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Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation.

Szöőr B, Simon DV, Rojas F, Young J, Robinson DR, Krüger T, Engstler M, Matthews KR.

MBio. 2019 Jul 9;10(4). pii: e00875-19. doi: 10.1128/mBio.00875-19.


Eutectic modification by ternary compound cluster formation in Al-Si alloys.

Barrirero J, Pauly C, Engstler M, Ghanbaja J, Ghafoor N, Li J, Schumacher P, Odén M, Mücklich F.

Sci Rep. 2019 Apr 2;9(1):5506. doi: 10.1038/s41598-019-41919-2.


Trypanosomes can initiate nuclear export co-transcriptionally.

Goos C, Dejung M, Wehman AM, M-Natus E, Schmidt J, Sunter J, Engstler M, Butter F, Kramer S.

Nucleic Acids Res. 2019 Jan 10;47(1):266-282. doi: 10.1093/nar/gky1136.


The Fantastic Voyage of the Trypanosome: A Protean Micromachine Perfected during 500 Million Years of Engineering.

Krüger T, Engstler M.

Micromachines (Basel). 2018 Feb 2;9(2). pii: E63. doi: 10.3390/mi9020063. Review.


Beyond Blood: African Trypanosomes on the Move.

Krüger T, Schuster S, Engstler M.

Trends Parasitol. 2018 Dec;34(12):1056-1067. doi: 10.1016/ Epub 2018 Sep 1. Review.


Advanced Steel Microstructural Classification by Deep Learning Methods.

Azimi SM, Britz D, Engstler M, Fritz M, Mücklich F.

Sci Rep. 2018 Feb 1;8(1):2128. doi: 10.1038/s41598-018-20037-5.


Tailored environments to study motile cells and pathogens.

Muthinja JM, Ripp J, Krüger T, Imle A, Haraszti T, Fackler OT, Spatz JP, Engstler M, Frischknecht F.

Cell Microbiol. 2018 Mar;20(3). doi: 10.1111/cmi.12820. Epub 2018 Jan 29. Review.


Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.

Bartossek T, Jones NG, Schäfer C, Cvitković M, Glogger M, Mott HR, Kuper J, Brennich M, Carrington M, Smith AS, Fenz S, Kisker C, Engstler M.

Nat Microbiol. 2017 Nov;2(11):1523-1532. doi: 10.1038/s41564-017-0013-6. Epub 2017 Sep 11.


Developmental adaptations of trypanosome motility to the tsetse fly host environments unravel a multifaceted in vivo microswimmer system.

Schuster S, Krüger T, Subota I, Thusek S, Rotureau B, Beilhack A, Engstler M.

Elife. 2017 Aug 15;6. pii: e27656. doi: 10.7554/eLife.27656.


3D subcellular localization with superresolution array tomography on ultrathin sections of various species.

Markert SM, Bauer V, Muenz TS, Jones NG, Helmprobst F, Britz S, Sauer M, Rössler W, Engstler M, Stigloher C.

Methods Cell Biol. 2017;140:21-47. doi: 10.1016/bs.mcb.2017.03.004. Epub 2017 Apr 19.


A quorum sensing-independent path to stumpy development in Trypanosoma brucei.

Zimmermann H, Subota I, Batram C, Kramer S, Janzen CJ, Jones NG, Engstler M.

PLoS Pathog. 2017 Apr 10;13(4):e1006324. doi: 10.1371/journal.ppat.1006324. eCollection 2017 Apr.


Facilitating trypanosome imaging.

Glogger M, Subota I, Pezzarossa A, Denecke AL, Carrington M, Fenz SF, Engstler M.

Exp Parasitol. 2017 Sep;180:13-18. doi: 10.1016/j.exppara.2017.03.010. Epub 2017 Mar 29.


Let's get fISSical: fast in silico synchronization as a new tool for cell division cycle analysis.

Morriswood B, Engstler M.

Parasitology. 2018 Feb;145(2):196-209. doi: 10.1017/S0031182017000038. Epub 2017 Feb 7. Review.


N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold.

Hartel AJ, Glogger M, Jones NG, Abuillan W, Batram C, Hermann A, Fenz SF, Tanaka M, Engstler M.

Nat Commun. 2016 Sep 19;7:12870. doi: 10.1038/ncomms12870.


Feature Adaptive Sampling for Scanning Electron Microscopy.

Dahmen T, Engstler M, Pauly C, Trampert P, de Jonge N, Mücklich F, Slusallek P.

Sci Rep. 2016 May 6;6:25350. doi: 10.1038/srep25350.


Quantitative Proteomics Uncovers Novel Factors Involved in Developmental Differentiation of Trypanosoma brucei.

Dejung M, Subota I, Bucerius F, Dindar G, Freiwald A, Engstler M, Boshart M, Butter F, Janzen CJ.

PLoS Pathog. 2016 Feb 24;12(2):e1005439. doi: 10.1371/journal.ppat.1005439. eCollection 2016 Feb.


Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.

Bargul JL, Jung J, McOdimba FA, Omogo CO, Adung'a VO, Krüger T, Masiga DK, Engstler M.

PLoS Pathog. 2016 Feb 12;12(2):e1005448. doi: 10.1371/journal.ppat.1005448. eCollection 2016 Feb.


Flagellar motility in eukaryotic human parasites.

Krüger T, Engstler M.

Semin Cell Dev Biol. 2015 Oct;46:113-27. doi: 10.1016/j.semcdb.2015.10.034. Epub 2015 Oct 30. Review.


The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane.

Hartel AJ, Glogger M, Guigas G, Jones NG, Fenz SF, Weiss M, Engstler M.

Sci Rep. 2015 Jun 11;5:10394. doi: 10.1038/srep10394.


Microfluidics-based single cell analysis reveals drug-dependent motility changes in trypanosomes.

Hochstetter A, Stellamanns E, Deshpande S, Uppaluri S, Engstler M, Pfohl T.

Lab Chip. 2015 Apr 21;15(8):1961-8. doi: 10.1039/c5lc00124b.


Simulating the complex cell design of Trypanosoma brucei and its motility.

Alizadehrad D, Krüger T, Engstler M, Stark H.

PLoS Comput Biol. 2015 Jan 8;11(1):e1003967. doi: 10.1371/journal.pcbi.1003967. eCollection 2015 Jan.


Anti-trypanosomal activities and structural chemical properties of selected compound classes.

Ponte-Sucre A, Bruhn H, Schirmeister T, Cecil A, Albert CR, Buechold C, Tischer M, Schlesinger S, Goebel T, Fuß A, Mathein D, Merget B, Sotriffer CA, Stich A, Krohne G, Engstler M, Bringmann G, Holzgrabe U.

Parasitol Res. 2015 Feb;114(2):501-12. doi: 10.1007/s00436-014-4210-4. Epub 2014 Nov 23.


Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei.

Stellamanns E, Uppaluri S, Hochstetter A, Heddergott N, Engstler M, Pfohl T.

Sci Rep. 2014 Oct 1;4:6515. doi: 10.1038/srep06515.


Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.

Batram C, Jones NG, Janzen CJ, Markert SM, Engstler M.

Elife. 2014 May 20;3:e02324. doi: 10.7554/eLife.02324.


Trypanosome motion represents an adaptation to the crowded environment of the vertebrate bloodstream.

Heddergott N, Krüger T, Babu SB, Wei A, Stellamanns E, Uppaluri S, Pfohl T, Stark H, Engstler M.

PLoS Pathog. 2012;8(11):e1003023. doi: 10.1371/journal.ppat.1003023. Epub 2012 Nov 15.


Flow loading induces oscillatory trajectories in a bloodstream parasite.

Uppaluri S, Heddergott N, Stellamanns E, Herminghaus S, Zöttl A, Stark H, Engstler M, Pfohl T.

Biophys J. 2012 Sep 19;103(6):1162-9. doi: 10.1016/j.bpj.2012.08.020.


Novel African trypanocidal agents: membrane rigidifying peptides.

Harrington JM, Scelsi C, Hartel A, Jones NG, Engstler M, Capewell P, MacLeod A, Hajduk S.

PLoS One. 2012;7(9):e44384. doi: 10.1371/journal.pone.0044384. Epub 2012 Sep 7.


A quantitative 3D motility analysis of Trypanosoma brucei by use of digital in-line holographic microscopy.

Weiße S, Heddergott N, Heydt M, Pflästerer D, Maier T, Haraszti T, Grunze M, Engstler M, Rosenhahn A.

PLoS One. 2012;7(5):e37296. doi: 10.1371/journal.pone.0037296. Epub 2012 May 22.


Synthesis and structure-activity relationships of new quinolone-type molecules against Trypanosoma brucei.

Hiltensperger G, Jones NG, Niedermeier S, Stich A, Kaiser M, Jung J, Puhl S, Damme A, Braunschweig H, Meinel L, Engstler M, Holzgrabe U.

J Med Chem. 2012 Mar 22;55(6):2538-48. doi: 10.1021/jm101439s. Epub 2012 Mar 12.


ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation.

Subota I, Rotureau B, Blisnick T, Ngwabyt S, Durand-Dubief M, Engstler M, Bastin P.

Mol Biol Cell. 2011 Nov;22(22):4205-19. doi: 10.1091/mbc.E11-06-0511. Epub 2011 Sep 30.


Impact of microscopic motility on the swimming behavior of parasites: straighter trypanosomes are more directional.

Uppaluri S, Nagler J, Stellamanns E, Heddergott N, Herminghaus S, Engstler M, Pfohl T.

PLoS Comput Biol. 2011 Jun;7(6):e1002058. doi: 10.1371/journal.pcbi.1002058. Epub 2011 Jun 16.


Langevin dynamics deciphers the motility pattern of swimming parasites.

Zaburdaev V, Uppaluri S, Pfohl T, Engstler M, Friedrich R, Stark H.

Phys Rev Lett. 2011 May 20;106(20):208103. Epub 2011 May 20.


snRNA-specific role of SMN in trypanosome snRNP biogenesis in vivo.

Jaé N, Preusser C, Krüger T, Tkacz ID, Engstler M, Michaeli S, Bindereif A.

RNA Biol. 2011 Jan-Feb;8(1):90-100. Epub 2011 Jan 1.


The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes.

Schwede A, Jones N, Engstler M, Carrington M.

Mol Biochem Parasitol. 2011 Feb;175(2):201-4. doi: 10.1016/j.molbiopara.2010.11.004. Epub 2010 Nov 11.


Depletion of 14-3-3 proteins in bloodstream-form Trypanosoma brucei inhibits variant surface glycoprotein recycling.

Benz C, Engstler M, Hillmer S, Clayton C.

Int J Parasitol. 2010 Apr;40(5):629-34. doi: 10.1016/j.ijpara.2009.10.015. Epub 2009 Nov 17.


Macromolecular trafficking and immune evasion in african trypanosomes.

Field MC, Lumb JH, Adung'a VO, Jones NG, Engstler M.

Int Rev Cell Mol Biol. 2009;278:1-67. doi: 10.1016/S1937-6448(09)78001-3. Review.


Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei.

Goldshmidt H, Sheiner L, Bütikofer P, Roditi I, Uliel S, Günzel M, Engstler M, Michaeli S.

J Biol Chem. 2008 Nov 14;283(46):32085-98. doi: 10.1074/jbc.M801499200. Epub 2008 Sep 2.


Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes.

Engstler M, Pfohl T, Herminghaus S, Boshart M, Wiegertjes G, Heddergott N, Overath P.

Cell. 2007 Nov 2;131(3):505-15.


Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes.

Homann M, Lorger M, Engstler M, Zacharias M, Göringer HU.

Comb Chem High Throughput Screen. 2006 Aug;9(7):491-9.


Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest.

Chanez AL, Hehl AB, Engstler M, Schneider A.

J Cell Sci. 2006 Jul 15;119(Pt 14):2968-74. Epub 2006 Jun 20.


Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin.

van Luenen HG, Kieft R, Mussmann R, Engstler M, ter Riet B, Borst P.

Mol Microbiol. 2005 Oct;58(1):151-65.


Binding affinity and capacity of putative adaptor-mediated sorting of a Type I membrane protein in Leishmania mexicana.

Weise F, Thilo L, Engstler M, Wiese M, Benzel I, Kühn C, Bühring HJ, Overath P.

Mol Biochem Parasitol. 2005 Aug;142(2):203-11.


The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei.

Engstler M, Weise F, Bopp K, Grünfelder CG, Günzel M, Heddergott N, Overath P.

J Cell Sci. 2005 May 15;118(Pt 10):2105-18. Epub 2005 Apr 26.


New approaches to the microscopic imaging of Trypanosoma brucei.

Field MC, Allen CL, Dhir V, Goulding D, Hall BS, Morgan GW, Veazey P, Engstler M.

Microsc Microanal. 2004 Oct;10(5):621-36. Review.


Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei.

Mussmann R, Engstler M, Gerrits H, Kieft R, Toaldo CB, Onderwater J, Koerten H, van Luenen HG, Borst P.

J Biol Chem. 2004 Sep 24;279(39):40690-8. Epub 2004 Jul 19.


Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei.

Engstler M, Thilo L, Weise F, Grünfelder CG, Schwarz H, Boshart M, Overath P.

J Cell Sci. 2004 Mar 1;117(Pt 7):1105-15. Erratum in: J Cell Sci. 2004 Jul 15;117(Pt 16):3703.

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