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Items: 1 to 50 of 146

1.

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A.

Nat Commun. 2020 Jan 14;11(1):252. doi: 10.1038/s41467-019-14112-2.

2.

The regulation of CD4+ T cells during malaria.

Kumar R, Loughland JR, Ng SS, Boyle MJ, Engwerda CR.

Immunol Rev. 2020 Jan;293(1):70-87. doi: 10.1111/imr.12804. Epub 2019 Nov 1. Review.

PMID:
31674682
3.

IgM in human immunity to Plasmodium falciparum malaria.

Boyle MJ, Chan JA, Handayuni I, Reiling L, Feng G, Hilton A, Kurtovic L, Oyong D, Piera KA, Barber BE, William T, Eisen DP, Minigo G, Langer C, Drew DR, de Labastida Rivera F, Amante FH, Williams TN, Kinyanjui S, Marsh K, Doolan DL, Engwerda C, Fowkes FJI, Grigg MJ, Mueller I, McCarthy JS, Anstey NM, Beeson JG.

Sci Adv. 2019 Sep 25;5(9):eaax4489. doi: 10.1126/sciadv.aax4489. eCollection 2019 Sep.

4.

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection.

Oyong DA, Loughland JR, SheelaNair A, Andrew D, Rivera FDL, Piera KA, William T, Grigg MJ, Barber BE, Haque A, Engwerda CR, McCarthy JS, Anstey NM, Boyle MJ.

Malar J. 2019 Sep 18;18(1):312. doi: 10.1186/s12936-019-2962-0.

5.

A molecular signature for CD8+ T cells from visceral leishmaniasis patients.

Singh B, Bhushan Chauhan S, Kumar R, Singh SS, Ng S, Amante F, de Labastida Rivera F, Singh OP, Rai M, Nylen S, Sundar S, Engwerda C.

Parasite Immunol. 2019 Nov;41(11):e12669. doi: 10.1111/pim.12669. Epub 2019 Sep 30.

PMID:
31494954
6.

The Role of IL-10 in Malaria: A Double Edged Sword.

Kumar R, Ng S, Engwerda C.

Front Immunol. 2019 Feb 12;10:229. doi: 10.3389/fimmu.2019.00229. eCollection 2019. Review.

7.

Interleukin 2 is an Upstream Regulator of CD4+ T Cells From Visceral Leishmaniasis Patients With Therapeutic Potential.

Chauhan SB, Faleiro R, Kumar R, Ng S, Singh B, Singh OP, Singh SS, Amante F, Rivera FL, Rai M, Chakravarty J, Sacks D, Nylen S, Sundar S, Engwerda C.

J Infect Dis. 2019 Jun 5;220(1):163-173. doi: 10.1093/infdis/jiz074.

PMID:
30796820
8.

Innate Lymphocytes and Malaria - Players or Spectators?

Ng SS, Engwerda CR.

Trends Parasitol. 2019 Feb;35(2):154-162. doi: 10.1016/j.pt.2018.11.012. Epub 2018 Dec 19. Review.

PMID:
30579700
9.

The Role of BACH2 in T Cells in Experimental Malaria Caused by Plasmodium chabaudi chabaudi AS.

Edwards CL, de Oca MM, de Labastida Rivera F, Kumar R, Ng SS, Wang Y, Amante FH, Kometani K, Kurosaki T, Sidwell T, Kallies A, Engwerda CR.

Front Immunol. 2018 Nov 6;9:2578. doi: 10.3389/fimmu.2018.02578. eCollection 2018.

10.

Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10-Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani.

Bunn PT, Montes de Oca M, de Labastida Rivera F, Kumar R, Ng SS, Edwards CL, Faleiro RJ, Sheel M, Amante FH, Frame TCM, Muller W, Haque A, Uzonna JE, Hill GR, Engwerda CR.

J Immunol. 2018 Dec 1;201(11):3362-3372. doi: 10.4049/jimmunol.1701582. Epub 2018 Oct 24.

11.

Plasmodium falciparum Activates CD16+ Dendritic Cells to Produce Tumor Necrosis Factor and Interleukin-10 in Subpatent Malaria.

Loughland JR, Woodberry T, Boyle MJ, Tipping PE, Piera KA, Amante FH, Kenangalem E, Price RN, Engwerda CR, Anstey NM, McCarthy JS, Minigo G.

J Infect Dis. 2019 Jan 29;219(4):660-671. doi: 10.1093/infdis/jiy555.

12.

Myeloma escape after stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade.

Minnie SA, Kuns RD, Gartlan KH, Zhang P, Wilkinson AN, Samson L, Guillerey C, Engwerda C, MacDonald KPA, Smyth MJ, Markey KA, Vuckovic S, Hill GR.

Blood. 2018 Oct 18;132(16):1675-1688. doi: 10.1182/blood-2018-01-825240. Epub 2018 Aug 28.

PMID:
30154111
13.

Peripheral Blood Monocytes With an Antiinflammatory Phenotype Display Limited Phagocytosis and Oxidative Burst in Patients With Visceral Leishmaniasis.

Singh N, Kumar R, Chauhan SB, Engwerda C, Sundar S.

J Infect Dis. 2018 Aug 24;218(7):1130-1141. doi: 10.1093/infdis/jiy228.

14.

Long-term prognosis, treatment, and outcome of patients with fever of unknown origin in whom no diagnosis was made despite extensive investigation: A questionnaire based study.

Mulders-Manders CM, Engwerda C, Simon A, van der Meer JWM, Bleeker-Rovers CP.

Medicine (Baltimore). 2018 Jun;97(25):e11241. doi: 10.1097/MD.0000000000011241.

15.

Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice.

Eichenberger RM, Ryan S, Jones L, Buitrago G, Polster R, Montes de Oca M, Zuvelek J, Giacomin PR, Dent LA, Engwerda CR, Field MA, Sotillo J, Loukas A.

Front Immunol. 2018 Apr 30;9:850. doi: 10.3389/fimmu.2018.00850. eCollection 2018.

16.

Early Changes in CD4+ T-Cell Activation During Blood-Stage Plasmodium falciparum Infection.

Edwards CL, Ng SS, Corvino D, Montes de Oca M, de Labastida Rivera F, Nones K, Lakis V, Waddell N, Amante FH, McCarthy JS, Engwerda CR.

J Infect Dis. 2018 Aug 24;218(7):1119-1129. doi: 10.1093/infdis/jiy281.

PMID:
29757416
17.

Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection.

Ng SS, Souza-Fonseca-Guimaraes F, Rivera FL, Amante FH, Kumar R, Gao Y, Sheel M, Beattie L, Montes de Oca M, Guillerey C, Edwards CL, Faleiro RJ, Frame T, Bunn PT, Vivier E, Godfrey DI, Pellicci DG, Lopez JA, Andrews KT, Huntington ND, Smyth MJ, McCarthy J, Engwerda CR.

Clin Transl Immunology. 2018 Jan 12;7(1):e1003. doi: 10.1002/cti2.1003. eCollection 2018.

18.

IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection.

James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A.

J Immunol. 2018 Feb 15;200(4):1443-1456. doi: 10.4049/jimmunol.1700782. Epub 2018 Jan 10.

19.

Immune Checkpoint Targets for Host-Directed Therapy to Prevent and Treat Leishmaniasis.

Kumar R, Chauhan SB, Ng SS, Sundar S, Engwerda CR.

Front Immunol. 2017 Nov 8;8:1492. doi: 10.3389/fimmu.2017.01492. eCollection 2017. Review.

20.

Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis.

Bunn PT, Montes de Oca M, Rivera FL, Kumar R, Edwards CL, Faleiro RJ, Ng SS, Sheel M, Wang Y, Amante FH, Haque A, Engwerda CR.

Front Immunol. 2017 Oct 12;8:1307. doi: 10.3389/fimmu.2017.01307. eCollection 2017.

21.

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.

Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng SS, Young A, Ngiow SF, Rautela J, Straube J, Waddell N, Blake SJ, Yan J, Bartholin L, Lee JS, Vivier E, Takeda K, Messaoudene M, Zitvogel L, Teng MWL, Belz GT, Engwerda CR, Huntington ND, Nakamura K, Hölzel M, Smyth MJ.

Nat Immunol. 2017 Sep;18(9):1004-1015. doi: 10.1038/ni.3800. Epub 2017 Jul 31.

PMID:
28759001
22.

IL-6 promotes CD4+ T-cell and B-cell activation during Plasmodium infection.

Sebina I, Fogg LG, James KR, Soon MSF, Akter J, Thomas BS, Hill GR, Engwerda CR, Haque A.

Parasite Immunol. 2017 Oct;39(10). doi: 10.1111/pim.12455. Epub 2017 Aug 17.

23.

Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.

24.

Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation.

Loughland JR, Minigo G, Sarovich DS, Field M, Tipping PE, Montes de Oca M, Piera KA, Amante FH, Barber BE, Grigg MJ, William T, Good MF, Doolan DL, Engwerda CR, Anstey NM, McCarthy JS, Woodberry T.

Sci Rep. 2017 Jun 1;7(1):2596. doi: 10.1038/s41598-017-02096-2.

25.

Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria.

Lönnberg T, Svensson V, James KR, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MS, Fogg LG, Nair AS, Liligeto U, Stubbington MJ, Ly LH, Bagger FO, Zwiessele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegle O, Haque A, Teichmann SA.

Sci Immunol. 2017 Mar 3;2(9). pii: eaal2192. doi: 10.1126/sciimmunol.aal2192. Erratum in: Sci Immunol. 2018 Mar 9;3(21):.

26.

Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c+ Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation.

Woodberry T, Loughland JR, Minigo G, Burel JG, Amante FH, Piera KA, McNeil Y, Yeo TW, Good MF, Doolan DL, Engwerda CR, McCarthy JS, Anstey NM.

Infect Immun. 2017 May 23;85(6). pii: e00986-16. doi: 10.1128/IAI.00986-16. Print 2017 Jun.

27.

The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria.

Montes de Oca M, Good MF, McCarthy JS, Engwerda CR.

J Immunol. 2016 Dec 15;197(12):4518-4526. Review.

28.

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection.

Sebina I, James KR, Soon MS, Fogg LG, Best SE, Labastida Rivera F, Montes de Oca M, Amante FH, Thomas BS, Beattie L, Souza-Fonseca-Guimaraes F, Smyth MJ, Hertzog PJ, Hill GR, Hutloff A, Engwerda CR, Haque A.

PLoS Pathog. 2016 Nov 3;12(11):e1005999. doi: 10.1371/journal.ppat.1005999. eCollection 2016 Nov.

29.

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma.

Navarro S, Pickering DA, Ferreira IB, Jones L, Ryan S, Troy S, Leech A, Hotez PJ, Zhan B, Laha T, Prentice R, Sparwasser T, Croese J, Engwerda CR, Upham JW, Julia V, Giacomin PR, Loukas A.

Sci Transl Med. 2016 Oct 26;8(362):362ra143.

PMID:
27797959
30.

Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection.

Montes de Oca M, Kumar R, Rivera FL, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Boyle GM, Price RN, Anstey NM, Loughland JR, Burel J, Doolan DL, Haque A, McCarthy JS, Engwerda CR.

Cell Rep. 2016 Oct 4;17(2):399-412. doi: 10.1016/j.celrep.2016.09.015.

31.

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.

Le Texier L, Lineburg KE, Cao B, McDonald-Hyman C, Leveque-El Mouttie L, Nicholls J, Melino M, Nalkurthi BC, Alexander KA, Teal B, Blake SJ, Souza-Fonseca-Guimaraes F, Engwerda CR, Kuns RD, Lane SW, Teng M, Teh C, Gray D, Clouston AD, Nilsson SK, Blazar BR, Hill GR, MacDonald KP.

JCI Insight. 2016 Sep 22;1(15):e86850. doi: 10.1172/jci.insight.86850.

32.

Tumor necrosis factor alpha neutralization has no direct effect on parasite burden, but causes impaired IFN-γ production by spleen cells from human visceral leishmaniasis patients.

Singh N, Kumar R, Engwerda C, Sacks D, Nylen S, Sundar S.

Cytokine. 2016 Sep;85:184-90. doi: 10.1016/j.cyto.2016.06.013. Epub 2016 Jun 30.

33.

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection.

Kho S, Marfurt J, Handayuni I, Pava Z, Noviyanti R, Kusuma A, Piera KA, Burdam FH, Kenangalem E, Lampah DA, Engwerda CR, Poespoprodjo JR, Price RN, Anstey NM, Minigo G, Woodberry T.

Malar J. 2016 Jun 21;15:328. doi: 10.1186/s12936-016-1382-7.

34.

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions.

Beattie L, Sawtell A, Mann J, Frame TCM, Teal B, de Labastida Rivera F, Brown N, Walwyn-Brown K, Moore JWJ, MacDonald S, Lim EK, Dalton JE, Engwerda CR, MacDonald KP, Kaye PM.

J Hepatol. 2016 Oct;65(4):758-768. doi: 10.1016/j.jhep.2016.05.037. Epub 2016 Jun 1.

35.

Profoundly Reduced CD1c+ Myeloid Dendritic Cell HLA-DR and CD86 Expression and Increased Tumor Necrosis Factor Production in Experimental Human Blood-Stage Malaria Infection.

Loughland JR, Minigo G, Burel J, Tipping PE, Piera KA, Amante FH, Engwerda CR, Good MF, Doolan DL, Anstey NM, McCarthy JS, Woodberry T.

Infect Immun. 2016 Apr 22;84(5):1403-1412. doi: 10.1128/IAI.01522-15. Print 2016 May.

36.

Combined Immune Therapy for the Treatment of Visceral Leishmaniasis.

Faleiro RJ, Kumar R, Bunn PT, Singh N, Chauhan SB, Sheel M, Amante FH, Montes de Oca M, Edwards CL, Ng SS, Best SE, Haque A, Beattie L, Hafner LM, Sacks D, Nylen S, Sundar S, Engwerda CR.

PLoS Negl Trop Dis. 2016 Feb 12;10(2):e0004415. doi: 10.1371/journal.pntd.0004415. eCollection 2016 Feb.

37.

Correction: Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR.

PLoS Pathog. 2016 Feb 12;12(2):e1005460. doi: 10.1371/journal.ppat.1005460. eCollection 2016 Feb. No abstract available.

38.

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology.

Montes de Oca M, Kumar R, de Labastida Rivera F, Amante FH, Sheel M, Faleiro RJ, Bunn PT, Best SE, Beattie L, Ng SS, Edwards CL, Muller W, Cretney E, Nutt SL, Smyth MJ, Haque A, Hill GR, Sundar S, Kallies A, Engwerda CR.

PLoS Pathog. 2016 Jan 14;12(1):e1005398. doi: 10.1371/journal.ppat.1005398. eCollection 2016 Jan. Erratum in: PLoS Pathog. 2016 Feb;12(2):e1005460.

39.

Plasmodium berghei bio-burden correlates with parasite lactate dehydrogenase: application to murine Plasmodium diagnostics.

De SL, Stanisic DI, Rivera F, Batzloff MR, Engwerda C, Good MF.

Malar J. 2016 Jan 4;15:3. doi: 10.1186/s12936-015-1027-2.

40.

IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR.

J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4.

41.

Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.

42.

Development of Leishmania vaccines in the era of visceral leishmaniasis elimination.

Engwerda CR, Matlashewski G.

Trans R Soc Trop Med Hyg. 2015 Jul;109(7):423-4. doi: 10.1093/trstmh/trv039. Epub 2015 Jun 4.

PMID:
26048873
43.

Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.

Kho S, Marfurt J, Noviyanti R, Kusuma A, Piera KA, Burdam FH, Kenangalem E, Lampah DA, Engwerda CR, Poespoprodjo JR, Price RN, Anstey NM, Minigo G, Woodberry T.

Infect Immun. 2015 Aug;83(8):3224-32. doi: 10.1128/IAI.00226-15. Epub 2015 Jun 1.

44.

Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity.

Matar CG, Anthony NR, O'Flaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ.

PLoS Pathog. 2015 May 21;11(5):e1004858. doi: 10.1371/journal.ppat.1004858. eCollection 2015 May.

45.

Coinfection with Blood-Stage Plasmodium Promotes Systemic Type I Interferon Production during Pneumovirus Infection but Impairs Inflammation and Viral Control in the Lung.

Edwards CL, Zhang V, Werder RB, Best SE, Sebina I, James KR, Faleiro RJ, de Labastida Rivera F, Amante FH, Engwerda CR, Phipps S, Haque A.

Clin Vaccine Immunol. 2015 May;22(5):477-83. doi: 10.1128/CVI.00051-15. Epub 2015 Feb 25.

46.

Vaccines to prevent leishmaniasis.

Kumar R, Engwerda C.

Clin Transl Immunology. 2014 Mar 14;3(3):e13. doi: 10.1038/cti.2014.4. eCollection 2014 Mar. Review.

47.

The Regulation of CD4(+) T Cell Responses during Protozoan Infections.

Engwerda CR, Ng SS, Bunn PT.

Front Immunol. 2014 Oct 13;5:498. doi: 10.3389/fimmu.2014.00498. eCollection 2014. Review.

48.

Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection.

Edwards CL, Best SE, Gun SY, Claser C, James KR, de Oca MM, Sebina I, Rivera Fde L, Amante FH, Hertzog PJ, Engwerda CR, Renia L, Haque A.

Eur J Immunol. 2015 Jan;45(1):130-41. doi: 10.1002/eji.201444824. Epub 2014 Nov 13.

49.

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease.

Croese J, Giacomin P, Navarro S, Clouston A, McCann L, Dougall A, Ferreira I, Susianto A, O'Rourke P, Howlett M, McCarthy J, Engwerda C, Jones D, Loukas A.

J Allergy Clin Immunol. 2015 Feb;135(2):508-16. doi: 10.1016/j.jaci.2014.07.022. Epub 2014 Sep 20.

PMID:
25248819
50.

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.

Alexander KA, Flynn R, Lineburg KE, Kuns RD, Teal BE, Olver SD, Lor M, Raffelt NC, Koyama M, Leveque L, Le Texier L, Melino M, Markey KA, Varelias A, Engwerda C, Serody JS, Janela B, Ginhoux F, Clouston AD, Blazar BR, Hill GR, MacDonald KP.

J Clin Invest. 2014 Oct;124(10):4266-80. doi: 10.1172/JCI75935. Epub 2014 Aug 26.

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