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Items: 1 to 50 of 76

1.

Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular Matrix.

Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Mauck RL, Iozzo RV, Birk DE, Han L.

ACS Nano. 2019 Oct 1. doi: 10.1021/acsnano.9b04477. [Epub ahead of print]

PMID:
31550133
2.

Control of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons.

Izumi S, Otsuru S, Adachi N, Akabudike N, Enomoto-Iwamoto M.

PLoS One. 2019 Mar 18;14(3):e0213912. doi: 10.1371/journal.pone.0213912. eCollection 2019.

3.

Periarticular Mesenchymal Progenitors Initiate and Contribute to Secondary Ossification Center Formation During Mouse Long Bone Development.

Tong W, Tower RJ, Chen C, Wang L, Zhong L, Wei Y, Sun H, Cao G, Jia H, Pacifici M, Koyama E, Enomoto-Iwamoto M, Qin L.

Stem Cells. 2019 May;37(5):677-689. doi: 10.1002/stem.2975. Epub 2019 Feb 6.

PMID:
30681752
4.

Possible Contribution of Wnt-Responsive Chondroprogenitors to the Postnatal Murine Growth Plate.

Usami Y, Gunawardena AT, Francois NB, Otsuru S, Takano H, Hirose K, Matsuoka M, Suzuki A, Huang J, Qin L, Iwamoto M, Yang W, Toyosawa S, Enomoto-Iwamoto M.

J Bone Miner Res. 2019 May;34(5):964-974. doi: 10.1002/jbmr.3658. Epub 2019 Jan 28.

5.

Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta.

Scheiber AL, Guess AJ, Kaito T, Abzug JM, Enomoto-Iwamoto M, Leikin S, Iwamoto M, Otsuru S.

Biochem Biophys Res Commun. 2019 Jan 29;509(1):235-240. doi: 10.1016/j.bbrc.2018.12.111. Epub 2018 Dec 20.

PMID:
30579604
6.

Extracellular Matrix and Adhesion Molecule Gene Expression in the Normal and Injured Murine Intervertebral Disc.

Zhang Y, Tian Z, Ashley JW, Wang L, Tower RJ, Wei Y, Qin L, Yang S, Enomoto-Iwamoto M.

Am J Phys Med Rehabil. 2019 Jan;98(1):35-42. doi: 10.1097/PHM.0000000000001012.

PMID:
30085932
7.

Modulating Glucose Metabolism and Lactate Synthesis in Injured Mouse Tendons: Treatment With Dichloroacetate, a Lactate Synthesis Inhibitor, Improves Tendon Healing.

Zhang K, Hast MW, Izumi S, Usami Y, Shetye S, Akabudike N, Philp NJ, Iwamoto M, Nissim I, Soslowsky LJ, Enomoto-Iwamoto M.

Am J Sports Med. 2018 Jul;46(9):2222-2231. doi: 10.1177/0363546518778789. Epub 2018 Jun 21.

8.

Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis.

Jia H, Ma X, Wei Y, Tong W, Tower RJ, Chandra A, Wang L, Sun Z, Yang Z, Badar F, Zhang K, Tseng WJ, Kramer I, Kneissel M, Xia Y, Liu XS, Wang JHC, Han L, Enomoto-Iwamoto M, Qin L.

Arthritis Rheumatol. 2018 Feb;70(2):230-241. doi: 10.1002/art.40351. Epub 2017 Dec 29.

9.

Intervertebral Disc Degeneration in a Percutaneous Mouse Tail Injury Model.

Tian Z, Ma X, Yasen M, Mauck RL, Qin L, Shofer FS, Smith LJ, Pacifici M, Enomoto-Iwamoto M, Zhang Y.

Am J Phys Med Rehabil. 2018 Mar;97(3):170-177. doi: 10.1097/PHM.0000000000000818.

10.

Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs.

Decker RS, Um HB, Dyment NA, Cottingham N, Usami Y, Enomoto-Iwamoto M, Kronenberg MS, Maye P, Rowe DW, Koyama E, Pacifici M.

Dev Biol. 2017 Jun 1;426(1):56-68. doi: 10.1016/j.ydbio.2017.04.006. Epub 2017 Apr 21.

11.

Cell therapy for the degenerating intervertebral disc.

Tong W, Lu Z, Qin L, Mauck RL, Smith HE, Smith LJ, Malhotra NR, Heyworth MF, Caldera F, Enomoto-Iwamoto M, Zhang Y.

Transl Res. 2017 Mar;181:49-58. doi: 10.1016/j.trsl.2016.11.008. Epub 2016 Nov 28. Review.

12.

EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation.

Jia H, Ma X, Tong W, Doyran B, Sun Z, Wang L, Zhang X, Zhou Y, Badar F, Chandra A, Lu XL, Xia Y, Han L, Enomoto-Iwamoto M, Qin L.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14360-14365. Epub 2016 Nov 28.

13.

Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis.

Doyran B, Tong W, Li Q, Jia H, Zhang X, Chen C, Enomoto-Iwamoto M, Lu XL, Qin L, Han L.

Osteoarthritis Cartilage. 2017 Jan;25(1):108-117. doi: 10.1016/j.joca.2016.08.008. Epub 2016 Aug 25.

14.

Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation.

Uchibe K, Son J, Larmour C, Pacifici M, Enomoto-Iwamoto M, Iwamoto M.

J Orthop Res. 2017 May;35(5):1096-1105. doi: 10.1002/jor.23347. Epub 2016 Jul 22.

15.

Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints.

Candela ME, Wang C, Gunawardena AT, Zhang K, Cantley L, Yasuhara R, Usami Y, Francois N, Iwamoto M, van der Flier A, Zhang Y, Qin L, Han L, Enomoto-Iwamoto M.

PLoS One. 2016 Jun 9;11(6):e0156783. doi: 10.1371/journal.pone.0156783. eCollection 2016.

16.

Intervertebral disc development and disease-related genetic polymorphisms.

Ashley JW, Enomoto-Iwamoto M, Smith LJ, Mauck RL, Chan D, Lee J, Heyworth MF, An H, Zhang Y.

Genes Dis. 2016 Apr 23;3(3):171-177. doi: 10.1016/j.gendis.2016.04.006. eCollection 2016 Sep. Review.

17.

Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model.

Zhang K, Asai S, Hast MW, Liu M, Usami Y, Iwamoto M, Soslowsky LJ, Enomoto-Iwamoto M.

Matrix Biol. 2016 May-Jul;52-54:315-324. doi: 10.1016/j.matbio.2016.01.015. Epub 2016 Jan 26.

18.

Wnt signaling in cartilage development and diseases: lessons from animal studies.

Usami Y, Gunawardena AT, Iwamoto M, Enomoto-Iwamoto M.

Lab Invest. 2016 Feb;96(2):186-96. doi: 10.1038/labinvest.2015.142. Epub 2015 Dec 7. Review.

19.

Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.

Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg MW, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M.

Arthritis Rheumatol. 2015 Oct;67(10):2679-90. doi: 10.1002/art.39243.

20.

IL-1β irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro.

Zhang K, Asai S, Yu B, Enomoto-Iwamoto M.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):667-72. doi: 10.1016/j.bbrc.2015.05.122. Epub 2015 Jun 4.

21.

Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses.

Huegel J, Enomoto-Iwamoto M, Sgariglia F, Koyama E, Pacifici M.

Am J Pathol. 2015 Jun;185(6):1676-85. doi: 10.1016/j.ajpath.2015.02.014. Epub 2015 Apr 8.

22.

The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: insights into pathogenesis.

Sgariglia F, Pedrini E, Bradfield JP, Bhatti TR, D'Adamo P, Dormans JP, Gunawardena AT, Hakonarson H, Hecht JT, Sangiorgi L, Pacifici M, Enomoto-Iwamoto M, Grant SF.

Bone. 2015 Mar;72:123-7. doi: 10.1016/j.bone.2014.11.024. Epub 2014 Dec 9.

23.

Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin.

Decker RS, Koyama E, Enomoto-Iwamoto M, Maye P, Rowe D, Zhu S, Schultz PG, Pacifici M.

Dev Biol. 2014 Nov 15;395(2):255-67. doi: 10.1016/j.ydbio.2014.09.011. Epub 2014 Sep 18.

24.

Tendon progenitor cells in injured tendons have strong chondrogenic potential: the CD105-negative subpopulation induces chondrogenic degeneration.

Asai S, Otsuru S, Candela ME, Cantley L, Uchibe K, Hofmann TJ, Zhang K, Wapner KL, Soslowsky LJ, Horwitz EM, Enomoto-Iwamoto M.

Stem Cells. 2014 Dec;32(12):3266-77. doi: 10.1002/stem.1847.

25.

Resident mesenchymal progenitors of articular cartilage.

Candela ME, Yasuhara R, Iwamoto M, Enomoto-Iwamoto M.

Matrix Biol. 2014 Oct;39:44-9. doi: 10.1016/j.matbio.2014.08.015. Epub 2014 Aug 29. Review.

26.

Distribution of slow-cycling cells in epiphyseal cartilage and requirement of β-catenin signaling for their maintenance in growth plate.

Candela ME, Cantley L, Yasuaha R, Iwamoto M, Pacifici M, Enomoto-Iwamoto M.

J Orthop Res. 2014 May;32(5):661-8. doi: 10.1002/jor.22583. Epub 2014 Jan 10.

27.

Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model.

Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin LS, Beier F, Enomoto-Iwamoto M, Qin L.

Bone Res. 2014 Aug 5;2:14015. doi: 10.1038/boneres.2014.15. eCollection 2014.

28.

Toward regeneration of articular cartilage.

Iwamoto M, Ohta Y, Larmour C, Enomoto-Iwamoto M.

Birth Defects Res C Embryo Today. 2013 Sep;99(3):192-202. doi: 10.1002/bdrc.21042. Review.

29.

Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways.

Zhang X, Zhu J, Li Y, Lin T, Siclari VA, Chandra A, Candela EM, Koyama E, Enomoto-Iwamoto M, Qin L.

J Biol Chem. 2013 Nov 8;288(45):32229-40. doi: 10.1074/jbc.M113.463554. Epub 2013 Sep 18.

30.

Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice.

Sgariglia F, Candela ME, Huegel J, Jacenko O, Koyama E, Yamaguchi Y, Pacifici M, Enomoto-Iwamoto M.

Bone. 2013 Nov;57(1):220-31. doi: 10.1016/j.bone.2013.08.012. Epub 2013 Aug 17.

31.

Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses.

Huegel J, Sgariglia F, Enomoto-Iwamoto M, Koyama E, Dormans JP, Pacifici M.

Dev Dyn. 2013 Sep;242(9):1021-32. doi: 10.1002/dvdy.24010. Epub 2013 Jul 29. Review.

32.

Human umbilical cord blood-derived mesenchymal stem cells in the cultured rabbit intervertebral disc: a novel cell source for disc repair.

Anderson DG, Markova D, An HS, Chee A, Enomoto-Iwamoto M, Markov V, Saitta B, Shi P, Gupta C, Zhang Y.

Am J Phys Med Rehabil. 2013 May;92(5):420-9. doi: 10.1097/PHM.0b013e31825f148a.

33.

Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice.

Cantley L, Saunders C, Guttenberg M, Candela ME, Ohta Y, Yasuhara R, Kondo N, Sgariglia F, Asai S, Zhang X, Qin L, Hecht JT, Chen D, Yamamoto M, Toyosawa S, Dormans JP, Esko JD, Yamaguchi Y, Iwamoto M, Pacifici M, Enomoto-Iwamoto M.

Am J Pathol. 2013 Mar;182(3):917-27. doi: 10.1016/j.ajpath.2012.11.012. Epub 2012 Dec 25.

34.

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells.

Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

Lab Invest. 2011 Dec;91(12):1739-52. doi: 10.1038/labinvest.2011.144. Epub 2011 Oct 3.

35.

The critical role of the epidermal growth factor receptor in endochondral ossification.

Zhang X, Siclari VA, Lan S, Zhu J, Koyama E, Dupuis HL, Enomoto-Iwamoto M, Beier F, Qin L.

J Bone Miner Res. 2011 Nov;26(11):2622-33. doi: 10.1002/jbmr.502.

36.

Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-γ agonists.

Shimono K, Tung WE, Macolino C, Chi AH, Didizian JH, Mundy C, Chandraratna RA, Mishina Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M.

Nat Med. 2011 Apr;17(4):454-60. doi: 10.1038/nm.2334. Epub 2011 Apr 3. Erratum in: Nat Med. 2012 Oct;18(10):1592.

37.

Intervertebral disc development is regulated by Wnt/β-catenin signaling.

Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y, Iwamoto M, Enomoto-Iwamoto M.

Spine (Phila Pa 1976). 2011 Apr 15;36(8):E513-8. doi: 10.1097/BRS.0b013e3181f52cb5.

38.

Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine.

Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M.

Dev Biol. 2011 Mar 1;351(1):70-81. doi: 10.1016/j.ydbio.2010.12.022. Epub 2010 Dec 23.

39.

Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover.

Williams JA, Kane M, Okabe T, Enomoto-Iwamoto M, Napoli JL, Pacifici M, Iwamoto M.

J Biol Chem. 2010 Nov 19;285(47):36674-81. doi: 10.1074/jbc.M110.151878. Epub 2010 Sep 14.

40.

Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover.

Yasuhara R, Yuasa T, Williams JA, Byers SW, Shah S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

J Biol Chem. 2010 Jan 1;285(1):317-27. doi: 10.1074/jbc.M109.053926. Epub 2009 Oct 26.

41.

Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice.

Yuasa T, Kondo N, Yasuhara R, Shimono K, Mackem S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M.

Am J Pathol. 2009 Nov;175(5):1993-2003. doi: 10.2353/ajpath.2009.081173. Epub 2009 Oct 8.

42.

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M.

Dev Biol. 2009 Apr 15;328(2):315-27. doi: 10.1016/j.ydbio.2009.01.031. Epub 2009 Feb 3.

43.

Wnt/beta-catenin signaling regulates cranial base development and growth.

Nagayama M, Iwamoto M, Hargett A, Kamiya N, Tamamura Y, Young B, Morrison T, Takeuchi H, Pacifici M, Enomoto-Iwamoto M, Koyama E.

J Dent Res. 2008 Mar;87(3):244-9.

PMID:
18296608
44.

A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis.

Koyama E, Shibukawa Y, Nagayama M, Sugito H, Young B, Yuasa T, Okabe T, Ochiai T, Kamiya N, Rountree RB, Kingsley DM, Iwamoto M, Enomoto-Iwamoto M, Pacifici M.

Dev Biol. 2008 Apr 1;316(1):62-73. doi: 10.1016/j.ydbio.2008.01.012. Epub 2008 Jan 26.

45.

Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes.

Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M.

Exp Cell Res. 2008 Apr 1;314(6):1301-12. doi: 10.1016/j.yexcr.2007.12.029. Epub 2008 Jan 18.

46.

Wnt/beta-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration.

Yuasa T, Otani T, Koike T, Iwamoto M, Enomoto-Iwamoto M.

Lab Invest. 2008 Mar;88(3):264-74. doi: 10.1038/labinvest.3700747. Epub 2008 Jan 28.

47.

Synovial joint formation during mouse limb skeletogenesis: roles of Indian hedgehog signaling.

Koyama E, Ochiai T, Rountree RB, Kingsley DM, Enomoto-Iwamoto M, Iwamoto M, Pacifici M.

Ann N Y Acad Sci. 2007 Nov;1116:100-12.

48.

Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.

Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H.

Mol Endocrinol. 2007 Nov;21(11):2805-20. Epub 2007 Aug 7.

PMID:
17684115
49.

Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.

Koyama E, Young B, Nagayama M, Shibukawa Y, Enomoto-Iwamoto M, Iwamoto M, Maeda Y, Lanske B, Song B, Serra R, Pacifici M.

Development. 2007 Jun;134(11):2159-69.

50.

Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis.

Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams JA, Nakamura T, Enomoto-Iwamoto M, Pacifici M.

Dev Biol. 2007 May 1;305(1):40-51. Epub 2007 Feb 7.

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