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Items: 48

1.

A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity.

Birkou M, Chasapis CT, Marousis KD, Loutsidou AK, Bentrop D, Lelli M, Herrmann T, Carthy JM, Episkopou V, Spyroulias GA.

J Mol Biol. 2017 Jul 21;429(15):2373-2386. doi: 10.1016/j.jmb.2017.06.012. Epub 2017 Jun 22.

2.

Coordination of progenitor specification and growth in mouse and chick spinal cord.

Kicheva A, Bollenbach T, Ribeiro A, Valle HP, Lovell-Badge R, Episkopou V, Briscoe J.

Science. 2014 Sep 26;345(6204):1254927. doi: 10.1126/science.1254927.

3.

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension.

Kelly CE, Thymiakou E, Dixon JE, Tanaka S, Godwin J, Episkopou V.

PLoS Biol. 2013;11(4):e1001538. doi: 10.1371/journal.pbio.1001538. Epub 2013 Apr 16.

4.

Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.

Martin N, Popov N, Aguilo F, O'Loghlen A, Raguz S, Snijders AP, Dharmalingam G, Li S, Thymiakou E, Carroll T, Zeisig BB, So CW, Peters G, Episkopou V, Walsh MJ, Gil J.

EMBO J. 2013 Apr 3;32(7):982-95. doi: 10.1038/emboj.2013.37. Epub 2013 Mar 1.

5.

TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.

Redshaw N, Camps C, Sharma V, Motallebipour M, Guzman-Ayala M, Oikonomopoulos S, Thymiakou E, Ragoussis J, Episkopou V.

PLoS One. 2013;8(1):e55186. doi: 10.1371/journal.pone.0055186. Epub 2013 Jan 30.

6.

NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase.

Chasapis CT, Kandias NG, Episkopou V, Bentrop D, Spyroulias GA.

Proteins. 2012 May;80(5):1484-9. doi: 10.1002/prot.24048. Epub 2012 Mar 13.

PMID:
22411132
7.

Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.

Sharma V, Antonacopoulou AG, Tanaka S, Panoutsopoulos AA, Bravou V, Kalofonos HP, Episkopou V.

Cancer Res. 2011 Oct 15;71(20):6438-49. doi: 10.1158/0008-5472.CAN-11-1645.

8.

Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors.

Bami M, Episkopou V, Gavalas A, Gouti M.

PLoS One. 2011;6(5):e20197. doi: 10.1371/journal.pone.0020197. Epub 2011 May 26.

9.

Detection of signaling effector-complexes downstream of bmp4 using PLA, a proximity ligation assay.

Thymiakou E, Episkopou V.

J Vis Exp. 2011 Mar 3;(49). pii: 2631. doi: 10.3791/2631.

10.

The TGF-β signaling modulators TRAP1/TGFBRAP1 and VPS39/Vam6/TLP are essential for early embryonic development.

Messler S, Kropp S, Episkopou V, Felici A, Würthner J, Lemke R, Jerabek-Willemsen M, Willecke R, Scheu S, Pfeffer K, Wurthner JU.

Immunobiology. 2011 Mar;216(3):343-50. doi: 10.1016/j.imbio.2010.07.006. Epub 2010 Aug 19.

PMID:
20961651
11.

Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.

Guzman-Ayala M, Lee KL, Mavrakis KJ, Goggolidou P, Norris DP, Episkopou V.

PLoS One. 2009;4(1):e4268. doi: 10.1371/journal.pone.0004268. Epub 2009 Jan 27. Erratum in: PLoS One. 2009;4(2). doi: 10.1371/annotation/8f64f0c8-6767-4701-8ded-7f937d953cb6.

12.

TGF-beta repressors SnoN and Ski are implicated in human colorectal carcinogenesis.

Bravou V, Antonacopoulou A, Papadaki H, Floratou K, Stavropoulos M, Episkopou V, Petropoulou C, Kalofonos H.

Cell Oncol. 2009;31(1):41-51.

13.

High yield expression and NMR characterization of Arkadia E3 ubiquitin ligase RING-H2 finger domain.

Kandias NG, Chasapis CT, Bentrop D, Episkopou V, Spyroulias GA.

Biochem Biophys Res Commun. 2009 Jan 16;378(3):498-502. doi: 10.1016/j.bbrc.2008.11.055. Epub 2008 Nov 24.

PMID:
19032943
14.

Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors.

Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A.

Stem Cells. 2008 Jan;26(1):3-16. Epub 2007 Oct 11.

15.

Dual function of Sox1 in telencephalic progenitor cells.

Kan L, Jalali A, Zhao LR, Zhou X, McGuire T, Kazanis I, Episkopou V, Bassuk AG, Kessler JA.

Dev Biol. 2007 Oct 1;310(1):85-98. Epub 2007 Jul 27.

16.

Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.

Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS.

Mol Cell Biol. 2007 Sep;27(17):6068-83. Epub 2007 Jun 25.

17.

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.

Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K.

J Biol Chem. 2007 Jul 13;282(28):20492-501. Epub 2007 May 16.

18.

Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.

Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V.

PLoS Biol. 2007 Mar;5(3):e67.

19.

Pax6 is misexpressed in Sox1 null lens fiber cells.

Donner AL, Ko F, Episkopou V, Maas RL.

Gene Expr Patterns. 2007 Apr;7(5):606-13. Epub 2007 Jan 11.

20.

Sox2 and Pou2f1 interact to control lens and olfactory placode development.

Donner AL, Episkopou V, Maas RL.

Dev Biol. 2007 Mar 15;303(2):784-99. Epub 2006 Nov 6.

21.

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS.

Diabetes. 2005 Dec;54(12):3402-9.

22.

Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V.

PLoS Biol. 2005 Jun;3(6):e186. Epub 2005 May 17.

23.

SOX2 functions in adult neural stem cells.

Episkopou V.

Trends Neurosci. 2005 May;28(5):219-21. Review.

PMID:
15866195
24.

Sox1-deficient mice suffer from epilepsy associated with abnormal ventral forebrain development and olfactory cortex hyperexcitability.

Malas S, Postlethwaite M, Ekonomou A, Whalley B, Nishiguchi S, Wood H, Meldrum B, Constanti A, Episkopou V.

Neuroscience. 2003;119(2):421-32.

PMID:
12770556
25.

Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation.

Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, Fujiyama A, Fisher AG, Merkenschlager M.

Mamm Genome. 2001 Jul;12(7):554-60.

PMID:
11420619
26.

Arkadia enhances nodal-related signalling to induce mesendoderm.

Niederländer C, Walsh JJ, Episkopou V, Jones CM.

Nature. 2001 Apr 12;410(6830):830-4.

PMID:
11298453
27.

Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.

Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D.

Nature. 2001 Apr 12;410(6830):825-30.

PMID:
11298452
28.

Differentiation of osteoblasts and in vitro bone formation from murine embryonic stem cells.

Buttery LD, Bourne S, Xynos JD, Wood H, Hughes FJ, Hughes SP, Episkopou V, Polak JM.

Tissue Eng. 2001 Feb;7(1):89-99.

PMID:
11224927
29.

Biochemical basis for depressed serum retinol levels in transthyretin-deficient mice.

van Bennekum AM, Wei S, Gamble MV, Vogel S, Piantedosi R, Gottesman M, Episkopou V, Blaner WS.

J Biol Chem. 2001 Jan 12;276(2):1107-13.

30.

Transthyretin regulates thyroid hormone levels in the choroid plexus, but not in the brain parenchyma: study in a transthyretin-null mouse model.

Palha JA, Fernandes R, de Escobar GM, Episkopou V, Gottesman M, Saraiva MJ.

Endocrinology. 2000 Sep;141(9):3267-72.

31.
32.

The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3.

Malas S, Duthie S, Deloukas P, Episkopou V.

Mamm Genome. 1999 Sep;10(9):934-7. No abstract available.

PMID:
10441749
33.

Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice.

Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R, Episkopou V.

Genes Dev. 1998 Mar 15;12(6):776-81.

34.

Serum amyloid P component enhances induction of murine amyloidosis.

Togashi S, Lim SK, Kawano H, Ito S, Ishihara T, Okada Y, Nakano S, Kinoshita T, Horie K, Episkopou V, Gottesman ME, Costantini F, Shimada K, Maeda S.

Lab Invest. 1997 Nov;77(5):525-31.

PMID:
9389795
35.

Complementation of null CF mice with a human CFTR YAC transgene.

Manson AL, Trezise AE, MacVinish LJ, Kasschau KD, Birchall N, Episkopou V, Vassaux G, Evans MJ, Colledge WH, Cuthbert AW, Huxley C.

EMBO J. 1997 Jul 16;16(14):4238-49.

36.

Analysis of amyloid deposition in a transgenic mouse model of homozygous familial amyloidotic polyneuropathy.

Kohno K, Palha JA, Miyakawa K, Saraiva MJ, Ito S, Mabuchi T, Blaner WS, Iijima H, Tsukahara S, Episkopou V, Gottesman ME, Shimada K, Takahashi K, Yamamura K, Maeda S.

Am J Pathol. 1997 Apr;150(4):1497-508.

37.

Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice.

Palha JA, Hays MT, Morreale de Escobar G, Episkopou V, Gottesman ME, Saraiva MJ.

Am J Physiol. 1997 Mar;272(3 Pt 1):E485-93.

PMID:
9124556
38.

Cloning and mapping of the human SOX1: a highly conserved gene expressed in the developing brain.

Malas S, Duthie SM, Mohri F, Lovell-Badge R, Episkopou V.

Mamm Genome. 1997;8(11):866-8. No abstract available.

PMID:
9337405
40.

Genetic and physical mapping of the murine Sox1 gene.

Malas S, Sartor M, Duthie S, Hadjantonakis K, Lovell-Badge R, Episkopou V.

Mamm Genome. 1996 Aug;7(8):620-1. No abstract available.

PMID:
8678988
41.

Xist expression from an Xist YAC transgene carried on the mouse Y chromosome.

Matsuura S, Episkopou V, Hamvas R, Brown SD.

Hum Mol Genet. 1996 Apr;5(4):451-9.

PMID:
8845837
42.

Studies on the metabolism of retinol and retinol-binding protein in transthyretin-deficient mice produced by homologous recombination.

Wei S, Episkopou V, Piantedosi R, Maeda S, Shimada K, Gottesman ME, Blaner WS.

J Biol Chem. 1995 Jan 13;270(2):866-70.

43.

Thyroid hormone metabolism in a transthyretin-null mouse strain.

Palha JA, Episkopou V, Maeda S, Shimada K, Gottesman ME, Saraiva MJ.

J Biol Chem. 1994 Dec 30;269(52):33135-9.

44.
45.

Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone.

Episkopou V, Maeda S, Nishiguchi S, Shimada K, Gaitanaris GA, Gottesman ME, Robertson EJ.

Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9.

46.

Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family.

Soares MB, Turken A, Ishii D, Mills L, Episkopou V, Cotter S, Zeitlin S, Efstratiadis A.

J Mol Biol. 1986 Dec 20;192(4):737-52.

PMID:
2438416
47.

Guinea pig preproinsulin gene: an evolutionary compromise?

Chan SJ, Episkopou V, Zeitlin S, Karathanasis SK, MacKrell A, Steiner DF, Efstratiadis A.

Proc Natl Acad Sci U S A. 1984 Aug;81(16):5046-50.

48.

Cell-specified expression of a selectable hybrid gene.

Episkopou V, Murphy AJ, Efstratiadis A.

Proc Natl Acad Sci U S A. 1984 Aug;81(15):4657-61.

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