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Items: 39

1.

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.

Matsumoto M, Yashiro H, Ogino H, Aoyama K, Nambu T, Nakamura S, Nishida M, Wang X, Erion DM, Kaneko M.

PLoS One. 2020 Jan 28;15(1):e0228212. doi: 10.1371/journal.pone.0228212. eCollection 2020.

2.

Adipocyte OGT governs diet-induced hyperphagia and obesity.

Li MD, Vera NB, Yang Y, Zhang B, Ni W, Ziso-Qejvanaj E, Ding S, Zhang K, Yin R, Wang S, Zhou X, Fang EX, Xu T, Erion DM, Yang X.

Nat Commun. 2018 Nov 30;9(1):5103. doi: 10.1038/s41467-018-07461-x.

3.

Differential mobility spectrometry (DMS) reveals the elevation of urinary acetylcarnitine in non-human primates (NHPs) exposed to radiation.

Vera NB, Chen Z, Pannkuk E, Laiakis EC, Fornace AJ Jr, Erion DM, Coy SL, Pfefferkorn JA, Vouros P.

J Mass Spectrom. 2018 Jul;53(7):548-559. doi: 10.1002/jms.4085.

4.

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ.

Diabetes. 2018 Feb;67(2):208-221. doi: 10.2337/db17-0524. Epub 2017 Dec 4.

5.

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.

Mottillo EP, Desjardins EM, Fritzen AM, Zou VZ, Crane JD, Yabut JM, Kiens B, Erion DM, Lanba A, Granneman JG, Talukdar S, Steinberg GR.

Mol Metab. 2017 Apr 5;6(6):471-481. doi: 10.1016/j.molmet.2017.04.001. eCollection 2017 Jun.

6.

Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.

Pajor AM, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM.

Mol Pharmacol. 2016 Dec;90(6):755-765. Epub 2016 Sep 28.

PMID:
27683012
7.

Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.

Riccardi K, Li Z, Brown JA, Gorgoglione MF, Niosi M, Gosset J, Huard K, Erion DM, Di L.

Drug Metab Dispos. 2016 Oct;44(10):1633-42. doi: 10.1124/dmd.116.071837. Epub 2016 Jul 14.

PMID:
27417179
8.

Model-Based Assessment of Plasma Citrate Flux Into the Liver: Implications for NaCT as a Therapeutic Target.

Li Z, Erion DM, Maurer TS.

CPT Pharmacometrics Syst Pharmacol. 2016 Mar;5(3):132-9. doi: 10.1002/psp4.12062. Epub 2016 Mar 4.

9.

Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus.

Kazierad DJ, Bergman A, Tan B, Erion DM, Somayaji V, Lee DS, Rolph T.

Diabetes Obes Metab. 2016 Aug;18(8):795-802. doi: 10.1111/dom.12672. Epub 2016 May 12.

PMID:
27059951
10.

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects.

Talukdar S, Zhou Y, Li D, Rossulek M, Dong J, Somayaji V, Weng Y, Clark R, Lanba A, Owen BM, Brenner MB, Trimmer JK, Gropp KE, Chabot JR, Erion DM, Rolph TP, Goodwin B, Calle RA.

Cell Metab. 2016 Mar 8;23(3):427-40. doi: 10.1016/j.cmet.2016.02.001.

11.

Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.

Huard K, Gosset JR, Montgomery JI, Gilbert A, Hayward MM, Magee TV, Cabral S, Uccello DP, Bahnck K, Brown J, Purkal J, Gorgoglione M, Lanba A, Futatsugi K, Herr M, Genung NE, Aspnes G, Polivkova J, Garcia-Irizarry CN, Li Q, Canterbury D, Niosi M, Vera NB, Li Z, Khunte B, Siderewicz J, Rolph T, Erion DM.

J Med Chem. 2016 Feb 11;59(3):1165-75. doi: 10.1021/acs.jmedchem.5b01752. Epub 2016 Jan 27.

PMID:
26734723
12.
13.

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice.

Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ.

Endocrinology. 2016 Feb;157(2):570-85. doi: 10.1210/en.2015-1866. Epub 2015 Dec 9.

14.

Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis.

Khatun I, Clark RW, Vera NB, Kou K, Erion DM, Coskran T, Bobrowski WF, Okerberg C, Goodwin B.

J Biol Chem. 2016 Feb 5;291(6):2602-15. doi: 10.1074/jbc.M115.683359. Epub 2015 Dec 7.

15.

Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).

Huard K, Brown J, Jones JC, Cabral S, Futatsugi K, Gorgoglione M, Lanba A, Vera NB, Zhu Y, Yan Q, Zhou Y, Vernochet C, Riccardi K, Wolford A, Pirman D, Niosi M, Aspnes G, Herr M, Genung NE, Magee TV, Uccello DP, Loria P, Di L, Gosset JR, Hepworth D, Rolph T, Pfefferkorn JA, Erion DM.

Sci Rep. 2015 Dec 1;5:17391. doi: 10.1038/srep17391.

16.

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).

Futatsugi K, Kung DW, Orr ST, Cabral S, Hepworth D, Aspnes G, Bader S, Bian J, Boehm M, Carpino PA, Coffey SB, Dowling MS, Herr M, Jiao W, Lavergne SY, Li Q, Clark RW, Erion DM, Kou K, Lee K, Pabst BA, Perez SM, Purkal J, Jorgensen CC, Goosen TC, Gosset JR, Niosi M, Pettersen JC, Pfefferkorn JA, Ahn K, Goodwin B.

J Med Chem. 2015 Sep 24;58(18):7173-85. doi: 10.1021/acs.jmedchem.5b01006.

PMID:
26349027
17.

FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.

Bernardo B, Lu M, Bandyopadhyay G, Li P, Zhou Y, Huang J, Levin N, Tomas EM, Calle RA, Erion DM, Rolph TP, Brenner M, Talukdar S.

Sci Rep. 2015 Jul 8;5:11382. doi: 10.1038/srep11382.

18.

The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats.

Erion DM, Lapworth A, Amor PA, Bai G, Vera NB, Clark RW, Yan Q, Zhu Y, Ross TT, Purkal J, Gorgoglione M, Zhang G, Bonato V, Baker L, Barucci N, D'Aquila T, Robertson A, Aiello RJ, Yan J, Trimmer J, Rolph TP, Pfefferkorn JA.

PLoS One. 2014 May 23;9(5):e97139. doi: 10.1371/journal.pone.0097139. eCollection 2014.

19.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.

Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI.

Nature. 2014 Jun 26;510(7506):542-6. doi: 10.1038/nature13270. Epub 2014 May 21.

20.

Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.

Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, Finck BN.

Diabetes. 2014 Jul;63(7):2284-96. doi: 10.2337/db13-1502. Epub 2014 Mar 4.

21.

The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.

Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, Püschel GP, Birkenfeld AL.

Diabetes. 2014 Mar;63(3):1048-57. doi: 10.2337/db13-0749. Epub 2013 Nov 12.

22.

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

Vatner DF, Weismann D, Beddow SA, Kumashiro N, Erion DM, Liao XH, Grover GJ, Webb P, Phillips KJ, Weiss RE, Bogan JS, Baxter J, Shulman GI, Samuel VT.

Am J Physiol Endocrinol Metab. 2013 Jul 1;305(1):E89-100. doi: 10.1152/ajpendo.00573.2012. Epub 2013 May 7.

23.

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

Erion DM, Kotas ME, McGlashon J, Yonemitsu S, Hsiao JJ, Nagai Y, Iwasaki T, Murray SF, Bhanot S, Cline GW, Samuel VT, Shulman GI, Gillum MP.

J Biol Chem. 2013 May 31;288(22):16167-76. doi: 10.1074/jbc.M113.460246. Epub 2013 Apr 17.

24.

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.

Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI.

Hepatology. 2013 May;57(5):1763-72. doi: 10.1002/hep.26170. Epub 2013 Jan 25.

25.

The role of the carbohydrate response element-binding protein in male fructose-fed rats.

Erion DM, Popov V, Hsiao JJ, Vatner D, Mitchell K, Yonemitsu S, Nagai Y, Kahn M, Gillum MP, Dong J, Murray SF, Manchem VP, Bhanot S, Cline GW, Shulman GI, Samuel VT.

Endocrinology. 2013 Jan;154(1):36-44. doi: 10.1210/en.2012-1725. Epub 2012 Nov 16.

26.

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

Brown WH, Gillum MP, Lee HY, Camporez JP, Zhang XM, Jeong JK, Alves TC, Erion DM, Guigni BA, Kahn M, Samuel VT, Cravatt BF, Diano S, Shulman GI.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14966-71. doi: 10.1073/pnas.1212887109. Epub 2012 Aug 21.

27.

SirT1 regulates adipose tissue inflammation.

Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI.

Diabetes. 2011 Dec;60(12):3235-45. doi: 10.2337/db11-0616.

28.

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.

Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16381-5. doi: 10.1073/pnas.1113359108. Epub 2011 Sep 19.

29.

GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.

Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB.

Neurobiol Dis. 2011 Jul;43(1):152-62. doi: 10.1016/j.nbd.2011.03.005. Epub 2011 Mar 13.

30.

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance.

Weismann D, Erion DM, Ignatova-Todorava I, Nagai Y, Stark R, Hsiao JJ, Flannery C, Birkenfeld AL, May T, Kahn M, Zhang D, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Shulman GI, Samuel VT.

Diabetologia. 2011 Apr;54(4):935-44. doi: 10.1007/s00125-010-1984-5. Epub 2010 Dec 29.

31.

Sirtuin-1 regulation of mammalian metabolism.

Gillum MP, Erion DM, Shulman GI.

Trends Mol Med. 2011 Jan;17(1):8-13. doi: 10.1016/j.molmed.2010.09.005. Review.

32.

Diacylglycerol-mediated insulin resistance.

Erion DM, Shulman GI.

Nat Med. 2010 Apr;16(4):400-2. doi: 10.1038/nm0410-400.

33.

Uncoupling protein-2 decreases the lipogenic actions of ghrelin.

Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL.

Endocrinology. 2010 May;151(5):2078-86. doi: 10.1210/en.2009-0850. Epub 2010 Feb 26.

34.

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.

Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI.

Cell Metab. 2009 Dec;10(6):499-506. doi: 10.1016/j.cmet.2009.10.007.

35.

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.

Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11288-93. doi: 10.1073/pnas.0812931106. Epub 2009 Jun 22.

36.

STAT3 inhibition of gluconeogenesis is downregulated by SirT1.

Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q.

Nat Cell Biol. 2009 Apr;11(4):492-500. doi: 10.1038/ncb1857. Epub 2009 Mar 22.

37.

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Löffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI.

Cell Metab. 2009 Mar;9(3):252-64. doi: 10.1016/j.cmet.2009.01.011.

38.

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, Shulman GI.

Cell. 2008 Nov 28;135(5):813-24. doi: 10.1016/j.cell.2008.10.043.

39.

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.

Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S.

Nature. 2008 Aug 14;454(7206):846-51. doi: 10.1038/nature07181. Epub 2008 Jul 30.

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