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Items: 1 to 50 of 208

1.

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection.

Stalin Raj V, Okba NMA, Gutierrez-Alvarez J, Drabek D, van Dieren B, Widagdo W, Lamers MM, Widjaja I, Fernandez-Delgado R, Sola I, Bensaid A, Koopmans MP, Segalés J, Osterhaus ADME, Bosch BJ, Enjuanes L, Haagmans BL.

Sci Adv. 2018 Aug 8;4(8):eaas9667. doi: 10.1126/sciadv.aas9667. eCollection 2018 Aug.

PMID:
30101189
2.

Role of Severe Acute Respiratory Syndrome Coronavirus Viroporins E, 3a, and 8a in Replication and Pathogenesis.

Castaño-Rodriguez C, Honrubia JM, Gutiérrez-Álvarez J, DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Verdia-Báguena C, Queralt-Martín M, Kochan G, Perlman S, Aguilella VM, Sola I, Enjuanes L.

MBio. 2018 May 22;9(3). pii: e02325-17. doi: 10.1128/mBio.02325-17.

3.

MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection.

Canton J, Fehr AR, Fernandez-Delgado R, Gutierrez-Alvarez FJ, Sanchez-Aparicio MT, García-Sastre A, Perlman S, Enjuanes L, Sola I.

PLoS Pathog. 2018 Jan 25;14(1):e1006838. doi: 10.1371/journal.ppat.1006838. eCollection 2018 Jan.

4.

Erratum to: Role of transcription regulatory sequence in regulation of gene expression and replication of porcine reproductive and respiratory syndrome virus.

Wang C, Meng H, Gao Y, Gao H, Guo K, Almazan F, Sola I, Enjuanes L, Zhang Y, Abrahamyan L.

Vet Res. 2017 Sep 20;48(1):54. doi: 10.1186/s13567-017-0464-z.

5.

Role of transcription regulatory sequence in regulation of gene expression and replication of porcine reproductive and respiratory syndrome virus.

Wang C, Meng H, Gao Y, Gao H, Guo K, Almazan F, Sola I, Enjuanes L, Zhang Y, Abrahamyan L.

Vet Res. 2017 Aug 10;48(1):41. doi: 10.1186/s13567-017-0445-2. Erratum in: Vet Res. 2017 Sep 20;48(1):54.

6.

Generation of a DNA-Launched Reporter Replicon Based on Dengue Virus Type 2 as a Multipurpose Platform.

Usme-Ciro JA, Lopera JA, Alvarez DA, Enjuanes L, Almazán F.

Intervirology. 2016;59(5-6):275-282. doi: 10.1159/000476066. Epub 2017 Jun 23.

7.

Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.

Santiago C, Mudgal G, Reguera J, Recacha R, Albrecht S, Enjuanes L, Casasnovas JM.

Sci Rep. 2017 Apr 10;7:46045. doi: 10.1038/srep46045.

8.

SARS-CoV-Encoded Small RNAs Contribute to Infection-Associated Lung Pathology.

Morales L, Oliveros JC, Fernandez-Delgado R, tenOever BR, Enjuanes L, Sola I.

Cell Host Microbe. 2017 Mar 8;21(3):344-355. doi: 10.1016/j.chom.2017.01.015. Epub 2017 Feb 16.

9.

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.

Rabouw HH, Langereis MA, Knaap RC, Dalebout TJ, Canton J, Sola I, Enjuanes L, Bredenbeek PJ, Kikkert M, de Groot RJ, van Kuppeveld FJ.

PLoS Pathog. 2016 Oct 26;12(10):e1005982. doi: 10.1371/journal.ppat.1005982. eCollection 2016 Oct.

10.

Molecular Basis of Coronavirus Virulence and Vaccine Development.

Enjuanes L, Zuñiga S, Castaño-Rodriguez C, Gutierrez-Alvarez J, Canton J, Sola I.

Adv Virus Res. 2016;96:245-286. doi: 10.1016/bs.aivir.2016.08.003. Epub 2016 Aug 30. Review.

PMID:
27712626
11.

Virulence factors in porcine coronaviruses and vaccine design.

Zuñiga S, Pascual-Iglesias A, Sanchez CM, Sola I, Enjuanes L.

Virus Res. 2016 Dec 2;226:142-151. doi: 10.1016/j.virusres.2016.07.003. Epub 2016 Jul 7. Review.

12.

Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.

Becares M, Pascual-Iglesias A, Nogales A, Sola I, Enjuanes L, Zuñiga S.

J Virol. 2016 May 12;90(11):5399-5414. doi: 10.1128/JVI.03259-15. Print 2016 Jun 1.

13.

Continuous and Discontinuous RNA Synthesis in Coronaviruses.

Sola I, Almazán F, Zúñiga S, Enjuanes L.

Annu Rev Virol. 2015 Nov;2(1):265-88. doi: 10.1146/annurev-virology-100114-055218. Review.

14.

Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine.

Jimenez-Guardeño JM, Regla-Nava JA, Nieto-Torres JL, DeDiego ML, Castaño-Rodriguez C, Fernandez-Delgado R, Perlman S, Enjuanes L.

PLoS Pathog. 2015 Oct 29;11(10):e1005215. doi: 10.1371/journal.ppat.1005215. eCollection 2015 Oct.

15.

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome.

Nieto-Torres JL, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Torres J, Aguilella VM, Enjuanes L.

Virology. 2015 Nov;485:330-9. doi: 10.1016/j.virol.2015.08.010. Epub 2015 Aug 29.

16.

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis.

Nieto-Torres JL, Verdiá-Báguena C, Castaño-Rodriguez C, Aguilella VM, Enjuanes L.

Viruses. 2015 Jul 3;7(7):3552-73. doi: 10.3390/v7072786. Review.

17.

A G-quadruplex-binding macrodomain within the "SARS-unique domain" is essential for the activity of the SARS-coronavirus replication-transcription complex.

Kusov Y, Tan J, Alvarez E, Enjuanes L, Hilgenfeld R.

Virology. 2015 Oct;484:313-22. doi: 10.1016/j.virol.2015.06.016. Epub 2015 Jul 3.

18.

Virus Research. Foreword. Nidoviruses II.

Frieman M, Sola I, Enjuanes L.

Virus Res. 2015 Apr 16;202:1-2. doi: 10.1016/j.virusres.2015.05.013. No abstract available.

PMID:
26025418
19.
20.

Engineering infectious cDNAs of coronavirus as bacterial artificial chromosomes.

Almazán F, Márquez-Jurado S, Nogales A, Enjuanes L.

Methods Mol Biol. 2015;1282:135-52. doi: 10.1007/978-1-4939-2438-7_13.

21.

Porcine aminopeptidase N mediated polarized infection by porcine epidemic diarrhea virus in target cells.

Cong Y, Li X, Bai Y, Lv X, Herrler G, Enjuanes L, Zhou X, Qu B, Meng F, Cong C, Ren X, Li G.

Virology. 2015 Apr;478:1-8. doi: 10.1016/j.virol.2015.01.020. Epub 2015 Feb 11.

22.

Severe acute respiratory syndrome coronaviruses with mutations in the E protein are attenuated and promising vaccine candidates.

Regla-Nava JA, Nieto-Torres JL, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodríguez C, Perlman S, Enjuanes L, DeDiego ML.

J Virol. 2015 Apr;89(7):3870-87. doi: 10.1128/JVI.03566-14. Epub 2015 Jan 21.

23.

Virus Research. Nidoviruses I. Foreword.

Enjuanes L, Sola I, Frieman MB.

Virus Res. 2014 Dec 19;194:1-2. doi: 10.1016/j.virusres.2014.11.017. No abstract available.

PMID:
25483881
24.

Reprint of: Coronavirus reverse genetic systems: infectious clones and replicons.

Almazán F, Sola I, Zuñiga S, Marquez-Jurado S, Morales L, Becares M, Enjuanes L.

Virus Res. 2014 Dec 19;194:67-75. doi: 10.1016/j.virusres.2014.09.006. Epub 2014 Sep 26.

PMID:
25261606
25.

The PDZ-binding motif of severe acute respiratory syndrome coronavirus envelope protein is a determinant of viral pathogenesis.

Jimenez-Guardeño JM, Nieto-Torres JL, DeDiego ML, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Enjuanes L.

PLoS Pathog. 2014 Aug 14;10(8):e1004320. doi: 10.1371/journal.ppat.1004320. eCollection 2014 Aug.

26.

Antigenic structures stably expressed by recombinant TGEV-derived vectors.

Becares M, Sanchez CM, Sola I, Enjuanes L, Zuñiga S.

Virology. 2014 Sep;464-465:274-286. doi: 10.1016/j.virol.2014.07.027. Epub 2014 Aug 9.

27.

Coronavirus virulence genes with main focus on SARS-CoV envelope gene.

DeDiego ML, Nieto-Torres JL, Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C, Fernandez-Delgado R, Usera F, Enjuanes L.

Virus Res. 2014 Dec 19;194:124-37. doi: 10.1016/j.virusres.2014.07.024. Epub 2014 Aug 2. Review.

28.

Coronavirus reverse genetic systems: infectious clones and replicons.

Almazán F, Sola I, Zuñiga S, Marquez-Jurado S, Morales L, Becares M, Enjuanes L.

Virus Res. 2014 Aug 30;189:262-70. doi: 10.1016/j.virusres.2014.05.026. Epub 2014 Jun 12. Review.

29.

Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.

Nieto-Torres JL, DeDiego ML, Verdiá-Báguena C, Jimenez-Guardeño JM, Regla-Nava JA, Fernandez-Delgado R, Castaño-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L.

PLoS Pathog. 2014 May 1;10(5):e1004077. doi: 10.1371/journal.ppat.1004077. eCollection 2014 May.

30.

Rapid generation of a mouse model for Middle East respiratory syndrome.

Zhao J, Li K, Wohlford-Lenane C, Agnihothram SS, Fett C, Zhao J, Gale MJ Jr, Baric RS, Enjuanes L, Gallagher T, McCray PB Jr, Perlman S.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4970-5. doi: 10.1073/pnas.1323279111. Epub 2014 Mar 5.

31.

Development of a novel DNA-launched dengue virus type 2 infectious clone assembled in a bacterial artificial chromosome.

Usme-Ciro JA, Lopera JA, Enjuanes L, Almazán F, Gallego-Gomez JC.

Virus Res. 2014 Feb 13;180:12-22. doi: 10.1016/j.virusres.2013.12.001. Epub 2013 Dec 14.

PMID:
24342140
32.

Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival.

DeDiego ML, Nieto-Torres JL, Regla-Nava JA, Jimenez-Guardeño JM, Fernandez-Delgado R, Fett C, Castaño-Rodriguez C, Perlman S, Enjuanes L.

J Virol. 2014 Jan;88(2):913-24. doi: 10.1128/JVI.02576-13. Epub 2013 Nov 6.

33.

A novel porcine reproductive and respiratory syndrome virus vector system that stably expresses enhanced green fluorescent protein as a separate transcription unit.

Wang C, Huang B, Kong N, Li Q, Ma Y, Li Z, Gao J, Zhang C, Wang X, Liang C, Dang L, Xiao S, Mu Y, Zhao Q, Sun Y, Almazan F, Enjuanes L, Zhou EM.

Vet Res. 2013 Oct 31;44:104. doi: 10.1186/1297-9716-44-104.

34.

Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate.

Almazán F, DeDiego ML, Sola I, Zuñiga S, Nieto-Torres JL, Marquez-Jurado S, Andrés G, Enjuanes L.

MBio. 2013 Sep 10;4(5):e00650-13. doi: 10.1128/mBio.00650-13.

35.

Transmissible gastroenteritis coronavirus genome packaging signal is located at the 5' end of the genome and promotes viral RNA incorporation into virions in a replication-independent process.

Morales L, Mateos-Gomez PA, Capiscol C, del Palacio L, Enjuanes L, Sola I.

J Virol. 2013 Nov;87(21):11579-90. doi: 10.1128/JVI.01836-13. Epub 2013 Aug 21.

36.

The replication of a mouse adapted SARS-CoV in a mouse cell line stably expressing the murine SARS-CoV receptor mACE2 efficiently induces the expression of proinflammatory cytokines.

Regla-Nava JA, Jimenez-Guardeño JM, Nieto-Torres JL, Gallagher TM, Enjuanes L, DeDiego ML.

J Virol Methods. 2013 Nov;193(2):639-46. doi: 10.1016/j.jviromet.2013.07.039. Epub 2013 Aug 1.

37.

Alphacoronavirus protein 7 modulates host innate immune response.

Cruz JL, Becares M, Sola I, Oliveros JC, Enjuanes L, Zúñiga S.

J Virol. 2013 Sep;87(17):9754-67. doi: 10.1128/JVI.01032-13. Epub 2013 Jul 3.

38.

Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge.

Verdiá-Báguena C, Nieto-Torres JL, Alcaraz A, Dediego ML, Enjuanes L, Aguilella VM.

Biochim Biophys Acta. 2013 Sep;1828(9):2026-31. doi: 10.1016/j.bbamem.2013.05.008. Epub 2013 May 18.

39.

Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group.

de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J.

J Virol. 2013 Jul;87(14):7790-2. doi: 10.1128/JVI.01244-13. Epub 2013 May 15. No abstract available.

40.

Complete protection against severe acute respiratory syndrome coronavirus-mediated lethal respiratory disease in aged mice by immunization with a mouse-adapted virus lacking E protein.

Fett C, DeDiego ML, Regla-Nava JA, Enjuanes L, Perlman S.

J Virol. 2013 Jun;87(12):6551-9. doi: 10.1128/JVI.00087-13. Epub 2013 Apr 10.

41.

The use of transient expression systems for the rapid production of virus-like particles in plants.

Thuenemann EC, Lenzi P, Love AJ, Taliansky M, Bécares M, Zuñiga S, Enjuanes L, Zahmanova GG, Minkov IN, Matić S, Noris E, Meyers A, Hattingh A, Rybicki EP, Kiselev OI, Ravin NV, Eldarov MA, Skryabin KG, Lomonossoff GP.

Curr Pharm Des. 2013;19(31):5564-73. Review.

PMID:
23394559
42.

Long-distance RNA-RNA interactions in the coronavirus genome form high-order structures promoting discontinuous RNA synthesis during transcription.

Mateos-Gomez PA, Morales L, Zuñiga S, Enjuanes L, Sola I.

J Virol. 2013 Jan;87(1):177-86. doi: 10.1128/JVI.01782-12. Epub 2012 Oct 10.

43.

Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread.

Mahlakõiv T, Ritz D, Mordstein M, DeDiego ML, Enjuanes L, Müller MA, Drosten C, Staeheli P.

J Gen Virol. 2012 Dec;93(Pt 12):2601-5. doi: 10.1099/vir.0.046284-0. Epub 2012 Sep 5.

PMID:
22956738
44.

Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.

Reguera J, Santiago C, Mudgal G, Ordoño D, Enjuanes L, Casasnovas JM.

PLoS Pathog. 2012;8(8):e1002859. doi: 10.1371/journal.ppat.1002859. Epub 2012 Aug 2.

45.

Severe acute respiratory syndrome coronavirus nsp1 facilitates efficient propagation in cells through a specific translational shutoff of host mRNA.

Tanaka T, Kamitani W, DeDiego ML, Enjuanes L, Matsuura Y.

J Virol. 2012 Oct;86(20):11128-37. Epub 2012 Aug 1.

46.

Coronavirus E protein forms ion channels with functionally and structurally-involved membrane lipids.

Verdiá-Báguena C, Nieto-Torres JL, Alcaraz A, DeDiego ML, Torres J, Aguilella VM, Enjuanes L.

Virology. 2012 Oct 25;432(2):485-94. doi: 10.1016/j.virol.2012.07.005. Epub 2012 Jul 24.

47.

Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase.

Adedeji AO, Singh K, Calcaterra NE, DeDiego ML, Enjuanes L, Weiss S, Sarafianos SG.

Antimicrob Agents Chemother. 2012 Sep;56(9):4718-28. doi: 10.1128/AAC.00957-12. Epub 2012 Jun 25.

48.

Molecular characterization of feline infectious peritonitis virus strain DF-2 and studies of the role of ORF3abc in viral cell tropism.

Bálint Á, Farsang A, Zádori Z, Hornyák Á, Dencso L, Almazán F, Enjuanes L, Belák S.

J Virol. 2012 Jun;86(11):6258-67. doi: 10.1128/JVI.00189-12. Epub 2012 Mar 21.

49.

Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles.

Nogales A, Márquez-Jurado S, Galán C, Enjuanes L, Almazán F.

J Virol. 2012 Jan;86(2):1261-6. doi: 10.1128/JVI.06428-11. Epub 2011 Nov 16.

50.

Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.

DeDiego ML, Nieto-Torres JL, Jiménez-Guardeño JM, Regla-Nava JA, Alvarez E, Oliveros JC, Zhao J, Fett C, Perlman S, Enjuanes L.

PLoS Pathog. 2011 Oct;7(10):e1002315. doi: 10.1371/journal.ppat.1002315. Epub 2011 Oct 20.

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