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Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice.

Guo J, Zhang T, Guo Y, Sun T, Li H, Zhang X, Yin H, Cao G, Yin Y, Wang H, Shi L, Guo X, Sha J, Eppig JJ, Su YQ.

Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5326-E5333. doi: 10.1073/pnas.1800352115. Epub 2018 May 21.


Reproduction: Oocytes Call, Granulosa Cells Connect.

Eppig JJ.

Curr Biol. 2018 Apr 23;28(8):R354-R356. doi: 10.1016/j.cub.2018.03.005.


SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes.

Hwang G, Sun F, O'Brien M, Eppig JJ, Handel MA, Jordan PW.

Development. 2017 May 1;144(9):1648-1660. doi: 10.1242/dev.145607. Epub 2017 Mar 16.


Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.

Guo J, Shi L, Gong X, Jiang M, Yin Y, Zhang X, Yin H, Li H, Emori C, Sugiura K, Eppig JJ, Su YQ.

J Cell Sci. 2016 Aug 15;129(16):3091-103. doi: 10.1242/jcs.182642. Epub 2016 Jun 29.


Histone reader BRWD1 targets and restricts recombination to the Igk locus.

Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR.

Nat Immunol. 2015 Oct;16(10):1094-103. doi: 10.1038/ni.3249. Epub 2015 Aug 24.


Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.

Pattabiraman S, Baumann C, Guisado D, Eppig JJ, Schimenti JC, De La Fuente R.

J Cell Biol. 2015 Jan 5;208(1):53-69. doi: 10.1083/jcb.201404109. Epub 2014 Dec 29.


Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles.

Wigglesworth K, Lee KB, Emori C, Sugiura K, Eppig JJ.

Biol Reprod. 2015 Jan;92(1):23. doi: 10.1095/biolreprod.114.121756. Epub 2014 Nov 5.


Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities.

Peng J, Wigglesworth K, Rangarajan A, Eppig JJ, Thompson TB, Matzuk MM.

Biol Reprod. 2014 Dec;91(6):142. doi: 10.1095/biolreprod.114.123158. Epub 2014 Sep 24.


Applying "Gold Standards" to In-Vitro-Derived Germ Cells.

Handel MA, Eppig JJ, Schimenti JC.

Cell. 2014 Sep 25;159(1):216. doi: 10.1016/j.cell.2014.09.018. Epub 2014 Sep 25. No abstract available.


Applying "gold standards" to in-vitro-derived germ cells.

Handel MA, Eppig JJ, Schimenti JC.

Cell. 2014 Jun 5;157(6):1257-61. doi: 10.1016/j.cell.2014.05.019. Erratum in: Cell. 2014 Sep 25;159(1):216.


Cooperative effects of 17β-estradiol and oocyte-derived paracrine factors on the transcriptome of mouse cumulus cells.

Emori C, Wigglesworth K, Fujii W, Naito K, Eppig JJ, Sugiura K.

Endocrinology. 2013 Dec;154(12):4859-72. doi: 10.1210/en.2013-1536. Epub 2013 Sep 13. Erratum in: Endocrinology. 2014 May;155(5):2047.


Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes.

Wigglesworth K, Lee KB, O'Brien MJ, Peng J, Matzuk MM, Eppig JJ.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3723-9. doi: 10.1073/pnas.1314829110. Epub 2013 Aug 26.


Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions.

Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2258. No abstract available.


Oocyte differentiation is genetically dissociable from meiosis in mice.

Dokshin GA, Baltus AE, Eppig JJ, Page DC.

Nat Genet. 2013 Aug;45(8):877-83. doi: 10.1038/ng.2672. Epub 2013 Jun 16.


Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions.

Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E776-85. doi: 10.1073/pnas.1218020110. Epub 2013 Feb 4.


Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells.

Lee KB, Zhang M, Sugiura K, Wigglesworth K, Uliasz T, Jaffe LA, Eppig JJ.

Biol Reprod. 2013 Feb 21;88(2):42. doi: 10.1095/biolreprod.112.104810. Print 2013 Feb.


Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.

Su YQ, Sun F, Handel MA, Schimenti JC, Eppig JJ.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18653-60. doi: 10.1073/pnas.1216904109. Epub 2012 Oct 22.


Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.

Robinson JW, Zhang M, Shuhaibar LC, Norris RP, Geerts A, Wunder F, Eppig JJ, Potter LR, Jaffe LA.

Dev Biol. 2012 Jun 15;366(2):308-16. doi: 10.1016/j.ydbio.2012.04.019. Epub 2012 Apr 21.


MARF1 regulates essential oogenic processes in mice.

Su YQ, Sugiura K, Sun F, Pendola JK, Cox GA, Handel MA, Schimenti JC, Eppig JJ.

Science. 2012 Mar 23;335(6075):1496-9. doi: 10.1126/science.1214680.


Origins of granulosa cells clarified and complexified by waves.

Eppig JJ, Handel MA.

Biol Reprod. 2012 Feb 14;86(2):34. doi: 10.1095/biolreprod.111.096651. Print 2012 Feb.


Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro.

Zhang M, Su YQ, Sugiura K, Wigglesworth K, Xia G, Eppig JJ.

Endocrinology. 2011 Nov;152(11):4377-85. doi: 10.1210/en.2011-1118. Epub 2011 Sep 13.


A-MYB (MYBL1) transcription factor is a master regulator of male meiosis.

Bolcun-Filas E, Bannister LA, Barash A, Schimenti KJ, Hartford SA, Eppig JJ, Handel MA, Shen L, Schimenti JC.

Development. 2011 Aug;138(15):3319-30. doi: 10.1242/dev.067645.


Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Mol Endocrinol. 2010 Dec;24(12):2303-14. doi: 10.1210/me.2010-0260. Epub 2010 Nov 3.


Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.

Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ.

Science. 2010 Oct 15;330(6002):366-9. doi: 10.1126/science.1193573.


Does bone morphogenetic protein 6 (BMP6) affect female fertility in the mouse?

Sugiura K, Su YQ, Eppig JJ.

Biol Reprod. 2010 Dec;83(6):997-1004. doi: 10.1095/biolreprod.110.086777. Epub 2010 Aug 11.


Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling.

Su YQ, Sugiura K, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Mol Endocrinol. 2010 Jun;24(6):1230-9. doi: 10.1210/me.2009-0497. Epub 2010 Apr 9.


Probe-level analysis of expression microarrays characterizes isoform-specific degradation during mouse oocyte maturation.

Salisbury J, Hutchison KW, Wigglesworth K, Eppig JJ, Graber JH.

PLoS One. 2009 Oct 16;4(10):e7479. doi: 10.1371/journal.pone.0007479.


Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Biol Reprod. 2009 Nov;81(5):833-41. doi: 10.1095/biolreprod.109.078485. Epub 2009 Jun 24.


Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism.

Su YQ, Sugiura K, Eppig JJ.

Semin Reprod Med. 2009 Jan;27(1):32-42. doi: 10.1055/s-0028-1108008. Epub 2009 Feb 5. Review.


Effect of in vitro maturation of mouse oocytes on the health and lifespan of adult offspring.

Eppig JJ, O'Brien MJ, Wigglesworth K, Nicholson A, Zhang W, King BA.

Hum Reprod. 2009 Apr;24(4):922-8. doi: 10.1093/humrep/den466. Epub 2009 Jan 16.


Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression.

Sugiura K, Su YQ, Eppig JJ.

Mol Reprod Dev. 2009 Jun;76(6):537-47. doi: 10.1002/mrd.20971.


The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition.

Philipps DL, Wigglesworth K, Hartford SA, Sun F, Pattabiraman S, Schimenti K, Handel M, Eppig JJ, Schimenti JC.

Dev Biol. 2008 May 1;317(1):72-82. doi: 10.1016/j.ydbio.2008.02.018. Epub 2008 Feb 21.


Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells.

Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ.

Development. 2008 Jan;135(1):111-21. Epub 2007 Nov 28.


Regulation of Pcsk6 expression during the preantral to antral follicle transition in mice: opposing roles of FSH and oocytes.

Diaz FJ, Sugiura K, Eppig JJ.

Biol Reprod. 2008 Jan;78(1):176-83. Epub 2007 Oct 3.


Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.

Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC.

PLoS Genet. 2007 Aug;3(8):e139. Epub 2007 Jul 6.


Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.

Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ.

Development. 2007 Jul;134(14):2593-603. Epub 2007 Jun 6. Erratum in: Development. 2008 Feb;135(4):786.


Oocytes determine cumulus cell lineage in mouse ovarian follicles.

Diaz FJ, Wigglesworth K, Eppig JJ.

J Cell Sci. 2007 Apr 15;120(Pt 8):1330-40. Epub 2007 Mar 27.


Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice.

Diaz FJ, Wigglesworth K, Eppig JJ.

Dev Biol. 2007 May 1;305(1):300-11. Epub 2007 Feb 21.


Selective degradation of transcripts during meiotic maturation of mouse oocytes.

Su YQ, Sugiura K, Woo Y, Wigglesworth K, Kamdar S, Affourtit J, Eppig JJ.

Dev Biol. 2007 Feb 1;302(1):104-17. Epub 2006 Sep 12.


Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.

Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB.

Genes Dev. 2006 Oct 1;20(19):2713-27.


The preantral granulosa cell to cumulus cell transition in the mouse ovary: development of competence to undergo expansion.

Diaz FJ, O'Brien MJ, Wigglesworth K, Eppig JJ.

Dev Biol. 2006 Nov 1;299(1):91-104. Epub 2006 Jul 15.


Mutagenesis as an unbiased approach to identify novel contraceptive targets.

Handel MA, Lessard C, Reinholdt L, Schimenti J, Eppig JJ.

Mol Cell Endocrinol. 2006 May 16;250(1-2):201-5. Epub 2006 Jan 18.


Transcript profiling during mouse oocyte development and the effect of gonadotropin priming and development in vitro.

Pan H, O'brien MJ, Wigglesworth K, Eppig JJ, Schultz RM.

Dev Biol. 2005 Oct 15;286(2):493-506. Epub 2005 Oct 5.


Mouse oocytes regulate metabolic cooperativity between granulosa cells and oocytes: amino acid transport.

Eppig JJ, Pendola FL, Wigglesworth K, Pendola JK.

Biol Reprod. 2005 Aug;73(2):351-7. Epub 2005 Apr 20.


The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.

Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA.

Science. 2004 Dec 10;306(5703):1947-50.


H1FOO is coupled to the initiation of oocytic growth.

Tanaka M, Kihara M, Hennebold JD, Eppig JJ, Viveiros MM, Emery BR, Carrell DT, Kirkman NJ, Meczekalski B, Zhou J, Bondy CA, Becker M, Schultz RM, Misteli T, De La Fuente R, King GJ, Adashi EY.

Biol Reprod. 2005 Jan;72(1):135-42. Epub 2004 Sep 15.


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