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Items: 1 to 50 of 203

1.

Behavioral facilitation and increased brain responses from a high interference working memory context.

Samrani G, Marklund P, Engström L, Broman D, Persson J.

Sci Rep. 2018 Oct 17;8(1):15308. doi: 10.1038/s41598-018-33616-3.

2.

DNase-capture reveals differential transcription factor binding modalities.

Kang D, Sherwood R, Barkal A, Hashimoto T, Engstrom L, Gifford D.

PLoS One. 2017 Dec 28;12(12):e0187046. doi: 10.1371/journal.pone.0187046. eCollection 2017.

3.

The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy.

Briere D, Sudhakar N, Woods DM, Hallin J, Engstrom LD, Aranda R, Chiang H, Sodré AL, Olson P, Weber JS, Christensen JG.

Cancer Immunol Immunother. 2018 Mar;67(3):381-392. doi: 10.1007/s00262-017-2091-y. Epub 2017 Nov 9.

PMID:
29124315
4.

Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models.

Engstrom LD, Aranda R, Lee M, Tovar EA, Essenburg CJ, Madaj Z, Chiang H, Briere D, Hallin J, Lopez-Casas PP, Baños N, Menendez C, Hidalgo M, Tassell V, Chao R, Chudova DI, Lanman RB, Olson P, Bazhenova L, Patel SP, Graveel C, Nishino M, Shapiro GI, Peled N, Awad MM, Jänne PA, Christensen JG.

Clin Cancer Res. 2017 Nov 1;23(21):6661-6672. doi: 10.1158/1078-0432.CCR-17-1192. Epub 2017 Aug 1.

5.

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.

St Pierre C, Guo J, Shin JD, Engstrom LW, Lee HH, Herbert A, Surdi L, Baker J, Salmon M, Shah S, Ellis JM, Houshyar H, Crackower MA, Kleinschek MA, Jones DC, Hicks A, Zaller DM, Alves SE, Ramadas RA.

PLoS One. 2017 Jul 18;12(7):e0180870. doi: 10.1371/journal.pone.0180870. eCollection 2017.

6.

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity.

Guo Y, MacIsaac KD, Chen Y, Miller RJ, Jain R, Joyce-Shaikh B, Ferguson H, Wang IM, Cristescu R, Mudgett J, Engstrom L, Piers KJ, Baltus GA, Barr K, Zhang H, Mehmet H, Hegde LG, Hu X, Carter LL, Aicher TD, Glick G, Zaller D, Hawwari A, Correll CC, Jones DC, Cua DJ.

Cell Rep. 2016 Dec 20;17(12):3206-3218. doi: 10.1016/j.celrep.2016.11.073.

7.

X-ray absorption spectroscopic characterization of the diferric-peroxo intermediate of human deoxyhypusine hydroxylase in the presence of its substrate eIF5a.

Jasniewski AJ, Engstrom LM, Vu VV, Park MH, Que L Jr.

J Biol Inorg Chem. 2016 Sep;21(5-6):605-18. doi: 10.1007/s00775-016-1373-8. Epub 2016 Jul 5.

8.

PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models.

Zou HY, Friboulet L, Kodack DP, Engstrom LD, Li Q, West M, Tang RW, Wang H, Tsaparikos K, Wang J, Timofeevski S, Katayama R, Dinh DM, Lam H, Lam JL, Yamazaki S, Hu W, Patel B, Bezwada D, Frias RL, Lifshits E, Mahmood S, Gainor JF, Affolter T, Lappin PB, Gukasyan H, Lee N, Deng S, Jain RK, Johnson TW, Shaw AT, Fantin VR, Smeal T.

Cancer Cell. 2015 Jul 13;28(1):70-81. doi: 10.1016/j.ccell.2015.05.010. Epub 2015 Jul 2.

9.

PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.

Zou HY, Li Q, Engstrom LD, West M, Appleman V, Wong KA, McTigue M, Deng YL, Liu W, Brooun A, Timofeevski S, McDonnell SR, Jiang P, Falk MD, Lappin PB, Affolter T, Nichols T, Hu W, Lam J, Johnson TW, Smeal T, Charest A, Fantin VR.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3493-8. doi: 10.1073/pnas.1420785112. Epub 2015 Mar 2.

10.

A zinc linchpin motif in the MUTYH glycosylase interdomain connector is required for efficient repair of DNA damage.

Engstrom LM, Brinkmeyer MK, Ha Y, Raetz AG, Hedman B, Hodgson KO, Solomon EI, David SS.

J Am Chem Soc. 2014 Jun 4;136(22):7829-32. doi: 10.1021/ja502942d. Epub 2014 May 23.

11.

Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.

Johnson TW, Richardson PF, Bailey S, Brooun A, Burke BJ, Collins MR, Cui JJ, Deal JG, Deng YL, Dinh D, Engstrom LD, He M, Hoffman J, Hoffman RL, Huang Q, Kania RS, Kath JC, Lam H, Lam JL, Le PT, Lingardo L, Liu W, McTigue M, Palmer CL, Sach NW, Smeal T, Smith GL, Stewart AE, Timofeevski S, Zhu H, Zhu J, Zou HY, Edwards MP.

J Med Chem. 2014 Jun 12;57(11):4720-44. doi: 10.1021/jm500261q. Epub 2014 Jun 3.

PMID:
24819116
12.

Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.

Huang Q, Johnson TW, Bailey S, Brooun A, Bunker KD, Burke BJ, Collins MR, Cook AS, Cui JJ, Dack KN, Deal JG, Deng YL, Dinh D, Engstrom LD, He M, Hoffman J, Hoffman RL, Johnson PS, Kania RS, Lam H, Lam JL, Le PT, Li Q, Lingardo L, Liu W, Lu MW, McTigue M, Palmer CL, Richardson PF, Sach NW, Shen H, Smeal T, Smith GL, Stewart AE, Timofeevski S, Tsaparikos K, Wang H, Zhu H, Zhu J, Zou HY, Edwards MP.

J Med Chem. 2014 Feb 27;57(4):1170-87. doi: 10.1021/jm401805h. Epub 2014 Feb 6.

13.

Adult atopic dermatitis patients and physical exercise: a Swedish questionnaire study.

Lonne-Rahm SB, Sundström I, Nordlind K, Engström LM.

Acta Derm Venereol. 2014 Mar;94(2):185-7. doi: 10.2340/00015555-1556.

14.

Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells.

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A.

Endocrinology. 2012 Oct;153(10):4849-61. Epub 2012 Aug 7.

PMID:
22872578
15.

An iron-sulfur cluster loop motif in the Archaeoglobus fulgidus uracil-DNA glycosylase mediates efficient uracil recognition and removal.

Engstrom LM, Partington OA, David SS.

Biochemistry. 2012 Jun 26;51(25):5187-97. doi: 10.1021/bi3000462. Epub 2012 Jun 12.

16.

Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor.

Zou HY, Li Q, Lee JH, Arango ME, Burgess K, Qiu M, Engstrom LD, Yamazaki S, Parker M, Timofeevski S, Cui JJ, McTigue M, Los G, Bender SL, Smeal T, Christensen JG.

Mol Cancer Ther. 2012 Apr;11(4):1036-47. doi: 10.1158/1535-7163.MCT-11-0839. Epub 2012 Mar 2.

17.

Direct fluorescence monitoring of DNA base excision repair.

Ono T, Wang S, Koo CK, Engstrom L, David SS, Kool ET.

Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1689-92. doi: 10.1002/anie.201108135. Epub 2012 Jan 12. No abstract available.

18.

Quality of life, physical function and MRI T2* in elderly low-risk MDS patients treated to a haemoglobin level of ≥120 g/L with darbepoetin alfa ± filgrastim or erythrocyte transfusions.

Nilsson-Ehle H, Birgegård G, Samuelsson J, Antunovic P, Astermark J, Garelius H, Engström LM, Kjeldsen L, Nilsson L, Olsson A, Skov-Holm M, Wallvik J, Gulbrandsen N, Hellström-Lindberg E.

Eur J Haematol. 2011 Sep;87(3):244-52. doi: 10.1111/j.1600-0609.2011.01654.x. Epub 2011 Jul 26.

PMID:
21623919
19.

Brain abscess associated with Aggregatibacter actinomycetemcomitans: case report and review of literature.

Rahamat-Langendoen JC, van Vonderen MG, Engström LJ, Manson WL, van Winkelhoff AJ, Mooi-Kokenberg EA.

J Clin Periodontol. 2011 Aug;38(8):702-6. doi: 10.1111/j.1600-051X.2011.01737.x. Epub 2011 May 3. Review.

PMID:
21539594
20.

Insecure social relations at work and long-term sickness absence due to burnout and other mental diagnoses.

Eriksson UB, Engström LG, Starrin B, Janson S.

Work. 2011;38(4):319-27. doi: 10.3233/WOR-2011-1135.

PMID:
21508521
21.

Drug-induced hemolytic anemia and thrombocytopenia associated with alterations of cell membrane lipids and acanthocyte formation.

Poulet FM, Penraat K, Collins N, Evans E, Thackaberry E, Manfra D, Engstrom L, Geissler R, Geraci-Erck M, Frugone C, Abutarif M, Fine JS, Peterson BL, Cummings BS, Johnson RC.

Toxicol Pathol. 2010 Oct;38(6):907-22. doi: 10.1177/0192623310378865. Epub 2010 Aug 30.

PMID:
20805317
22.

Poor outcome of adenovirus infections in adult hematopoietic stem cell transplant patients with sustained adenovirus viremia.

Omar H, Yun Z, Lewensohn-Fuchs I, Pérez-Bercoff L, Orvell C, Engström L, Vuong GK, Ljungman P.

Transpl Infect Dis. 2010 Oct;12(5):465-9. doi: 10.1111/j.1399-3062.2010.00528.x.

PMID:
20553439
23.

Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy.

Grövdal M, Karimi M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P, Engström LM, Kjeldsen L, Linder O, Nilsson L, Olsson A, Holm MS, Tangen JM, Wallvik J, Oberg G, Hokland P, Jacobsen SE, Porwit A, Hellström-Lindberg E.

Br J Haematol. 2010 Aug;150(3):293-302. doi: 10.1111/j.1365-2141.2010.08235.x. Epub 2010 May 20.

PMID:
20497178
24.

Kinetic assessment and therapeutic modulation of metabolic and inflammatory profiles in mice on a high-fat and cholesterol diet.

Engstrom LW, Bober L, Chen SC, Fine JS, Li Y, Stanton MC, Kinsley D, Cui L, Jackson JV, Rojas-Triana A, Lundell D, Laverty M, Gustafson EL, Jenh CH, Kowalski TJ, Manfra DJ.

PPAR Res. 2010;2010:970164. doi: 10.1155/2010/970164. Epub 2010 Apr 22.

25.

Independent associations of physical activity and cardiovascular fitness with cardiovascular risk in adults.

Ekblom-Bak E, Hellénius ML, Ekblom O, Engström LM, Ekblom B.

Eur J Cardiovasc Prev Rehabil. 2010 Apr;17(2):175-80. doi: 10.1097/HJR.0b013e32833254f2.

PMID:
19809331
26.

Predictors of work presence--sickness absence in a salutogenic perspective.

Engström LG, Janson S.

Work. 2009;33(3):287-95. doi: 10.3233/WOR-2009-0876.

PMID:
19759427
27.

Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: role for p38 kinase.

Engstrom L, Pinzon-Ortiz MC, Li Y, Chen SC, Kinsley D, Nelissen R, Fine JS, Mihara K, Manfra D.

Int Immunopharmacol. 2009 Sep;9(10):1218-27. doi: 10.1016/j.intimp.2009.07.003. Epub 2009 Jul 16.

PMID:
19616132
28.

Fitness and abdominal obesity are independently associated with cardiovascular risk.

Ekblom-Bak E, Hellenius ML, Ekblom O, Engström LM, Ekblom B.

J Intern Med. 2009 Dec;266(6):547-57. doi: 10.1111/j.1365-2796.2009.02131.x. Epub 2009 May 31.

29.

Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge.

Elander L, Engström L, Ruud J, Mackerlova L, Jakobsson PJ, Engblom D, Nilsberth C, Blomqvist A.

J Neurosci. 2009 Feb 4;29(5):1404-13. doi: 10.1523/JNEUROSCI.5247-08.2009.

30.

The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.

Nilsberth C, Elander L, Hamzic N, Norell M, Lönn J, Engström L, Blomqvist A.

Endocrinology. 2009 Apr;150(4):1850-60. doi: 10.1210/en.2008-0806. Epub 2008 Nov 20.

PMID:
19022895
31.

Comparison of hamstring neuromechanical properties between healthy males and females and the influence of musculotendinous stiffness.

Blackburn JT, Bell DR, Norcross MF, Hudson JD, Engstrom LA.

J Electromyogr Kinesiol. 2009 Oct;19(5):e362-9. doi: 10.1016/j.jelekin.2008.08.005. Epub 2008 Sep 30.

PMID:
18829346
32.

Congenital CMV infection: prevalence in newborns and the impact on hearing deficit.

Engman ML, Malm G, Engstrom L, Petersson K, Karltorp E, Tear Fahnehjelm K, Uhlen I, Guthenberg C, Lewensohn-Fuchs I.

Scand J Infect Dis. 2008;40(11-12):935-42. doi: 10.1080/00365540802308431.

PMID:
18720260
33.

Quantification of adenovirus DNA in unrelated donor hematopoietic stem cell transplant recipients.

Gustafson I, Lindblom A, Yun Z, Omar H, Engstrom L, Lewensohn-Fuchs I, Ljungman P, Broliden K.

J Clin Virol. 2008 Sep;43(1):79-85. doi: 10.1016/j.jcv.2008.04.014. Epub 2008 Jun 11.

PMID:
18550426
34.

Falling between two stools; how a weak co-operation between the social security and the unemployment agencies obstructs rehabilitation of unemployed sick-listed persons.

Eriksson UB, Engström LG, Starrin B, Janson S.

Disabil Rehabil. 2008;30(8):569-76. doi: 10.1080/09638280701355827.

PMID:
18382898
35.

Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland.

Engström L, Rosén K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D, Blomqvist A.

Endocrinology. 2008 Apr;149(4):1436-50. doi: 10.1210/en.2007-1456. Epub 2008 Jan 3.

PMID:
18174279
36.

Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome.

Grövdal M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P, Engström LM, Kjeldsen L, Linder O, Nilsson L, Olsson A, Wallvik J, Tangen JM, Oberg G, Jacobsen SE, Hokland P, Porwit A, Hellström-Lindberg E.

Clin Cancer Res. 2007 Dec 1;13(23):7107-12.

37.

Self-rated pain and perceived health in relation to stress and physical activity among school-students: a 3-year follow-up.

Sundblad GB, Jansson A, Saartok T, Renström P, Engström LM.

Pain. 2008 Jun;136(3):239-49. Epub 2007 Aug 20.

PMID:
17709208
38.

Secular trends of physical fitness in Swedish adults.

Ekblom B, Engström LM, Ekblom O.

Scand J Med Sci Sports. 2007 Jun;17(3):267-73.

PMID:
17501867
39.

Stress-related sickness absence and return to labour market in Sweden.

Engström LG, Janson S.

Disabil Rehabil. 2007 Mar 15;29(5):411-6.

PMID:
17364794
40.

Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies.

Sköld C, Winiwarter S, Wernevik J, Bergström F, Engström L, Allen R, Box K, Comer J, Mole J, Hallberg A, Lennernäs H, Lundstedt T, Ungell AL, Karlén A.

J Med Chem. 2006 Nov 16;49(23):6660-71.

PMID:
17154497
41.

Use of limestone karst forests by Bornean orangutans (Pongo pygmaeus morio) in the Sangkulirang peninsula, east Kalimantan, Indonesia.

Marshall AJ, Salas LA, Stephens S; Nardiyono, Engström L, Meijaard E, Stanley SA.

Am J Primatol. 2007 Feb;69(2):212-9.

PMID:
17146797
42.

Child-parent agreement on reports of disease, injury and pain.

Sundblad GM, Saartok T, Engström LM.

BMC Public Health. 2006 Nov 8;6:276.

44.

IL-1beta and LPS induce anorexia by distinct mechanisms differentially dependent on microsomal prostaglandin E synthase-1.

Elander L, Engström L, Hallbeck M, Blomqvist A.

Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R258-67. Epub 2006 Aug 31.

45.

Prevalence and co-occurrence of self-rated pain and perceived health in school-children: Age and gender differences.

Brun Sundblad GM, Saartok T, Engström LM.

Eur J Pain. 2007 Feb;11(2):171-80. Epub 2006 Mar 20.

PMID:
16542860
46.

Measurement of iron and zinc isotopes in human whole blood: preliminary application to the study of HFE genotypes.

Stenberg A, Malinovsky D, Ohlander B, Andrén H, Forsling W, Engström LM, Wahlin A, Engström E, Rodushkin I, Baxter DC.

J Trace Elem Med Biol. 2005;19(1):55-60.

PMID:
16240673
47.

Injuries during physical activity in school children.

Sundblad G, Saartok T, Engström LM, Renström P.

Scand J Med Sci Sports. 2005 Oct;15(5):313-23.

PMID:
16181255
48.

Patient adherence in an individualized rehabilitation programme: a clinical follow-up.

Engström LO, Oberg B.

Scand J Public Health. 2005;33(1):11-8.

PMID:
15764236
49.

Impaired febrile responses to immune challenge in mice deficient in microsomal prostaglandin E synthase-1.

Saha S, Engström L, Mackerlova L, Jakobsson PJ, Blomqvist A.

Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1100-7. Epub 2005 Jan 27.

50.

Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas.

Engstrom LD, Youkilis AS, Gorelick JL, Zheng D, Ackley V, Petroff CA, Benson LQ, Coon MR, Zhu X, Hanash SM, Wechsler DS.

Neoplasia. 2004 Sep-Oct;6(5):660-73.

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