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Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67.

Gu J, Yan X, Dai X, Wang Y, Lin Q, Xiao J, Zhou S, Zhang J, Wang K, Zeng J, Xin Y, Barati MT, Zhang C, Bai Y, Li Y, Epstein PN, Wintergerst KA, Li X, Tan Y, Cai L.

Diabetes. 2020 Feb;69(2):267. doi: 10.2337/db20-er02a. Epub 2019 Dec 16. No abstract available.


Sex differences in progression of diabetic nephropathy in OVE26 type 1 diabetic mice.

Wang W, Jiang S, Tang X, Cai L, Epstein PN, Cheng Y, Sun W, Xu Z, Tan Y.

Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165589. doi: 10.1016/j.bbadis.2019.165589. Epub 2019 Oct 31.


Neutrophil exocytosis induces podocyte cytoskeletal reorganization and proteinuria in experimental glomerulonephritis.

Caster DJ, Korte EA, Tan M, Barati MT, Tandon S, Creed TM, Salant DJ, Hata JL, Epstein PN, Huang H, Powell DW, McLeish KR.

Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F595-F606. doi: 10.1152/ajprenal.00039.2018. Epub 2018 May 23.


Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts.

Gu J, Yan X, Dai X, Wang Y, Lin Q, Xiao J, Zhou S, Zhang J, Wang K, Zeng J, Xin Y, Barati MT, Zhang C, Bai Y, Li Y, Epstein PN, Wintergerst KA, Li X, Tan Y, Cai L.

Diabetes. 2018 Mar;67(3):507-517. doi: 10.2337/db17-0219. Epub 2017 Oct 27. Erratum in: Diabetes. 2020 Feb;69(2):267.


Exercise-Induced Changes in Glucose Metabolism Promote Physiological Cardiac Growth.

Gibb AA, Epstein PN, Uchida S, Zheng Y, McNally LA, Obal D, Katragadda K, Trainor P, Conklin DJ, Brittian KR, Tseng MT, Wang J, Jones SP, Bhatnagar A, Hill BG.

Circulation. 2017 Nov 28;136(22):2144-2157. doi: 10.1161/CIRCULATIONAHA.117.028274. Epub 2017 Aug 31.


Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia.

Dai X, Yan X, Zeng J, Chen J, Wang Y, Chen J, Li Y, Barati MT, Wintergerst KA, Pan K, Nystoriak MA, Conklin DJ, Rokosh G, Epstein PN, Li X, Tan Y.

Circ Res. 2017 Mar 3;120(5):e7-e23. doi: 10.1161/CIRCRESAHA.117.310619. Epub 2017 Jan 30.


Impaired Albumin Uptake and Processing Promote Albuminuria in OVE26 Diabetic Mice.

Long YS, Zheng S, Kralik PM, Benz FW, Epstein PN.

J Diabetes Res. 2016;2016:8749417. Epub 2016 Oct 16.


Renoprotection From Diabetic Complications in OVE Transgenic Mice by Endothelial Cell Specific Overexpression of Metallothionein: A TEM Stereological Analysis.

Carlson EC, Chhoun JM, Grove BD, Laturnus DI, Zheng S, Epstein PN, Tan Y.

Anat Rec (Hoboken). 2017 Mar;300(3):560-576. doi: 10.1002/ar.23511. Epub 2017 Jan 11.


C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21.

Wu H, Kong L, Tan Y, Epstein PN, Zeng J, Gu J, Liang G, Kong M, Chen X, Miao L, Cai L.

Diabetologia. 2016 Jul;59(7):1558-1568. doi: 10.1007/s00125-016-3958-8. Epub 2016 Apr 26.


Diabetes Induced Changes in Podocyte Morphology and Gene Expression Evaluated Using GFP Transgenic Podocytes.

Xu J, Zheng S, Kralik PM, Krishnan L, Huang H, Hoying JB, Cai L, Carlson EC, Tan Y, Epstein PN.

Int J Biol Sci. 2016 Jan 1;12(2):210-8. doi: 10.7150/ijbs.13057. eCollection 2016.


Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice.

Zheng S, Coventry S, Cai L, Powell DW, Jala VR, Haribabu B, Epstein PN.

J Diabetes Res. 2016;2016:5362506. doi: 10.1155/2016/5362506. Epub 2015 Dec 20.


Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice.

Barati MT, Powell DW, Kechavarzi BD, Isaacs SM, Zheng S, Epstein PN, Cai L, Coventry S, Rane MJ, Klein JB.

Cell Stress Chaperones. 2016 Jan;21(1):155-166. doi: 10.1007/s12192-015-0648-2.


Zinc rescue of Akt2 gene deletion-linked murine cardiac dysfunction and pathological changes is metallothionein-dependent.

Sun W, Miao X, Zhou S, Zhang L, Epstein PN, Mellen N, Zheng Y, Fu Y, Wang Y, Cai L.

J Mol Cell Cardiol. 2014 Sep;74:88-97. doi: 10.1016/j.yjmcc.2014.04.023. Epub 2014 May 10.


Metallothionein as a compensatory component prevents intermittent hypoxia-induced cardiomyopathy in mice.

Yin X, Zhou S, Zheng Y, Tan Y, Kong M, Wang B, Feng W, Epstein PN, Cai J, Cai L.

Toxicol Appl Pharmacol. 2014 May 15;277(1):58-66. doi: 10.1016/j.taap.2014.03.007. Epub 2014 Mar 18.


Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt, but not Akt2.

Sun W, Wang Y, Miao X, Wang Y, Zhang L, Xin Y, Zheng S, Epstein PN, Fu Y, Cai L.

Free Radic Biol Med. 2014 Mar;68:22-34. doi: 10.1016/j.freeradbiomed.2013.11.015. Epub 2013 Dec 1.


Associations between structural and functional changes to the kidney in diabetic humans and mice.

Powell DW, Kenagy DN, Zheng S, Coventry SC, Xu J, Cai L, Carlson EC, Epstein PN.

Life Sci. 2013 Aug 28;93(7):257-64. doi: 10.1016/j.lfs.2013.06.016. Epub 2013 Jun 22. Review.


Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes.

Xu X, Kobayashi S, Chen K, Timm D, Volden P, Huang Y, Gulick J, Yue Z, Robbins J, Epstein PN, Liang Q.

J Biol Chem. 2013 Jun 21;288(25):18077-92. doi: 10.1074/jbc.M113.474650. Epub 2013 May 8.


Reduced cardiac fructose 2,6 bisphosphate increases hypertrophy and decreases glycolysis following aortic constriction.

Wang J, Xu J, Wang Q, Brainard RE, Watson LJ, Jones SP, Epstein PN.

PLoS One. 2013;8(1):e53951. doi: 10.1371/journal.pone.0053951. Epub 2013 Jan 7.


Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB.

Wang Y, Sun W, Du B, Miao X, Bai Y, Xin Y, Tan Y, Cui W, Liu B, Cui T, Epstein PN, Fu Y, Cai L.

Am J Physiol Heart Circ Physiol. 2013 Feb 15;304(4):H567-78. doi: 10.1152/ajpheart.00650.2012. Epub 2012 Dec 7.


Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice.

Cui W, Li B, Bai Y, Miao X, Chen Q, Sun W, Tan Y, Luo P, Zhang C, Zheng S, Epstein PN, Miao L, Cai L.

Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E87-99. doi: 10.1152/ajpendo.00430.2012. Epub 2012 Nov 6.


Podocyte-specific overexpression of metallothionein mitigates diabetic complications in the glomerular filtration barrier and glomerular histoarchitecture: a transmission electron microscopy stereometric analysis.

Carlson EC, Chhoun JM, Laturnus DI, Bikash KC, Berg B, Zheng S, Epstein PN.

Diabetes Metab Res Rev. 2013 Feb;29(2):113-24. doi: 10.1002/dmrr.2342.


Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction.

Wang J, Wang Q, Watson LJ, Jones SP, Epstein PN.

Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2073-80. doi: 10.1152/ajpheart.00157.2011. Epub 2011 Aug 26.


TEM stereometric analyses of glomeruli in aging OVE26 transgenic diabetic mice.

Teiken JM, Epstein PN, Carlson EC.

Am J Nephrol. 2011;33 Suppl 1:8-14. doi: 10.1159/000327031. Epub 2011 Jun 10.


Uninephrectomy of diabetic OVE26 mice greatly accelerates albuminuria, fibrosis, inflammatory cell infiltration and changes in gene expression.

Zheng S, Huang Y, Yang L, Chen T, Xu J, Epstein PN.

Nephron Exp Nephrol. 2011;119(1):e21-32. doi: 10.1159/000327586. Epub 2011 Jun 9.


Inflammatory gene expression in OVE26 diabetic kidney during the development of nephropathy.

Yang L, Brozovic S, Xu J, Long Y, Kralik PM, Waigel S, Zacharias W, Zheng S, Epstein PN.

Nephron Exp Nephrol. 2011;119(1):e8-20. doi: 10.1159/000324407. Epub 2011 May 23.


Angiotensin II plays a critical role in diabetic pulmonary fibrosis most likely via activation of NADPH oxidase-mediated nitrosative damage.

Yang J, Tan Y, Zhao F, Ma Z, Wang Y, Zheng S, Epstein PN, Yu J, Yin X, Zheng Y, Li X, Miao L, Cai L.

Am J Physiol Endocrinol Metab. 2011 Jul;301(1):E132-44. doi: 10.1152/ajpendo.00629.2010. Epub 2011 Apr 12.


FVB mouse genotype confers susceptibility to OVE26 diabetic albuminuria.

Xu J, Huang Y, Li F, Zheng S, Epstein PN.

Am J Physiol Renal Physiol. 2010 Sep;299(3):F487-94. doi: 10.1152/ajprenal.00018.2010. Epub 2010 Jul 7.


Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice.

Yan B, Li L, Harden SW, Epstein PN, Wurster RD, Cheng ZJ.

Exp Neurol. 2009 Nov;220(1):34-43. doi: 10.1016/j.expneurol.2009.07.006. Epub 2009 Jul 15.


Diabetic albuminuria is due to a small fraction of nephrons distinguished by albumin-stained tubules and glomerular adhesions.

Kralik PM, Long Y, Song Y, Yang L, Wei H, Coventry S, Zheng S, Epstein PN.

Am J Pathol. 2009 Aug;175(2):500-9. doi: 10.2353/ajpath.2009.080939. Epub 2009 Jul 2.


Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules.

Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ.

Am J Physiol Renal Physiol. 2009 Aug;297(2):F380-8. doi: 10.1152/ajprenal.90433.2008. Epub 2009 May 27.


Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

Doser TA, Turdi S, Thomas DP, Epstein PN, Li SY, Ren J.

Circulation. 2009 Apr 14;119(14):1941-9. doi: 10.1161/CIRCULATIONAHA.108.823799. Epub 2009 Mar 30.


Impaired baroreflex control of renal sympathetic nerve activity in type 1 diabetic mice (OVE26).

Gu H, Zhang ZH, Epstein PN, Li L, Harden SW, Wurster RD, Cheng ZJ.

Neuroscience. 2009 Jun 16;161(1):78-85. doi: 10.1016/j.neuroscience.2009.02.083. Epub 2009 Mar 19.


Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.

Villafuerte BC, Barati MT, Song Y, Moore JP, Epstein PN, Portillo J.

Endocrinology. 2009 Jun;150(6):2611-7. doi: 10.1210/en.2008-1294. Epub 2009 Feb 12.


Metallothionein over-expression in podocytes reduces adriamycin nephrotoxicity.

Yang L, Zheng S, Epstein PN.

Free Radic Res. 2009 Feb;43(2):174-82. doi: 10.1080/10715760802657308.


Beta-cell death and proliferation after intermittent hypoxia: role of oxidative stress.

Xu J, Long YS, Gozal D, Epstein PN.

Free Radic Biol Med. 2009 Mar 15;46(6):783-90. doi: 10.1016/j.freeradbiomed.2008.11.026. Epub 2008 Dec 14.


Renal tubulointerstitial fibrosis in OVE26 type 1 diabetic mice.

Powell DW, Bertram CC, Cummins TD, Barati MT, Zheng S, Epstein PN, Klein JB.

Nephron Exp Nephrol. 2009;111(1):e11-9. doi: 10.1159/000178763. Epub 2008 Dec 2.


Malic enzyme is present in mouse islets and modulates insulin secretion.

Xu J, Han J, Long YS, Lock J, Weir GC, Epstein PN, Liu YQ.

Diabetologia. 2008 Dec;51(12):2281-9. doi: 10.1007/s00125-008-1155-0. Epub 2008 Sep 19.


The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells.

Xu J, Han J, Long YS, Epstein PN, Liu YQ.

Diabetologia. 2008 Nov;51(11):2022-30. doi: 10.1007/s00125-008-1130-9. Epub 2008 Sep 4.


Podocyte-specific overexpression of the antioxidant metallothionein reduces diabetic nephropathy.

Zheng S, Carlson EC, Yang L, Kralik PM, Huang Y, Epstein PN.

J Am Soc Nephrol. 2008 Nov;19(11):2077-85. doi: 10.1681/ASN.2007080967. Epub 2008 Jul 16.


Cardiac phosphatase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase increases glycolysis, hypertrophy, and myocyte resistance to hypoxia.

Wang Q, Donthi RV, Wang J, Lange AJ, Watson LJ, Jones SP, Epstein PN.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2889-97. doi: 10.1152/ajpheart.91501.2007. Epub 2008 May 2.


Functional changes in baroreceptor afferent, central and efferent components of the baroreflex circuitry in type 1 diabetic mice (OVE26).

Gu H, Epstein PN, Li L, Wurster RD, Cheng ZJ.

Neuroscience. 2008 Mar 27;152(3):741-52. doi: 10.1016/j.neuroscience.2007.11.030. Epub 2007 Dec 4.


Altering and analyzing glucose metabolism in perfused hearts of transgenic mice.

Donthi RV, Epstein PN.

Methods Mol Med. 2007;139:151-61.


Podocyte loss in aging OVE26 diabetic mice.

Teiken JM, Audettey JL, Laturnus DI, Zheng S, Epstein PN, Carlson EC.

Anat Rec (Hoboken). 2008 Jan;291(1):114-21.


Diabetic Cardiomyopathy in OVE26 Mice Shows Mitochondrial ROS Production and Divergence Between In Vivo and In Vitro Contractility.

Song Y, Du Y, Prabhu SD, Epstein PN.

Rev Diabet Stud. 2007 Fall;4(3):159-68. Epub 2007 Nov 10.


Morphology and topography of nucleus ambiguus projections to cardiac ganglia in rats and mice.

Ai J, Epstein PN, Gozal D, Yang B, Wurster R, Cheng ZJ.

Neuroscience. 2007 Nov 23;149(4):845-60. Epub 2007 Sep 11.


Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice.

Thongboonkerd V, Zheng S, McLeish KR, Epstein PN, Klein JB.

Rev Diabet Stud. 2005 Spring;2(1):19-26. Epub 2005 May 10.


Causes and characteristics of diabetic cardiomyopathy.

Wang J, Song Y, Wang Q, Kralik PM, Epstein PN.

Rev Diabet Stud. 2006 Fall;3(3):108-17. Epub 2006 Nov 10.


Hyperglycemia alters enzyme activity and cell number in spinal sensory ganglia.

Zaruba RA, Epstein PN, Carr PA.

J Brachial Plex Peripher Nerve Inj. 2007 Apr 25;2:11.


Rat maternal diabetes impairs pancreatic beta-cell function in the offspring.

Han J, Xu J, Long YS, Epstein PN, Liu YQ.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E228-36. Epub 2007 Mar 27.

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