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Mixed chimerism and acceptance of kidney transplants after immunosuppressive drug withdrawal.

Busque S, Scandling JD, Lowsky R, Shizuru J, Jensen K, Waters J, Wu HH, Sheehan K, Shori A, Choi O, Pham T, Fernandez Vina MA, Hoppe R, Tamaresis J, Lavori P, Engleman EG, Meyer E, Strober S.

Sci Transl Med. 2020 Jan 29;12(528). pii: eaax8863. doi: 10.1126/scitranslmed.aax8863.


Peri-adolescent alcohol consumption increases sensitivity and dopaminergic response to nicotine during adulthood in female alcohol-preferring (P) rats: Alterations to α7 nicotinic acetylcholine receptor expression.

Waeiss RA, Knight CP, Carvajal GB, Bell RL, Engleman EA, McBride WJ, Hauser SR, Rodd ZA.

Behav Brain Res. 2019 Dec 30;376:112190. doi: 10.1016/j.bbr.2019.112190. Epub 2019 Aug 29.


A Novel Type of Blood Biomarker: Distinct Changes of Cytokine-Induced STAT Phosphorylation in Blood T Cells Between Colorectal Cancer Patients and Healthy Individuals.

Yun JW, Lee S, Kim HM, Chun S, Engleman EG, Kim HC, Kang ES.

Cancers (Basel). 2019 Aug 12;11(8). pii: E1157. doi: 10.3390/cancers11081157.


Myeloid sphingosine-1-phosphate receptor 1 is important for CNS autoimmunity and neuroinflammation.

Tsai HC, Nguyen K, Hashemi E, Engleman E, Hla T, Han MH.

J Autoimmun. 2019 Dec;105:102290. doi: 10.1016/j.jaut.2019.06.001. Epub 2019 Jun 12.


Structure of the IFNγ receptor complex guides design of biased agonists.

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC.

Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27.


Caenorhabditis elegans as a model system to identify therapeutics for alcohol use disorders.

Katner SN, Bredhold KE, Steagall KB 2nd, Bell RL, Neal-Beliveau BS, Cheong MC, Engleman EA.

Behav Brain Res. 2019 Jun 3;365:7-16. doi: 10.1016/j.bbr.2019.02.015. Epub 2019 Feb 22.


A gut punch fights cancer and infection.

Reticker-Flynn NE, Engleman EG.

Nature. 2019 Jan;565(7741):573-574. doi: 10.1038/d41586-019-00133-w. No abstract available.


Polysubstance addiction vulnerability in mental illness: Concurrent alcohol and nicotine self-administration in the neurodevelopmental hippocampal lesion rat model of schizophrenia.

Sentir AM, Bell RL, Engleman EA, Chambers RA.

Addict Biol. 2020 Jan;25(1):e12704. doi: 10.1111/adb.12704. Epub 2018 Dec 28.


Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases.

Vallania F, Tam A, Lofgren S, Schaffert S, Azad TD, Bongen E, Haynes W, Alsup M, Alonso M, Davis M, Engleman E, Khatri P.

Nat Commun. 2018 Nov 9;9(1):4735. doi: 10.1038/s41467-018-07242-6.


Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell-mediated remissions.

Dutt S, Atallah MB, Minamida Y, Filatenkov A, Jensen KP, Iliopoulou BP, Tamosiuniene R, Waters J, Engleman EG, Strober S.

Blood Adv. 2018 Oct 9;2(19):2568-2580. doi: 10.1182/bloodadvances.2018023119.


Caenorhabditis elegans Show Preference for Stimulants and Potential as a Model Organism for Medications Screening.

Engleman EA, Steagall KB 2nd, Bredhold KE, Breach M, Kline HL, Bell RL, Katner SN, Neal-Beliveau BS.

Front Physiol. 2018 Aug 30;9:1200. doi: 10.3389/fphys.2018.01200. eCollection 2018.


Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection.

Tsai S, Clemente-Casares X, Zhou AC, Lei H, Ahn JJ, Chan YT, Choi O, Luck H, Woo M, Dunn SE, Engleman EG, Watts TH, Winer S, Winer DA.

Cell Metab. 2018 Dec 4;28(6):922-934.e4. doi: 10.1016/j.cmet.2018.08.003. Epub 2018 Aug 30.


Use of Flow Cytometry for Diagnosis of Epilepsy Associated With Homozygous PIGW Variants.

Foskett GK, Engleman E, Klotz J, Choi O, Tolentino L, Kochhar A, Yang QZ, Stevenson DA.

Pediatr Neurol. 2018 Aug;85:67-70. doi: 10.1016/j.pediatrneurol.2018.05.010. Epub 2018 Jun 5.


Selective breeding for high alcohol consumption and response to nicotine: locomotor activity, dopaminergic in the mesolimbic system, and innate genetic differences in male and female alcohol-preferring, non-preferring, and replicate lines of high-alcohol drinking and low-alcohol drinking rats.

Deehan GA Jr, Hauser SR, Getachew B, Waeiss RA, Engleman EA, Knight CP, McBride WJ, Truitt WA, Bell RL, Rodd ZA.

Psychopharmacology (Berl). 2018 Sep;235(9):2755-2769. doi: 10.1007/s00213-018-4970-0. Epub 2018 Jul 24.


Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes.

Santana-Magal N, Rasoulouniriana D, Saperia C, Gutwillig A, Rider P, Engleman EG, Carmi Y.

J Vis Exp. 2018 May 31;(135). doi: 10.3791/57188.


Tumor-binding antibodies induce potent dendritic cell-mediated tumor immunity.

Carmi Y, Prestwood T, Engleman EG.

Oncoimmunology. 2018 May 7;8(10):e1078063. doi: 10.1080/2162402X.2015.1078063. eCollection 2019.


The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC.

Pancreas. 2018 May/Jun;47(5):516-525. doi: 10.1097/MPA.0000000000001037.


N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2.

Zhou MN, Delaveris CS, Kramer JR, Kenkel JA, Engleman EG, Bertozzi CR.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3137-3142. doi: 10.1002/anie.201713075. Epub 2018 Feb 21.


In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC-MS/MS.

Sun W, Nguyen KD, Fitch WL, Banister SD, Tang H, Zhang X, Yu L, Engleman EG, Rajadas J.

Rapid Commun Mass Spectrom. 2018 Jan 15. doi: 10.1002/rcm.8060. [Epub ahead of print]


Macrochimerism and clinical transplant tolerance.

Scandling JD, Busque S, Lowsky R, Shizuru J, Shori A, Engleman E, Jensen K, Strober S.

Hum Immunol. 2018 May;79(5):266-271. doi: 10.1016/j.humimm.2018.01.002. Epub 2018 Jan 9. Review.


High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.

Alcántara-Hernández M, Leylek R, Wagar LE, Engleman EG, Keler T, Marinkovich MP, Davis MM, Nolan GP, Idoyaga J.

Immunity. 2017 Dec 19;47(6):1037-1050.e6. doi: 10.1016/j.immuni.2017.11.001. Epub 2017 Dec 5.


An Immunosuppressive Dendritic Cell Subset Accumulates at Secondary Sites and Promotes Metastasis in Pancreatic Cancer.

Kenkel JA, Tseng WW, Davidson MG, Tolentino LL, Choi O, Bhattacharya N, Seeley ES, Winer DA, Reticker-Flynn NE, Engleman EG.

Cancer Res. 2017 Aug 1;77(15):4158-4170. doi: 10.1158/0008-5472.CAN-16-2212. Epub 2017 Jun 13.


Type I Interferon Responses Drive Intrahepatic T cells to Promote Metabolic Syndrome.

Ghazarian M, Revelo XS, Nøhr MK, Luck H, Zeng K, Lei H, Tsai S, Schroer SA, Park YJ, Chng MHY, Shen L, D'Angelo JA, Horton P, Chapman WC, Brockmeier D, Woo M, Engleman EG, Adeyi O, Hirano N, Jin T, Gehring AJ, Winer S, Winer DA.

Sci Immunol. 2017 Apr 21;2(10). pii: eaai7616. doi: 10.1126/sciimmunol.aai7616.


High-fat diet induces systemic B-cell repertoire changes associated with insulin resistance.

Pham TD, Chng MHY, Roskin KM, Jackson KJL, Nguyen KD, Glanville J, Lee JY, Engleman EG, Boyd SD.

Mucosal Immunol. 2017 Nov;10(6):1468-1479. doi: 10.1038/mi.2017.25. Epub 2017 Apr 19.


A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes.

Zhang H, Gregorio JD, Iwahori T, Zhang X, Choi O, Tolentino LL, Prestwood T, Carmi Y, Engleman EG.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1988-1993. doi: 10.1073/pnas.1610630114. Epub 2017 Feb 6.


Adipose tissue macrophages impair preadipocyte differentiation in humans.

Liu LF, Craig CM, Tolentino LL, Choi O, Morton J, Rivas H, Cushman SW, Engleman EG, McLaughlin T.

PLoS One. 2017 Feb 2;12(2):e0170728. doi: 10.1371/journal.pone.0170728. eCollection 2017.


Systemic Immunity Is Required for Effective Cancer Immunotherapy.

Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG.

Cell. 2017 Jan 26;168(3):487-502.e15. doi: 10.1016/j.cell.2016.12.022. Epub 2017 Jan 19.


Tolerogenic interactions between CD8+ dendritic cells and NKT cells prevent rejection of bone marrow and organ grafts.

Hongo D, Tang X, Zhang X, Engleman EG, Strober S.

Blood. 2017 Mar 23;129(12):1718-1728. doi: 10.1182/blood-2016-07-723015. Epub 2017 Jan 17.


Role of innate and adaptive immunity in obesity-associated metabolic disease.

McLaughlin T, Ackerman SE, Shen L, Engleman E.

J Clin Invest. 2017 Jan 3;127(1):5-13. doi: 10.1172/JCI88876. Epub 2017 Jan 3. Review.


Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.

Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG.

JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020.


Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.

Penny HL, Prestwood TR, Bhattacharya N, Sun F, Kenkel JA, Davidson MG, Shen L, Zuniga LA, Seeley ES, Pai R, Choi O, Tolentino L, Wang J, Napoli JL, Engleman EG.

Cancer Immunol Res. 2016 Nov;4(11):917-926. Epub 2016 Sep 16.


Prescription drug monitoring program data tracking of opioid addiction treatment outcomes in integrated dual diagnosis care involving injectable naltrexone.

Sajid A, Whiteman A, Bell RL, Greene MS, Engleman EA, Chambers RA.

Am J Addict. 2016 Oct;25(7):557-64. doi: 10.1111/ajad.12441. Epub 2016 Sep 20.


Toward early estimation and treatment of addiction vulnerability: radial arm maze and N-acetyl cysteine before cocaine sensitization or nicotine self-administration in neonatal ventral hippocampal lesion rats.

Rao KN, Sentir AM, Engleman EA, Bell RL, Hulvershorn LA, Breier A, Chambers RA.

Psychopharmacology (Berl). 2016 Dec;233(23-24):3933-3945. Epub 2016 Sep 17.


Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Bhattacharya N, Yuan R, Prestwood TR, Penny HL, DiMaio MA, Reticker-Flynn NE, Krois CR, Kenkel JA, Pham TD, Carmi Y, Tolentino L, Choi O, Hulett R, Wang J, Winer DA, Napoli JL, Engleman EG.

Immunity. 2016 Sep 20;45(3):641-655. doi: 10.1016/j.immuni.2016.08.008. Epub 2016 Aug 30.


Progression of EGFR-Mutant Lung Adenocarcinoma is Driven By Alveolar Macrophages.

Wang DH, Lee HS, Yoon D, Berry G, Wheeler TM, Sugarbaker DJ, Kheradmand F, Engleman E, Burt BM.

Clin Cancer Res. 2017 Feb 1;23(3):778-788. doi: 10.1158/1078-0432.CCR-15-2597. Epub 2016 Aug 5.


Hypothesis: The Intratumoral Immune Response against a Cancer Progenitor Cell Impacts the Development of Well-Differentiated versus Dedifferentiated Disease in Liposarcoma.

Tseng WW, Chopra S, Engleman EG, Pollock RE.

Front Oncol. 2016 Jun 10;6:134. doi: 10.3389/fonc.2016.00134. eCollection 2016.


Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance.

Revelo XS, Ghazarian M, Chng MH, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Liu CL, Tangsombatvisit S, Tsui H, Sima C, Xiao C, Shen L, Li X, Jin T, Lewis GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, Winer DA.

Cell Rep. 2016 Jul 19;16(3):717-30. doi: 10.1016/j.celrep.2016.06.024. Epub 2016 Jun 30.


Peripheral Administration of Ethanol Results in a Correlated Increase in Dopamine and Serotonin Within the Posterior Ventral Tegmental Area.

Deehan GA Jr, Knight CP, Waeiss RA, Engleman EA, Toalston JE, McBride WJ, Hauser SR, Rodd ZA.

Alcohol Alcohol. 2016 Sep;51(5):535-40. doi: 10.1093/alcalc/agw037. Epub 2016 Jun 15.


Embryonic Methamphetamine Exposure Inhibits Methamphetamine Cue Conditioning and Reduces Dopamine Concentrations in Adult N2 Caenorhabditis elegans.

Katner SN, Neal-Beliveau BS, Engleman EA.

Dev Neurosci. 2016;38(2):139-49. doi: 10.1159/000445761. Epub 2016 May 28.


A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.

Bell RL, Hauser S, Rodd ZA, Liang T, Sari Y, McClintick J, Rahman S, Engleman EA.

Int Rev Neurobiol. 2016;126:179-261. doi: 10.1016/bs.irn.2016.02.017. Epub 2016 Mar 21. Review.


Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction.

Engleman EA, Katner SN, Neal-Beliveau BS.

Prog Mol Biol Transl Sci. 2016;137:229-52. doi: 10.1016/bs.pmbts.2015.10.019. Epub 2015 Nov 24. Review.


Recent Advances in Nicotinic Receptor Signaling in Alcohol Abuse and Alcoholism.

Rahman S, Engleman EA, Bell RL.

Prog Mol Biol Transl Sci. 2016;137:183-201. doi: 10.1016/bs.pmbts.2015.10.004. Epub 2015 Nov 3. Review.


Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.

Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.


Pharmacological depletion of serotonin in the basolateral amygdala complex reduces anxiety and disrupts fear conditioning.

Johnson PL, Molosh A, Fitz SD, Arendt D, Deehan GA, Federici LM, Bernabe C, Engleman EA, Rodd ZA, Lowry CA, Shekhar A.

Pharmacol Biochem Behav. 2015 Nov;138:174-9. doi: 10.1016/j.pbb.2015.09.021.


Tumor-binding antibodies and tumor immunity.

Carmi Y, Engleman EG.

Oncotarget. 2015 Nov 3;6(34):35129-30. No abstract available.


IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system.

Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP.

Science. 2015 Jul 10;349(6244):1259425. doi: 10.1126/science.1259425.


Adaptive Immunity and Antigen-Specific Activation in Obesity-Associated Insulin Resistance.

Chng MH, Alonso MN, Barnes SE, Nguyen KD, Engleman EG.

Mediators Inflamm. 2015;2015:593075. doi: 10.1155/2015/593075. Epub 2015 Jun 4. Review.


The reinforcing properties of ethanol are quantitatively enhanced in adulthood by peri-adolescent ethanol, but not saccharin, consumption in female alcohol-preferring (P) rats.

Toalston JE, Deehan GA Jr, Hauser SR, Engleman EA, Bell RL, Murphy JM, McBride WJ, Rodd ZA.

Alcohol. 2015 Aug;49(5):513-8. doi: 10.1016/j.alcohol.2015.04.007. Epub 2015 May 22.


Targeting glutamate uptake to treat alcohol use disorders.

Rao PS, Bell RL, Engleman EA, Sari Y.

Front Neurosci. 2015 Apr 23;9:144. doi: 10.3389/fnins.2015.00144. eCollection 2015. Review.

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