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Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization.

Jackson L, Dong G, Althomali W, Sayed MA, Eldahshan W, Baban B, Johnson MH, Filosa J, Fagan SC, Ergul A.

Transl Stroke Res. 2019 Dec 3. doi: 10.1007/s12975-019-00752-5. [Epub ahead of print]


Eastern Anatolian apples with a unique population structure are genetically different from Anatolian apples.

Öz MH, Büyük İ, Akpinar AE, Yüksel Özmen C, Kazan K, Vurgun H, Bacaksiz A, Çukadar K, Ünlü HM, Ergül A.

Gene. 2020 Jan 10;723:144149. doi: 10.1016/j.gene.2019.144149. Epub 2019 Oct 4.


Inflammation within the neurovascular unit: Focus on microglia for stroke injury and recovery.

Eldahshan W, Fagan SC, Ergul A.

Pharmacol Res. 2019 Sep;147:104349. doi: 10.1016/j.phrs.2019.104349. Epub 2019 Jul 14. Review.


Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells.

Jackson L, Li W, Abdul Y, Dong G, Baban B, Ergul A.

Neuromolecular Med. 2019 Dec;21(4):445-453. doi: 10.1007/s12017-019-08554-6. Epub 2019 Jun 13.


Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study.

Eldahshan W, Ishrat T, Pillai B, Sayed MA, Alwhaibi A, Fouda AY, Ergul A, Fagan SC.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1192-H1201. doi: 10.1152/ajpheart.00446.2018. Epub 2019 Mar 1.


NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.

Ward R, Li W, Abdul Y, Jackson L, Dong G, Jamil S, Filosa J, Fagan SC, Ergul A.

Pharmacol Res. 2019 Apr;142:237-250. doi: 10.1016/j.phrs.2019.01.035. Epub 2019 Feb 25.


Brain Vasculature and Cognition.

Fouda AY, Fagan SC, Ergul A.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):593-602. doi: 10.1161/ATVBAHA.118.311906. Review.


Inhibition of Ephrin-B2 in brain pericytes decreases cerebral pathological neovascularization in diabetic rats.

Coucha M, Barrett AC, Elgebaly M, Ergul A, Abdelsaid M.

PLoS One. 2019 Jan 8;14(1):e0210523. doi: 10.1371/journal.pone.0210523. eCollection 2019.


Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury.

Artham S, Gao F, Verma A, Alwhaibi A, Sabbineni H, Hafez S, Ergul A, Somanath PR.

Pharmacol Res. 2019 Mar;141:249-263. doi: 10.1016/j.phrs.2019.01.006. Epub 2019 Jan 3.


Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals-A randomized double- blind pre-clinical study.

Ahmed HA, Ishrat T, Pillai B, Bunting KM, Vazdarjanova A, Waller JL, Ergul A, Fagan SC.

Behav Brain Res. 2019 Feb 1;359:560-569. doi: 10.1016/j.bbr.2018.10.010. Epub 2018 Oct 5.


Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation.

Li W, Valenzuela JP, Ward R, Abdelbary M, Dong G, Fagan SC, Ergul A.

Exp Neurol. 2019 Jan;311:106-114. doi: 10.1016/j.expneurol.2018.09.013. Epub 2018 Sep 19.


Poststroke cognitive impairment and hippocampal neurovascular remodeling: the impact of diabetes and sex.

Ward R, Valenzuela JP, Li W, Dong G, Fagan SC, Ergul A.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1402-H1413. doi: 10.1152/ajpheart.00390.2018. Epub 2018 Aug 17.


RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial.

Ahmed HA, Ishrat T, Pillai B, Fouda AY, Sayed MA, Eldahshan W, Waller JL, Ergul A, Fagan SC.

J Neuroinflammation. 2018 Aug 13;15(1):229. doi: 10.1186/s12974-018-1262-x.


Silencing VEGF-B Diminishes the Neuroprotective Effect of Candesartan Treatment After Experimental Focal Cerebral Ischemia.

Ishrat T, Soliman S, Eldahshan W, Pillai B, Ergul A, Fagan SC.

Neurochem Res. 2018 Oct;43(10):1869-1878. doi: 10.1007/s11064-018-2604-x. Epub 2018 Aug 7.


Assessment of inappropriate antibiotic use in pediatric patients: Point-prevalence study.

Ergül AB, Gökçek İ, Çelik T, Torun YA.

Turk Pediatri Ars. 2018 Mar 1;53(1):17-23. doi: 10.5152/TurkPediatriArs.2018.5644. eCollection 2018 Mar.


Endothelin and diabetic complications: a brain-centric view.

Li W, Abdul Y, Ward R, Ergul A.

Physiol Res. 2018 Jun 27;67(Suppl 1):S83-S94. Review.


Using a high-flow nasal cannula provides superior results to OxyMask delivery in moderate to severe bronchiolitis: a randomized controlled study.

Ergul AB, Calıskan E, Samsa H, Gokcek I, Kaya A, Zararsiz GE, Torun YA.

Eur J Pediatr. 2018 Aug;177(8):1299-1307. doi: 10.1007/s00431-018-3191-1. Epub 2018 Jun 18.


Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4.

Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, Ergul A.

Mol Neurobiol. 2019 Mar;56(3):1607-1617. doi: 10.1007/s12035-018-1184-8. Epub 2018 Jun 16.


Use of a chlorhexidine-impregnated dressing reduced catheter-related bloodstream infections caused by Gram-positive microorganisms.

Ergul AB, Gokcek I, Ozcan A, Cetin S, Gultekin N, Torun YA.

Pak J Med Sci. 2018 Mar-Apr;34(2):347-351. doi: 10.12669/pjms.342.14810.


Impact of Metabolic Diseases on Cerebral Circulation: Structural and Functional Consequences.

Coucha M, Abdelsaid M, Ward R, Abdul Y, Ergul A.

Compr Physiol. 2018 Mar 25;8(2):773-799. doi: 10.1002/cphy.c170019. Review.


Within the Brain: The Renin Angiotensin System.

Jackson L, Eldahshan W, Fagan SC, Ergul A.

Int J Mol Sci. 2018 Mar 15;19(3). pii: E876. doi: 10.3390/ijms19030876. Review.


Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke.

Ishrat T, Fouda AY, Pillai B, Eldahshan W, Ahmed H, Waller JL, Ergul A, Fagan SC.

J Cereb Blood Flow Metab. 2019 Aug;39(8):1635-1647. doi: 10.1177/0271678X18764773. Epub 2018 Mar 14.


Increased Iron Deficiency and Iron Deficiency Anemia in Children with Zinc Deficiency.

Ergul AB, Turanoglu C, Karakukcu C, Karaman S, Torun YA.

Eurasian J Med. 2018 Feb;50(1):34-37. doi: 10.5152/eurasianjmed.2017.17237. Epub 2018 Feb 1.


High Doses of Boron Have No Protective Effect Against Nephrolithiasis or Oxidative Stress in a Rat Model.

Ergul AB, Kara M, Karakukcu C, Tasdemir A, Aslaner H, Ergul MA, Muhtaroglu S, Zararsiz GE, Torun YA.

Biol Trace Elem Res. 2018 Nov;186(1):218-225. doi: 10.1007/s12011-018-1294-1. Epub 2018 Mar 8.


Profiling of proteasome activity in Alyssum species on serpentine soils in Turkey reveals possible insight into nickel tolerance and accumulation.

Van Hoewyk D, Taskin MB, Yaprak AE, Turgay OC, Ergul A.

Plant Physiol Biochem. 2018 Mar;124:184-189. doi: 10.1016/j.plaphy.2018.01.022. Epub 2018 Feb 4.


Congenital Hemophilia A Presenting With Hashimoto's Encephalopathy and Myocarditis: The First Reported Case.

Ergul AB, Altuner Torun Y, Altug U, Mutlu FT, Celik SF, Guven AS.

J Pediatr Hematol Oncol. 2018 Oct;40(7):e435-e438. doi: 10.1097/MPH.0000000000001045.


Role of angiotensin system modulation on progression of cognitive impairment and brain MRI changes in aged hypertensive animals - A randomized double- blind pre-clinical study.

Ahmed HA, Ishrat T, Pillai B, Bunting KM, Patel A, Vazdarjanova A, Waller JL, Arbab AS, Ergul A, Fagan SC.

Behav Brain Res. 2018 Jul 2;346:29-40. doi: 10.1016/j.bbr.2017.12.007. Epub 2017 Dec 8.


A retrospective evaluation of blood cultures in a pediatric intensive care unit: a three year evaluation.

Ergül AB, Işık H, Altıntop YA, Torun YA.

Turk Pediatri Ars. 2017 Sep 1;52(3):154-161. doi: 10.5152/TurkPediatriArs.2017.5451. eCollection 2017 Sep.


Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator.

Hafez S, Abdelsaid M, Fagan SC, Ergul A.

Neurochem Res. 2018 Feb;43(2):259-266. doi: 10.1007/s11064-017-2411-9. Epub 2017 Oct 3.


Spatial and temporal distribution of phase slips in Josephson junction chains.

Ergül A, Weißl T, Johansson J, Lidmar J, Haviland DB.

Sci Rep. 2017 Sep 13;7(1):11447. doi: 10.1038/s41598-017-11670-7.


Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial.

Fouda AY, Newsome AS, Spellicy S, Waller JL, Zhi W, Hess DC, Ergul A, Edwards DJ, Fagan SC, Switzer JA.

Stroke. 2017 Oct;48(10):2885-2887. doi: 10.1161/STROKEAHA.117.018658. Epub 2017 Sep 8.


Interstitial deletion 5p14.1-p15.2 and 5q14.3-q23.2 in a patient with clubfoot, blepharophimosis, arthrogryposis, and multiple congenital abnormalities.

Balta B, Erdogan M, Ergul AB, Sahin Y, Ozcan A.

Am J Med Genet A. 2017 Oct;173(10):2798-2802. doi: 10.1002/ajmg.a.38386. Epub 2017 Aug 16.


Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension.

Alhusban A, Kozak A, Pillai B, Ahmed H, Sayed MA, Johnson MH, Ishrat T, Ergul A, Fagan SC.

PLoS One. 2017 Jun 22;12(6):e0178867. doi: 10.1371/journal.pone.0178867. eCollection 2017.


Evaluation of Microorganisms Causing Ventilator-Associated Pneumonia in a Pediatric Intensive Care Unit.

Ergul AB, Cetin S, Altintop YA, Bozdemir SE, Ozcan A, Altug U, Samsa H, Torun YA.

Eurasian J Med. 2017 Jun;49(2):87-91. doi: 10.5152/eurasianjmed.2017.16262. Epub 2017 Apr 28.


Clinical Toxicity of Acute Overdoses With L-Thyroxin in Children.

Ergul AB, Altuner Torun Y, Serbetci MC, Ozcan A, Bas VN.

Pediatr Emerg Care. 2019 Nov;35(11):787-790. doi: 10.1097/PEC.0000000000001141.


TLR2 knockout protects against diabetes-mediated changes in cerebral perfusion and cognitive deficits.

Hardigan T, Hernandez C, Ward R, Hoda MN, Ergul A.

Am J Physiol Regul Integr Comp Physiol. 2017 Jun 1;312(6):R927-R937. doi: 10.1152/ajpregu.00482.2016. Epub 2017 Feb 22.


Diabetes Worsens Functional Outcomes in Young Female Rats: Comparison of Stroke Models, Tissue Plasminogen Activator Effects, and Sexes.

Li W, Ward R, Valenzuela JP, Dong G, Fagan SC, Ergul A.

Transl Stroke Res. 2017 Mar 1. doi: 10.1007/s12975-017-0525-7. [Epub ahead of print]


Role of interleukin-10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury.

Fouda AY, Pillai B, Dhandapani KM, Ergul A, Fagan SC.

Eur J Pharmacol. 2017 Mar 15;799:128-134. doi: 10.1016/j.ejphar.2017.02.016. Epub 2017 Feb 10.


Enhanced VEGF signalling mediates cerebral neovascularisation via downregulation of guidance protein ROBO4 in a rat model of diabetes.

Abdelsaid M, Coucha M, Hafez S, Yasir A, Johnson MH, Ergul A.

Diabetologia. 2017 Apr;60(4):740-750. doi: 10.1007/s00125-017-4214-6. Epub 2017 Jan 23.


Acute necrotizing encephalopathy causing human bocavirus.

Ergul AB, Altug U, Aydin K, Guven AS, Altuner Torun Y.

Neuroradiol J. 2017 Apr;30(2):164-167. doi: 10.1177/1971400916687586. Epub 2017 Jan 6.


Reduction in serum paraoxonase level in newborns with hyperbilirubinemia as a marker of oxidative stress.

Altuner Torun Y, Ertural U, Ergul AB, Karakukcu C, Akin MA.

J Matern Fetal Neonatal Med. 2017 Oct;30(19):2297-2300. doi: 10.1080/14767058.2016.1247154. Epub 2016 Nov 9.


Cerebrovascular complications of diabetes: focus on cognitive dysfunction.

Hardigan T, Ward R, Ergul A.

Clin Sci (Lond). 2016 Oct 1;130(20):1807-22. doi: 10.1042/CS20160397. Review.


Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle.

Coucha M, Abdelsaid M, Li W, Johnson MH, Orfi L, El-Remessy AB, Fagan SC, Ergul A.

Life Sci. 2016 Oct 15;163:46-54. doi: 10.1016/j.lfs.2016.08.018. Epub 2016 Aug 21.


Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes.

Hardigan T, Yasir A, Abdelsaid M, Coucha M, El-Shaffey S, Li W, Johnson MH, Ergul A.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R466-77. doi: 10.1152/ajpregu.00057.2016. Epub 2016 Jun 29.


The Fourteenth International Conference on Endothelin (ET-14), Savannah, U.S.A.

Pollock DM, Gulati A, Ergul A.

Life Sci. 2016 Aug 15;159:2-9. doi: 10.1016/j.lfs.2016.06.015. Epub 2016 Jun 16. No abstract available.


Erratum to: Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke.

Alhusban A, Kozak A, Eldahshan W, Ergul A, Fagan SC.

Exp Transl Stroke Med. 2016 Jun 14;8:5. doi: 10.1186/s13231-016-0019-9. eCollection 2016.

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