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Items: 1 to 50 of 113


Substrate stiffness directs diverging vascular fates.

Wong L, Kumar A, Gabela-Zuniga B, Chua J, Singh G, Happe CL, Engler AJ, Fan Y, McCloskey KE.

Acta Biomater. 2019 Sep 15;96:321-329. doi: 10.1016/j.actbio.2019.07.030. Epub 2019 Jul 19.


Non-invasive and real-time measurement of microvascular barrier in intact lungs.

Engler AJ, Raredon MSB, Le AV, Yuan Y, Oczkowicz YA, Kan EL, Baevova P, Niklason LE.

Biomaterials. 2019 Oct;217:119313. doi: 10.1016/j.biomaterials.2019.119313. Epub 2019 Jun 30.


3D collagen architecture regulates cell adhesion through degradability, thereby controlling metabolic and oxidative stress.

Velez DO, Ranamukhaarachchi SK, Kumar A, Modi RN, Lim EW, Engler AJ, Metallo CM, Fraley SI.

Integr Biol (Camb). 2019 May 1;11(5):221-234. doi: 10.1093/intbio/zyz019.


Rationally engineered advances in cancer research.

Engler AJ, Discher DE.

APL Bioeng. 2018 Sep 26;2(3):031601. doi: 10.1063/1.5056176. eCollection 2018 Sep.


Combinatorial interactions of genetic variants in human cardiomyopathy.

Deacon DC, Happe CL, Chen C, Tedeschi N, Manso AM, Li T, Dalton ND, Peng Q, Farah EN, Gu Y, Tenerelli KP, Tran VD, Chen J, Peterson KL, Schork NJ, Adler ED, Engler AJ, Ross RS, Chi NC.

Nat Biomed Eng. 2019 Feb;3(2):147-157. doi: 10.1038/s41551-019-0348-9. Epub 2019 Feb 7.


Mechanical activation of noncoding-RNA-mediated regulation of disease-associated phenotypes in human cardiomyocytes.

Kumar A, Thomas SK, Wong KC, Lo Sardo V, Cheah DS, Hou YH, Placone JK, Tenerelli KP, Ferguson WC, Torkamani A, Topol EJ, Baldwin KK, Engler AJ.

Nat Biomed Eng. 2019 Feb;3(2):137-146. doi: 10.1038/s41551-018-0344-5. Epub 2019 Jan 28.


Mechanical influences on cardiovascular differentiation and disease modeling.

Teng EL, Engler AJ.

Exp Cell Res. 2019 Apr 15;377(1-2):103-108. doi: 10.1016/j.yexcr.2019.02.019. Epub 2019 Feb 19. Review.


Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling.

Ondeck MG, Kumar A, Placone JK, Plunkett CM, Matte BF, Wong KC, Fattet L, Yang J, Engler AJ.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3502-3507. doi: 10.1073/pnas.1814204116. Epub 2019 Feb 12.


Epac agonist improves barrier function in iPSC-derived endothelial colony forming cells for whole organ tissue engineering.

Yuan Y, Engler AJ, Raredon MS, Le A, Baevova P, Yoder MC, Niklason LE.

Biomaterials. 2019 Apr;200:25-34. doi: 10.1016/j.biomaterials.2019.02.005. Epub 2019 Feb 7.


Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma.

Matte BF, Kumar A, Placone JK, Zanella VG, Martins MD, Engler AJ, Lamers ML.

J Cell Sci. 2019 Jan 9;132(1). pii: jcs224360. doi: 10.1242/jcs.224360.


Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing.

Lo Sardo V, Chubukov P, Ferguson W, Kumar A, Teng EL, Duran M, Zhang L, Cost G, Engler AJ, Urnov F, Topol EJ, Torkamani A, Baldwin KK.

Cell. 2018 Dec 13;175(7):1796-1810.e20. doi: 10.1016/j.cell.2018.11.014. Epub 2018 Dec 6.


Macromolecular crowding tunes 3D collagen architecture and cell morphogenesis.

Ranamukhaarachchi SK, Modi RN, Han A, Velez DO, Kumar A, Engler AJ, Fraley SI.

Biomater Sci. 2019 Jan 29;7(2):618-633. doi: 10.1039/c8bm01188e.


Biomaterials to model and measure epithelial cancers.

Beri P, Matte BF, Fattet L, Kim D, Yang J, Engler AJ.

Nat Rev Mater. 2018 Nov;3(11):418-430. Epub 2018 Sep 6.


RAP2 mediates mechanoresponses of the Hippo pathway.

Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, Park HW, Wang X, Yu FX, Chien S, Wang CY, Ren B, Engler AJ, Guan KL.

Nature. 2018 Aug;560(7720):655-660. doi: 10.1038/s41586-018-0444-0. Epub 2018 Aug 22.


Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span.

Sessions AO, Min P, Cordes T, Weickert BJ, Divakaruni AS, Murphy AN, Metallo CM, Engler AJ.

APL Bioeng. 2018 Sep;2(3). pii: 036101. doi: 10.1063/1.5019592. Epub 2018 Jul 17.


Extracellular matrix in lung development, homeostasis and disease.

Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ.

Matrix Biol. 2018 Nov;73:77-104. doi: 10.1016/j.matbio.2018.03.005. Epub 2018 Mar 8. Review.


Heterogeneous muscle gene expression patterns in patients with massive rotator cuff tears.

Gibbons MC, Fisch KM, Pichika R, Cheng T, Engler AJ, Schenk S, Lane JG, Singh A, Ward SR.

PLoS One. 2018 Jan 2;13(1):e0190439. doi: 10.1371/journal.pone.0190439. eCollection 2018.


Recent Advances in Extrusion-Based 3D Printing for Biomedical Applications.

Placone JK, Engler AJ.

Adv Healthc Mater. 2018 Apr;7(8):e1701161. doi: 10.1002/adhm.201701161. Epub 2017 Dec 28. Review.


Understanding the extracellular forces that determine cell fate and maintenance.

Kumar A, Placone JK, Engler AJ.

Development. 2017 Dec 1;144(23):4261-4270. doi: 10.1242/dev.158469. Review.


The role of mechanobiology in progression of rotator cuff muscle atrophy and degeneration.

Gibbons MC, Singh A, Engler AJ, Ward SR.

J Orthop Res. 2018 Feb;36(2):546-556. doi: 10.1002/jor.23662. Epub 2017 Aug 11. Review.


The provisional matrix: setting the stage for tissue repair outcomes.

Barker TH, Engler AJ.

Matrix Biol. 2017 Jul;60-61:1-4. doi: 10.1016/j.matbio.2017.04.003. Review.


Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels.

Hadden WJ, Young JL, Holle AW, McFetridge ML, Kim DY, Wijesinghe P, Taylor-Weiner H, Wen JH, Lee AR, Bieback K, Vo BN, Sampson DD, Kennedy BF, Spatz JP, Engler AJ, Choi YS.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5647-5652. doi: 10.1073/pnas.1618239114. Epub 2017 May 15.


Mechanically patterned neuromuscular junctions-in-a-dish have improved functional maturation.

Happe CL, Tenerelli KP, Gromova AK, Kolb F, Engler AJ.

Mol Biol Cell. 2017 Jul 7;28(14):1950-1958. doi: 10.1091/mbc.E17-01-0046. Epub 2017 May 11.


Mechanical regulation of cardiac fibroblast profibrotic phenotypes.

Herum KM, Choppe J, Kumar A, Engler AJ, McCulloch AD.

Mol Biol Cell. 2017 Jul 7;28(14):1871-1882. doi: 10.1091/mbc.E17-01-0014. Epub 2017 May 3.


Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.

Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ.

Biophys J. 2017 Feb 28;112(4):736-745. doi: 10.1016/j.bpj.2016.12.038.


Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease.

Gibbons MC, Singh A, Anakwenze O, Cheng T, Pomerantz M, Schenk S, Engler AJ, Ward SR.

J Bone Joint Surg Am. 2017 Feb 1;99(3):190-199. doi: 10.2106/JBJS.16.00335.


Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline.

Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A.

Aging Cell. 2017 Feb;16(1):93-103. doi: 10.1111/acel.12543.


Controlled gas exchange in whole lung bioreactors.

Engler AJ, Le AV, Baevova P, Niklason LE.

J Tissue Eng Regen Med. 2018 Jan;12(1):e119-e129. doi: 10.1002/term.2408. Epub 2017 Jun 15.


Extracellular matrix downregulation in the Drosophila heart preserves contractile function and improves lifespan.

Sessions AO, Kaushik G, Parker S, Raedschelders K, Bodmer R, Van Eyk JE, Engler AJ.

Matrix Biol. 2017 Oct;62:15-27. doi: 10.1016/j.matbio.2016.10.008. Epub 2016 Oct 25.


High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.

Holle AW, McIntyre AJ, Kehe J, Wijesekara P, Young JL, Vincent LG, Engler AJ.

Integr Biol (Camb). 2016 Oct 10;8(10):1049-1058.


Rotator cuff tear state modulates self-renewal and differentiation capacity of human skeletal muscle progenitor cells.

Thomas KA, Gibbons MC, Lane JG, Singh A, Ward SR, Engler AJ.

J Orthop Res. 2017 Aug;35(8):1816-1823. doi: 10.1002/jor.23453. Epub 2016 Oct 16.


Sixth International AFM BioMed Conference on AFM in life sciences and medicine, December 13 to 17, 2014, San Diego, California.

Engler AJ, Parot P, Pellequer JL.

J Mol Recognit. 2016 Sep;29(9):404-5. doi: 10.1002/jmr.2556. No abstract available.


Equal channel angular extrusion of ultra-high molecular weight polyethylene.

Reinitz SD, Engler AJ, Carlson EM, Van Citters DW.

Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:623-628. doi: 10.1016/j.msec.2016.05.085. Epub 2016 May 20.


Mechanical Regulation of Cardiac Aging in Model Systems.

Sessions AO, Engler AJ.

Circ Res. 2016 May 13;118(10):1553-62. doi: 10.1161/CIRCRESAHA.116.307472. Review.


Muscle architectural changes after massive human rotator cuff tear.

Gibbons MC, Sato EJ, Bachasson D, Cheng T, Azimi H, Schenk S, Engler AJ, Singh A, Ward SR.

J Orthop Res. 2016 Dec;34(12):2089-2095. doi: 10.1002/jor.23256. Epub 2016 Apr 21.


Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction.

Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3185-90. doi: 10.1073/pnas.1521255113. Epub 2016 Mar 4.


Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis.

Happe CL, Engler AJ.

Circ Res. 2016 Jan 22;118(2):296-310. doi: 10.1161/CIRCRESAHA.115.305139. Review.


Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel.

Ondeck MG, Engler AJ.

J Biomech Eng. 2016 Feb;138(2):021003. doi: 10.1115/1.4032429.


Haptotaxis is cell type specific and limited by substrate adhesiveness.

Wen JH, Choi O, Taylor-Weiner H, Fuhrmann A, Karpiak JV, Almutairi A, Engler AJ.

Cell Mol Bioeng. 2015 Dec 1;8(4):530-542. Epub 2015 Jun 3.


The cytoskeleton regulates cell attachment strength.

Fuhrmann A, Engler AJ.

Biophys J. 2015 Jul 7;109(1):57-65. doi: 10.1016/j.bpj.2015.06.003.


Digital Plasmonic Patterning for Localized Tuning of Hydrogel Stiffness.

Hribar KC, Choi YS, Ondeck M, Engler AJ, Chen S.

Adv Funct Mater. 2014 Aug 20;24(31):4922-4926.


Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.

Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC.

Cell Stem Cell. 2015 Jul 2;17(1):89-100. doi: 10.1016/j.stem.2015.04.020. Epub 2015 Jun 18.


Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart.

Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ.

Sci Transl Med. 2015 Jun 17;7(292):292ra99. doi: 10.1126/scitranslmed.aaa5843.


Epimuscular Fat in the Human Rotator Cuff Is a Novel Beige Depot.

Meyer GA, Gibbons MC, Sato E, Lane JG, Ward SR, Engler AJ.

Stem Cells Transl Med. 2015 Jul;4(7):764-74. doi: 10.5966/sctm.2014-0287. Epub 2015 May 21.


Traction forces mediated by integrin signaling are necessary for definitive endoderm specification.

Taylor-Weiner H, Ravi N, Engler AJ.

J Cell Sci. 2015 May 15;128(10):1961-8. doi: 10.1242/jcs.166157. Epub 2015 Apr 23.


Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties.

Jun I, Lee YB, Choi YS, Engler AJ, Park H, Shin H.

Biomaterials. 2015 Jun;54:44-54. doi: 10.1016/j.biomaterials.2015.03.016. Epub 2015 Mar 29.


Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture.

Hribar KC, Finlay D, Ma X, Qu X, Ondeck MG, Chung PH, Zanella F, Engler AJ, Sheikh F, Vuori K, Chen SC.

Lab Chip. 2015 Jun 7;15(11):2412-8. doi: 10.1039/c5lc00159e. Epub 2015 Apr 22.


Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.

Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J.

Nat Cell Biol. 2015 May;17(5):678-88. doi: 10.1038/ncb3157. Epub 2015 Apr 20.


3D surface topology guides stem cell adhesion and differentiation.

Viswanathan P, Ondeck MG, Chirasatitsin S, Ngamkham K, Reilly GC, Engler AJ, Battaglia G.

Biomaterials. 2015 Jun;52:140-7. doi: 10.1016/j.biomaterials.2015.01.034. Epub 2015 Feb 24.


Effectiveness of a perinatal and pediatric End-of-Life Nursing Education Consortium (ELNEC) curricula integration.

O'Shea ER, Campbell SH, Engler AJ, Beauregard R, Chamberlin EC, Currie LM.

Nurse Educ Today. 2015 Jun;35(6):765-70. doi: 10.1016/j.nedt.2015.02.015. Epub 2015 Mar 5.


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