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Items: 50

1.

Radiographic Honeycombing and Altered Lung Microbiota in Patients with Idiopathic Pulmonary Fibrosis.

Dickson RP, Huffnagle GB, Flaherty KR, White ES, Martinez FJ, Erb-Downward JR, Moore BB, O'Dwyer DN.

Am J Respir Crit Care Med. 2019 Aug 16. doi: 10.1164/rccm.201903-0680LE. [Epub ahead of print] No abstract available.

PMID:
31419390
2.

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis.

O'Dwyer DN, Ashley SL, Gurczynski SJ, Xia M, Wilke C, Falkowski NR, Norman KC, Arnold KB, Huffnagle GB, Salisbury ML, Han MK, Flaherty KR, White ES, Martinez FJ, Erb-Downward JR, Murray S, Moore BB, Dickson RP.

Am J Respir Crit Care Med. 2019 May 1;199(9):1127-1138. doi: 10.1164/rccm.201809-1650OC.

PMID:
30789747
3.

Gut microbiota relationships to lung function and adult asthma phenotype: a pilot study.

Begley L, Madapoosi S, Opron K, Ndum O, Baptist A, Rysso K, Erb-Downward JR, Huang YJ.

BMJ Open Respir Res. 2018 Sep 23;5(1):e000324. doi: 10.1136/bmjresp-2018-000324. eCollection 2018.

4.

Symptom-related sputum microbiota in stable chronic obstructive pulmonary disease.

Diao W, Shen N, Du Y, Erb-Downward JR, Sun X, Guo C, Ke Q, Huffnagle GB, Gyetko MR, He B.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 30;13:2289-2299. doi: 10.2147/COPD.S167618. eCollection 2018.

5.

Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation.

O'Dwyer DN, Zhou X, Wilke CA, Xia M, Falkowski NR, Norman KC, Arnold KB, Huffnagle GB, Murray S, Erb-Downward JR, Yanik GA, Moore BB, Dickson RP.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1312-1321. doi: 10.1164/rccm.201712-2456OC.

6.

The Lung Microbiota of Healthy Mice Are Highly Variable, Cluster by Environment, and Reflect Variation in Baseline Lung Innate Immunity.

Dickson RP, Erb-Downward JR, Falkowski NR, Hunter EM, Ashley SL, Huffnagle GB.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):497-508. doi: 10.1164/rccm.201711-2180OC.

7.

Genome Sequences of 12 Pseudomonas lundensis Strains Isolated from the Lungs of Humans.

Scales BS, Erb-Downward JR, Falkowski NR, LiPuma JJ, Huffnagle GB.

Genome Announc. 2018 Feb 15;6(7). pii: e01461-17. doi: 10.1128/genomeA.01461-17.

8.

Bacterial Dissemination to the Brain in Sepsis.

Singer BH, Dickson RP, Denstaedt SJ, Newstead MW, Kim K, Falkowski NR, Erb-Downward JR, Schmidt TM, Huffnagle GB, Standiford TJ.

Am J Respir Crit Care Med. 2018 Mar 15;197(6):747-756. doi: 10.1164/rccm.201708-1559OC.

9.

Reply: Clinical Metagenomics for the Diagnosis of Hospital-acquired Infections: Promises and Hurdles.

Pendleton KM, Erb-Downward JR, Bao Y, Branton WR, Falkowski NR, Newton DW, Huffnagle GB, Dickson RP.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1618-1619. doi: 10.1164/rccm.201706-1144LE. No abstract available.

10.

Rapid Pathogen Identification in Bacterial Pneumonia Using Real-Time Metagenomics.

Pendleton KM, Erb-Downward JR, Bao Y, Branton WR, Falkowski NR, Newton DW, Huffnagle GB, Dickson RP.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1610-1612. doi: 10.1164/rccm.201703-0537LE. No abstract available.

11.

Bacterial Topography of the Healthy Human Lower Respiratory Tract.

Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Falkowski NR, Huffnagle GB, Curtis JL.

MBio. 2017 Feb 14;8(1). pii: e02287-16. doi: 10.1128/mBio.02287-16.

12.

Microbes Are Associated with Host Innate Immune Response in Idiopathic Pulmonary Fibrosis.

Huang Y, Ma SF, Espindola MS, Vij R, Oldham JM, Huffnagle GB, Erb-Downward JR, Flaherty KR, Moore BB, White ES, Zhou T, Li J, Lussier YA, Han MK, Kaminski N, Garcia JGN, Hogaboam CM, Martinez FJ, Noth I; COMET-IPF Investigators.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):208-219. doi: 10.1164/rccm.201607-1525OC.

13.

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome.

Dickson RP, Singer BH, Newstead MW, Falkowski NR, Erb-Downward JR, Standiford TJ, Huffnagle GB.

Nat Microbiol. 2016 Jul 18;1(10):16113. doi: 10.1038/nmicrobiol.2016.113.

14.

Understanding the role of the microbiome in chronic obstructive pulmonary disease: principles, challenges, and future directions.

Huang YJ, Erb-Downward JR, Dickson RP, Curtis JL, Huffnagle GB, Han MK.

Transl Res. 2017 Jan;179:71-83. doi: 10.1016/j.trsl.2016.06.007. Epub 2016 Jun 23. Review.

15.

Comparative genomics of Pseudomonas fluorescens subclade III strains from human lungs.

Scales BS, Erb-Downward JR, Huffnagle IM, LiPuma JJ, Huffnagle GB.

BMC Genomics. 2015 Dec 7;16:1032. doi: 10.1186/s12864-015-2261-2.

16.

The Microbiome and the Respiratory Tract.

Dickson RP, Erb-Downward JR, Martinez FJ, Huffnagle GB.

Annu Rev Physiol. 2016;78:481-504. doi: 10.1146/annurev-physiol-021115-105238. Epub 2015 Nov 2. Review.

17.

Homeostasis and its disruption in the lung microbiome.

Dickson RP, Erb-Downward JR, Huffnagle GB.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1047-55. doi: 10.1152/ajplung.00279.2015. Epub 2015 Oct 2. Review.

18.

Draft Genome Sequences of Five Pseudomonas fluorescens Subclade I and II Strains, Isolated from Human Respiratory Samples.

Scales BS, Erb-Downward JR, LiPuma JJ, Huffnagle GB.

Genome Announc. 2015 Jul 30;3(4). pii: e00837-15. doi: 10.1128/genomeA.00837-15.

19.

Intraalveolar Catecholamines and the Human Lung Microbiome.

Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):257-9. doi: 10.1164/rccm.201502-0326LE. No abstract available.

20.

Host Response to the Lung Microbiome in Chronic Obstructive Pulmonary Disease.

Sze MA, Dimitriu PA, Suzuki M, McDonough JE, Campbell JD, Brothers JF, Erb-Downward JR, Huffnagle GB, Hayashi S, Elliott WM, Cooper J, Sin DD, Lenburg ME, Spira A, Mohn WW, Hogg JC.

Am J Respir Crit Care Med. 2015 Aug 15;192(4):438-45. doi: 10.1164/rccm.201502-0223OC.

21.

Spatial Variation in the Healthy Human Lung Microbiome and the Adapted Island Model of Lung Biogeography.

Dickson RP, Erb-Downward JR, Freeman CM, McCloskey L, Beck JM, Huffnagle GB, Curtis JL.

Ann Am Thorac Soc. 2015 Jun;12(6):821-30. doi: 10.1513/AnnalsATS.201501-029OC.

22.

Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals.

Bassis CM, Erb-Downward JR, Dickson RP, Freeman CM, Schmidt TM, Young VB, Beck JM, Curtis JL, Huffnagle GB.

MBio. 2015 Mar 3;6(2):e00037. doi: 10.1128/mBio.00037-15.

23.

Draft Genome Sequences of Seven Pseudomonas fluorescens Subclade III Strains Isolated from Cystic Fibrosis Patients.

Scales BS, Erb-Downward JR, Huffnagle IM, LiPuma JJ, Huffnagle GB.

Genome Announc. 2015 Jan 29;3(1). pii: e01285-14. doi: 10.1128/genomeA.01285-14.

24.

The role of Gr-1(+) cells and tumour necrosis factor-α signalling during Clostridium difficile colitis in mice.

McDermott AJ, Higdon KE, Muraglia R, Erb-Downward JR, Falkowski NR, McDonald RA, Young VB, Huffnagle GB.

Immunology. 2015 Apr;144(4):704-16. doi: 10.1111/imm.12425.

25.

[Preparation of metagenomic DNA from bronchoalveolar lavage fluids of patients with chronic obstructive pulmonary diseases].

Wang J, Shen N, Du Y, Erb-Downward JR, Huffnagle GB, Gyetko MR, He B.

Wei Sheng Wu Xue Bao. 2014 Aug 4;54(8):943-9. Chinese.

PMID:
25345027
26.

Cell-associated bacteria in the human lung microbiome.

Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB.

Microbiome. 2014 Aug 18;2:28. doi: 10.1186/2049-2618-2-28. eCollection 2014.

27.

Analysis of culture-dependent versus culture-independent techniques for identification of bacteria in clinically obtained bronchoalveolar lavage fluid.

Dickson RP, Erb-Downward JR, Prescott HC, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB.

J Clin Microbiol. 2014 Oct;52(10):3605-13. doi: 10.1128/JCM.01028-14. Epub 2014 Jul 30.

28.

Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations.

Dickson RP, Erb-Downward JR, Freeman CM, Walker N, Scales BS, Beck JM, Martinez FJ, Curtis JL, Lama VN, Huffnagle GB.

PLoS One. 2014 May 15;9(5):e97214. doi: 10.1371/journal.pone.0097214. eCollection 2014.

29.

The systemic inflammatory response to Clostridium difficile infection.

Rao K, Erb-Downward JR, Walk ST, Micic D, Falkowski N, Santhosh K, Mogle JA, Ring C, Young VB, Huffnagle GB, Aronoff DM.

PLoS One. 2014 Mar 18;9(3):e92578. doi: 10.1371/journal.pone.0092578. eCollection 2014.

30.

Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis.

Dickson RP, Erb-Downward JR, Huffnagle GB.

Lancet Respir Med. 2014 Mar;2(3):238-46. doi: 10.1016/S2213-2600(14)70028-1.

31.

Significance of the microbiome in chronic obstructive pulmonary disease.

Martinez FJ, Erb-Downward JR, Huffnagle GB.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S170-9. doi: 10.1513/AnnalsATS.201306-204AW.

32.

Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans.

Erb Downward JR, Falkowski NR, Mason KL, Muraglia R, Huffnagle GB.

Sci Rep. 2013;3:2191. doi: 10.1038/srep02191.

33.

The role of the bacterial microbiome in lung disease.

Dickson RP, Erb-Downward JR, Huffnagle GB.

Expert Rev Respir Med. 2013 Jun;7(3):245-57. doi: 10.1586/ers.13.24. Review.

34.

Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response.

Sadighi Akha AA, Theriot CM, Erb-Downward JR, McDermott AJ, Falkowski NR, Tyra HM, Rutkowski DT, Young VB, Huffnagle GB.

Immunology. 2013 Sep;140(1):111-22. doi: 10.1111/imm.12122.

35.

Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.

Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH.

J Immunol. 2013 Apr 1;190(7):3447-57. doi: 10.4049/jimmunol.1200604. Epub 2013 Mar 6.

36.

Use of direct gradient analysis to uncover biological hypotheses in 16s survey data and beyond.

Erb-Downward JR, Sadighi Akha AA, Wang J, Shen N, He B, Martinez FJ, Gyetko MR, Curtis JL, Huffnagle GB.

Sci Rep. 2012;2:774. doi: 10.1038/srep00774. Epub 2012 Oct 26.

37.

Candida albicans and bacterial microbiota interactions in the cecum during recolonization following broad-spectrum antibiotic therapy.

Mason KL, Erb Downward JR, Mason KD, Falkowski NR, Eaton KA, Kao JY, Young VB, Huffnagle GB.

Infect Immun. 2012 Oct;80(10):3371-80. doi: 10.1128/IAI.00449-12. Epub 2012 Jul 9.

38.

The microbiota in respiratory disease.

Erb-Downward JR, Huffnagle GB, Martinez FJ.

Am J Respir Crit Care Med. 2012 May 15;185(10):1037-8. doi: 10.1164/rccm.201203-0567ED. No abstract available.

PMID:
22589308
39.

Ecological succession of bacterial communities during conventionalization of germ-free mice.

Gillilland MG 3rd, Erb-Downward JR, Bassis CM, Shen MC, Toews GB, Young VB, Huffnagle GB.

Appl Environ Microbiol. 2012 Apr;78(7):2359-66. doi: 10.1128/AEM.05239-11. Epub 2012 Jan 27.

40.

Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis.

Mason KL, Erb Downward JR, Falkowski NR, Young VB, Kao JY, Huffnagle GB.

Infect Immun. 2012 Jan;80(1):150-8. doi: 10.1128/IAI.05162-11. Epub 2011 Oct 10.

41.

Analysis of the lung microbiome in the "healthy" smoker and in COPD.

Erb-Downward JR, Thompson DL, Han MK, Freeman CM, McCloskey L, Schmidt LA, Young VB, Toews GB, Curtis JL, Sundaram B, Martinez FJ, Huffnagle GB.

PLoS One. 2011 Feb 22;6(2):e16384. doi: 10.1371/journal.pone.0016384.

42.

CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death.

Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, Olszewski MA.

Am J Pathol. 2010 Jan;176(1):218-26. doi: 10.2353/ajpath.2010.081027. Epub 2009 Nov 30.

43.

The role of laccase in prostaglandin production by Cryptococcus neoformans.

Erb-Downward JR, Noggle RM, Williamson PR, Huffnagle GB.

Mol Microbiol. 2008 Jun;68(6):1428-37. doi: 10.1111/j.1365-2958.2008.06245.x. Epub 2008 Apr 11.

44.

Role of oxylipins and other lipid mediators in fungal pathogenesis.

Erb-Downward JR, Huffnagle GB.

Future Microbiol. 2006 Aug;1(2):219-27. Review.

PMID:
17661667
45.

Characterization of prostaglandin E2 production by Candida albicans.

Erb-Downward JR, Noverr MC.

Infect Immun. 2007 Jul;75(7):3498-505. Epub 2007 Apr 30.

46.

Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase.

Erb-Downward JR, Huffnagle GB.

Eukaryot Cell. 2007 Feb;6(2):346-50. Epub 2006 Dec 8.

47.

Role of IFN-gamma in regulating T2 immunity and the development of alternatively activated macrophages during allergic bronchopulmonary mycosis.

Arora S, Hernandez Y, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB.

J Immunol. 2005 May 15;174(10):6346-56.

48.

Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis.

Hernandez Y, Arora S, Erb-Downward JR, McDonald RA, Toews GB, Huffnagle GB.

J Immunol. 2005 Jan 15;174(2):1027-36.

49.

Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.

Noverr MC, Erb-Downward JR, Huffnagle GB.

Clin Microbiol Rev. 2003 Jul;16(3):517-33. Review.

50.

Development of Kinetic Ligand-binding Assays Using a Fiber Optic Sensor.

Smith RH, Lemon WJ, Erb JL, Erb-Downward JR, Downward JG, Ulrich OE, Wittliff JL.

Clin Chem. 1999 Sep;45(9):1683-1685. No abstract available.

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