D, Rahn-Hotze K, Erkel G, Opatz T.

Org Biomol Chem. 2016 Apr 12;14(15):3695-8. doi: 10.1039/c6ob00430j.

PMID:
27035902
5.

Correction: Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type.

Tauber J, Rohr M, Walter T, Erkel G, Opatz T.

Org Biomol Chem. 2015 Sep 7;13(33):8945-6. doi: 10.1039/c5ob90127h. Epub 2015 Aug 5. No abstract available.

PMID:
26244410
6.

Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type.

Tauber J, Rohr M, Walter T, Erkel G, Opatz T.

Org Biomol Chem. 2015 Jul 28;13(28):7813-21. doi: 10.1039/c5ob01044f. Epub 2015 Jun 24. Erratum in: Org Biomol Chem. 2015 Sep 7;13(33):8945-6.

PMID:
26106910
7.

Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice.

Bollmann F, Jäckel S, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U, Kleinert H, Pautz A.

PLoS One. 2015 Jun 15;10(6):e0130401. doi: 10.1371/journal.pone.0130401. eCollection 2015.

8.

4-Dechloro-14-deoxy-oxacyclododecindione and 14-deoxy-oxacylododecindione, two inhibitors of inducible connective tissue growth factor expression from the imperfect fungus Exserohilum rostratum.

Richter J, Sandjo LP, Liermann JC, Opatz T, Erkel G.

Bioorg Med Chem. 2015 Feb 1;23(3):556-63. doi: 10.1016/j.bmc.2014.12.004. Epub 2014 Dec 8.

PMID:
25537529
9.

Total synthesis and biological evaluation of the natural product (-)-cyclonerodiol, a new inhibitor of IL-4 signaling.

Langhanki J, Rudolph K, Erkel G, Opatz T.

Org Biomol Chem. 2014 Dec 21;12(47):9707-15. doi: 10.1039/c4ob02021a. Epub 2014 Oct 28.

PMID:
25350537
10.

Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species.

Felix S, Sandjo LP, Opatz T, Erkel G.

Bioorg Med Chem. 2014 Jun 1;22(11):2912-8. doi: 10.1016/j.bmc.2014.04.015. Epub 2014 Apr 18.

PMID:
24792812
11.

The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease.

Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke J, Pautz A.

Kidney Int. 2014 Oct;86(4):780-9. doi: 10.1038/ki.2014.109. Epub 2014 Apr 9.

12.

SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression.

Felix S, Sandjo LP, Opatz T, Erkel G.

Beilstein J Org Chem. 2013 Dec 13;9:2866-76. doi: 10.3762/bjoc.9.323. eCollection 2013.

13.

Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone.

Rudolph K, Serwe A, Erkel G.

Cytokine. 2013 Jan;61(1):285-96. doi: 10.1016/j.cyto.2012.10.011. Epub 2012 Nov 5.

PMID:
23134667
14.

The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.

Schmidt N, Art J, Forsch I, Werner A, Erkel G, Jung M, Horke S, Kleinert H, Pautz A.

J Pharmacol Exp Ther. 2012 Oct;343(1):106-14. doi: 10.1124/jpet.112.192047. Epub 2012 Jul 5.

PMID:
22767531
15.

3'-Demethyldihydromaldoxin and dihydromaldoxin, two anti-inflammtory diaryl ethers from a Steganospora species.

Schreiber D, Jung M, Sandjo LP, Liermann JC, Opatz T, Erkel G.

J Antibiot (Tokyo). 2012 Sep;65(9):473-7. doi: 10.1038/ja.2012.46. Epub 2012 Jun 13.

PMID:
22692347
16.

Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum.

Jung M, Liermann JC, Opatz T, Erkel G.

J Antibiot (Tokyo). 2011 Oct;64(10):683-686. doi: 10.1038/ja.2011.64. Epub 2011 Jul 27.

PMID:
21792205
17.

Inhibition of TGF-β signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol.

Serwe A, Rudolph K, Anke T, Erkel G.

Invest New Drugs. 2012 Jun;30(3):898-915. doi: 10.1007/s10637-011-9643-3. Epub 2011 Feb 22.

PMID:
21340508
18.

Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

Hausding M, Tepe M, Ubel C, Lehr HA, Röhrig B, Höhn Y, Pautz A, Eigenbrod T, Anke T, Kleinert H, Erkel G, Finotto S.

Int Immunol. 2011 Jan;23(1):1-15. doi: 10.1093/intimm/dxq451. Epub 2010 Dec 6.

PMID:
21135031
19.

Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes.

Schmidt N, Pautz A, Art J, Rauschkolb P, Jung M, Erkel G, Goldring MB, Kleinert H.

Biochem Pharmacol. 2010 Mar 1;79(5):722-32. doi: 10.1016/j.bcp.2009.10.012. Epub 2009 Oct 23.

20.

Influence of apple polyphenols on inflammatory gene expression.

Jung M, Triebel S, Anke T, Richling E, Erkel G.

Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

PMID:
19764067
21.

The fungal secondary metabolite trichodimerol inhibits TGF-β dependent cellular effects and tube formation of MDA-MB-231 cells.

Serwe A, Anke T, Erkel G.

Invest New Drugs. 2009 Dec;27(6):491-502. doi: 10.1007/s10637-008-9201-9. Epub 2008 Nov 14.

PMID:
19009233
22.

Oxacyclododecindione, a novel inhibitor of IL-4 signaling from Exserohilum rostratum.

Erkel G, Belahmer H, Serwe A, Anke T, Kunz H, Kolshorn H, Liermann J, Opatz T.

J Antibiot (Tokyo). 2008 May;61(5):285-90. doi: 10.1038/ja.2008.40.

PMID:
18653993
23.

Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues.

Elzner S, Schmidt D, Schollmeyer D, Erkel G, Anke T, Kleinert H, Förstermann U, Kunz H.

ChemMedChem. 2008 Jun;3(6):924-39. doi: 10.1002/cmdc.200800022.

PMID:
18366037
24.

Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-alpha expression in T cells.

Rether J, Erkel G, Anke T, Bajtner J, Sterner O.

Bioorg Med Chem. 2008 Feb 1;16(3):1236-41. Epub 2007 Nov 26.

PMID:
18035545
25.
26.

Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells.

Erkel G, Wisser G, Anke T.

Int Immunopharmacol. 2007 May;7(5):612-24. Epub 2007 Jan 29.

PMID:
17386409
27.

Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca.

Rether J, Erkel G, Sterner O, Anke T.

Z Naturforsch C. 2005 May-Jun;60(5-6):478-84.

PMID:
16042350
29.
30.

S14-95, a novel inhibitor of the JAK/STAT pathway from a Penicillium species.

Erkel G, Rether J, Anke T, Sterner O.

J Antibiot (Tokyo). 2003 Apr;56(4):337-43.

31.

Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi.

Yao Y, Hausding M, Erkel G, Anke T, Förstermann U, Kleinert H.

Mol Pharmacol. 2003 Feb;63(2):383-91.

PMID:
12527810
32.

Induction of differentiation in acute promyelocytic leukemia cells (HL-60) by the verticillin derivative Sch 52900.

Erkel G, Gehrt A, Anke T, Sterner O.

Z Naturforsch C. 2002 Jul-Aug;57(7-8):759-67.

PMID:
12241008
33.

Gerronemins A-F, cytotoxic biscatechols from a Gerronema species.

Silberborth S, Stumpf A, Erkel G, Anke T, Sterner O.

Phytochemistry. 2002 Mar;59(6):643-8.

PMID:
11867096
34.

New bioactive cyclopentenone derivatives as inhibitors of the IL-6 dependent signal transduction.

Weidler M, Rether J, Anke T, Erkel G, Sterner O.

J Antibiot (Tokyo). 2001 Aug;54(8):679-81. No abstract available.

35.

Trichodion, a new bioactive pyrone from a Trichosporiella species.

Erkel G, Rether J, Anke T, Sterner O.

J Antibiot (Tokyo). 2000 Dec;53(12):1401-4. No abstract available.

36.

The irpexans, a new group of biologically active metabolites produced by the basidiomycete Irpex sp. 93028.

Silberborth S, Erkel G, Anke T, Sterner O.

J Antibiot (Tokyo). 2000 Oct;53(10):1137-44.

37.

Inhibition of interleukin-6 signaling by galiellalactone.

Weidler M, Rether J, Anke T, Erkel G.

FEBS Lett. 2000 Oct 27;484(1):1-6.

38.

Inhibition of interleukin-6 signaling and Stat3 activation by a new class of bioactive cyclopentenone derivatives.

Weidler M, Rether J, Anke T, Erkel G.

Biochem Biophys Res Commun. 2000 Sep 24;276(2):447-53.

PMID:
11027495
40.

Sesquicillin, an inhibitor of glucocorticoid mediated signal transduction.

Engel L, Erkel G, Anke T, Sterner O.

J Antibiot (Tokyo). 1998 May;51(5):518-21. No abstract available.

42.

Nitidon, a new bioactive metabolite from the basidiomycete Junghuhnia nitida (Pers.: Fr.) Ryv.

Gehrt A, Erkel G, Anke T, Sterner O.

Z Naturforsch C. 1998 Jan-Feb;53(1-2):89-92.

PMID:
9528126
43.

Pulvinatal, a novel bioactive metabolite from the basidiomycete Nidularia pulvinata (Schw.) Fr.

Becker U, Erkel G, Kocksch G, Anke T, Sterner O.

Z Naturforsch C. 1997 May-Jun;52(5-6):313-8.

PMID:
9232889
44.

Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida.

Erkel G, Becker U, Anke T, Sterner O.

J Antibiot (Tokyo). 1996 Dec;49(12):1189-95.

45.

Inhibition of NF-kappa B activation by panepoxydone.

Erkel G, Anke T, Sterner O.

Biochem Biophys Res Commun. 1996 Sep 4;226(1):214-21.

PMID:
8806616
46.

Kuehneromycins A and B, two new biological active compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes).

Erkel G, Lorenzen K, Anke T, Velten R, Gimenez A, Steglich W.

Z Naturforsch C. 1995 Jan-Feb;50(1-2):1-9.

PMID:
7535532
47.

Hyphodontal, a new antifungal inhibitor of reverse transcriptases from Hyphodontia sp. (Corticiaceae, Basidiomycetes).

Erkel G, Anke T, Velten R, Gimenez A, Steglich W.

Z Naturforsch C. 1994 Sep-Oct;49(9-10):561-70.

PMID:
7524515
48.
49.

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