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MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.

Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimham P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD.

Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7.


Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function.

Nam DH, Kim E, Benham A, Park HK, Soibam B, Taffet GE, Kaelber JT, Suh JH, Taegtmeyer H, Entman ML, Reineke EL.

FASEB J. 2019 Jan;33(1):711-721. doi: 10.1096/fj.201800602R. Epub 2018 Jul 19.


Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors.

Cieslik KA, Sekhar RV, Granillo A, Reddy A, Medrano G, Heredia CP, Entman ML, Hamilton DJ, Li S, Reineke E, Gupte AA, Zhang A, Taffet GE.

J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1167-1177. doi: 10.1093/gerona/gly034.


Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis.

Suh JH, Lai L, Nam D, Kim J, Jo J, Taffet GE, Kim E, Kaelber JT, Lee HK, Entman ML, Cooke JP, Reineke EL.

J Biol Chem. 2017 Dec 29;292(52):21643-21652. doi: 10.1074/jbc.M117.804740. Epub 2017 Nov 10.


Aicar treatment reduces interstitial fibrosis in aging mice: Suppression of the inflammatory fibroblast.

Cieslik KA, Trial J, Entman ML.

J Mol Cell Cardiol. 2017 Oct;111:81-85. doi: 10.1016/j.yjmcc.2017.08.003. Epub 2017 Aug 4.


AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis.

Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y.

Kidney Int. 2018 Jan;93(1):81-94. doi: 10.1016/j.kint.2017.04.033. Epub 2017 Jul 21.


Dissecting the role of myeloid and mesenchymal fibroblasts in age-dependent cardiac fibrosis.

Trial J, Heredia CP, Taffet GE, Entman ML, Cieslik KA.

Basic Res Cardiol. 2017 Jul;112(4):34. doi: 10.1007/s00395-017-0623-4. Epub 2017 May 6.


The role of C-reactive protein in innate and acquired inflammation: new perspectives.

Trial J, Potempa LA, Entman ML.

Inflamm Cell Signal. 2016;3(2). pii: e1409. Epub 2016 Sep 5.


Phosphocholine-containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states.

Trial J, Cieslik KA, Entman ML.

Immun Inflamm Dis. 2016 Jun 20;4(3):274-88. doi: 10.1002/iid3.112. eCollection 2016 Sep.


Circulating Aldosterone Levels and Disease Severity in Pulmonary Arterial Hypertension.

Safdar Z, Thakur A, Singh S, Ji Y, Guffey D, Minard CG, Entman ML.

J Pulm Respir Med. 2015 Oct;5(5). pii: 295. Epub 2015 Oct 31.


TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function.

Mayr M, Duerrschmid C, Medrano G, Taffet GE, Wang Y, Entman ML, Haudek SB.

Physiol Rep. 2016 Apr;4(8). pii: e12765. doi: 10.14814/phy2.12765. Epub 2016 Apr 27.


Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease.

Crawford JR, Trial J, Nambi V, Hoogeveen RC, Taffet GE, Entman ML.

J Cardiovasc Transl Res. 2016 Jun;9(3):184-93. doi: 10.1007/s12265-016-9678-0. Epub 2016 Feb 18.


Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart.

Trial J, Entman ML, Cieslik KA.

J Mol Cell Cardiol. 2016 Feb;91:28-34. doi: 10.1016/j.yjmcc.2015.12.017. Epub 2015 Dec 22. Review.


Left Atrial Volume and Pulmonary Artery Diameter Are Noninvasive Measures of Age-Related Diastolic Dysfunction in Mice.

Medrano G, Hermosillo-Rodriguez J, Pham T, Granillo A, Hartley CJ, Reddy A, Osuna PM, Entman ML, Taffet GE.

J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1141-50. doi: 10.1093/gerona/glv143. Epub 2015 Oct 28.


Collagen Metabolism Biomarkers and Health Related Quality of Life in Pulmonary Arterial Hypertension.

Safdar Z, Tamez E, Frost A, Guffey D, Minard CG, Entman ML.

Int J Cardiovasc Res. 2015;4(2). doi: 10.4172/2324-8602.1000198.


PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban.

Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C.

J Clin Invest. 2015 Jul 1;125(7):2759-71. doi: 10.1172/JCI80369. Epub 2015 Jun 15.


Tumor necrosis factor: a mechanistic link between angiotensin-II-induced cardiac inflammation and fibrosis.

Duerrschmid C, Trial J, Wang Y, Entman ML, Haudek SB.

Circ Heart Fail. 2015 Mar;8(2):352-61. doi: 10.1161/CIRCHEARTFAILURE.114.001893. Epub 2014 Dec 30.


CXCR6 plays a critical role in angiotensin II-induced renal injury and fibrosis.

Xia Y, Jin X, Yan J, Entman ML, Wang Y.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1422-8. doi: 10.1161/ATVBAHA.113.303172. Epub 2014 May 22.


Steroid receptor coactivator-2 is a dual regulator of cardiac transcription factor function.

Reineke EL, Benham A, Soibam B, Stashi E, Taegtmeyer H, Entman ML, Schwartz RJ, O'Malley BW.

J Biol Chem. 2014 Jun 20;289(25):17721-31. doi: 10.1074/jbc.M113.539908. Epub 2014 May 8.


The chemokine receptor CXCR6 contributes to recruitment of bone marrow-derived fibroblast precursors in renal fibrosis.

Xia Y, Yan J, Jin X, Entman ML, Wang Y.

Kidney Int. 2014 Aug;86(2):327-37. doi: 10.1038/ki.2014.64. Epub 2014 Mar 19.


Rho associated coiled-coil kinase-1 regulates collagen-induced phosphatidylserine exposure in platelets.

Dasgupta SK, Le A, Haudek SB, Entman ML, Rumbaut RE, Thiagarajan P.

PLoS One. 2013 Dec 16;8(12):e84649. doi: 10.1371/journal.pone.0084649. eCollection 2013.


Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts.

Cieslik KA, Trial J, Crawford JR, Taffet GE, Entman ML.

J Mol Cell Cardiol. 2014 May;70:56-63. doi: 10.1016/j.yjmcc.2013.10.017. Epub 2013 Oct 31. Review.


CCR2 regulates the uptake of bone marrow-derived fibroblasts in renal fibrosis.

Xia Y, Entman ML, Wang Y.

PLoS One. 2013 Oct 10;8(10):e77493. doi: 10.1371/journal.pone.0077493. eCollection 2013.


microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.

Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A.

PLoS One. 2013 Sep 27;8(9):e75882. doi: 10.1371/journal.pone.0075882. eCollection 2013.


Th1/M1 conversion to th2/m2 responses in models of inflammation lacking cell death stimulates maturation of monocyte precursors to fibroblasts.

Trial J, Cieslik KA, Haudek SB, Duerrschmid C, Entman ML.

Front Immunol. 2013 Sep 18;4:287. doi: 10.3389/fimmu.2013.00287. eCollection 2013.


Critical role of CXCL16 in hypertensive kidney injury and fibrosis.

Xia Y, Entman ML, Wang Y.

Hypertension. 2013 Dec;62(6):1129-37. doi: 10.1161/HYPERTENSIONAHA.113.01837. Epub 2013 Sep 23.


AICAR-dependent AMPK activation improves scar formation in the aged heart in a murine model of reperfused myocardial infarction.

Cieslik KA, Taffet GE, Crawford JR, Trial J, Mejia Osuna P, Entman ML.

J Mol Cell Cardiol. 2013 Oct;63:26-36. doi: 10.1016/j.yjmcc.2013.07.005. Epub 2013 Jul 19.


Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis.

Yang J, Lin SC, Chen G, He L, Hu Z, Chan L, Trial J, Entman ML, Wang Y.

J Am Soc Nephrol. 2013 Oct;24(10):1644-59. doi: 10.1681/ASN.2013030217. Epub 2013 Jul 5.


Coronary microvascular pericytes are the cellular target of sunitinib malate-induced cardiotoxicity.

Chintalgattu V, Rees ML, Culver JC, Goel A, Jiffar T, Zhang J, Dunner K Jr, Pati S, Bankson JA, Pasqualini R, Arap W, Bryan NS, Taegtmeyer H, Langley RR, Yao H, Kupferman ME, Entman ML, Dickinson ME, Khakoo AY.

Sci Transl Med. 2013 May 29;5(187):187ra69. doi: 10.1126/scitranslmed.3005066.


Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart.

Sen S, Kundu BK, Wu HC, Hashmi SS, Guthrie P, Locke LW, Roy RJ, Matherne GP, Berr SS, Terwelp M, Scott B, Carranza S, Frazier OH, Glover DK, Dillmann WH, Gambello MJ, Entman ML, Taegtmeyer H.

J Am Heart Assoc. 2013 May 17;2(3):e004796. doi: 10.1161/JAHA.113.004796.


Young little mice express a premature cardiovascular aging phenotype.

Reddy AK, Hartley CJ, Pham TT, Darlington G, Entman ML, Taffet GE.

J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):152-9. doi: 10.1093/gerona/glt055. Epub 2013 May 16.


TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis.

Duerrschmid C, Crawford JR, Reineke E, Taffet GE, Trial J, Entman ML, Haudek SB.

J Mol Cell Cardiol. 2013 Apr;57:59-67. doi: 10.1016/j.yjmcc.2013.01.006. Epub 2013 Jan 18.


Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels.

Cieslik KA, Trial J, Carlson S, Taffet GE, Entman ML.

FASEB J. 2013 Apr;27(4):1761-71. doi: 10.1096/fj.12-220145. Epub 2013 Jan 9.


SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart.

Reineke EL, York B, Stashi E, Chen X, Tsimelzon A, Xu J, Newgard CB, Taffet GE, Taegtmeyer H, Entman ML, O'Malley BW.

PLoS One. 2012;7(12):e53395. doi: 10.1371/journal.pone.0053395. Epub 2012 Dec 31.


Origin of developmental precursors dictates the pathophysiologic role of cardiac fibroblasts.

Crawford JR, Haudek SB, Cieslik KA, Trial J, Entman ML.

J Cardiovasc Transl Res. 2012 Dec;5(6):749-59. doi: 10.1007/s12265-012-9402-7. Epub 2012 Sep 13. Review.


Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.

Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ Jr, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A.

Circulation. 2012 Jun 5;125(22):2751-61. doi: 10.1161/CIRCULATIONAHA.111.044354. Epub 2012 May 8.


Defective myofibroblast formation from mesenchymal stem cells in the aging murine heart rescue by activation of the AMPK pathway.

Cieslik KA, Trial J, Entman ML.

Am J Pathol. 2011 Oct;179(4):1792-806. doi: 10.1016/j.ajpath.2011.06.022. Epub 2011 Aug 3.


CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis.

Chen G, Lin SC, Chen J, He L, Dong F, Xu J, Han S, Du J, Entman ML, Wang Y.

J Am Soc Nephrol. 2011 Oct;22(10):1876-86. doi: 10.1681/ASN.2010080881. Epub 2011 Aug 4.


CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis.

Xu J, Lin SC, Chen J, Miao Y, Taffet GE, Entman ML, Wang Y.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H538-47. doi: 10.1152/ajpheart.01114.2010. Epub 2011 May 13.


Doppler velocity measurements from large and small arteries of mice.

Hartley CJ, Reddy AK, Madala S, Entman ML, Michael LH, Taffet GE.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H269-78. doi: 10.1152/ajpheart.00320.2011. Epub 2011 May 13. Review.


Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction.

Carlson S, Trial J, Soeller C, Entman ML.

Cardiovasc Res. 2011 Jul 1;91(1):99-107. doi: 10.1093/cvr/cvr061. Epub 2011 Feb 28.


Coronary flow reserve in mice: effects of age, coronary disease, and vascular loading.

Hartley CJ, Reddy AK, Michael LH, Entman ML, Chintalagattu V, Khakoo AY, Taffet GE.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:3780-3. doi: 10.1109/IEMBS.2010.5627571.


Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart.

Cieslik KA, Taffet GE, Carlson S, Hermosillo J, Trial J, Entman ML.

J Mol Cell Cardiol. 2011 Jan;50(1):248-56. doi: 10.1016/j.yjmcc.2010.10.019. Epub 2010 Oct 23.


Feasibility of dual Doppler velocity measurements to estimate volume pulsations of an arterial segment.

Hartley CJ, Reddy AK, Madala S, Entman ML, Taffet GE.

Ultrasound Med Biol. 2010 Jul;36(7):1169-75. doi: 10.1016/j.ultrasmedbio.2010.04.002.


Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy.

Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML.

J Mol Cell Cardiol. 2010 Sep;49(3):499-507. doi: 10.1016/j.yjmcc.2010.05.005. Epub 2010 May 19.


Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.

Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY.

J Clin Invest. 2010 Feb;120(2):472-84. doi: 10.1172/JCI39434. Epub 2010 Jan 11.


Coronary flow reserve as an index of cardiac function in mice with cardiovascular abnormalities.

Hartley CJ, Reddy AK, Michael LH, Entman ML, Taffet GE.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1094-7. doi: 10.1109/IEMBS.2009.5332488.


Adaptive and maladptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading.

Divakaran V, Adrogue J, Ishiyama M, Entman ML, Haudek S, Sivasubramanian N, Mann DL.

Circ Heart Fail. 2009 Nov;2(6):633-42. doi: 10.1161/CIRCHEARTFAILURE.108.823070. Epub 2009 Sep 24.


The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heart.

Burchfield JS, Dong JW, Sakata Y, Gao F, Tzeng HP, Topkara VK, Entman ML, Sivasubramanian N, Mann DL.

Circ Heart Fail. 2010 Jan;3(1):157-64. doi: 10.1161/CIRCHEARTFAILURE.109.899732. Epub 2009 Oct 30.

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