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Proteomic Analysis of Longitudinal Changes in Blood Pressure.

Lin YT, Fall T, Hammar U, Gustafsson S, Ingelsson E, Ärnlöv J, Lind L, Engström G, Sundström J.

J Clin Med. 2019 Oct 2;8(10). pii: E1585. doi: 10.3390/jcm8101585.


Evaluation of a Multicomponent Care Transitions Program for High-Risk Hospitalized Older Adults.

Huckfeldt PJ, Reyes B, Engstrom G, Yang Q, Diaz S, Fahmy S, Ouslander JG.

J Am Geriatr Soc. 2019 Oct 1. doi: 10.1111/jgs.16189. [Epub ahead of print]


Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: Meta-Analysis of Population-Based Studies Involving 17 180 Individuals.

Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Peters A, Seshadri S, Myint PK, Nilsson J, de Lemos JA, Dichgans M.

Circ Res. 2019 Sep 27;125(8):773-782. doi: 10.1161/CIRCRESAHA.119.315380. Epub 2019 Sep 3.


Genetic Predisposition for Renal Dysfunction and Incidence of CKD in the Malmö Diet and Cancer Study.

Schulz CA, Engström G, Christensson A, Nilsson PM, Melander O, Orho-Melander M.

Kidney Int Rep. 2019 May 16;4(8):1143-1151. doi: 10.1016/j.ekir.2019.05.003. eCollection 2019 Aug.


The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study.

Ekström MP, Blomberg A, Bergström G, Brandberg J, Caidahl K, Engström G, Engvall J, Eriksson M, Gränsbo K, Hansen T, Jernberg T, Nilsson L, Nilsson U, Olin AC, Persson L, Rosengren A, Sandelin M, Sköld M, Sundström J, Swahn E, Söderberg S, Tanash HA, Torén K, Östgren CJ, Lindberg E.

Thorax. 2019 Oct;74(10):958-964. doi: 10.1136/thoraxjnl-2019-213349. Epub 2019 Aug 21.


Platelet Indices and Risk of Death and Cardiovascular Events: Results from a Large Population-Based Cohort Study.

Patti G, Di Martino G, Ricci F, Renda G, Gallina S, Hamrefors V, Melander O, Sutton R, Engström G, De Caterina R, Fedorowski A.

Thromb Haemost. 2019 Aug 20. doi: 10.1055/s-0039-1694969. [Epub ahead of print]


CHA2DS2VASc score and adverse outcomes in middle-aged individuals without atrial fibrillation.

Renda G, Ricci F, Patti G, Aung N, Petersen SE, Gallina S, Hamrefors V, Melander O, Sutton R, Engstrom G, Caterina R, Fedorowski A.

Eur J Prev Cardiol. 2019 Aug 14:2047487319868320. doi: 10.1177/2047487319868320. [Epub ahead of print]


Heart rate and premature atrial contractions at 24hECG independently predict atrial fibrillation in a population-based study.

Persson AP, Fedorowski A, Hedblad B, Persson M, Juul-Möller S, Engström G, Johnson LSB.

Heart. 2019 Aug 12. pii: heartjnl-2019-315119. doi: 10.1136/heartjnl-2019-315119. [Epub ahead of print]


Risk factors for subarachnoid haemorrhage: a nationwide cohort of 950 000 adults.

Sundström J, Söderholm M, Söderberg S, Alfredsson L, Andersson M, Bellocco R, Björck M, Broberg P, Eriksson M, Eriksson M, Forsberg B, Fransson EI, Giedraitis V, Theorell-Haglöw J, Hallqvist J, Hansson PO, Heller S, Håkansson N, Ingelsson M, Janson C, Järvholm B, Khalili P, Knutsson A, Lager A, Lagerros YT, Larsson SC, Leander K, Leppert J, Lind L, Lindberg E, Magnusson C, Magnusson PKE, Malfert M, Michaëlsson K, Nilsson P, Olsson H, Pedersen NL, Pennlert J, Rosenblad A, Rosengren A, Torén K, Wanhainen A, Wolk A, Engström G, Svennblad B, Wiberg B.

Int J Epidemiol. 2019 Jul 30. pii: dyz163. doi: 10.1093/ije/dyz163. [Epub ahead of print]


sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events.

Gonçalves I, Singh P, Tengryd C, Cavalera M, Yao Mattisson I, Nitulescu M, Flor Persson A, Volkov P, Engström G, Orho-Melander M, Nilsson J, Edsfeldt A.

Stroke. 2019 Aug;50(8):1989-1996. doi: 10.1161/STROKEAHA.119.024379. Epub 2019 Jul 5.


A Vascular Aging Index as Independent Predictor of Cardiovascular Events and Total Mortality in an Elderly Urban Population.

Nilsson Wadström B, Fatehali AH, Engström G, Nilsson PM.

Angiology. 2019 Nov;70(10):929-937. doi: 10.1177/0003319719857270. Epub 2019 Jun 24.


Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD.

Fatemi S, Acosta S, Gottsäter A, Melander O, Engström G, Dakhel A, Zarrouk M.

Biomarkers. 2019 Sep;24(6):615-621. doi: 10.1080/1354750X.2019.1631886. Epub 2019 Jul 17.


Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study.

Muhammad IF, Borné Y, Bao X, Melander O, Orho-Melander M, Nilsson PM, Nilsson J, Engström G.

Diabetes Care. 2019 Aug;42(8):1582-1588. doi: 10.2337/dc18-2556. Epub 2019 Jun 14.


Smoking-induced risk of future cardiovascular disease is partly mediated by cadmium in tobacco: Malmö Diet and Cancer Cohort Study.

Li H, Fagerberg B, Sallsten G, Borné Y, Hedblad B, Engström G, Barregard L, Andersson EM.

Environ Health. 2019 Jun 14;18(1):56. doi: 10.1186/s12940-019-0495-1.


Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study.

Borné Y, Fagerberg B, Sallsten G, Hedblad B, Persson M, Melander O, Nilsson J, Orho-Melander M, Barregard L, Engström G.

Clin Proteomics. 2019 May 15;16:21. doi: 10.1186/s12014-019-9231-7. eCollection 2019.


Skin autofluorescence as a measure of advanced glycation end product levels is associated with carotid atherosclerotic plaque burden in an elderly population.

Jujić A, Östling G, Persson M, Engström G, Nilsson PM, Melander O, Magnusson M.

Diab Vasc Dis Res. 2019 Sep;16(5):466-473. doi: 10.1177/1479164119845319. Epub 2019 May 8.


Factors associated with health-related quality of life among adults with tetralogy of Fallot.

Sandtröm A, Sandberg C, Rinnström D, Engström G, Dellborg M, Thilén U, Sörensson P, Nielsen NE, Christersson C, Johansson B.

Open Heart. 2019 Feb 27;6(1):e000932. doi: 10.1136/openhrt-2018-000932. eCollection 2019.


Lp-PLA2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease.

Fatemi S, Gottsäter A, Zarrouk M, Engström G, Melander O, Persson M, Acosta S.

Sci Rep. 2019 Apr 4;9(1):5609. doi: 10.1038/s41598-019-42154-5.


High Plasma sRAGE (Soluble Receptor for Advanced Glycation End Products) Is Associated With Slower Carotid Intima-Media Thickness Progression and Lower Risk for First-Time Coronary Events and Mortality.

Grauen Larsen H, Marinkovic G, Nilsson PM, Nilsson J, Engström G, Melander O, Orho-Melander M, Schiopu A.

Arterioscler Thromb Vasc Biol. 2019 May;39(5):925-933. doi: 10.1161/ATVBAHA.118.312319.


Breathlessness and incidence of COPD, cardiac events and all-cause mortality: A 44-year follow-up from middle age throughout life.

Sandberg J, Engström G, Ekström M.

PLoS One. 2019 Mar 18;14(3):e0214083. doi: 10.1371/journal.pone.0214083. eCollection 2019.


Valuing individual characteristics and the multifunctionality of urban green spaces: The integration of sociotope mapping and hedonic pricing.

Czembrowski P, Łaszkiewicz E, Kronenberg J, Engström G, Andersson E.

PLoS One. 2019 Mar 6;14(3):e0212277. doi: 10.1371/journal.pone.0212277. eCollection 2019.


Association of menopausal characteristics and risk of coronary heart disease: a pan-European case-cohort analysis.

Dam V, van der Schouw YT, Onland-Moret NC, Groenwold RHH, Peters SAE, Burgess S, Wood AM, Chirlaque MD, Moons KGM, Oliver-Williams C, Schuit E, Tikk K, Weiderpass E, Holm M, Tjønneland A, Kühn T, Fortner RT, Trichopoulou A, Karakatsani A, La Vecchia C, Ferrari P, Gunter M, Masala G, Sieri S, Tumino R, Panico S, Boer JMA, Verschuren WMM, Salamanca-Fernández E, Arriola L, Moreno-Iribas C, Engström G, Melander O, Nordendahl M, Wennberg P, Key TJ, Colorado-Yohar S, Matullo G, Overvad K, Clavel-Chapelon F, Boeing H, Quiros JR, di Angelantonio E, Langenberg C, Sweeting MJ, Riboli E, Wareham NJ, Danesh J, Butterworth A.

Int J Epidemiol. 2019 Feb 22. pii: dyz016. doi: 10.1093/ije/dyz016. [Epub ahead of print]


Complement C3 and incident hospitalization due to chronic kidney disease: a population-based cohort study.

Bao X, Borné Y, Muhammad IF, Schulz CA, Persson M, Orho-Melander M, Niu K, Christensson A, Engström G.

BMC Nephrol. 2019 Feb 21;20(1):61. doi: 10.1186/s12882-019-1248-7.


The co-predictive value of a cardiovascular score for CV outcomes in diabetic patients with no atrial fibrillation.

Patti G, Sticchi A, Pasceri V, Ricci F, Renda G, Hamrefors V, Melander O, Sutton R, Engström G, De Caterina R, Fedorowski A.

Diabetes Metab Res Rev. 2019 Jul;35(5):e3145. doi: 10.1002/dmrr.3145. Epub 2019 Mar 18.


Matrix Metalloproteinases in COPD and atherosclerosis with emphasis on the effects of smoking.

Kraen M, Frantz S, Nihlén U, Engström G, Löfdahl CG, Wollmer P, Dencker M.

PLoS One. 2019 Feb 21;14(2):e0211987. doi: 10.1371/journal.pone.0211987. eCollection 2019.


High Levels of Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Carotid Plaque Inflammation and Increased Risk of Ischemic Stroke.

Markstad H, Edsfeldt A, Yao Mattison I, Bengtsson E, Singh P, Cavalera M, Asciutto G, Björkbacka H, Fredrikson GN, Dias N, Volkov P, Orho-Melander M, Nilsson J, Engström G, Gonçalves I.

J Am Heart Assoc. 2019 Feb 19;8(4):e009874. doi: 10.1161/JAHA.118.009874.


A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm.

Tagetti A, Bonafini S, Ohlsson T, Engström G, Almgren P, Minuz P, Smith G, Melander O, Fava C.

J Hum Hypertens. 2019 Sep;33(9):658-663. doi: 10.1038/s41371-018-0159-6. Epub 2019 Jan 18.


Difference in the risk profiles of carotid-femoral pulse wave velocity: results from two community-based studies in China and Sweden.

Guo QH, Muhammad IF, Borné Y, Sheng CS, Persson M, Wang JG, Engström G, Li Y, Nilsson PM.

J Hum Hypertens. 2019 Jan 15. doi: 10.1038/s41371-018-0160-0. [Epub ahead of print]


Plasma kidney injury molecule-1 (p-KIM-1) levels and deterioration of kidney function over 16 years.

Schulz CA, Engström G, Nilsson J, Almgren P, Petkovic M, Christensson A, Nilsson PM, Melander O, Orho-Melander M.

Nephrol Dial Transplant. 2019 Jan 9. doi: 10.1093/ndt/gfy382. [Epub ahead of print]


AXIN1 in Plasma or Serum Is a Potential New Biomarker for Endometriosis.

Ek M, Roth B, Engström G, Ohlsson B.

Int J Mol Sci. 2019 Jan 7;20(1). pii: E189. doi: 10.3390/ijms20010189.


Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.

Muller DC, Larose TL, Hodge A, Guida F, Langhammer A, Grankvist K, Meyer K, Cai Q, Arslan AA, Zeleniuch-Jacquotte A, Albanes D, Giles GG, Sesso HD, Lee IM, Gaziano JM, Yuan JM, Hoffman Bolton J, Buring JE, Visvanathan K, Le Marchand L, Purdue MP, Caporaso NE, Midttun Ø, Ueland PM, Prentice RL, Weinstein SJ, Stevens VL, Zheng W, Blot WJ, Shu XO, Zhang X, Xiang YB, Koh WP, Hveem K, Thomson CA, Pettinger M, Engström G, Brunnström H, Milne RL, Stampfer MJ, Han J, Johansson M, Brennan P, Severi G, Johansson M.

BMJ. 2019 Jan 3;364:k4981. doi: 10.1136/bmj.k4981.


Association between added sugar intake and mortality is nonlinear and dependent on sugar source in 2 Swedish population-based prospective cohorts.

Ramne S, Alves Dias J, González-Padilla E, Olsson K, Lindahl B, Engström G, Ericson U, Johansson I, Sonestedt E.

Am J Clin Nutr. 2019 Feb 1;109(2):411-423. doi: 10.1093/ajcn/nqy268.


Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study.

Dybjer E, Nilsson PM, Engström G, Helmer C, Nägga K.

BMC Endocr Disord. 2018 Dec 4;18(1):91. doi: 10.1186/s12902-018-0318-3.


Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.

Pennells L, Kaptoge S, Wood A, Sweeting M, Zhao X, White I, Burgess S, Willeit P, Bolton T, Moons KGM, van der Schouw YT, Selmer R, Khaw KT, Gudnason V, Assmann G, Amouyel P, Salomaa V, Kivimaki M, Nordestgaard BG, Blaha MJ, Kuller LH, Brenner H, Gillum RF, Meisinger C, Ford I, Knuiman MW, Rosengren A, Lawlor DA, Völzke H, Cooper C, Marín Ibañez A, Casiglia E, Kauhanen J, Cooper JA, Rodriguez B, Sundström J, Barrett-Connor E, Dankner R, Nietert PJ, Davidson KW, Wallace RB, Blazer DG, Björkelund C, Donfrancesco C, Krumholz HM, Nissinen A, Davis BR, Coady S, Whincup PH, Jørgensen T, Ducimetiere P, Trevisan M, Engström G, Crespo CJ, Meade TW, Visser M, Kromhout D, Kiechl S, Daimon M, Price JF, Gómez de la Cámara A, Wouter Jukema J, Lamarche B, Onat A, Simons LA, Kavousi M, Ben-Shlomo Y, Gallacher J, Dekker JM, Arima H, Shara N, Tipping RW, Roussel R, Brunner EJ, Koenig W, Sakurai M, Pavlovic J, Gansevoort RT, Nagel D, Goldbourt U, Barr ELM, Palmieri L, Njølstad I, Sato S, Monique Verschuren WM, Varghese CV, Graham I, Onuma O, Greenland P, Woodward M, Ezzati M, Psaty BM, Sattar N, Jackson R, Ridker PM, Cook NR, D'Agostino RB, Thompson SG, Danesh J, Di Angelantonio E; Emerging Risk Factors Collaboration.

Eur Heart J. 2019 Feb 14;40(7):621-631. doi: 10.1093/eurheartj/ehy653.


Management of Acute Changes in Condition in Skilled Nursing Facilities.

Ouslander JG, Engstrom G, Reyes B, Tappen R, Rojido C, Gray-Miceli D.

J Am Geriatr Soc. 2018 Dec;66(12):2259-2266. doi: 10.1111/jgs.15632. Epub 2018 Nov 19.


High prevalence of undiagnosed COPD among patients evaluated for suspected myocardial ischaemia.

Jönsson A, Fedorowski A, Engström G, Wollmer P, Hamrefors V.

Open Heart. 2018 Oct 25;5(2):e000848. doi: 10.1136/openhrt-2018-000848. eCollection 2018. Erratum in: Open Heart. 2019 May 8;6(1):e000848corr1.


Measures of low lung function and the prediction of incident COPD events and acute coronary events.

Zaigham S, Johnson L, Wollmer P, Engström G.

Respir Med. 2018 Nov;144:68-73. doi: 10.1016/j.rmed.2018.10.007. Epub 2018 Oct 11.


FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke.

Muhammad IF, Borné Y, Melander O, Orho-Melander M, Nilsson J, Söderholm M, Engström G.

Stroke. 2018 Sep;49(9):2224-2226. doi: 10.1161/STROKEAHA.118.022063.


Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus: the Malmö Diet and Cancer-Cardiovascular Cohort.

Bao X, Borné Y, Muhammad IF, Nilsson J, Lind L, Melander O, Niu K, Orho-Melander M, Engström G.

Diabetologia. 2019 Jan;62(1):78-86. doi: 10.1007/s00125-018-4751-7. Epub 2018 Oct 22.


Increased vascular endothelial growth factor D is associated with atrial fibrillation and ischaemic stroke.

Berntsson J, Smith JG, Johnson LSB, Söderholm M, Borné Y, Melander O, Orho-Melander M, Nilsson J, Engström G.

Heart. 2019 Apr;105(7):553-558. doi: 10.1136/heartjnl-2018-313684. Epub 2018 Oct 16.


Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I, Lin HJ, McLachlan S, Bokemark L, Ronkainen K, Amato M, Schminke U, Srinivasan SR, Lind L, Okazaki S, Stehouwer CDA, Willeit P, Polak JF, Steinmetz H, Sander D, Poppert H, Desvarieux M, Ikram MA, Johnsen SH, Staub D, Sirtori CR, Iglseder B, Beloqui O, Engström G, Friera A, Rozza F, Xie W, Parraga G, Grigore L, Plichart M, Blankenberg S, Su TC, Schmidt C, Tuomainen TP, Veglia F, Völzke H, Nijpels G, Willeit J, Sacco RL, Franco OH, Uthoff H, Hedblad B, Suarez C, Izzo R, Zhao D, Wannarong T, Catapano A, Ducimetiere P, Espinola-Klein C, Chien KL, Price JF, Bergström G, Kauhanen J, Tremoli E, Dörr M, Berenson G, Kitagawa K, Dekker JM, Kiechl S, Sitzer M, Bickel H, Rundek T, Hofman A, Mathiesen EB, Castelnuovo S, Landecho MF, Rosvall M, Gabriel R, de Luca N, Liu J, Baldassarre D, Kavousi M, de Groot E, Bots ML, Yanez DN, Thompson SG; PROG-IMT study group.

PLoS One. 2018 Sep 20;13(9):e0204633. doi: 10.1371/journal.pone.0204633. eCollection 2018.


Evaluation of Nursing Facility Resident Safety During Implementation of the INTERACT Quality Improvement Program.

Tappen RM, Newman D, Huckfeldt P, Yang Z, Engstrom G, Wolf DG, Shutes J, Rojido C, Ouslander JG.

J Am Med Dir Assoc. 2018 Oct;19(10):907-913.e1. doi: 10.1016/j.jamda.2018.06.017. Epub 2018 Aug 11.


Degree of Implementation of the Interventions to Reduce Acute Care Transfers (INTERACT) Quality Improvement Program Associated with Number of Hospitalizations.

Huckfeldt PJ, Kane RL, Yang Z, Engstrom G, Tappen R, Rojido C, Newman D, Reyes B, Ouslander JG.

J Am Geriatr Soc. 2018 Sep;66(9):1830-1837. doi: 10.1111/jgs.15476. Epub 2018 Aug 10.


Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity.

Olsson M, Stanne TM, Pedersen A, Lorentzen E, Kara E, Martinez-Palacian A, Rønnow Sand NP, Jacobsen AF, Sandset PM, Sidelmann JJ, Engström G, Melander O, Kanse SM, Jern C.

J Thromb Haemost. 2018 Oct;16(10):2024-2034. doi: 10.1111/jth.14258. Epub 2018 Aug 24.


Factors Associated With Physical Performance Measures in a Multiethnic Cohort of Older Adults.

Granic A, Mossop H, Engstrom G, Davies K, Dodds R, Galvin J, Ouslander JG, Tappen R, Sayer AA.

Gerontol Geriatr Med. 2018 Jun 13;4:2333721418778623. doi: 10.1177/2333721418778623. eCollection 2018 Jan-Dec.


Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the 'common soil' hypothesis.

Bao X, Borné Y, Johnson L, Muhammad IF, Persson M, Niu K, Engström G.

Cardiovasc Diabetol. 2018 Jun 12;17(1):87. doi: 10.1186/s12933-018-0733-9.


Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.

Fernandez C, Rysä J, Almgren P, Nilsson J, Engström G, Orho-Melander M, Ruskoaho H, Melander O.

J Intern Med. 2018 Oct;284(4):377-387. doi: 10.1111/joim.12783. Epub 2018 Jul 2.


High Serum Level of Matrix Metalloproteinase-7 Is Associated With Increased Risk of Spontaneous Subarachnoid Hemorrhage.

Söderholm M, Nordin Fredrikson G, Nilsson J, Engström G.

Stroke. 2018 Jul;49(7):1626-1631. doi: 10.1161/STROKEAHA.118.020660. Epub 2018 Jun 7.


Dysregulation of the "inflammatory reflex" with abnormal neurohumoral activation may contribute to proinflammatory activity driving the progression of COPD.

Ricci F, Wollmer P, Engström G, Fedorowski A, Hamrefors V.

Eur Respir J. 2018 Jun 7;51(6). pii: 1800806. doi: 10.1183/13993003.00806-2018. Print 2018 Jun. No abstract available.


Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.

Ricci C, Wood A, Muller D, Gunter MJ, Agudo A, Boeing H, van der Schouw YT, Warnakula S, Saieva C, Spijkerman A, Sluijs I, Tjønneland A, Kyrø C, Weiderpass E, Kühn T, Kaaks R, Sánchez MJ, Panico S, Agnoli C, Palli D, Tumino R, Engström G, Melander O, Bonnet F, Boer JMA, Key TJ, Travis RC, Overvad K, Verschuren WMM, Quirós JR, Trichopoulou A, Papatesta EM, Peppa E, Iribas CM, Gavrila D, Forslund AS, Jansson JH, Matullo G, Arriola L, Freisling H, Lassale C, Tzoulaki I, Sharp SJ, Forouhi NG, Langenberg C, Saracci R, Sweeting M, Brennan P, Butterworth AS, Riboli E, Wareham NJ, Danesh J, Ferrari P.

BMJ. 2018 May 29;361:k934. doi: 10.1136/bmj.k934.

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