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Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.

Andersson CK, Shikhagaie M, Mori M, Al-Garawi A, Reed JL, Humbles AA, Welliver R, Mauad T, Bjermer L, Jordana M, Erjefält JS.

ERJ Open Res. 2018 Nov 23;4(4). pii: 00038-2018. doi: 10.1183/23120541.00038-2018. eCollection 2018 Oct.


Unravelling the complexity of tissue inflammation in uncontrolled and severe asthma.

Erjefält JS.

Curr Opin Pulm Med. 2019 Jan;25(1):79-86. doi: 10.1097/MCP.0000000000000536.


IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity.

Ravanetti L, Dijkhuis A, Dekker T, Sabogal Pineros YS, Ravi A, Dierdorp BS, Erjefält JS, Mori M, Pavlidis S, Adcock IM, Rao NL, Lutter R.

J Allergy Clin Immunol. 2018 Oct 12. pii: S0091-6749(18)31434-9. doi: 10.1016/j.jaci.2018.08.051. [Epub ahead of print]


Bronchoscopic mucosal cryobiopsies as a method for studying airway disease.

Hvidtfeldt M, Pulga A, Hostrup M, Sanden C, Mori M, Bornesund D, Larsen KR, Erjefält JS, Porsbjerg C.

Clin Exp Allergy. 2018 Sep 23. doi: 10.1111/cea.13281. [Epub ahead of print]


Osteopontin protects against lung injury caused by extracellular histones.

Kasetty G, Papareddy P, Bhongir RKV, Ali MN, Mori M, Wygrecka M, Erjefält JS, Hultgårdh-Nilsson A, Palmberg L, Herwald H, Egesten A.

Mucosal Immunol. 2018 Aug 16. doi: 10.1038/s41385-018-0079-3. [Epub ahead of print]


Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.

Scott IC, Majithiya JB, Sanden C, Thornton P, Sanders PN, Moore T, Guscott M, Corkill DJ, Erjefält JS, Cohen ES.

Sci Rep. 2018 Feb 20;8(1):3363. doi: 10.1038/s41598-018-21589-2.


Uncontrolled asthmatics have increased FceRI+ and TGF-β-positive MCTC mast cells and collagen VI in the alveolar parenchyma.

Andersson CK, Weitoft M, Rydell-Törmänen K, Bjermer L, Westergren-Thorsson G, Erjefält JS.

Clin Exp Allergy. 2018 Mar;48(3):266-277. doi: 10.1111/cea.13092. Epub 2018 Feb 15.


Intratumoural leukocyte infiltration is a prognostic indicator among pancreatic cancer patients with type 2 diabetes.

Karnevi E, Sasor A, Hilmersson KS, Ansari D, Erjefält JS, Rosendahl AH, Andersson R.

Pancreatology. 2018 Jan;18(1):85-93. doi: 10.1016/j.pan.2017.11.003. Epub 2017 Nov 11.


IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

Briend E, Ferguson GJ, Mori M, Damera G, Stephenson K, Karp NA, Sethi S, Ward CK, Sleeman MA, Erjefält JS, Finch DK.

Respir Res. 2017 Aug 22;18(1):159. doi: 10.1186/s12931-017-0641-7.


Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, Nagasawa M, Erjefält JS, Mori M, Flodström-Tullberg M, Bergquist A, Ljunggren HG, Westgren M, Lindforss U, Friberg D, Jorns C, Ellis E, Björkström NK, Mjösberg J.

Eur J Immunol. 2017 Aug;47(8):1280-1294. doi: 10.1002/eji.201646890. Epub 2017 Jul 11.


Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis.

Sanden C, Mori M, Jogdand P, Jönsson J, Krishnan R, Wang X, Erjefält JS.

Immun Inflamm Dis. 2017 Sep;5(3):300-309. doi: 10.1002/iid3.164. Epub 2017 May 12.

Free PMC Article

Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF.

Roos AB, Mori M, Gura HK, Lorentz A, Bjermer L, Hoffmann HJ, Erjefält JS, Stampfli MR.

Respir Res. 2017 Mar 15;18(1):48. doi: 10.1186/s12931-017-0534-9.


Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates.

Shikhagaie MM, Björklund ÅK, Mjösberg J, Erjefält JS, Cornelissen AS, Ros XR, Bal SM, Koning JJ, Mebius RE, Mori M, Bruchard M, Blom B, Spits H.

Cell Rep. 2017 Feb 14;18(7):1761-1773. doi: 10.1016/j.celrep.2017.01.063.


Eosinophilic airway inflammation in asthmatic patients is associated with an altered airway microbiome.

Sverrild A, Kiilerich P, Brejnrod A, Pedersen R, Porsbjerg C, Bergqvist A, Erjefält JS, Kristiansen K, Backer V.

J Allergy Clin Immunol. 2017 Aug;140(2):407-417.e11. doi: 10.1016/j.jaci.2016.10.046. Epub 2016 Dec 29.


Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: Clinical and histopathologic correlations.

Pretolani M, Bergqvist A, Thabut G, Dombret MC, Knapp D, Hamidi F, Alavoine L, Taillé C, Chanez P, Erjefält JS, Aubier M.

J Allergy Clin Immunol. 2017 Apr;139(4):1176-1185. doi: 10.1016/j.jaci.2016.08.009. Epub 2016 Sep 5.


Inducible nitric oxide synthase expression is increased in the alveolar compartment of asthmatic patients.

Tufvesson E, Andersson C, Weidner J, Erjefält JS, Bjermer L.

Allergy. 2017 Apr;72(4):627-635. doi: 10.1111/all.13052. Epub 2016 Oct 14.


Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005c. No abstract available.


Pulmonary and pleural lymphatic endothelial cells from pediatric, but not adult, patients with Gorham-Stout disease and generalized lymphatic anomaly, show a high proliferation rate.

Mori M, Dictor M, Brodszki N, López-Gutiérrez JC, Beato M, Erjefält JS, Eklund EA.

Orphanet J Rare Dis. 2016 May 18;11(1):67. doi: 10.1186/s13023-016-0449-4.


IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs.

Bal SM, Bernink JH, Nagasawa M, Groot J, Shikhagaie MM, Golebski K, van Drunen CM, Lutter R, Jonkers RE, Hombrink P, Bruchard M, Villaudy J, Munneke JM, Fokkens W, Erjefält JS, Spits H, Ros XR.

Nat Immunol. 2016 Jun;17(6):636-45. doi: 10.1038/ni.3444. Epub 2016 Apr 25.


Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jun;17(6):626-35. doi: 10.1038/ni.3443. Epub 2016 Apr 25. Erratum in: Nat Immunol. 2016 Jul 19;17 (8):1005.


Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours.

Braekeveldt N, Wigerup C, Tadeo I, Beckman S, Sandén C, Jönsson J, Erjefält JS, Berbegall AP, Börjesson A, Backman T, Øra I, Navarro S, Noguera R, Gisselsson D, Påhlman S, Bexell D.

Cancer Lett. 2016 Jun 1;375(2):384-389. doi: 10.1016/j.canlet.2016.02.046. Epub 2016 Mar 18.


IL-33 is related to innate immune activation and sensitization to HDM in mild steroid-free asthma.

Porsbjerg C, Baines K, Gibson P, Bergqvist A, Erjefält JS, Sverrild A, Backer V.

Clin Exp Allergy. 2016 Apr;46(4):564-74. doi: 10.1111/cea.12702.


Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

Gela A, Bhongir RK, Mori M, Keenan P, Mörgelin M, Erjefält JS, Herwald H, Egesten A, Kasetty G.

PLoS One. 2016 Jan 5;11(1):e0146192. doi: 10.1371/journal.pone.0146192. eCollection 2016.


Small airway epithelial-C/EBPβ is increased in patients with advanced COPD.

Mori M, Bjermer L, Erjefält JS, Stampfli MR, Roos AB.

Respir Res. 2015 Oct 29;16:133. doi: 10.1186/s12931-015-0297-0.


Osteopontin binds and modulates functions of eosinophil-recruiting chemokines.

Gela A, Kasetty G, Mörgelin M, Bergqvist A, Erjefält JS, Pease JE, Egesten A.

Allergy. 2016 Jan;71(1):58-67. doi: 10.1111/all.12771. Epub 2015 Oct 20.


Airway responsiveness to mannitol in asthma is associated with chymase-positive mast cells and eosinophilic airway inflammation.

Sverrild A, Bergqvist A, Baines KJ, Porsbjerg C, Andersson CK, Thomsen SF, Hoffmann HJ, Gibson P, Erjefält JS, Backer V.

Clin Exp Allergy. 2016 Feb;46(2):288-97. doi: 10.1111/cea.12609.


IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Roos AB, Sethi S, Nikota J, Wrona CT, Dorrington MG, Sandén C, Bauer CM, Shen P, Bowdish D, Stevenson CS, Erjefält JS, Stampfli MR.

Am J Respir Crit Care Med. 2015 Aug 15;192(4):428-37. doi: 10.1164/rccm.201409-1689OC.


The neutrophil-recruiting chemokine GCP-2/CXCL6 is expressed in cystic fibrosis airways and retains its functional properties after binding to extracellular DNA.

Jovic S, Linge HM, Shikhagaie MM, Olin AI, Lannefors L, Erjefält JS, Mörgelin M, Egesten A.

Mucosal Immunol. 2016 Jan;9(1):112-23. doi: 10.1038/mi.2015.43. Epub 2015 May 20.


IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis.

Roos AB, Sandén C, Mori M, Bjermer L, Stampfli MR, Erjefält JS.

Am J Respir Crit Care Med. 2015 Jun 1;191(11):1232-41. doi: 10.1164/rccm.201410-1861OC.


Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

Kearley J, Silver JS, Sanden C, Liu Z, Berlin AA, White N, Mori M, Pham TH, Ward CK, Criner GJ, Marchetti N, Mustelin T, Erjefalt JS, Kolbeck R, Humbles AA.

Immunity. 2015 Mar 17;42(3):566-79. doi: 10.1016/j.immuni.2015.02.011.


The polyamine spermine promotes survival and activation of human eosinophils.

Ilmarinen P, Moilanen E, Erjefält JS, Kankaanranta H.

J Allergy Clin Immunol. 2015 Aug;136(2):482-4.e11. doi: 10.1016/j.jaci.2014.12.1922. Epub 2015 Jan 30. No abstract available.


Osteopontin is increased in cystic fibrosis and can skew the functional balance between ELR-positive and ELR-negative CXC-chemokines.

Jovic S, Shikhagaie M, Mörgelin M, Erjefält JS, Kjellström S, Egesten A.

J Cyst Fibros. 2015 Jul;14(4):453-63. doi: 10.1016/j.jcf.2014.11.010. Epub 2014 Dec 6.


A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.

Holmkvist P, Roepstorff K, Uronen-Hansson H, Sandén C, Gudjonsson S, Patschan O, Grip O, Marsal J, Schmidtchen A, Hornum L, Erjefält JS, Håkansson K, Agace WW.

Mucosal Immunol. 2015 May;8(3):545-58. doi: 10.1038/mi.2014.87. Epub 2014 Oct 1.


Mast cells in human airways: the culprit?

Erjefält JS.

Eur Respir Rev. 2014 Sep;23(133):299-307. doi: 10.1183/09059180.00005014. Review.


Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.

J Exp Med. 2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.


Alveolar T-helper type-2 immunity in atopic asthma is associated with poor clinical control.

Bergqvist A, Andersson CK, Mori M, Walls AF, Bjermer L, Erjefält JS.

Clin Sci (Lond). 2015 Jan;128(1):47-56. doi: 10.1042/CS20140309.


Oral iodinated activated charcoal improves lung function in patients with COPD.

Skogvall S, Erjefält JS, Olin AI, Ankerst J, Bjermer L.

Respir Med. 2014 Jun;108(6):905-9. doi: 10.1016/j.rmed.2014.03.001. Epub 2014 Mar 12.


Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS.

Roos AB, Mori M, Grönneberg R, Österlund C, Claesson HE, Wahlström J, Grunewald J, Eklund A, Erjefält JS, Lundberg JO, Nord M.

PLoS One. 2014 Feb 28;9(2):e90018. doi: 10.1371/journal.pone.0090018. eCollection 2014.


Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma.

Shikhagaie MM, Andersson CK, Mori M, Kortekaas Krohn I, Bergqvist A, Dahl R, Ekblad E, Hoffmann HJ, Bjermer L, Erjefält JS.

Clin Exp Allergy. 2014 Feb;44(2):184-96. doi: 10.1111/cea.12176.


Marked epithelial cell pathology and leukocyte paucity in persistently symptomatic severe asthma.

Bergqvist A, Andersson CK, Hoffmann HJ, Mori M, Shikhagaie M, Krohn IK, Dahl R, Bjermer L, Erjefält JS.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1475-7. doi: 10.1164/rccm.201308-1444LE. No abstract available.


Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF.

Swärd K, Sadegh MK, Mori M, Erjefält JS, Rippe C.

Physiol Rep. 2013 Jun;1(1):e00008. doi: 10.1002/PHY2.8. Epub 2013 Jun 7.


Cultured mast cells from patients with asthma and controls respond with similar sensitivity to recombinant Der p2-induced, IgE-mediated activation.

Krohn IK, Sverrild A, Lund G, Dahl R, Erjefält JS, Backer V, Hoffmann HJ.

Scand J Immunol. 2013 Oct;78(4):352-6. doi: 10.1111/sji.12085.


Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD.

Mori M, Andersson CK, Graham GJ, Löfdahl CG, Erjefält JS.

Respir Res. 2013 Jun 11;14:65. doi: 10.1186/1465-9921-14-65.


Appearance of remodelled and dendritic cell-rich alveolar-lymphoid interfaces provides a structural basis for increased alveolar antigen uptake in chronic obstructive pulmonary disease.

Mori M, Andersson CK, Svedberg KA, Glader P, Bergqvist A, Shikhagaie M, Löfdahl CG, Erjefält JS.

Thorax. 2013 Jun;68(6):521-31. doi: 10.1136/thoraxjnl-2012-202879. Epub 2013 Feb 14.


Late onset vascular dysfunction in the R6/1 model of Huntington's disease.

Rahman A, Ekman M, Shakirova Y, Andersson KE, Mörgelin M, Erjefält JS, Brundin P, Li JY, Swärd K.

Eur J Pharmacol. 2013 Jan 5;698(1-3):345-53. doi: 10.1016/j.ejphar.2012.10.026. Epub 2012 Oct 29.


Enhanced ROCK1 dependent contractility in fibroblast from chronic obstructive pulmonary disease patients.

Hallgren O, Rolandsson S, Andersson-Sjöland A, Nihlberg K, Wieslander E, Kvist-Reimer M, Dahlbäck M, Eriksson L, Bjermer L, Erjefält JS, Löfdahl CG, Westergren-Thorsson G.

J Transl Med. 2012 Aug 22;10:171. doi: 10.1186/1479-5876-10-171.


Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis.

Andersson CK, Andersson-Sjöland A, Mori M, Hallgren O, Pardo A, Eriksson L, Bjermer L, Löfdahl CG, Selman M, Westergren-Thorsson G, Erjefält JS.

Respir Res. 2011 Oct 20;12:139. doi: 10.1186/1465-9921-12-139.


Peptidylarginine deiminases present in the airways during tobacco smoking and inflammation can citrullinate the host defense peptide LL-37, resulting in altered activities.

Kilsgård O, Andersson P, Malmsten M, Nordin SL, Linge HM, Eliasson M, Sörenson E, Erjefält JS, Bylund J, Olin AI, Sørensen OE, Egesten A.

Am J Respir Cell Mol Biol. 2012 Feb;46(2):240-8. doi: 10.1165/rcmb.2010-0500OC. Epub 2011 Sep 29.


Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology.

Andersson CK, Tufvesson E, Aronsson D, Bergqvist A, Mori M, Bjermer L, Erjefält JS.

Allergy. 2011 Dec;66(12):1590-7. doi: 10.1111/j.1398-9995.2011.02723.x. Epub 2011 Sep 29.


Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.

Al-Garawi A, Fattouh R, Botelho F, Walker TD, Goncharova S, Moore CL, Mori M, Erjefalt JS, Chu DK, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

Mucosal Immunol. 2011 Nov;4(6):682-94. doi: 10.1038/mi.2011.35. Epub 2011 Aug 31.


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