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Protein Composition Reflects Extracellular Vesicle Heterogeneity.

Vagner T, Chin A, Mariscal J, Bannykh S, Engman DM, Di Vizio D.

Proteomics. 2019 Apr;19(8):e1800167. doi: 10.1002/pmic.201800167. Epub 2019 Apr 2. Review.


Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Walts AE, Frye J, Engman DM, Marchevsky AM.

Ann Diagn Pathol. 2019 Feb;38:71-79. doi: 10.1016/j.anndiagpath.2018.11.006. Epub 2018 Nov 22.


Pathology and Pathogenesis of Chagas Heart Disease.

Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM.

Annu Rev Pathol. 2019 Jan 24;14:421-447. doi: 10.1146/annurev-pathol-020117-043711. Epub 2018 Oct 24.


Cell Cycle Inhibition To Treat Sleeping Sickness.

Epting CL, Emmer BT, Du NY, Taylor JM, Makanji MY, Olson CL, Engman DM.

MBio. 2017 Sep 19;8(5). pii: e01427-17. doi: 10.1128/mBio.01427-17.


The Lipid Raft Proteome of African Trypanosomes Contains Many Flagellar Proteins.

Sharma AI, Olson CL, Engman DM.

Pathogens. 2017 Aug 24;6(3). pii: E39. doi: 10.3390/pathogens6030039.


Sterol targeting drugs reveal life cycle stage-specific differences in trypanosome lipid rafts.

Sharma AI, Olson CL, Mamede JI, Gazos-Lopes F, Epting CL, Almeida IC, Engman DM.

Sci Rep. 2017 Aug 22;7(1):9105. doi: 10.1038/s41598-017-08770-9.


Dynamic protein S-palmitoylation mediates parasite life cycle progression and diverse mechanisms of virulence.

Brown RW, Sharma AI, Engman DM.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):145-162. doi: 10.1080/10409238.2017.1287161. Epub 2017 Feb 20. Review.


Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei.

Pasternack DA, Sharma AI, Olson CL, Epting CL, Engman DM.

MBio. 2015 Oct 6;6(5):e01291-15. doi: 10.1128/mBio.01291-15.


Calcium-dependent membrane association of a flagellar calcium sensor does not require calcium binding.

Maric D, Olson CL, Xu X, Ames JB, Engman DM.

Mol Biochem Parasitol. 2015 May;201(1):72-75. doi: 10.1016/j.molbiopara.2015.06.003. Epub 2015 Jun 19.


Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead.

Bonney KM, Engman DM.

Am J Pathol. 2015 Jun;185(6):1537-47. doi: 10.1016/j.ajpath.2014.12.023. Epub 2015 Apr 7. Review.


Depletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease.

Bonney KM, Taylor JM, Thorp EB, Epting CL, Engman DM.

Parasitol Res. 2015 Mar;114(3):1167-78. doi: 10.1007/s00436-014-4300-3. Epub 2015 Jan 11.


Acylation in trypanosomatids: an essential process and potential drug target.

Goldston AM, Sharma AI, Paul KS, Engman DM.

Trends Parasitol. 2014 Jul;30(7):350-60. doi: 10.1016/ Epub 2014 Jun 19. Review.


Endothelial transmigration by Trypanosoma cruzi.

Coates BM, Sullivan DP, Makanji MY, Du NY, Olson CL, Muller WA, Engman DM, Epting CL.

PLoS One. 2013 Dec 2;8(12):e81187. doi: 10.1371/journal.pone.0081187. eCollection 2013.


Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction.

Wan E, Yeap XY, Dehn S, Terry R, Novak M, Zhang S, Iwata S, Han X, Homma S, Drosatos K, Lomasney J, Engman DM, Miller SD, Vaughan DE, Morrow JP, Kishore R, Thorp EB.

Circ Res. 2013 Sep 27;113(8):1004-12. doi: 10.1161/CIRCRESAHA.113.301198. Epub 2013 Jul 8.


NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.

Xu X, Olson CL, Engman DM, Ames JB.

Protein Sci. 2012 Dec;21(12):1942-7. doi: 10.1002/pro.2167. Epub 2012 Oct 26.


Cardiac damage induced by immunization with heat-killed Trypanosoma cruzi is not antibody mediated.

Bonney KM, Gifford KM, Taylor JM, Chen CI, Engman DM.

Parasite Immunol. 2013 Jan;35(1):1-10. doi: 10.1111/pim.12008.


(1)H, (15)N, and (13)C chemical shift assignments of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.

Xu X, Olson CL, Engman DM, Ames JB.

Biomol NMR Assign. 2013 Apr;7(1):9-12. doi: 10.1007/s12104-012-9366-1. Epub 2012 Mar 2.


Molecular determinants of ciliary membrane localization of Trypanosoma cruzi flagellar calcium-binding protein.

Maric D, McGwire BS, Buchanan KT, Olson CL, Emmer BT, Epting CL, Engman DM.

J Biol Chem. 2011 Sep 23;286(38):33109-17. doi: 10.1074/jbc.M111.240895. Epub 2011 Jul 22.


Gene profiling for assessment of cell-based therapies.

Engman DM.

Cell Cycle. 2011 Jul 1;10(13):2054. Epub 2011 Jul 1. No abstract available.


Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity.

Bonney KM, Taylor JM, Daniels MD, Epting CL, Engman DM.

PLoS One. 2011 Jan 21;6(1):e14571. doi: 10.1371/journal.pone.0014571. Erratum in: PLoS One. 2011;6(2). doi:10.1371/annotation/118b702e-9609-4f91-afba-6a76f8f1f14a.


Global analysis of protein palmitoylation in African trypanosomes.

Emmer BT, Nakayasu ES, Souther C, Choi H, Sobreira TJ, Epting CL, Nesvizhskii AI, Almeida IC, Engman DM.

Eukaryot Cell. 2011 Mar;10(3):455-63. doi: 10.1128/EC.00248-10. Epub 2010 Dec 30.


Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.

de Paulo Martins V, Okura M, Maric D, Engman DM, Vieira M, Docampo R, Moreno SN.

J Biol Chem. 2010 Oct 1;285(40):30906-17. doi: 10.1074/jbc.M110.142190. Epub 2010 Jul 20.


Molecular mechanisms of host cell invasion by Trypanosoma cruzi.

Epting CL, Coates BM, Engman DM.

Exp Parasitol. 2010 Nov;126(3):283-91. doi: 10.1016/j.exppara.2010.06.023. Epub 2010 Jun 18. Review. Erratum in: Exp Parasitol. 2011 Feb;127(2):607.


Composition and sensory function of the trypanosome flagellar membrane.

Maric D, Epting CL, Engman DM.

Curr Opin Microbiol. 2010 Aug;13(4):466-72. doi: 10.1016/j.mib.2010.06.001. Epub 2010 Jun 30. Review.


Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection.

Emmer BT, Daniels MD, Taylor JM, Epting CL, Engman DM.

Eukaryot Cell. 2010 Jun;9(6):934-42. doi: 10.1128/EC.00086-10. Epub 2010 Apr 23.


Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.

Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS.

Acad Med. 2010 Apr;85(4):692-701. doi: 10.1097/ACM.0b013e3181d3ca17.


Molecular mechanisms of protein and lipid targeting to ciliary membranes.

Emmer BT, Maric D, Engman DM.

J Cell Sci. 2010 Feb 15;123(Pt 4):529-36. doi: 10.1242/jcs.062968. Review.


Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection.

Kulkarni MM, Olson CL, Engman DM, McGwire BS.

Infect Immun. 2009 May;77(5):2193-200. doi: 10.1128/IAI.01542-08. Epub 2009 Mar 9.


Flagellar membrane localization via association with lipid rafts.

Tyler KM, Fridberg A, Toriello KM, Olson CL, Cieslak JA, Hazlett TL, Engman DM.

J Cell Sci. 2009 Mar 15;122(Pt 6):859-66. doi: 10.1242/jcs.037721. Epub 2009 Feb 24.


Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane.

Emmer BT, Souther C, Toriello KM, Olson CL, Epting CL, Engman DM.

J Cell Sci. 2009 Mar 15;122(Pt 6):867-74. doi: 10.1242/jcs.041764. Epub 2009 Feb 24.


Chagas heart disease pathogenesis: one mechanism or many?

Bonney KM, Engman DM.

Curr Mol Med. 2008 Sep;8(6):510-8. Review.


Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.

Daniels MD, Hyland KV, Wang K, Engman DM.

Autoimmunity. 2008 Sep;41(6):490-9. doi: 10.1080/08916930802167902.


Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi.

Wingard JN, Ladner J, Vanarotti M, Fisher AJ, Robinson H, Buchanan KT, Engman DM, Ames JB.

J Biol Chem. 2008 Aug 22;283(34):23388-96. doi: 10.1074/jbc.M803178200. Epub 2008 Jun 17.


Bioluminescent imaging of Trypanosoma cruzi infection.

Hyland KV, Asfaw SH, Olson CL, Daniels MD, Engman DM.

Int J Parasitol. 2008 Oct;38(12):1391-400. doi: 10.1016/j.ijpara.2008.04.002. Epub 2008 Apr 25.


Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei.

Fridberg A, Olson CL, Nakayasu ES, Tyler KM, Almeida IC, Engman DM.

J Cell Sci. 2008 Feb 15;121(Pt 4):522-35. doi: 10.1242/jcs.016741. Epub 2008 Jan 29.


Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis.

Bahk TJ, Daniels MD, Leon JS, Wang K, Engman DM.

Int J Cardiol. 2008 Mar 28;125(1):85-93. Epub 2007 Jun 22.


Treatment of experimental myocarditis via modulation of the renin-angiotensin system.

Daniels MD, Hyland KV, Engman DM.

Curr Pharm Des. 2007;13(13):1299-305. Review.


Modulation of autoimmunity by treatment of an infectious disease.

Hyland KV, Leon JS, Daniels MD, Giafis N, Woods LM, Bahk TJ, Wang K, Engman DM.

Infect Immun. 2007 Jul;75(7):3641-50. Epub 2007 May 7.


The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing.

Kulkarni MM, McMaster WR, Kamysz E, Kamysz W, Engman DM, McGwire BS.

Mol Microbiol. 2006 Dec;62(5):1484-97. Epub 2006 Oct 27.


Flagellar membrane trafficking in kinetoplastids.

Fridberg A, Buchanan KT, Engman DM.

Parasitol Res. 2007 Jan;100(2):205-12. Epub 2006 Oct 21. Review. No abstract available.


Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry.

Cunha-Neto E, Bilate AM, Hyland KV, Fonseca SG, Kalil J, Engman DM.

Autoimmunity. 2006 Feb;39(1):41-54. Review.


Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease.

Hyland KV, Engman DM.

Trends Parasitol. 2006 Mar;22(3):101-2; author reply 103. Epub 2006 Jan 30. No abstract available.


Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression.

Croxford JL, Wang K, Miller SD, Engman DM, Tyler KM.

Cell Microbiol. 2005 Nov;7(11):1592-602.


Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi.

Tyler KM, Luxton GW, Applewhite DA, Murphy SC, Engman DM.

Cell Microbiol. 2005 Nov;7(11):1579-91.


A flagellum-specific calcium sensor.

Buchanan KT, Ames JB, Asfaw SH, Wingard JN, Olson CL, Campana PT, Ara├║jo AP, Engman DM.

J Biol Chem. 2005 Dec 2;280(48):40104-11. Epub 2005 Sep 7.


A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins.

Leon JS, Daniels MD, Toriello KM, Wang K, Engman DM.

Infect Immun. 2004 Jun;72(6):3410-7.


Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease.

Leon JS, Wang K, Engman DM.

J Immunol. 2003 Oct 15;171(8):4271-7.


Killing of African trypanosomes by antimicrobial peptides.

McGwire BS, Olson CL, Tack BF, Engman DM.

J Infect Dis. 2003 Jul 1;188(1):146-52. Epub 2003 Jun 16.


Captopril prevents experimental autoimmune myocarditis.

Godsel LM, Leon JS, Wang K, Fornek JL, Molteni A, Engman DM.

J Immunol. 2003 Jul 1;171(1):346-52.


Captopril ameliorates myocarditis in acute experimental Chagas disease.

Leon JS, Wang K, Engman DM.

Circulation. 2003 May 6;107(17):2264-9. Epub 2003 Apr 21.


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