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Items: 1 to 50 of 65

1.

The mechanisms of a mammalian splicing enhancer.

Jobbins AM, Reichenbach LF, Lucas CM, Hudson AJ, Burley GA, Eperon IC.

Nucleic Acids Res. 2018 Mar 16;46(5):2145-2158. doi: 10.1093/nar/gky056.

2.

Specific G-quadruplex ligands modulate the alternative splicing of Bcl-X.

Weldon C, Dacanay JG, Gokhale V, Boddupally PVL, Behm-Ansmant I, Burley GA, Branlant C, Hurley LH, Dominguez C, Eperon IC.

Nucleic Acids Res. 2018 Jan 25;46(2):886-896. doi: 10.1093/nar/gkx1122.

3.

Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?

Weldon C, Eperon IC, Dominguez C.

Biochem Soc Trans. 2016 Dec 15;44(6):1761-1768.

4.

Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA.

Weldon C, Behm-Ansmant I, Hurley LH, Burley GA, Branlant C, Eperon IC, Dominguez C.

Nat Chem Biol. 2017 Jan;13(1):18-20. doi: 10.1038/nchembio.2228. Epub 2016 Nov 7.

5.

Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways.

Chen L, Weinmeister R, Kralovicova J, Eperon LP, Vorechovsky I, Hudson AJ, Eperon IC.

Nucleic Acids Res. 2017 Feb 28;45(4):2051-2067. doi: 10.1093/nar/gkw860.

6.

Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.

Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang HS, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C.

Nat Commun. 2016 Jan 13;7:10355. doi: 10.1038/ncomms10355.

7.

Single-Fluorophore Detection in Femtoliter Droplets Generated by Flow Focusing.

Weinmeister R, Freeman E, Eperon IC, Stuart AM, Hudson AJ.

ACS Nano. 2015 Oct 27;9(10):9718-30. doi: 10.1021/acsnano.5b02422. Epub 2015 Sep 18.

PMID:
26365461
8.

A targeted oligonucleotide enhancer of SMN2 exon 7 splicing forms competing quadruplex and protein complexes in functional conditions.

Smith LD, Dickinson RL, Lucas CM, Cousins A, Malygin AA, Weldon C, Perrett AJ, Bottrill AR, Searle MS, Burley GA, Eperon IC.

Cell Rep. 2014 Oct 9;9(1):193-205. doi: 10.1016/j.celrep.2014.08.051. Epub 2014 Sep 25.

9.

Intron retention in the alternatively spliced region of RON results from weak 3' splice site recognition.

Smith LD, Lucas CM, Eperon IC.

PLoS One. 2013 Oct 14;8(10):e77208. doi: 10.1371/journal.pone.0077208. eCollection 2013.

10.

The splicing landscape is globally reprogrammed during male meiosis.

Schmid R, Grellscheid SN, Ehrmann I, Dalgliesh C, Danilenko M, Paronetto MP, Pedrotti S, Grellscheid D, Dixon RJ, Sette C, Eperon IC, Elliott DJ.

Nucleic Acids Res. 2013 Dec;41(22):10170-84. doi: 10.1093/nar/gkt811. Epub 2013 Sep 12.

11.

MBNL1 and PTB cooperate to repress splicing of Tpm1 exon 3.

Gooding C, Edge C, Lorenz M, Coelho MB, Winters M, Kaminski CF, Cherny D, Eperon IC, Smith CW.

Nucleic Acids Res. 2013 May;41(9):4765-82. doi: 10.1093/nar/gkt168. Epub 2013 Mar 19.

12.

Pick one, but be quick: 5' splice sites and the problems of too many choices.

Roca X, Krainer AR, Eperon IC.

Genes Dev. 2013 Jan 15;27(2):129-44. doi: 10.1101/gad.209759.112. Review.

13.

A novel morpholino oligomer targeting ISS-N1 improves rescue of severe spinal muscular atrophy transgenic mice.

Zhou H, Janghra N, Mitrpant C, Dickinson RL, Anthony K, Price L, Eperon IC, Wilton SD, Morgan J, Muntoni F.

Hum Gene Ther. 2013 Mar;24(3):331-42. doi: 10.1089/hum.2012.211. Epub 2013 Mar 6.

14.

An RNA splicing enhancer that does not act by looping.

Lewis H, Perrett AJ, Burley GA, Eperon IC.

Angew Chem Int Ed Engl. 2012 Sep 24;51(39):9800-3. doi: 10.1002/anie.201202932. Epub 2012 Aug 31.

PMID:
22936639
15.

Defining the roles and interactions of PTB.

Kafasla P, Mickleburgh I, Llorian M, Coelho M, Gooding C, Cherny D, Joshi A, Kotik-Kogan O, Curry S, Eperon IC, Jackson RJ, Smith CW.

Biochem Soc Trans. 2012 Aug;40(4):815-20. doi: 10.1042/BST20120044. Review.

16.

The transition in spliceosome assembly from complex E to complex A purges surplus U1 snRNPs from alternative splice sites.

Hodson MJ, Hudson AJ, Cherny D, Eperon IC.

Nucleic Acids Res. 2012 Aug;40(14):6850-62. doi: 10.1093/nar/gks322. Epub 2012 Apr 13.

17.

Design principles for bifunctional targeted oligonucleotide enhancers of splicing.

Owen N, Zhou H, Malygin AA, Sangha J, Smith LD, Muntoni F, Eperon IC.

Nucleic Acids Res. 2011 Sep 1;39(16):7194-208. doi: 10.1093/nar/gkr152. Epub 2011 May 20.

18.

Stoichiometry of a regulatory splicing complex revealed by single-molecule analyses.

Cherny D, Gooding C, Eperon GE, Coelho MB, Bagshaw CR, Smith CW, Eperon IC.

EMBO J. 2010 Jul 7;29(13):2161-72. doi: 10.1038/emboj.2010.103. Epub 2010 May 25.

19.

Probing complexes with single fluorophores: factors contributing to dispersion of FRET in DNA/RNA duplexes.

Cherny DI, Eperon IC, Bagshaw CR.

Eur Biophys J. 2009 Apr;38(4):395-405. doi: 10.1007/s00249-008-0383-z. Epub 2008 Nov 18.

PMID:
19015840
20.

Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism.

Malygin AA, Parakhnevitch NM, Ivanov AV, Eperon IC, Karpova GG.

Nucleic Acids Res. 2007;35(19):6414-23. Epub 2007 Sep 18.

21.
22.
23.

A genome-wide survey demonstrates widespread non-linear mRNA in expressed sequences from multiple species.

Dixon RJ, Eperon IC, Hall L, Samani NJ.

Nucleic Acids Res. 2005 Oct 19;33(18):5904-13. Print 2005.

24.

The activity of a single-stranded promoter of plasmid ColIb-P9 depends on its secondary structure.

Nasim MT, Eperon IC, Wilkins BM, Brammar WJ.

Mol Microbiol. 2004 Jul;53(2):405-17.

25.

Exon repetition: a major pathway for processing mRNA of some genes is allele-specific.

Rigatti R, Jia JH, Samani NJ, Eperon IC.

Nucleic Acids Res. 2004 Jan 22;32(2):441-6. Print 2004.

26.

HnRNP G and Tra2beta: opposite effects on splicing matched by antagonism in RNA binding.

Nasim MT, Chernova TK, Chowdhury HM, Yue BG, Eperon IC.

Hum Mol Genet. 2003 Jun 1;12(11):1337-48. Erratum in: Hum Mol Genet. 2003 Aug 1;12(15):1941.

PMID:
12761049
27.

Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts.

Skordis LA, Dunckley MG, Yue B, Eperon IC, Muntoni F.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4114-9. Epub 2003 Mar 17.

28.
29.

Selection of alternative 5' splice sites: role of U1 snRNP and models for the antagonistic effects of SF2/ASF and hnRNP A1.

Eperon IC, Makarova OV, Mayeda A, Munroe SH, Cáceres JF, Hayward DG, Krainer AR.

Mol Cell Biol. 2000 Nov;20(22):8303-18.

30.

An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.

Elliott DJ, Venables JP, Newton CS, Lawson D, Boyle S, Eperon IC, Cooke HJ.

Hum Mol Genet. 2000 Sep 1;9(14):2117-24.

PMID:
10958650
31.

RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.

Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC.

Hum Mol Genet. 2000 Mar 22;9(5):685-94.

PMID:
10749975
32.

An exonic splicing silencer in the testes-specific DNA ligase III beta exon.

Chew SL, Baginsky L, Eperon IC.

Nucleic Acids Res. 2000 Jan 15;28(2):402-10.

33.

T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.

Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC.

Hum Mol Genet. 1999 Jun;8(6):959-69.

PMID:
10332027
34.

Exon repetition in mRNA.

Frantz SA, Thiara AS, Lodwick D, Ng LL, Eperon IC, Samani NJ.

Proc Natl Acad Sci U S A. 1999 May 11;96(10):5400-5.

36.

Modification of splicing in the dystrophin gene in cultured Mdx muscle cells by antisense oligoribonucleotides.

Dunckley MG, Manoharan M, Villiet P, Eperon IC, Dickson G.

Hum Mol Genet. 1998 Jul;7(7):1083-90.

PMID:
9618164
37.

Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development.

Elliott DJ, Oghene K, Makarov G, Makarova O, Hargreave TB, Chandley AC, Eperon IC, Cooke HJ.

J Cell Sci. 1998 May;111 ( Pt 9):1255-65.

39.

Modulation of pre-mRNA splicing in the Duchenne muscular dystrophy gene.

Dunckley MG, Eperon IC, Dickson G.

Biochem Soc Trans. 1996 May;24(2):276S. No abstract available.

PMID:
8736934
40.

The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.

Willmott CJ, Critchlow SE, Eperon IC, Maxwell A.

J Mol Biol. 1994 Sep 30;242(4):351-63.

PMID:
7932695
41.

Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF.

Eperon IC, Ireland DC, Smith RA, Mayeda A, Krainer AR.

EMBO J. 1993 Sep;12(9):3607-17.

42.
43.

Mutually exclusive splicing of calcium-binding domain exons in chick alpha-actinin.

Waites GT, Graham IR, Jackson P, Millake DB, Patel B, Blanchard AD, Weller PA, Eperon IC, Critchley DR.

J Biol Chem. 1992 Mar 25;267(9):6263-71.

44.
45.

Co-purification of a small RNA species with multicatalytic proteinase (proteasome) from rat liver.

Skilton HE, Eperon IC, Rivett AJ.

FEBS Lett. 1991 Feb 25;279(2):351-5.

46.

Influences of separation and adjacent sequences on the use of alternative 5' splice sites.

Cunningham SA, Else AJ, Potter BV, Eperon IC.

J Mol Biol. 1991 Jan 20;217(2):265-81.

PMID:
1825120
47.

Components of the multicatalytic proteinase complex.

Rivett AJ, Skilton HE, Rowe AJ, Eperon IC, Sweeney ST.

Biomed Biochim Acta. 1991;50(4-6):447-50. Review.

PMID:
1724905
48.

Hierarchy for 5' splice site preference determined in vivo.

Lear AL, Eperon LP, Wheatley IM, Eperon IC.

J Mol Biol. 1990 Jan 5;211(1):103-15.

PMID:
2299664
49.

RNA content of the multicatalytic proteinase complex.

Skilton HE, Eperon IC, Rivett AJ.

Biochem Soc Trans. 1989 Dec;17(6):1124. No abstract available.

PMID:
2483388
50.

Substitution of pre-mRNA with phosphorothioate linkages reveals a new splicing-related reaction.

Griffiths AD, Potter BV, Eperon IC.

J Biol Chem. 1988 Sep 5;263(25):12295-304.

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