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Items: 47


Sulfur-Oxidizing Symbionts without Canonical Genes for Autotrophic CO2 Fixation.

Seah BKB, Antony CP, Huettel B, Zarzycki J, Schada von Borzyskowski L, Erb TJ, Kouris A, Kleiner M, Liebeke M, Dubilier N, Gruber-Vodicka HR.

MBio. 2019 Jun 25;10(3). pii: e01112-19. doi: 10.1128/mBio.01112-19.


A critical comparison of cellular and cell-free bioproduction systems.

Claassens NJ, Burgener S, Vögeli B, Erb TJ, Bar-Even A.

Curr Opin Biotechnol. 2019 Jun 14;60:221-229. doi: 10.1016/j.copbio.2019.05.003. [Epub ahead of print] Review.


Awakening the Sleeping Carboxylase Function of Enzymes: Engineering the Natural CO2-Binding Potential of Reductases.

Bernhardsgrütter I, Schell K, Peter DM, Borjian F, Saez DA, Vöhringer-Martinez E, Erb TJ.

J Am Chem Soc. 2019 Jun 14. doi: 10.1021/jacs.9b03431. [Epub ahead of print]


Back to the future: Why we need enzymology to build a synthetic metabolism of the future.

Erb TJ.

Beilstein J Org Chem. 2019 Feb 26;15:551-557. doi: 10.3762/bjoc.15.49. eCollection 2019. Review.


Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme.

Vögeli B, Shima S, Erb TJ, Wagner T.

FEBS Lett. 2019 Mar;593(5):543-553. doi: 10.1002/1873-3468.13331. Epub 2019 Feb 22.


Editorial overview: Novel enzymes, coenzymes, and metabolic pathways.

Gerlt JA, Erb TJ.

Curr Opin Chem Biol. 2018 Dec;47:A4-A6. doi: 10.1016/j.cbpa.2018.11.008. Epub 2018 Nov 26. No abstract available.


Design and in vitro realization of carbon-conserving photorespiration.

Trudeau DL, Edlich-Muth C, Zarzycki J, Scheffen M, Goldsmith M, Khersonsky O, Avizemer Z, Fleishman SJ, Cotton CAR, Erb TJ, Tawfik DS, Bar-Even A.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11455-E11464. doi: 10.1073/pnas.1812605115. Epub 2018 Nov 20.


The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite.

Bernhardsgrütter I, Vögeli B, Wagner T, Peter DM, Cortina NS, Kahnt J, Bange G, Engilberge S, Girard E, Riobé F, Maury O, Shima S, Zarzycki J, Erb TJ.

Nat Chem Biol. 2018 Dec;14(12):1127-1132. doi: 10.1038/s41589-018-0153-x. Epub 2018 Oct 29.


'Negative' and 'positive catalysis': complementary principles that shape the catalytic landscape of enzymes.

Vögeli B, Erb TJ.

Curr Opin Chem Biol. 2018 Dec;47:94-100. doi: 10.1016/j.cbpa.2018.09.013. Epub 2018 Sep 27. Review.


InhA, the enoyl-thioester reductase from Mycobacterium tuberculosis forms a covalent adduct during catalysis.

Vögeli B, Rosenthal RG, Stoffel GMM, Wagner T, Kiefer P, Cortina NS, Shima S, Erb TJ.

J Biol Chem. 2018 Nov 2;293(44):17200-17207. doi: 10.1074/jbc.RA118.005405. Epub 2018 Sep 14.


MaxSynBio: Avenues Towards Creating Cells from the Bottom Up.

Schwille P, Spatz J, Landfester K, Bodenschatz E, Herminghaus S, Sourjik V, Erb TJ, Bastiaens P, Lipowsky R, Hyman A, Dabrock P, Baret JC, Vidakovic-Koch T, Bieling P, Dimova R, Mutschler H, Robinson T, Tang TD, Wegner S, Sundmacher K.

Angew Chem Int Ed Engl. 2018 Oct 8;57(41):13382-13392. doi: 10.1002/anie.201802288. Epub 2018 Sep 17. Review.


Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA Carboxylase/Reductases for Atypical Polyketide Extender Unit Biosynthesis.

Vögeli B, Geyer K, Gerlinger PD, Benkstein S, Cortina NS, Erb TJ.

Cell Chem Biol. 2018 Jul 19;25(7):833-839.e4. doi: 10.1016/j.chembiol.2018.04.009. Epub 2018 May 3.


An engineered Calvin-Benson-Bassham cycle for carbon dioxide fixation in Methylobacterium extorquens AM1.

Schada von Borzyskowski L, Carrillo M, Leupold S, Glatter T, Kiefer P, Weishaupt R, Heinemann M, Erb TJ.

Metab Eng. 2018 May;47:423-433. doi: 10.1016/j.ymben.2018.04.003. Epub 2018 Apr 4.


Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.

Vögeli B, Engilberge S, Girard E, Riobé F, Maury O, Erb TJ, Shima S, Wagner T.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3380-3385. doi: 10.1073/pnas.1718649115. Epub 2018 Mar 12.


Engineered Production of Short-Chain Acyl-Coenzyme A Esters in Saccharomyces cerevisiae.

Krink-Koutsoubelis N, Loechner AC, Lechner A, Link H, Denby CM, Vögeli B, Erb TJ, Yuzawa S, Jakociunas T, Katz L, Jensen MK, Sourjik V, Keasling JD.

ACS Synth Biol. 2018 Apr 20;7(4):1105-1115. doi: 10.1021/acssynbio.7b00466. Epub 2018 Mar 12.


Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase.

Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ.

Molecules. 2017 Dec 28;23(1). pii: E68. doi: 10.3390/molecules23010068.


Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family.

Schwander T, McLean R, Zarzycki J, Erb TJ.

J Biol Chem. 2018 Feb 2;293(5):1702-1712. doi: 10.1074/jbc.RA117.000764. Epub 2017 Dec 22.


Replacing the Ethylmalonyl-CoA Pathway with the Glyoxylate Shunt Provides Metabolic Flexibility in the Central Carbon Metabolism of Methylobacterium extorquens AM1.

Schada von Borzyskowski L, Sonntag F, Pöschel L, Vorholt JA, Schrader J, Erb TJ, Buchhaupt M.

ACS Synth Biol. 2018 Jan 19;7(1):86-97. doi: 10.1021/acssynbio.7b00229. Epub 2017 Dec 21.


A short history of RubisCO: the rise and fall (?) of Nature's predominant CO2 fixing enzyme.

Erb TJ, Zarzycki J.

Curr Opin Biotechnol. 2018 Feb;49:100-107. doi: 10.1016/j.copbio.2017.07.017. Epub 2017 Aug 29. Review.


A conserved threonine prevents self-intoxication of enoyl-thioester reductases.

Rosenthal RG, Vögeli B, Wagner T, Shima S, Erb TJ.

Nat Chem Biol. 2017 Jul;13(7):745-749. doi: 10.1038/nchembio.2375. Epub 2017 May 15.


A Family of Single Copy repABC-Type Shuttle Vectors Stably Maintained in the Alpha-Proteobacterium Sinorhizobium meliloti.

Döhlemann J, Wagner M, Happel C, Carrillo M, Sobetzko P, Erb TJ, Thanbichler M, Becker A.

ACS Synth Biol. 2017 Jun 16;6(6):968-984. doi: 10.1021/acssynbio.6b00320. Epub 2017 Mar 20.


In Vitro Characterization and Concerted Function of Three Core Enzymes of a Glycyl Radical Enzyme - Associated Bacterial Microcompartment.

Zarzycki J, Sutter M, Cortina NS, Erb TJ, Kerfeld CA.

Sci Rep. 2017 Feb 16;7:42757. doi: 10.1038/srep42757.


Synthetic metabolism: metabolic engineering meets enzyme design.

Erb TJ, Jones PR, Bar-Even A.

Curr Opin Chem Biol. 2017 Apr;37:56-62. doi: 10.1016/j.cbpa.2016.12.023. Epub 2017 Jan 30. Review.


A synthetic pathway for the fixation of carbon dioxide in vitro.

Schwander T, Schada von Borzyskowski L, Burgener S, Cortina NS, Erb TJ.

Science. 2016 Nov 18;354(6314):900-904.


Biochemical and synthetic biology approaches to improve photosynthetic CO2-fixation.

Erb TJ, Zarzycki J.

Curr Opin Chem Biol. 2016 Oct;34:72-79. doi: 10.1016/j.cbpa.2016.06.026. Epub 2016 Jul 9. Review.


A Chemo-Enzymatic Road Map to the Synthesis of CoA Esters.

Peter DM, Vögeli B, Cortina NS, Erb TJ.

Molecules. 2016 Apr 20;21(4):517. doi: 10.3390/molecules21040517.


Screening and Engineering the Synthetic Potential of Carboxylating Reductases from Central Metabolism and Polyketide Biosynthesis.

Peter DM, Schada von Borzyskowski L, Kiefer P, Christen P, Vorholt JA, Erb TJ.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13457-61. doi: 10.1002/anie.201505282. Epub 2015 Sep 18.


The use of ene adducts to study and engineer enoyl-thioester reductases.

Rosenthal RG, Vögeli B, Quade N, Capitani G, Kiefer P, Vorholt JA, Ebert MO, Erb TJ.

Nat Chem Biol. 2015 Jun;11(6):398-400. doi: 10.1038/nchembio.1794. Epub 2015 Apr 13.


Integration of untargeted metabolomics with transcriptomics reveals active metabolic pathways.

Cho K, Evans BS, Wood BM, Kumar R, Erb TJ, Warlick BP, Gerlt JA, Sweedler JV.

Metabolomics. 2014 Sep 3;2014(August). pii:


A set of versatile brick vectors and promoters for the assembly, expression, and integration of synthetic operons in Methylobacterium extorquens AM1 and other alphaproteobacteria.

Schada von Borzyskowski L, Remus-Emsermann M, Weishaupt R, Vorholt JA, Erb TJ.

ACS Synth Biol. 2015 Apr 17;4(4):430-43. doi: 10.1021/sb500221v. Epub 2014 Aug 8.


Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation.

Könneke M, Schubert DM, Brown PC, Hügler M, Standfest S, Schwander T, Schada von Borzyskowski L, Erb TJ, Stahl DA, Berg IA.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8239-44. doi: 10.1073/pnas.1402028111. Epub 2014 May 19.


An improved medium for the anaerobic growth of Paracoccus denitrificans Pd1222.

Hahnke SM, Moosmann P, Erb TJ, Strous M.

Front Microbiol. 2014 Jan 31;5:18. doi: 10.3389/fmicb.2014.00018. eCollection 2014.


Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes.

Rosenthal RG, Ebert MO, Kiefer P, Peter DM, Vorholt JA, Erb TJ.

Nat Chem Biol. 2014 Jan;10(1):50-5. doi: 10.1038/nchembio.1385. Epub 2013 Nov 17.


Evolutionary history and biotechnological future of carboxylases.

Schada von Borzyskowski L, Rosenthal RG, Erb TJ.

J Biotechnol. 2013 Nov;168(3):243-51. doi: 10.1016/j.jbiotec.2013.05.007. Epub 2013 May 20. Review.


A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.

Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.

Nat Chem Biol. 2012 Nov;8(11):926-32. doi: 10.1038/nchembio.1087. Epub 2012 Oct 7.


1-methylthio-D-xylulose 5-phosphate methylsulfurylase: a novel route to 1-deoxy-D-xylulose 5-phosphate in Rhodospirillum rubrum.

Warlick BP, Evans BS, Erb TJ, Ramagopal UA, Sriram J, Imker HJ, Sauder JM, Bonanno JB, Burley SK, Tabita FR, Almo SC, Sweedler JS, Gerlt JA.

Biochemistry. 2012 Oct 23;51(42):8324-6. doi: 10.1021/bi301215g. Epub 2012 Oct 8.


The molecular basis of phosphate discrimination in arsenate-rich environments.

Elias M, Wellner A, Goldin-Azulay K, Chabriere E, Vorholt JA, Erb TJ, Tawfik DS.

Nature. 2012 Nov 1;491(7422):134-7. doi: 10.1038/nature11517. Epub 2012 Oct 3.


GFAJ-1 is an arsenate-resistant, phosphate-dependent organism.

Erb TJ, Kiefer P, Hattendorf B, Günther D, Vorholt JA.

Science. 2012 Jul 27;337(6093):467-70. doi: 10.1126/science.1218455. Epub 2012 Jul 8.


Carboxylases in natural and synthetic microbial pathways.

Erb TJ.

Appl Environ Microbiol. 2011 Dec;77(24):8466-77. doi: 10.1128/AEM.05702-11. Epub 2011 Oct 14. Review.


A methylaspartate cycle in haloarchaea.

Khomyakova M, Bükmez Ö, Thomas LK, Erb TJ, Berg IA.

Science. 2011 Jan 21;331(6015):334-7. doi: 10.1126/science.1196544.


Methanol assimilation in Methylobacterium extorquens AM1: demonstration of all enzymes and their regulation.

Smejkalová H, Erb TJ, Fuchs G.

PLoS One. 2010 Oct 1;5(10). pii: e13001. doi: 10.1371/journal.pone.0013001.


(2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation.

Erb TJ, Fuchs G, Alber BE.

Mol Microbiol. 2009 Sep;73(6):992-1008. doi: 10.1111/j.1365-2958.2009.06837.x. Epub 2009 Aug 23.


Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase.

Erb TJ, Brecht V, Fuchs G, Müller M, Alber BE.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8871-6. doi: 10.1073/pnas.0903939106. Epub 2009 May 20.


Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.

Erb TJ, Rétey J, Fuchs G, Alber BE.

J Biol Chem. 2008 Nov 21;283(47):32283-93. doi: 10.1074/jbc.M805527200. Epub 2008 Sep 25.


Phenylacetate metabolism in thermophiles: characterization of phenylacetate-CoA ligase, the initial enzyme of the hybrid pathway in Thermus thermophilus.

Erb TJ, Ismail W, Fuchs G.

Curr Microbiol. 2008 Jul;57(1):27-32. doi: 10.1007/s00284-008-9147-3. Epub 2008 Apr 15.


Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway.

Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10631-6. Epub 2007 Jun 4.

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