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Items: 1 to 50 of 111

1.

Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria.

Loughland JR, Woodberry T, Boyle MJ, Tipping PE, Piera KA, Amante FH, Kenangalem E, Price RN, Engwerda CR, Anstey NM, McCarthy JS, Minigo G.

J Infect Dis. 2018 Sep 15. doi: 10.1093/infdis/jiy555. [Epub ahead of print]

PMID:
30239833
2.

Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice.

Eichenberger RM, Ryan S, Jones L, Buitrago G, Polster R, Montes de Oca M, Zuvelek J, Giacomin PR, Dent LA, Engwerda CR, Field MA, Sotillo J, Loukas A.

Front Immunol. 2018 Apr 30;9:850. doi: 10.3389/fimmu.2018.00850. eCollection 2018.

3.

Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection.

Edwards CL, Ng SS, Corvino D, Montes de Oca M, de Labastida Rivera F, Nones K, Lakis V, Waddell N, Amante FH, McCarthy JS, Engwerda CR.

J Infect Dis. 2018 Aug 24;218(7):1119-1129. doi: 10.1093/infdis/jiy281.

PMID:
29757416
4.

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection.

Ng SS, Souza-Fonseca-Guimaraes F, Rivera FL, Amante FH, Kumar R, Gao Y, Sheel M, Beattie L, Montes de Oca M, Guillerey C, Edwards CL, Faleiro RJ, Frame T, Bunn PT, Vivier E, Godfrey DI, Pellicci DG, Lopez JA, Andrews KT, Huntington ND, Smyth MJ, McCarthy J, Engwerda CR.

Clin Transl Immunology. 2018 Jan 12;7(1):e1003. doi: 10.1002/cti2.1003. eCollection 2018.

5.

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.

James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A.

J Immunol. 2018 Feb 15;200(4):1443-1456. doi: 10.4049/jimmunol.1700782. Epub 2018 Jan 10.

PMID:
29321276
6.

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis.

Kumar R, Chauhan SB, Ng SS, Sundar S, Engwerda CR.

Front Immunol. 2017 Nov 8;8:1492. doi: 10.3389/fimmu.2017.01492. eCollection 2017. Review.

7.

Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis.

Bunn PT, Montes de Oca M, Rivera FL, Kumar R, Edwards CL, Faleiro RJ, Ng SS, Sheel M, Wang Y, Amante FH, Haque A, Engwerda CR.

Front Immunol. 2017 Oct 12;8:1307. doi: 10.3389/fimmu.2017.01307. eCollection 2017.

8.

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, Rautela J, Straube J, Waddell N, Blake SJ, Yan J, Bartholin L, Lee JS, Vivier E, Takeda K, Messaoudene M, Zitvogel L, Teng MWL, Belz GT, Engwerda CR, Huntington ND, Nakamura K, Hölzel M, Smyth MJ.

Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31.

PMID:
28759001
9.

IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection.

Sebina I, Fogg LG, James KR, Soon MSF, Akter J, Thomas BS, Hill GR, Engwerda CR, Haque A.

Parasite Immunol. 2017 Oct;39(10). doi: 10.1111/pim.12455. Epub 2017 Aug 17.

PMID:
28748530
10.

Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.

11.

Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation.

Loughland JR, Minigo G, Sarovich DS, Field M, Tipping PE, Montes de Oca M, Piera KA, Amante FH, Barber BE, Grigg MJ, William T, Good MF, Doolan DL, Engwerda CR, Anstey NM, McCarthy JS, Woodberry T.

Sci Rep. 2017 Jun 1;7(1):2596. doi: 10.1038/s41598-017-02096-2.

12.

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MS, Fogg LG, Nair AS, Liligeto U, Stubbington MJ, Ly LH, Bagger FO, Zwiessele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA.

Sci Immunol. 2017 Mar 3;2(9). pii: eaal2192. doi: 10.1126/sciimmunol.aal2192. Erratum in: Sci Immunol. 2018 Mar 9;3(21):.

13.

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation.

Woodberry T, Loughland JR, Minigo G, Burel JG, Amante FH, Piera KA, McNeil Y, Yeo TW, Good MF, Doolan DL, Engwerda CR, McCarthy JS, Anstey NM.

Infect Immun. 2017 May 23;85(6). pii: e00986-16. doi: 10.1128/IAI.00986-16. Print 2017 Jun.

14.

The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria.

Montes de Oca M, Good MF, McCarthy JS, Engwerda CR.

J Immunol. 2016 Dec 15;197(12):4518-4526. Review.

15.

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection.

Sebina I, James KR, Soon MS, Fogg LG, Best SE, Labastida Rivera F, Montes de Oca M, Amante FH, Thomas BS, Beattie L, Souza-Fonseca-Guimaraes F, Smyth MJ, Hertzog PJ, Hill GR, Hutloff A, Engwerda CR, Haque A.

PLoS Pathog. 2016 Nov 3;12(11):e1005999. doi: 10.1371/journal.ppat.1005999. eCollection 2016 Nov.

16.

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A.

Sci Transl Med. 2016 Oct 26;8(362):362ra143.

PMID:
27797959
17.

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR.

Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015.

18.

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

Le Texier L, Lineburg KE, Cao B, McDonald-Hyman C, Leveque-El Mouttie L, Nicholls J, Melino M, Nalkurthi BC, Alexander KA, Teal B, Blake SJ, Souza-Fonseca-Guimaraes F, Engwerda CR, Kuns RD, Lane SW, Teng M, Teh C, Gray D, Clouston AD, Nilsson SK, Blazar BR, Hill GR, MacDonald KP.

JCI Insight. 2016 Sep 22;1(15):e86850.

19.

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection.

Kho S, Marfurt J, Handayuni I, Pava Z, Noviyanti R, Kusuma A, Piera KA, Burdam FH, Kenangalem E, Lampah DA, Engwerda CR, Poespoprodjo JR, Price RN, Anstey NM, Minigo G, Woodberry T.

Malar J. 2016 Jun 21;15:328. doi: 10.1186/s12936-016-1382-7.

20.

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions.

Beattie L, Sawtell A, Mann J, Frame TCM, Teal B, de Labastida Rivera F, Brown N, Walwyn-Brown K, Moore JWJ, MacDonald S, Lim EK, Dalton JE, Engwerda CR, MacDonald KP, Kaye PM.

J Hepatol. 2016 Oct;65(4):758-768. doi: 10.1016/j.jhep.2016.05.037. Epub 2016 Jun 1.

21.

Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.

Loughland JR, Minigo G, Burel J, Tipping PE, Piera KA, Amante FH, Engwerda CR, Good MF, Doolan DL, Anstey NM, McCarthy JS, Woodberry T.

Infect Immun. 2016 Apr 22;84(5):1403-1412. doi: 10.1128/IAI.01522-15. Print 2016 May.

22.

Combined Immune Therapy for the Treatment of Visceral Leishmaniasis.

Faleiro RJ, Kumar R, Bunn PT, Singh N, Chauhan SB, Sheel M, Amante FH, Montes de Oca M, Edwards CL, Ng SS, Best SE, Haque A, Beattie L, Hafner LM, Sacks D, Nylen S, Sundar S, Engwerda CR.

PLoS Negl Trop Dis. 2016 Feb 12;10(2):e0004415. doi: 10.1371/journal.pntd.0004415. eCollection 2016 Feb.

23.

Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR.

PLoS Pathog. 2016 Feb 12;12(2):e1005460. doi: 10.1371/journal.ppat.1005460. eCollection 2016 Feb. No abstract available.

24.

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR.

PLoS Pathog. 2016 Jan 14;12(1):e1005398. doi: 10.1371/journal.ppat.1005398. eCollection 2016 Jan. Erratum in: PLoS Pathog. 2016 Feb;12(2):e1005460.

25.

IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR.

J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4.

26.

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.

27.

Development of Leishmania vaccines in the era of visceral leishmaniasis elimination.

Engwerda CR, Matlashewski G.

Trans R Soc Trop Med Hyg. 2015 Jul;109(7):423-4. doi: 10.1093/trstmh/trv039. Epub 2015 Jun 4.

PMID:
26048873
28.

Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.

Kho S, Marfurt J, Noviyanti R, Kusuma A, Piera KA, Burdam FH, Kenangalem E, Lampah DA, Engwerda CR, Poespoprodjo JR, Price RN, Anstey NM, Minigo G, Woodberry T.

Infect Immun. 2015 Aug;83(8):3224-32. doi: 10.1128/IAI.00226-15. Epub 2015 Jun 1.

29.

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity.

Matar CG, Anthony NR, O'Flaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ.

PLoS Pathog. 2015 May 21;11(5):e1004858. doi: 10.1371/journal.ppat.1004858. eCollection 2015 May.

30.

Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung.

Edwards CL, Zhang V, Werder RB, Best SE, Sebina I, James KR, Faleiro RJ, de Labastida Rivera F, Amante FH, Engwerda CR, Phipps S, Haque A.

Clin Vaccine Immunol. 2015 May;22(5):477-83. doi: 10.1128/CVI.00051-15. Epub 2015 Feb 25.

31.

The Regulation of CD4(+) T Cell Responses during Protozoan Infections.

Engwerda CR, Ng SS, Bunn PT.

Front Immunol. 2014 Oct 13;5:498. doi: 10.3389/fimmu.2014.00498. eCollection 2014. Review.

32.

Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection.

Edwards CL, Best SE, Gun SY, Claser C, James KR, de Oca MM, Sebina I, Rivera Fde L, Amante FH, Hertzog PJ, Engwerda CR, Renia L, Haque A.

Eur J Immunol. 2015 Jan;45(1):130-41. doi: 10.1002/eji.201444824. Epub 2014 Nov 13.

33.

Immune regulation during chronic visceral leishmaniasis.

Faleiro RJ, Kumar R, Hafner LM, Engwerda CR.

PLoS Negl Trop Dis. 2014 Jul 10;8(7):e2914. doi: 10.1371/journal.pntd.0002914. eCollection 2014 Jul. Review.

34.

CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.

Lau LS, Fernandez-Ruiz D, Mollard V, Sturm A, Neller MA, Cozijnsen A, Gregory JL, Davey GM, Jones CM, Lin YH, Haque A, Engwerda CR, Nie CQ, Hansen DS, Murphy KM, Papenfuss AT, Miles JJ, Burrows SR, de Koning-Ward T, McFadden GI, Carbone FR, Crabb BS, Heath WR.

PLoS Pathog. 2014 May 22;10(5):e1004135. doi: 10.1371/journal.ppat.1004135. eCollection 2014 May.

35.

Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.

Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Rénia L, Ruedl C, MacDonald KP, Hill GR, Engwerda CR.

J Clin Invest. 2014 Jun;124(6):2483-96. doi: 10.1172/JCI70698. Epub 2014 May 1.

36.

Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection.

Bunn PT, Stanley AC, de Labastida Rivera F, Mulherin A, Sheel M, Alexander CE, Faleiro RJ, Amante FH, Montes De Oca M, Best SE, James KR, Kaye PM, Haque A, Engwerda CR.

J Immunol. 2014 Apr 15;192(8):3709-18. doi: 10.4049/jimmunol.1300768. Epub 2014 Mar 14.

37.

Effect of mature blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.

Khoury DS, Cromer D, Best SE, James KR, Kim PS, Engwerda CR, Haque A, Davenport MP.

Infect Immun. 2014 Jan;82(1):212-20. doi: 10.1128/IAI.00705-13. Epub 2013 Oct 21.

38.

Mast cells fuel the fire of malaria immunopathology.

Engwerda CR, Kumar R.

Nat Med. 2013 Jun;19(6):672-4. doi: 10.1038/nm.3227. No abstract available.

PMID:
23744145
39.

Immunology. Platelets kill the parasite within.

Engwerda CR, Good MF.

Science. 2012 Dec 7;338(6112):1304-5. doi: 10.1126/science.1232439. No abstract available.

PMID:
23224547
40.

Experimentally induced blood stage malaria infection as a tool for clinical research.

Engwerda CR, Minigo G, Amante FH, McCarthy JS.

Trends Parasitol. 2012 Nov;28(11):515-21. doi: 10.1016/j.pt.2012.09.001. Epub 2012 Oct 4. Review.

PMID:
23041118
41.

The diverse roles of monocytes in inflammation caused by protozoan parasitic diseases.

Sheel M, Engwerda CR.

Trends Parasitol. 2012 Oct;28(10):408-16. doi: 10.1016/j.pt.2012.07.008. Epub 2012 Aug 30. Review. Erratum in: Trends Parasitol. 2013 Jun;29(6)263.

PMID:
22951424
42.

Low-level Plasmodium falciparum blood-stage infection causes dendritic cell apoptosis and dysfunction in healthy volunteers.

Woodberry T, Minigo G, Piera KA, Amante FH, Pinzon-Charry A, Good MF, Lopez JA, Engwerda CR, McCarthy JS, Anstey NM.

J Infect Dis. 2012 Aug 1;206(3):333-40. doi: 10.1093/infdis/jis366. Epub 2012 May 21.

PMID:
22615323
43.

Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5898-908. doi: 10.1182/blood-2011-12-396119. Epub 2012 Apr 26.

44.

Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.

Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don AL, Varelias A, Robb RJ, Cheong M, Engwerda CR, Steptoe RJ, Ramshaw HS, Lopez AF, Vega-Ramos J, Lew AM, Villadangos JA, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5918-30. doi: 10.1182/blood-2011-12-398164. Epub 2012 Mar 13.

45.

Characterising the mucosal and systemic immune responses to experimental human hookworm infection.

Gaze S, McSorley HJ, Daveson J, Jones D, Bethony JM, Oliveira LM, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A.

PLoS Pathog. 2012 Feb;8(2):e1002520. doi: 10.1371/journal.ppat.1002520. Epub 2012 Feb 9.

46.

Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.

Koyama M, Kuns RD, Olver SD, Raffelt NC, Wilson YA, Don AL, Lineburg KE, Cheong M, Robb RJ, Markey KA, Varelias A, Malissen B, Hämmerling GJ, Clouston AD, Engwerda CR, Bhat P, MacDonald KP, Hill GR.

Nat Med. 2011 Nov 29;18(1):135-42. doi: 10.1038/nm.2597.

PMID:
22127134
47.

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

Stanley AC, de Labastida Rivera F, Haque A, Sheel M, Zhou Y, Amante FH, Bunn PT, Randall LM, Pfeffer K, Scheu S, Hickey MJ, Saunders BM, Ware C, Hill GR, Tamada K, Kaye PM, Engwerda CR.

PLoS Pathog. 2011 Oct;7(10):e1002279. doi: 10.1371/journal.ppat.1002279. Epub 2011 Oct 6.

48.

Suppression of inflammatory immune responses in celiac disease by experimental hookworm infection.

McSorley HJ, Gaze S, Daveson J, Jones D, Anderson RP, Clouston A, Ruyssers NE, Speare R, McCarthy JS, Engwerda CR, Croese J, Loukas A.

PLoS One. 2011;6(9):e24092. doi: 10.1371/journal.pone.0024092. Epub 2011 Sep 16.

49.

Type I interferons suppress CD4⁺ T-cell-dependent parasite control during blood-stage Plasmodium infection.

Haque A, Best SE, Ammerdorffer A, Desbarrieres L, de Oca MM, Amante FH, de Labastida Rivera F, Hertzog P, Boyle GM, Hill GR, Engwerda CR.

Eur J Immunol. 2011 Sep;41(9):2688-98. doi: 10.1002/eji.201141539. Epub 2011 Aug 8.

50.

An antioxidant link between sickle cell disease and severe malaria.

Haque A, Engwerda CR.

Cell. 2011 Apr 29;145(3):335-6. doi: 10.1016/j.cell.2011.04.004.

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