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Items: 1 to 50 of 66

1.

Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure.

Chen Z, Diaz G, Pollicino T, Zhao H, Engle RE, Schuck P, Shen CH, Zamboni F, Long Z, Kabat J, De Battista D, Bock KW, Moore IN, Wollenberg K, Soto C, Govindarajan S, Kwong PD, Kleiner DE, Purcell RH, Farci P.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11369-E11378. doi: 10.1073/pnas.1809028115. Epub 2018 Nov 12.

2.

Molecular Signature and Mechanisms of Hepatitis D Virus-Associated Hepatocellular Carcinoma.

Diaz G, Engle RE, Tice A, Melis M, Montenegro S, Rodriguez-Canales J, Hanson J, Emmert-Buck MR, Bock KW, Moore IN, Zamboni F, Govindarajan S, Kleiner DE, Farci P.

Mol Cancer Res. 2018 Sep;16(9):1406-1419. doi: 10.1158/1541-7786.MCR-18-0012. Epub 2018 Jun 1.

PMID:
29858376
3.

Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma.

Sekhar V, Pollicino T, Diaz G, Engle RE, Alayli F, Melis M, Kabat J, Tice A, Pomerenke A, Altan-Bonnet N, Zamboni F, Lusso P, Emerson SU, Farci P.

PLoS Pathog. 2018 Mar 14;14(3):e1006916. doi: 10.1371/journal.ppat.1006916. eCollection 2018 Mar.

4.

Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda.

Boon D, Redd AD, Laeyendecker O, Engle RE, Nguyen H, Ocama P, Boaz I, Ndyanabo A, Kiggundu V, Reynolds SJ, Gray RH, Wawer MJ, Purcell RH, Kirk GD, Quinn TC, Stabinski L; Rakai Health Sciences Program.

J Infect Dis. 2018 Feb 14;217(5):785-789. doi: 10.1093/infdis/jix610.

5.

Reply.

Fontana RJ, Engle RE, Purcell RH, Lee WM; ALFSG.

Hepatology. 2017 Jan;65(1):389-390. doi: 10.1002/hep.28794. Epub 2016 Oct 6. No abstract available.

6.

The role of hepatitis E virus infection in adult Americans with acute liver failure.

Fontana RJ, Engle RE, Scaglione S, Araya V, Shaikh O, Tillman H, Attar N, Purcell RH, Lee WM; US Acute Liver Failure Study Group.

Hepatology. 2016 Dec;64(6):1870-1880. doi: 10.1002/hep.28649. Epub 2016 Jun 23.

7.

Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue.

Harouaka D, Engle RE, Wollenberg K, Diaz G, Tice AB, Zamboni F, Govindarajan S, Alter H, Kleiner DE, Farci P.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1375-80. doi: 10.1073/pnas.1516879113. Epub 2016 Jan 19.

8.

The Association of Cytokines and Micronutrients with Hepatitis E Virus Infection During Pregnancy and the Postpartum Period in Rural Bangladesh.

Kmush BL, Labrique A, Li W, Klein SL, Schulze K, Shaikh S, Ali H, Engle RE, Wu L, Purcell RH, Mehra S, Christian P, West K Jr, Nelson K.

Am J Trop Med Hyg. 2016 Jan;94(1):203-11. doi: 10.4269/ajtmh.15-0238. Epub 2015 Nov 30.

9.

An Epidemiologic Investigation of a Case of Acute Hepatitis E.

Sarkar S, Rivera EM, Engle RE, Nguyen HT, Schechterly CA, Alter HJ, Liang TJ, Purcell RH, Hoofnagle JH, Ghany MG.

J Clin Microbiol. 2015 Nov;53(11):3547-52. doi: 10.1128/JCM.01189-15. Epub 2015 Sep 2.

10.

Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge.

Bukh J, Engle RE, Faulk K, Wang RY, Farci P, Alter HJ, Purcell RH.

J Virol. 2015 Sep;89(17):9128-32. doi: 10.1128/JVI.01194-15. Epub 2015 Jun 17.

11.

Declining prevalence of hepatitis E antibodies among Danish blood donors.

Holm DK, Moessner BK, Engle RE, Zaaijer HL, Georgsen J, Purcell RH, Christensen PB.

Transfusion. 2015 Jul;55(7):1662-7. doi: 10.1111/trf.13028. Epub 2015 Mar 27.

PMID:
25819381
12.

Nonalcoholic Steatohepatitis and Hepatic Fibrosis in HIV-1-Monoinfected Adults With Elevated Aminotransferase Levels on Antiretroviral Therapy.

Morse CG, McLaughlin M, Matthews L, Proschan M, Thomas F, Gharib AM, Abu-Asab M, Orenstein A, Engle RE, Hu X, Lempicki R, Hadigan C, Kleiner DE, Heller T, Kovacs JA.

Clin Infect Dis. 2015 May 15;60(10):1569-78. doi: 10.1093/cid/civ101. Epub 2015 Feb 13.

13.

Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus-associated hepatocellular carcinoma.

Melis M, Diaz G, Kleiner DE, Zamboni F, Kabat J, Lai J, Mogavero G, Tice A, Engle RE, Becker S, Brown CR, Hanson JC, Rodriguez-Canales J, Emmert-Buck M, Govindarajan S, Kew M, Farci P.

J Transl Med. 2014 Aug 21;12:230. doi: 10.1186/s12967-014-0230-1.

14.

Hepatitis E virus seroprevalence in the United States: no easy answers.

Kuniholm MH, Engle RE, Purcell RH, Nelson KE.

Hepatology. 2015 Apr;61(4):1441-2. doi: 10.1002/hep.27286. Epub 2014 Oct 24. No abstract available.

15.

Hepatitis E virus seroprevalence in the National Health and Nutrition Examination Survey: facts trump opinion.

Engle RE, Kuniholm MH, Nelson KE, Purcell RH.

Hepatology. 2015 Apr;61(4):1442. doi: 10.1002/hep.27292. Epub 2015 Feb 27. No abstract available.

PMID:
24995541
16.

Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors.

Engle RE, Bukh J, Alter HJ, Emerson SU, Trenbeath JL, Nguyen HT, Brockington A, Mitra T, Purcell RH.

Transfusion. 2014 Nov;54(11):2833-41. doi: 10.1111/trf.12682. Epub 2014 May 5.

17.

Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.

Wieland SF, Asabe S, Engle RE, Purcell RH, Chisari FV.

J Virol. 2014 May;88(9):5184-8. doi: 10.1128/JVI.03553-13. Epub 2014 Feb 12.

18.

Chronic hepatitis E with neurologic manifestations and rapid progression of liver fibrosis in a liver transplant recipient.

Maddukuri VC, Russo MW, Ahrens WA, Emerson SU, Engle RE, Purcell RH, Thompson EB, Bonkovsky HL.

Dig Dis Sci. 2013 Aug;58(8):2413-6. doi: 10.1007/s10620-013-2628-7. Epub 2013 Mar 20. No abstract available.

PMID:
23512404
19.

Pathobiology of hepatitis E: lessons learned from primate models.

Purcell RH, Engle RE, Govindarajan S, Herbert R, St Claire M, Elkins WR, Cook A, Shaver C, Beauregard M, Swerczek J, Emerson SU.

Emerg Microbes Infect. 2013 Mar;2(3):e9. doi: 10.1038/emi.2013.9. Epub 2013 Mar 13.

20.

Serological evidence for a hepatitis e virus-related agent in goats in the United States.

Sanford BJ, Emerson SU, Purcell RH, Engle RE, Dryman BA, Cecere TE, Buechner-Maxwell V, Sponenberg DP, Meng XJ.

Transbound Emerg Dis. 2013 Dec;60(6):538-45. doi: 10.1111/tbed.12001. Epub 2012 Aug 22.

21.

Profibrogenic chemokines and viral evolution predict rapid progression of hepatitis C to cirrhosis.

Farci P, Wollenberg K, Diaz G, Engle RE, Lai ME, Klenerman P, Purcell RH, Pybus OG, Alter HJ.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14562-7. doi: 10.1073/pnas.1210592109. Epub 2012 Jul 24.

22.

Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Shukla P, Nguyen HT, Faulk K, Mather K, Torian U, Engle RE, Emerson SU.

J Virol. 2012 May;86(10):5697-707. doi: 10.1128/JVI.00146-12. Epub 2012 Mar 7.

23.

Hepatitis E virus in rats, Los Angeles, California, USA.

Purcell RH, Engle RE, Rood MP, Kabrane-Lazizi Y, Nguyen HT, Govindarajan S, St Claire M, Emerson SU.

Emerg Infect Dis. 2011 Dec;17(12):2216-22. doi: 10.3201/eid1712.110482.

24.

A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture.

Nguyen HT, Torian U, Faulk K, Mather K, Engle RE, Thompson E, Bonkovsky HL, Emerson SU.

J Gen Virol. 2012 Mar;93(Pt 3):526-30. doi: 10.1099/vir.0.037259-0. Epub 2011 Nov 23.

25.

Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury.

Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH; Drug-Induced Liver Injury Network (DILIN).

Gastroenterology. 2011 Nov;141(5):1665-72.e1-9. doi: 10.1053/j.gastro.2011.07.051. Epub 2011 Aug 16.

26.

Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.

Shukla P, Nguyen HT, Torian U, Engle RE, Faulk K, Dalton HR, Bendall RP, Keane FE, Purcell RH, Emerson SU.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2438-43. doi: 10.1073/pnas.1018878108. Epub 2011 Jan 24.

27.

Pathogenesis of hepatitis E virus and hepatitis C virus in chimpanzees: similarities and differences.

Yu C, Boon D, McDonald SL, Myers TG, Tomioka K, Nguyen H, Engle RE, Govindarajan S, Emerson SU, Purcell RH.

J Virol. 2010 Nov;84(21):11264-78. doi: 10.1128/JVI.01205-10. Epub 2010 Aug 25.

28.

B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus-associated acute liver failure.

Farci P, Diaz G, Chen Z, Govindarajan S, Tice A, Agulto L, Pittaluga S, Boon D, Yu C, Engle RE, Haas M, Simon R, Purcell RH, Zamboni F.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8766-71. doi: 10.1073/pnas.1003854107. Epub 2010 Apr 26.

29.

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.

Bukh J, Meuleman P, Tellier R, Engle RE, Feinstone SM, Eder G, Satterfield WC, Govindarajan S, Krawczynski K, Miller RH, Leroux-Roels G, Purcell RH.

J Infect Dis. 2010 May 1;201(9):1381-9. doi: 10.1086/651579.

30.

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies.

Gottwein JM, Scheel TK, Callendret B, Li YP, Eccleston HB, Engle RE, Govindarajan S, Satterfield W, Purcell RH, Walker CM, Bukh J.

J Virol. 2010 May;84(10):5277-93. doi: 10.1128/JVI.02667-09. Epub 2010 Mar 3.

31.

Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins.

Takikawa S, Engle RE, Faulk KN, Emerson SU, Purcell RH, Bukh J.

J Gen Virol. 2010 Mar;91(Pt 3):727-33. doi: 10.1099/vir.0.015750-0. Epub 2009 Nov 11.

32.

The size of the viral inoculum contributes to the outcome of hepatitis B virus infection.

Asabe S, Wieland SF, Chattopadhyay PK, Roederer M, Engle RE, Purcell RH, Chisari FV.

J Virol. 2009 Oct;83(19):9652-62. doi: 10.1128/JVI.00867-09. Epub 2009 Jul 22.

33.

Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988-1994.

Kuniholm MH, Purcell RH, McQuillan GM, Engle RE, Wasley A, Nelson KE.

J Infect Dis. 2009 Jul 1;200(1):48-56. doi: 10.1086/599319.

34.

Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark.

Christensen PB, Engle RE, Hjort C, Homburg KM, Vach W, Georgsen J, Purcell RH.

Clin Infect Dis. 2008 Oct 15;47(8):1026-31. doi: 10.1086/591970.

35.

Apolipoprotein c1 association with hepatitis C virus.

Meunier JC, Russell RS, Engle RE, Faulk KN, Purcell RH, Emerson SU.

J Virol. 2008 Oct;82(19):9647-56. doi: 10.1128/JVI.00914-08. Epub 2008 Jul 30.

36.

Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus.

Russell RS, Meunier JC, Takikawa S, Faulk K, Engle RE, Bukh J, Purcell RH, Emerson SU.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4370-5. doi: 10.1073/pnas.0800422105. Epub 2008 Mar 11.

37.
38.
39.

Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.

Shata MT, Barrett A, Shire NJ, Abdelwahab SF, Sobhy M, Daef E, El-Kamary SS, Hashem M, Engle RE, Purcell RH, Emerson SU, Strickland GT, Sherman KE.

J Immunol Methods. 2007 Dec 1;328(1-2):152-61. Epub 2007 Sep 19.

40.
41.

Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention.

Goncalvez AP, Engle RE, St Claire M, Purcell RH, Lai CJ.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7. Epub 2007 May 15.

42.

Using improved technology for filter paper-based blood collection to survey wild Sika deer for antibodies to hepatitis E virus.

Yu C, Zimmerman C, Stone R, Engle RE, Elkins W, Nardone GA, Emerson SU, Purcell RH.

J Virol Methods. 2007 Jun;142(1-2):143-50. Epub 2007 Mar 2.

43.

Functional analyses of GB virus B p13 protein: development of a recombinant GB virus B hepatitis virus with a p7 protein.

Takikawa S, Engle RE, Emerson SU, Purcell RH, St Claire M, Bukh J.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3345-50. Epub 2006 Feb 21.

44.

Active surveillance for acute viral hepatitis in rural villages in the Nile Delta.

Meky FA, Stoszek SK, Abdel-Hamid M, Selim S, Abdel-Wahab A, Mikhail N, El-Kafrawy S, El-Daly M, Abdel-Aziz F, Sharaf S, Mohamed MK, Engle RE, Emerson SU, Purcell RH, Fix AD, Strickland GT.

Clin Infect Dis. 2006 Mar 1;42(5):628-33. Epub 2006 Jan 25.

PMID:
16447107
45.

Testing of CpG-optimized protein and DNA vaccines against the hepatitis B virus in chimpanzees for immunogenicity and protection from challenge.

Payette PJ, Ma X, Weeratna RD, McCluskie MJ, Shapiro M, Engle RE, Davis HL, Purcell RH.

Intervirology. 2006;49(3):144-51.

PMID:
16428890
46.

Hepatitis E antibody seroconversion without disease in highly endemic rural Egyptian communities.

Stoszek SK, Engle RE, Abdel-Hamid M, Mikhail N, Abdel-Aziz F, Medhat A, Fix AD, Emerson SU, Purcell RH, Strickland GT.

Trans R Soc Trop Med Hyg. 2006 Feb;100(2):89-94. Epub 2005 Oct 28.

PMID:
16257427
47.

High prevalence of hepatitis E antibodies in pregnant Egyptian women.

Stoszek SK, Abdel-Hamid M, Saleh DA, El Kafrawy S, Narooz S, Hawash Y, Shebl FM, El Daly M, Said A, Kassem E, Mikhail N, Engle RE, Sayed M, Sharaf S, Fix AD, Emerson SU, Purcell RH, Strickland GT.

Trans R Soc Trop Med Hyg. 2006 Feb;100(2):95-101. Epub 2005 Oct 28.

PMID:
16257426
48.

Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1.

Meunier JC, Engle RE, Faulk K, Zhao M, Bartosch B, Alter H, Emerson SU, Cosset FL, Purcell RH, Bukh J.

Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4560-5. Epub 2005 Mar 14.

49.
50.

In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes.

Bartosch B, Bukh J, Meunier JC, Granier C, Engle RE, Blackwelder WC, Emerson SU, Cosset FL, Purcell RH.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204. Epub 2003 Nov 14.

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