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Items: 1 to 50 of 157

1.

Tetrahydro-4 H-(pyrrolo[3,4- d]isoxazol-3-yl)methanamine: A Bicyclic Diamino Scaffold Stabilizing Parallel Turn Conformations.

Bucci R, Giofré S, Clerici F, Contini A, Pinto A, Erba E, Soave R, Pellegrino S, Gelmi ML.

J Org Chem. 2018 Oct 5;83(19):11493-11501. doi: 10.1021/acs.joc.8b01299. Epub 2018 Sep 18.

PMID:
30192540
2.

Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice.

Nardo G, Trolese MC, Verderio M, Mariani A, de Paola M, Riva N, Dina G, Panini N, Erba E, Quattrini A, Bendotti C.

Mol Neurodegener. 2018 Aug 9;13(1):42. doi: 10.1186/s13024-018-0271-7.

3.

Structure-activity relationships of β-hairpin mimics as modulators of amyloid β-peptide aggregation.

Tonali N, Kaffy J, Soulier JL, Gelmi ML, Erba E, Taverna M, van Heijenoort C, Ha-Duong T, Ongeri S.

Eur J Med Chem. 2018 Jun 25;154:280-293. doi: 10.1016/j.ejmech.2018.05.018. Epub 2018 May 18.

PMID:
29807333
4.

Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab.

Bizzaro F, Falcetta F, D'Agostini E, Decio A, Minoli L, Erba E, Alessandro Peccatori F, Scanziani E, Colombo N, Zucchetti M, Bani MR, Ubezio P, Giavazzi R.

Int J Cancer. 2018 Nov 1;143(9):2187-2199. doi: 10.1002/ijc.31596. Epub 2018 Aug 7.

PMID:
29752717
5.

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB.

Camorani S, Cerchia L, Fedele M, Erba E, D'Incalci M, Crescenzi E.

Oncotarget. 2018 Apr 13;9(28):19929-19944. doi: 10.18632/oncotarget.24961. eCollection 2018 Apr 13.

6.

Mesenchymal stem cells encapsulated into biomimetic hydrogel scaffold gradually release CCL2 chemokine in situ preserving cytoarchitecture and promoting functional recovery in spinal cord injury.

Papa S, Vismara I, Mariani A, Barilani M, Rimondo S, De Paola M, Panini N, Erba E, Mauri E, Rossi F, Forloni G, Lazzari L, Veglianese P.

J Control Release. 2018 May 28;278:49-56. doi: 10.1016/j.jconrel.2018.03.034. Epub 2018 Apr 3.

PMID:
29621597
7.

Trabectedin is a novel chemotherapy agent for diffuse large B cell lymphoma.

Spriano F, Chung EY, Panini N, Cascione L, Rinaldi A, Erba E, Stathis A, D'Incalci M, Bertoni F, Gatta R.

Br J Haematol. 2019 Mar;184(6):1022-1025. doi: 10.1111/bjh.15212. Epub 2018 Apr 2. No abstract available.

PMID:
29611184
8.

Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.

Contini A, Ferri N, Bucci R, Lupo MG, Erba E, Gelmi ML, Pellegrino S.

Biopolymers. 2017 Nov 27. doi: 10.1002/bip.23089. [Epub ahead of print]

PMID:
29178143
9.

Application of 3D Mass Spectrometry Imaging to TKIs.

Morosi L, Giordano S, Falcetta F, Frapolli R, Licandro SA, Matteo C, Zucchetti M, Ubezio P, Erba E, Visentin S, D'Incalci M, Davoli E.

Clin Pharmacol Ther. 2017 Nov;102(5):748-751. doi: 10.1002/cpt.786.

PMID:
29023728
10.

Ascites interferes with the activity of lurbinectedin and trabectedin: Potential role of their binding to alpha 1-acid glycoprotein.

Erba E, Romano M, Gobbi M, Zucchetti M, Ferrari M, Matteo C, Panini N, Colmegna B, Caratti G, Porcu L, Fruscio R, Perlangeli MV, Mezzanzanica D, Lorusso D, Raspagliesi F, D'Incalci M.

Biochem Pharmacol. 2017 Nov 15;144:52-62. doi: 10.1016/j.bcp.2017.08.001. Epub 2017 Aug 4.

PMID:
28782526
11.

FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients.

Tassi RA, Todeschini P, Siegel ER, Calza S, Cappella P, Ardighieri L, Cadei M, Bugatti M, Romani C, Bandiera E, Zanotti L, Tassone L, Guarino D, Santonocito C, Capoluongo ED, Beltrame L, Erba E, Marchini S, D'Incalci M, Donzelli C, Santin AD, Pecorelli S, Sartori E, Bignotti E, Odicino F, Ravaggi A.

J Exp Clin Cancer Res. 2017 May 8;36(1):63. doi: 10.1186/s13046-017-0536-y.

12.

β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.

Pellegrino S, Tonali N, Erba E, Kaffy J, Taverna M, Contini A, Taylor M, Allsop D, Gelmi ML, Ongeri S.

Chem Sci. 2017 Feb 1;8(2):1295-1302. doi: 10.1039/c6sc03176e. Epub 2016 Oct 7.

13.

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms.

Romano M, Della Porta MG, Gallì A, Panini N, Licandro SA, Bello E, Craparotta I, Rosti V, Bonetti E, Tancredi R, Rossi M, Mannarino L, Marchini S, Porcu L, Galmarini CM, Zambelli A, Zecca M, Locatelli F, Cazzola M, Biondi A, Rambaldi A, Allavena P, Erba E, D'Incalci M.

Br J Cancer. 2017 Jan;116(3):335-343. doi: 10.1038/bjc.2016.424. Epub 2017 Jan 10.

14.

A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia.

Mannarino L, Paracchini L, Craparotta I, Romano M, Marchini S, Gatta R, Erba E, Clivio L, Romualdi C, D'Incalci M, Beltrame L, Pattini L.

Pharmacogenomics J. 2018 Jan;18(1):56-63. doi: 10.1038/tpj.2016.76. Epub 2016 Dec 13.

15.

The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus.

Vázquez R, Riveiro ME, Astorgues-Xerri L, Odore E, Rezai K, Erba E, Panini N, Rinaldi A, Kwee I, Beltrame L, Bekradda M, Cvitkovic E, Bertoni F, Frapolli R, D'Incalci M.

Oncotarget. 2017 Jan 31;8(5):7598-7613. doi: 10.18632/oncotarget.13814.

16.

Rare donor program in Italy.

Paccapelo C, Truglio F, Villa MA, Revelli N, Manera MC, Erba E, Marconi M.

Immunohematology. 2016 Jun;32(2):47-48. Review. No abstract available.

PMID:
27901564
17.

Macrophages are essential for maintaining a M2 protective response early after ischemic brain injury.

Perego C, Fumagalli S, Zanier ER, Carlino E, Panini N, Erba E, De Simoni MG.

Neurobiol Dis. 2016 Dec;96:284-293. doi: 10.1016/j.nbd.2016.09.017. Epub 2016 Sep 30.

PMID:
27697537
18.

The HIV-protease inhibitor saquinavir reduces proliferation, invasion and clonogenicity in cervical cancer cell lines.

Bandiera E, Todeschini P, Romani C, Zanotti L, Erba E, Colmegna B, Bignotti E, Santin AD, Sartori E, Odicino FE, Pecorelli S, Tassi RA, Ravaggi A.

Oncol Lett. 2016 Oct;12(4):2493-2500. Epub 2016 Aug 16.

19.

Promising in vivo efficacy of the BET bromodomain inhibitor OTX015/MK-8628 in malignant pleural mesothelioma xenografts.

Vázquez R, Licandro SA, Astorgues-Xerri L, Lettera E, Panini N, Romano M, Erba E, Ubezio P, Bello E, Libener R, Orecchia S, Grosso F, Riveiro ME, Cvitkovic E, Bekradda M, D'Incalci M, Frapolli R.

Int J Cancer. 2017 Jan 1;140(1):197-207. doi: 10.1002/ijc.30412. Epub 2016 Sep 19.

20.

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin.

Colmegna B, Uboldi S, Frapolli R, Licandro SA, Panini N, Galmarini CM, Badri N, Spanswick VJ, Bingham JP, Kiakos K, Erba E, Hartley JA, D'Incalci M.

Br J Cancer. 2015 Dec 22;113(12):1687-93. doi: 10.1038/bjc.2015.407. Epub 2015 Dec 3.

21.

A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury.

Caron I, Rossi F, Papa S, Aloe R, Sculco M, Mauri E, Sacchetti A, Erba E, Panini N, Parazzi V, Barilani M, Forloni G, Perale G, Lazzari L, Veglianese P.

Biomaterials. 2016 Jan;75:135-147. doi: 10.1016/j.biomaterials.2015.10.024. Epub 2015 Oct 22.

PMID:
26497428
22.

Early modulation of pro-inflammatory microglia by minocycline loaded nanoparticles confers long lasting protection after spinal cord injury.

Papa S, Caron I, Erba E, Panini N, De Paola M, Mariani A, Colombo C, Ferrari R, Pozzer D, Zanier ER, Pischiutta F, Lucchetti J, Bassi A, Valentini G, Simonutti G, Rossi F, Moscatelli D, Forloni G, Veglianese P.

Biomaterials. 2016 Jan;75:13-24. doi: 10.1016/j.biomaterials.2015.10.015. Epub 2015 Oct 9.

PMID:
26474039
23.

3D Silicon Microstructures: A New Tool for Evaluating Biological Aggressiveness of Tumor Cells.

Mazzini G, Carpignano F, Surdo S, Aredia F, Panini N, Torchio M, Erba E, Danova M, Scovassi AI, Barillaro G, Merlo S.

IEEE Trans Nanobioscience. 2015 Oct;14(7):797-805. doi: 10.1109/TNB.2015.2476351. Epub 2015 Sep 3.

PMID:
26353377
24.

Molecular insights into dimerization inhibition of c-Maf transcription factor.

Pellegrino S, Ronda L, Annoni C, Contini A, Erba E, Gelmi ML, Piano R, Paredi G, Mozzarelli A, Bettati S.

Biochim Biophys Acta. 2014 Dec;1844(12):2108-15. doi: 10.1016/j.bbapap.2014.09.003. Epub 2014 Sep 16.

PMID:
25220806
25.

Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) plays a role in cell cycle progression and cytoskeletal dynamics.

Rovina D, Fontana L, Monti L, Novielli C, Panini N, Sirchia SM, Erba E, Magnani I, Larizza L.

Eur J Cell Biol. 2014 Aug-Sep;93(8-9):355-65. doi: 10.1016/j.ejcb.2014.07.004. Epub 2014 Jul 24.

PMID:
25123532
26.

Antiangiogenic activity of trabectedin in myxoid liposarcoma: involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1.

Dossi R, Frapolli R, Di Giandomenico S, Paracchini L, Bozzi F, Brich S, Castiglioni V, Borsotti P, Belotti D, Uboldi S, Sanfilippo R, Erba E, Giavazzi R, Marchini S, Pilotti S, D'Incalci M, Taraboletti G.

Int J Cancer. 2015 Feb 1;136(3):721-9. doi: 10.1002/ijc.29023. Epub 2014 Jun 19.

27.

Resistance to minor groove binders.

Colmegna B, Uboldi S, Erba E, D'Incalci M.

Drug Discov Today Technol. 2014 Mar;11:73-9. doi: 10.1016/j.ddtec.2014.03.001.

PMID:
24847656
28.

Comparative analysis of multilineage properties of mesenchymal stromal cells derived from fetal sources shows an advantage of mesenchymal stromal cells isolated from cord blood in chondrogenic differentiation potential.

Pievani A, Scagliotti V, Russo FM, Azario I, Rambaldi B, Sacchetti B, Marzorati S, Erba E, Giudici G, Riminucci M, Biondi A, Vergani P, Serafini M.

Cytotherapy. 2014 Jul;16(7):893-905. doi: 10.1016/j.jcyt.2014.02.008. Epub 2014 May 1.

29.

Asymmetric modular synthesis of a semirigid dipeptide mimetic by cascade cycloaddition/ring rearrangement and borohydride reduction.

Pellegrino S, Contini A, Gelmi ML, Lo Presti L, Soave R, Erba E.

J Org Chem. 2014 Apr 4;79(7):3094-102. doi: 10.1021/jo500237j. Epub 2014 Mar 25.

30.

ALDH enzymatic activity and CD133 positivity and response to chemotherapy in ovarian cancer patients.

Ricci F, Bernasconi S, Porcu L, Erba E, Panini N, Fruscio R, Sina F, Torri V, Broggini M, Damia G.

Am J Cancer Res. 2013 Apr 3;3(2):221-9. Print 2013.

31.

Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104).

Romano M, Frapolli R, Zangarini M, Bello E, Porcu L, Galmarini CM, García-Fernández LF, Cuevas C, Allavena P, Erba E, D'Incalci M.

Int J Cancer. 2013 Nov;133(9):2024-33. doi: 10.1002/ijc.28213. Epub 2013 May 25.

32.

Role of macrophage targeting in the antitumor activity of trabectedin.

Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F, Nebuloni M, van Rooijen N, Mortarini R, Beltrame L, Marchini S, Fuso Nerini I, Sanfilippo R, Casali PG, Pilotti S, Galmarini CM, Anichini A, Mantovani A, D'Incalci M, Allavena P.

Cancer Cell. 2013 Feb 11;23(2):249-62. doi: 10.1016/j.ccr.2013.01.008.

33.

The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer.

Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L.

Clin Cancer Res. 2012 Aug 15;18(16):4313-24. Epub 2012 Jun 25.

34.

A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma.

Uboldi S, Calura E, Beltrame L, Fuso Nerini I, Marchini S, Cavalieri D, Erba E, Chiorino G, Ostano P, D'Angelo D, D'Incalci M, Romualdi C.

PLoS One. 2012;7(4):e35423. doi: 10.1371/journal.pone.0035423. Epub 2012 Apr 16.

35.

Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo.

Sulaiman GM, Ad'hiah AH, Al-Sammarrae KW, Bagnati R, Frapolli R, Bello E, Uboldi S, Romano M, Panini N, Scanziani E, Pezzolato M, Erba E, D'Incalci M.

Food Chem Toxicol. 2012 May;50(5):1632-41. doi: 10.1016/j.fct.2012.01.022. Epub 2012 Jan 28.

PMID:
22306915
36.

Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.

Uboldi S, Bernasconi S, Romano M, Marchini S, Fuso Nerini I, Damia G, Ganzinelli M, Marangon E, Sala F, Clivio L, Chiorino G, Di Giandomenico S, Rocchi M, Capozzi O, Margison GP, Watson AJ, Caccuri AM, Pastore A, Fossati A, Mantovani R, Grosso F, Tercero JC, Erba E, D'Incalci M.

Int J Cancer. 2012 Jul 1;131(1):59-69. doi: 10.1002/ijc.26340. Epub 2011 Aug 30.

37.

Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells.

Lovejoy KS, Serova M, Bieche I, Emami S, D'Incalci M, Broggini M, Erba E, Gespach C, Cvitkovic E, Faivre S, Raymond E, Lippard SJ.

Mol Cancer Ther. 2011 Sep;10(9):1709-19. doi: 10.1158/1535-7163.MCT-11-0250. Epub 2011 Jul 12.

38.

Chemical characterization of Iraqi propolis samples and assessing their antioxidant potentials.

Sulaiman GM, Al Sammarrae KW, Ad'hiah AH, Zucchetti M, Frapolli R, Bello E, Erba E, D'Incalci M, Bagnati R.

Food Chem Toxicol. 2011 Sep;49(9):2415-21. doi: 10.1016/j.fct.2011.06.060. Epub 2011 Jun 24.

PMID:
21723909
39.

Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlates.

Mazzoletti M, Bortolin F, Brunelli L, Pastorelli R, Di Giandomenico S, Erba E, Ubezio P, Broggini M.

Cancer Res. 2011 Jul 1;71(13):4573-84. doi: 10.1158/0008-5472.CAN-10-4322. Epub 2011 May 20.

40.

A new fluorogenic peptide determines proteasome activity in single cells.

Urru SA, Veglianese P, De Luigi A, Fumagalli E, Erba E, Gonella Diaza R, Carrà A, Davoli E, Borsello T, Forloni G, Pengo N, Monzani E, Cascio P, Cenci S, Sitia R, Salmona M.

J Med Chem. 2010 Oct 28;53(20):7452-60. doi: 10.1021/jm100362x.

PMID:
20883027
41.

Calcareous nannoplankton response to surface-water acidification around Oceanic Anoxic Event 1a.

Erba E, Bottini C, Weissert HJ, Keller CE.

Science. 2010 Jul 23;329(5990):428-32. doi: 10.1126/science.1188886.

42.

Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells.

Germano G, Frapolli R, Simone M, Tavecchio M, Erba E, Pesce S, Pasqualini F, Grosso F, Sanfilippo R, Casali PG, Gronchi A, Virdis E, Tarantino E, Pilotti S, Greco A, Nebuloni M, Galmarini CM, Tercero JC, Mantovani A, D'Incalci M, Allavena P.

Cancer Res. 2010 Mar 15;70(6):2235-44. doi: 10.1158/0008-5472.CAN-09-2335. Epub 2010 Mar 9.

43.

The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo.

Brunelli D, Tavecchio M, Falcioni C, Frapolli R, Erba E, Iori R, Rollin P, Barillari J, Manzotti C, Morazzoni P, D'Incalci M.

Biochem Pharmacol. 2010 Apr 15;79(8):1141-8. doi: 10.1016/j.bcp.2009.12.008. Epub 2009 Dec 16.

PMID:
20006591
44.

Cytogenetic characterization and cell cycle analysis of three human colon adenocarcinoma cell lines: comparison between two- and three-dimensional cell culture systems.

Roncoroni L, Elli L, Bardella MT, Dogliotti E, Grimoldi MG, Viaggi S, Erba E, Zunino A, Doneda L.

Cancer Invest. 2010 Jan;28(1):7-12. doi: 10.3109/07357900802653431.

PMID:
19995228
45.

U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.

Carrassa L, Sanchez Y, Erba E, Damia G.

J Cell Mol Med. 2009 Aug;13(8A):1565-76. doi: 10.1111/j.1582-4934.2009.00362.x.

46.

The immunohaematology reference laboratory: the experience of the Policlinico Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan.

Revelli N, Villa MA, Paccapelo C, Manera MC, Erba E, Truglio F, Sala V, Cosco M, Mantovani R, Magagna V, Poli F, Marconi M.

Blood Transfus. 2009 Apr;7(2):94-9. doi: 10.2450/2008.0040-08. No abstract available.

47.

Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors.

Forni C, Minuzzo M, Virdis E, Tamborini E, Simone M, Tavecchio M, Erba E, Grosso F, Gronchi A, Aman P, Casali P, D'Incalci M, Pilotti S, Mantovani R.

Mol Cancer Ther. 2009 Feb;8(2):449-57. doi: 10.1158/1535-7163.MCT-08-0848. Epub 2009 Feb 3.

48.

The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy.

Marrazzo E, Marchini S, Tavecchio M, Alberio T, Previdi S, Erba E, Rotter V, Broggini M.

Eur J Cancer. 2009 Feb;45(3):443-53. doi: 10.1016/j.ejca.2008.09.024. Epub 2008 Nov 12.

PMID:
19008096
49.

Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.

Valli C, Paroni G, Di Francesco AM, Riccardi R, Tavecchio M, Erba E, Boldetti A, Gianni' M, Fratelli M, Pisano C, Merlini L, Antoccia A, Cenciarelli C, Terao M, Garattini E.

Mol Cancer Ther. 2008 Sep;7(9):2941-54. doi: 10.1158/1535-7163.MCT-08-0419.

50.

Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line.

Roncoroni L, Elli L, Dolfini E, Erba E, Dogliotti E, Terrani C, Doneda L, Grimoldi MG, Bardella MT.

Liver Int. 2008 Dec;28(10):1426-36. doi: 10.1111/j.1478-3231.2008.01749.x. Epub 2008 Apr 5.

PMID:
18397227

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