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GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis.

Pathania AS, Ren X, Mahdi MY, Shackleford GM, Erdreich-Epstein A.

Sci Rep. 2019 Sep 25;9(1):13902. doi: 10.1038/s41598-019-50157-5.


Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution.

Kaneva K, Yeo KK, Hawes D, Ji J, Biegel JA, Nelson MD, Bluml S, Krieger MD, Erdreich-Epstein A.

JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00138. Epub 2019 Mar 27. No abstract available.


Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma.

Shackleford GM, Mahdi MY, Moats RA, Hawes D, Tran HC, Finlay JL, Hoang TQ, Meng EF, Erdreich-Epstein A.

PLoS One. 2019 Jan 4;14(1):e0206394. doi: 10.1371/journal.pone.0206394. eCollection 2019.


Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126.

Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL.

Oncotarget. 2016 Nov 18;8(32):52193-52210. doi: 10.18632/oncotarget.13386. eCollection 2017 Aug 8.


PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NFκB.

Xu J, Ren X, Pathania AS, Fernandez GE, Tran A, Zhang Y, Moats RA, Shackleford GM, Erdreich-Epstein A.

Sci Rep. 2017 Apr 11;7(1):835. doi: 10.1038/s41598-017-00947-6.


Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Torchia J, Golbourn B, Feng S, Ho KC, Sin-Chan P, Vasiljevic A, Norman JD, Guilhamon P, Garzia L, Agamez NR, Lu M, Chan TS, Picard D, de Antonellis P, Khuong-Quang DA, Planello AC, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo DMA, Dzamba M, Barszczyk M, Medina T, Riemenschneider AN, Morrissy AS, Ra YS, Ramaswamy V, Remke M, Dunham CP, Yip S, Ng HK, Lu JQ, Mehta V, Albrecht S, Pimentel J, Chan JA, Somers GR, Faria CC, Roque L, Fouladi M, Hoffman LM, Moore AS, Wang Y, Choi SA, Hansford JR, Catchpoole D, Birks DK, Foreman NK, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret AS, Van Meter TE, Hwang EI, Gajjar A, Chiou SH, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat DD, Scheinemann K, Fleming AJ, Johnston DL, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay DA, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy RG, Lulla RR, Fangusaro JR, Druker H, Bartels U, Grant R, Malkin D, McGlade CJ, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader GD, Reddy AT, Gillespie GY, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins AR, Hawkins CE, Bouffet E, Kim SK, Dirks PB, Taylor MD, Erdreich-Epstein A, Arrowsmith CH, De Carvalho DD, Rutka JT, Jabado N, Huang A.

Cancer Cell. 2016 Dec 12;30(6):891-908. doi: 10.1016/j.ccell.2016.11.003.


CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study.

Yadav VN, Zamler D, Baker GJ, Kadiyala P, Erdreich-Epstein A, DeCarvalho AC, Mikkelsen T, Castro MG, Lowenstein PR.

Oncotarget. 2016 Dec 13;7(50):83701-83719. doi: 10.18632/oncotarget.13295.


BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.

Shackleford GM, Shi XH, Swanson KS, Mahdi MY, Gonzalez-Gomez I, Asgharzadeh S, D'Apuzzo M, Erdreich-Epstein A, Moats RA.

PLoS One. 2016 Jun 16;11(6):e0156907. doi: 10.1371/journal.pone.0156907. eCollection 2016.


Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature.

Wong K, Opimo AB, Olch AJ, All S, Waxer JF, Clark D, Cheng J, Chlebik A, Erdreich-Epstein A, Krieger MD, Tamrazi B, Dhall G, Finlay JL, Chang EL.

Cureus. 2016 Apr 25;8(4):e585. doi: 10.7759/cureus.585. Review.


Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia.

Xu J, Margol AS, Shukla A, Ren X, Finlay JL, Krieger MD, Gilles FH, Couch FJ, Aziz M, Fung ET, Asgharzadeh S, Barrett MT, Erdreich-Epstein A.

Front Oncol. 2015 Aug 27;5:191. doi: 10.3389/fonc.2015.00191. eCollection 2015.


Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy.

Blüml S, Margol AS, Sposto R, Kennedy RJ, Robison NJ, Vali M, Hung LT, Muthugounder S, Finlay JL, Erdreich-Epstein A, Gilles FH, Judkins AR, Krieger MD, Dhall G, Nelson MD, Asgharzadeh S.

Neuro Oncol. 2016 Jan;18(1):126-31. doi: 10.1093/neuonc/nov097. Epub 2015 Aug 8.


Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target.

Weingart MF, Roth JJ, Hutt-Cabezas M, Busse TM, Kaur H, Price A, Maynard R, Rubens J, Taylor I, Mao XG, Xu J, Kuwahara Y, Allen SJ, Erdreich-Epstein A, Weissman BE, Orr BA, Eberhart CG, Biegel JA, Raabe EH.

Oncotarget. 2015 Feb 20;6(5):3165-77.


The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity.

Kaur H, Hütt-Cabezas M, Weingart MF, Xu J, Kuwahara Y, Erdreich-Epstein A, Weissman BE, Eberhart CG, Raabe EH.

J Neuropathol Exp Neurol. 2015 Feb;74(2):177-85. doi: 10.1097/NEN.0000000000000161.


Tumor-associated macrophages in SHH subgroup of medulloblastomas.

Margol AS, Robison NJ, Gnanachandran J, Hung LT, Kennedy RJ, Vali M, Dhall G, Finlay JL, Erdreich-Epstein A, Krieger MD, Drissi R, Fouladi M, Gilles FH, Judkins AR, Sposto R, Asgharzadeh S.

Clin Cancer Res. 2015 Mar 15;21(6):1457-65. doi: 10.1158/1078-0432.CCR-14-1144. Epub 2014 Oct 24.


Wnt pathway in atypical teratoid rhabdoid tumors.

Chakravadhanula M, Hampton CN, Chodavadia P, Ozols V, Zhou L, Catchpoole D, Xu J, Erdreich-Epstein A, Bhardwaj RD.

Neuro Oncol. 2015 Apr;17(4):526-35. doi: 10.1093/neuonc/nou229. Epub 2014 Sep 21.


Pediatric brain tumor cell lines.

Xu J, Margol A, Asgharzadeh S, Erdreich-Epstein A.

J Cell Biochem. 2015 Feb;116(2):218-24. doi: 10.1002/jcb.24976.


Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas.

Nandhu MS, Hu B, Cole SE, Erdreich-Epstein A, Rodriguez-Gil DJ, Viapiano MS.

Cancer Res. 2014 Oct 1;74(19):5435-5448. doi: 10.1158/0008-5472.CAN-14-0685. Epub 2014 Aug 19.


A retrospective analysis of recurrent intracranial ependymoma.

Antony R, Wong KE, Patel M, Olch AJ, McComb G, Krieger M, Gilles F, Sposto R, Erdreich-Epstein A, Dhall G, Gardner S, Finlay JL.

Pediatr Blood Cancer. 2014 Jul;61(7):1195-201. doi: 10.1002/pbc.24996. Epub 2014 Feb 24.


A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1.

Lee JS, Xiao J, Patel P, Schade J, Wang J, Deneen B, Erdreich-Epstein A, Song HR.

Neuro Oncol. 2014 Jan;16(2):191-203. doi: 10.1093/neuonc/not167. Epub 2013 Dec 4.


PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.

Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol AS, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S.

Clin Cancer Res. 2014 Feb 15;20(4):827-36. doi: 10.1158/1078-0432.CCR-13-2053. Epub 2013 Dec 3. Erratum in: Clin Cancer Res. 2015 Sep 15;21(18):4243. Asgharazadeh, Shahab [corrected to Asgharzadeh, Shahab].


c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins αvβ3 and αvβ5.

Ren X, Xu J, Cooper JP, Kang MH, Erdreich-Epstein A.

PLoS One. 2012;7(8):e42291. doi: 10.1371/journal.pone.0042291. Epub 2012 Aug 3.


Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells.

Ridgway LD, Wetzel MD, Ngo JA, Erdreich-Epstein A, Marchetti D.

Mol Cancer Res. 2012 Jun;10(6):689-702. doi: 10.1158/1541-7786.MCR-11-0534. Epub 2012 Apr 18.


Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature.

Davidson TB, Sanchez-Lara PA, Randolph LM, Krieger MD, Wu SQ, Panigrahy A, Shimada H, Erdreich-Epstein A.

BMC Med Genet. 2012 Mar 22;13:19. doi: 10.1186/1471-2350-13-19. Review.


Novel cell lines established from pediatric brain tumors.

Xu J, Erdreich-Epstein A, Gonzalez-Gomez I, Melendez EY, Smbatyan G, Moats RA, Rosol M, Biegel JA, Reynolds CP.

J Neurooncol. 2012 Apr;107(2):269-80. doi: 10.1007/s11060-011-0756-5. Epub 2011 Nov 27.


Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro.

Chaitanya GV, Cromer WE, Wells SR, Jennings MH, Couraud PO, Romero IA, Weksler B, Erdreich-Epstein A, Mathis JM, Minagar A, Alexander JS.

J Neuroinflammation. 2011 Nov 23;8:162. doi: 10.1186/1742-2094-8-162.


Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children's Hospital Los Angeles (CHLA) experience, 1991-2010.

Gozali AE, Britt B, Shane L, Gonzalez I, Gilles F, McComb JG, Krieger MD, Lavey RS, Shlien A, Villablanca JG, Erdreich-Epstein A, Dhall G, Jubran R, Tabori U, Malkin D, Finlay JL.

Pediatr Blood Cancer. 2012 Jun;58(6):905-9. doi: 10.1002/pbc.23349. Epub 2011 Oct 11.


Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen.

Parekh C, Jubran R, Erdreich-Epstein A, Panigrahy A, Bluml S, Finlay J, Dhall G.

J Neurooncol. 2011 Jul;103(3):673-80. doi: 10.1007/s11060-010-0444-x. Epub 2010 Nov 1. Erratum in: J Neurooncol. 2011 Jul;103(3):681.


Nuclear factor IA is expressed in astrocytomas and is associated with improved survival.

Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A.

Neuro Oncol. 2010 Feb;12(2):122-32. doi: 10.1093/neuonc/nop044. Epub 2010 Jan 25.


c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin.

Xu J, Millard M, Ren X, Cox OT, Erdreich-Epstein A.

Blood. 2010 Apr 1;115(13):2709-18. doi: 10.1182/blood-2009-05-223776. Epub 2010 Feb 2.


Novel cancer vaccine based on genes of Salmonella pathogenicity island 2.

Xiong G, Husseiny MI, Song L, Erdreich-Epstein A, Shackleford GM, Seeger RC, Jäckel D, Hensel M, Metelitsa LS.

Int J Cancer. 2010 Jun 1;126(11):2622-34. doi: 10.1002/ijc.24957.


Metabolism of orthotopic mouse brain tumor models.

Rosol M, Harutyunyan I, Xu J, Melendez E, Smbatyan G, Finlay JL, Krieger MD, Gonzalez-Gomez I, Reynolds CP, Nelson MD, Erdreich-Epstein A, Blüml S.

Mol Imaging. 2009 Jul-Aug;8(4):199-208.


High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome.

Butturini AM, Jacob M, Aguajo J, Vander-Walde NA, Villablanca J, Jubran R, Erdreich-Epstein A, Marachelian A, Dhall G, Finlay JL.

Cancer. 2009 Jul 1;115(13):2956-63. doi: 10.1002/cncr.24341.


Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis.

Rosenne E, Shakhar G, Melamed R, Schwartz Y, Erdreich-Epstein A, Ben-Eliyahu S.

Brain Behav Immun. 2007 May;21(4):395-408. Epub 2006 Dec 16.


Progress in the treatment of childhood brain tumors: no room for complacency.

Finlay JL, Erdreich-Epstein A, Packer RJ.

Pediatr Hematol Oncol. 2007 Jan-Feb;24(1):79-84. No abstract available.


Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation.

Erdreich-Epstein A, Ganguly AK, Shi XH, Zimonjic DB, Shackleford GM.

Genes Chromosomes Cancer. 2006 Feb;45(2):169-81.


Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells.

Sohara Y, Shimada H, Minkin C, Erdreich-Epstein A, Nolta JA, DeClerck YA.

Cancer Res. 2005 Feb 15;65(4):1129-35.


Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways.

Erdreich-Epstein A, Tran LB, Cox OT, Huang EY, Laug WE, Shimada H, Millard M.

Blood. 2005 Jun 1;105(11):4353-61. Epub 2005 Feb 10.


Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience.

Jubran RF, Erdreich-Epstein A, Butturini A, Murphree AL, Villablanca JG.

J Pediatr Hematol Oncol. 2004 Jan;26(1):31-4.


Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors.

Stins MF, Pearce D, Di Cello F, Erdreich-Epstein A, Pardo CA, Sik Kim K.

Lab Invest. 2003 Dec;83(12):1787-98.


Placenta growth factor activates monocytes and correlates with sickle cell disease severity.

Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P.

Blood. 2003 Aug 15;102(4):1506-14. Epub 2003 Apr 24.


Ceramide signaling in fenretinide-induced endothelial cell apoptosis.

Erdreich-Epstein A, Tran LB, Bowman NN, Wang H, Cabot MC, Durden DL, Vlckova J, Reynolds CP, Stins MF, Groshen S, Millard M.

J Biol Chem. 2002 Dec 20;277(51):49531-7. Epub 2002 Oct 17.


Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary.

Erdreich-Epstein A, Monforte HL, Lavey RS, Joshi S, Phillips JD, Villablanca JG.

J Pediatr Hematol Oncol. 2002 Mar-Apr;24(3):229-33. Review.


Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin.

Isogai C, Laug WE, Shimada H, Declerck PJ, Stins MF, Durden DL, Erdreich-Epstein A, DeClerck YA.

Cancer Res. 2001 Jul 15;61(14):5587-94.


Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide.

Erdreich-Epstein A, Shimada H, Groshen S, Liu M, Metelitsa LS, Kim KS, Stins MF, Seeger RC, Durden DL.

Cancer Res. 2000 Feb 1;60(3):712-21.


Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.

Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL.

J Leukoc Biol. 1999 Apr;65(4):523-34.


Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling.

Izadi KD, Erdreich-Epstein A, Liu Y, Durden DL.

Exp Cell Res. 1998 Dec 15;245(2):330-42.


Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling.

Erdreich-Epstein A, Liu M, Liu Y, Durden DL.

Exp Cell Res. 1997 Dec 15;237(2):288-95.


Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome.

Sakamoto K, Erdreich-Epstein A, deClerck Y, Coates T.

Am J Pediatr Hematol Oncol. 1992 Nov;14(4):348-51.


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