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A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals.

Yun JW, Lee S, Kim HM, Chun S, Engleman EG, Kim HC, Kang ES.

Cancers (Basel). 2019 Aug 12;11(8). pii: E1157. doi: 10.3390/cancers11081157.


Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC.

Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27.


A gut punch fights cancer and infection.

Reticker-Flynn NE, Engleman EG.

Nature. 2019 Jan;565(7741):573-574. doi: 10.1038/d41586-019-00133-w. No abstract available.


Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell-mediated remissions.

Dutt S, Atallah MB, Minamida Y, Filatenkov A, Jensen KP, Iliopoulou BP, Tamosiuniene R, Waters J, Engleman EG, Strober S.

Blood Adv. 2018 Oct 9;2(19):2568-2580. doi: 10.1182/bloodadvances.2018023119.


Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection.

Tsai S, Clemente-Casares X, Zhou AC, Lei H, Ahn JJ, Chan YT, Choi O, Luck H, Woo M, Dunn SE, Engleman EG, Watts TH, Winer S, Winer DA.

Cell Metab. 2018 Dec 4;28(6):922-934.e4. doi: 10.1016/j.cmet.2018.08.003. Epub 2018 Aug 30.


Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes.

Santana-Magal N, Rasoulouniriana D, Saperia C, Gutwillig A, Rider P, Engleman EG, Carmi Y.

J Vis Exp. 2018 May 31;(135). doi: 10.3791/57188.


Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity.

Carmi Y, Prestwood T, Engleman EG.

Oncoimmunology. 2018 May 7;8(10):e1078063. doi: 10.1080/2162402X.2015.1078063. eCollection 2019.


The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC.

Pancreas. 2018 May/Jun;47(5):516-525. doi: 10.1097/MPA.0000000000001037.


N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2.

Zhou MN, Delaveris CS, Kramer JR, Kenkel JA, Engleman EG, Bertozzi CR.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3137-3142. doi: 10.1002/anie.201713075. Epub 2018 Feb 21.


In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC-MS/MS.

Sun W, Nguyen KD, Fitch WL, Banister SD, Tang H, Zhang X, Yu L, Engleman EG, Rajadas J.

Rapid Commun Mass Spectrom. 2018 Jan 15. doi: 10.1002/rcm.8060. [Epub ahead of print]


High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.

Alcántara-Hernández M, Leylek R, Wagar LE, Engleman EG, Keler T, Marinkovich MP, Davis MM, Nolan GP, Idoyaga J.

Immunity. 2017 Dec 19;47(6):1037-1050.e6. doi: 10.1016/j.immuni.2017.11.001. Epub 2017 Dec 5.


An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer.

Kenkel JA, Tseng WW, Davidson MG, Tolentino LL, Choi O, Bhattacharya N, Seeley ES, Winer DA, Reticker-Flynn NE, Engleman EG.

Cancer Res. 2017 Aug 1;77(15):4158-4170. doi: 10.1158/0008-5472.CAN-16-2212. Epub 2017 Jun 13.


Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.

Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA.

Sci Immunol. 2017 Apr 21;2(10). pii: eaai7616. doi: 10.1126/sciimmunol.aai7616.


High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance.

Pham TD, Chng MHY, Roskin KM, Jackson KJL, Nguyen KD, Glanville J, Lee JY, Engleman EG, Boyd SD.

Mucosal Immunol. 2017 Nov;10(6):1468-1479. doi: 10.1038/mi.2017.25. Epub 2017 Apr 19.


A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes.

Zhang H, Gregorio JD, Iwahori T, Zhang X, Choi O, Tolentino LL, Prestwood T, Carmi Y, Engleman EG.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1988-1993. doi: 10.1073/pnas.1610630114. Epub 2017 Feb 6.


Adipose tissue macrophages impair preadipocyte differentiation in humans.

Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T.

PLoS One. 2017 Feb 2;12(2):e0170728. doi: 10.1371/journal.pone.0170728. eCollection 2017.


Systemic Immunity Is Required for Effective Cancer Immunotherapy.

Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG.

Cell. 2017 Jan 26;168(3):487-502.e15. doi: 10.1016/j.cell.2016.12.022. Epub 2017 Jan 19.


Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts.

Hongo D, Tang X, Zhang X, Engleman EG, Strober S.

Blood. 2017 Mar 23;129(12):1718-1728. doi: 10.1182/blood-2016-07-723015. Epub 2017 Jan 17.


Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.

Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG.

JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020.


Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.

Penny HL, Prestwood TR, Bhattacharya N, Sun F, Kenkel JA, Davidson MG, Shen L, Zuniga LA, Seeley ES, Pai R, Choi O, Tolentino L, Wang J, Napoli JL, Engleman EG.

Cancer Immunol Res. 2016 Nov;4(11):917-926. Epub 2016 Sep 16.


Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Bhattacharya N, Yuan R, Prestwood TR, Penny HL, DiMaio MA, Reticker-Flynn NE, Krois CR, Kenkel JA, Pham TD, Carmi Y, Tolentino L, Choi O, Hulett R, Wang J, Winer DA, Napoli JL, Engleman EG.

Immunity. 2016 Sep 20;45(3):641-655. doi: 10.1016/j.immuni.2016.08.008. Epub 2016 Aug 30.


Hypothesis: The Intratumoral Immune Response against a Cancer Progenitor Cell Impacts the Development of Well-Differentiated versus Dedifferentiated Disease in Liposarcoma.

Tseng WW, Chopra S, Engleman EG, Pollock RE.

Front Oncol. 2016 Jun 10;6:134. doi: 10.3389/fonc.2016.00134. eCollection 2016.


Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.

Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.


Tumor-binding antibodies and tumor immunity.

Carmi Y, Engleman EG.

Oncotarget. 2015 Nov 3;6(34):35129-30. No abstract available.


IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system.

Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP.

Science. 2015 Jul 10;349(6244):1259425. doi: 10.1126/science.1259425.


Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance.

Chng MH, Alonso MN, Barnes SE, Nguyen KD, Engleman EG.

Mediators Inflamm. 2015;2015:593075. doi: 10.1155/2015/593075. Epub 2015 Jun 4. Review.


The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue.

Liu LF, Kodama K, Wei K, Tolentino LL, Choi O, Engleman EG, Butte AJ, McLaughlin T.

Diabetologia. 2015 Jul;58(7):1579-86. doi: 10.1007/s00125-015-3603-y. Epub 2015 May 9.


Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG.

Nature. 2015 May 7;521(7550):99-104. doi: 10.1038/nature14424. Epub 2015 Apr 29.


Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions.

Filatenkov A, Baker J, Mueller AM, Kenkel J, Ahn GO, Dutt S, Zhang N, Kohrt H, Jensen K, Dejbakhsh-Jones S, Shizuru JA, Negrin RN, Engleman EG, Strober S.

Clin Cancer Res. 2015 Aug 15;21(16):3727-39. doi: 10.1158/1078-0432.CCR-14-2824. Epub 2015 Apr 13.


Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.

Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.

Cell Metab. 2015 Apr 7;21(4):527-42. doi: 10.1016/j.cmet.2015.03.001.


Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation.

Scandling JD, Busque S, Shizuru JA, Lowsky R, Hoppe R, Dejbakhsh-Jones S, Jensen K, Shori A, Strober JA, Lavori P, Turnbull BB, Engleman EG, Strober S.

Am J Transplant. 2015 Mar;15(3):695-704. doi: 10.1111/ajt.13091.


Potential for immunotherapy in soft tissue sarcoma.

Tseng WW, Somaiah N, Engleman EG.

Hum Vaccin Immunother. 2014;10(11):3117-24. doi: 10.4161/21645515.2014.983003. Review.


Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.

Segal E, Prestwood TR, van der Linden WA, Carmi Y, Bhattacharya N, Withana N, Verdoes M, Habtezion A, Engleman EG, Bogyo M.

Chem Biol. 2015 Jan 22;22(1):148-58. doi: 10.1016/j.chembiol.2014.11.008. Epub 2015 Jan 8.


Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.

Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG.

Eur J Immunol. 2015 Feb;45(2):612-23. doi: 10.1002/eji.201444760. Epub 2014 Nov 27.


Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.

Hongo D, Tang X, Baker J, Engleman EG, Strober S.

Am J Transplant. 2014 Nov;14(11):2467-77. doi: 10.1111/ajt.12914. Epub 2014 Oct 13.


B-1a lymphocytes attenuate insulin resistance.

Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG.

Diabetes. 2015 Feb;64(2):593-603. doi: 10.2337/db14-0554. Epub 2014 Sep 23.


Treatment of 4T1 metastatic breast cancer with combined hypofractionated irradiation and autologous T-cell infusion.

Filatenkov A, Baker J, Müller AM, Ahn GO, Kohrt H, Dutt S, Jensen K, Dejbakhsh-Jones S, Negrin RS, Shizuru JA, Engleman EG, Strober S.

Radiat Res. 2014 Aug;182(2):163-9. doi: 10.1667/RR13471.1. Epub 2014 Jul 3.


Depletion of inflammatory dendritic cells with anti-CD209 conjugated to saporin toxin.

Alonso MN, Gregorio JG, Davidson MG, Gonzalez JC, Engleman EG.

Immunol Res. 2014 May;58(2-3):374-7. doi: 10.1007/s12026-014-8511-6.


B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance.

Winer DA, Winer S, Chng MH, Shen L, Engleman EG.

Cell Mol Life Sci. 2014 Mar;71(6):1033-43. doi: 10.1007/s00018-013-1486-y. Epub 2013 Oct 15. Review.


In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells.

Davidson MG, Alonso MN, Kenkel JA, Suhoski MM, González JC, Yuan R, Engleman EG.

PLoS One. 2013 Oct 2;8(10):e76258. doi: 10.1371/journal.pone.0076258. eCollection 2013.


Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.

Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG.

J Immunol. 2013 Aug 1;191(3):1175-87. doi: 10.4049/jimmunol.1203201. Epub 2013 Jun 21.


Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC.

Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28.


B lymphocytes as emerging mediators of insulin resistance.

Winer DA, Winer S, Shen L, Chng MH, Engleman EG.

Int J Obes Suppl. 2012 Jul;2(Suppl 1):S4-S7.


Cd14 SNPs regulate the innate immune response.

Liu HH, Hu Y, Zheng M, Suhoski MM, Engleman EG, Dill DL, Hudnall M, Wang J, Spolski R, Leonard WJ, Peltz G.

Mol Immunol. 2012 Jun;51(2):112-27. doi: 10.1016/j.molimm.2012.02.112. Epub 2012 Mar 23.


Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants.

Scandling JD, Busque S, Dejbakhsh-Jones S, Benike C, Sarwal M, Millan MT, Shizuru JA, Lowsky R, Engleman EG, Strober S.

Am J Transplant. 2012 May;12(5):1133-45. doi: 10.1111/j.1600-6143.2012.03992.x. Epub 2012 Mar 8.


Induced immune tolerance for kidney transplantation.

Scandling JD, Busque S, Shizuru JA, Engleman EG, Strober S.

N Engl J Med. 2011 Oct 6;365(14):1359-60. doi: 10.1056/NEJMc1107841. No abstract available.


T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets.

Alonso MN, Wong MT, Zhang AL, Winer D, Suhoski MM, Tolentino LL, Gaitan J, Davidson MG, Kung TH, Galel DM, Nadeau KC, Kim J, Utz PJ, Söderström K, Engleman EG.

Blood. 2011 Sep 22;118(12):3311-20. doi: 10.1182/blood-2011-03-341065. Epub 2011 Aug 2.


B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.

Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, Leong HX, Glassford A, Caimol M, Kenkel JA, Tedder TF, McLaughlin T, Miklos DB, Dosch HM, Engleman EG.

Nat Med. 2011 May;17(5):610-7. doi: 10.1038/nm.2353. Epub 2011 Apr 17.


The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP.

Zhang B, Lo C, Shen L, Sood R, Jones C, Cusmano-Ozog K, Park-Snyder S, Wong W, Jeng M, Cowan T, Engleman EG, Zehnder JL.

Blood. 2011 Apr 28;117(17):4569-79. doi: 10.1182/blood-2010-09-304931. Epub 2011 Feb 16.


Plasmacytoid dendritic cell dichotomy: identification of IFN-α producing cells as a phenotypically and functionally distinct subset.

Björck P, Leong HX, Engleman EG.

J Immunol. 2011 Feb 1;186(3):1477-85. doi: 10.4049/jimmunol.1000454. Epub 2010 Dec 20.

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