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Radiochemical isolation method for the production of 52gMn from natCr for accelerator targets.

Barrett KE, Aluicio-Sarduy E, Olson AP, Kutyreff CJ, Ellison PA, Barnhart TE, Nickles RJ, Engle JW.

Appl Radiat Isot. 2019 Feb 1;146:99-103. doi: 10.1016/j.apradiso.2019.01.025. [Epub ahead of print]


Antibody and fragment-based PET imaging of CTLA-4+ T-cells in humanized mouse models.

Ehlerding EB, Lee HJ, Jiang D, Ferreira CA, Zahm CD, Huang P, Engle JW, McNeel DG, Cai W.

Am J Cancer Res. 2019 Jan 1;9(1):53-63. eCollection 2019.


Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice.

Ni D, Jiang D, Kutyreff CJ, Lai J, Yan Y, Barnhart TE, Yu B, Im HJ, Kang L, Cho SY, Liu Z, Huang P, Engle JW, Cai W.

Nat Commun. 2018 Dec 21;9(1):5421. doi: 10.1038/s41467-018-07890-8.


DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury.

Jiang D, Ge Z, Im HJ, England CG, Ni D, Hou J, Zhang L, Kutyreff CJ, Yan Y, Liu Y, Cho SY, Engle JW, Shi J, Huang P, Fan C, Yan H, Cai W.

Nat Biomed Eng. 2018 Nov;2(11):865-877. doi: 10.1038/s41551-018-0317-8. Epub 2018 Nov 8.


In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem.

Shi S, Chen F, Goel S, Graves SA, Luo H, Theuer CP, Engle JW, Cai W.

Nanomicro Lett. 2018;10(4):65. doi: 10.1007/s40820-018-0216-2. Epub 2018 Jul 16.


Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy.

Ni D, Ferreira CA, Barnhart TE, Quach V, Yu B, Jiang D, Wei W, Liu H, Engle JW, Hu P, Cai W.

J Am Chem Soc. 2018 Nov 7;140(44):14971-14979. doi: 10.1021/jacs.8b09374. Epub 2018 Oct 29.


Simplified and automatable radiochemical separation strategy for the production of radiopharmaceutical quality 86Y using single column extraction chromatography.

Aluicio-Sarduy E, Hernandez R, Valdovinos HF, Kutyreff CJ, Ellison PA, Barnhart TE, Nickles RJ, Engle JW.

Appl Radiat Isot. 2018 Dec;142:28-31. doi: 10.1016/j.apradiso.2018.09.016. Epub 2018 Sep 14.


Saccadic impairment in chronic traumatic brain injury: examining the influence of cognitive load and injury severity.

Ettenhofer ML, Hershaw JN, Engle JR, Hungerford LD.

Brain Inj. 2018;32(13-14):1740-1748. doi: 10.1080/02699052.2018.1511067. Epub 2018 Sep 5.


Correction to Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer.

Shen S, Jiang D, Cheng L, Chao Y, Nie K, Dong Z, Kutyreff CJ, Engle JW, Huang P, Cai W, Liu Z.

ACS Nano. 2018 Sep 25;12(9):9633. doi: 10.1021/acsnano.8b04084. Epub 2018 Aug 22. No abstract available.


Lone-Pair-Induced Topicity Observed in Macrobicyclic Tetra-thia Lactams and Cryptands: Synthesis, Spectral Identification, and Computational Assessment.

Walker TL, Taschner IS, Chandra M S, Taschner MJ, Engle JT, Schrage BR, Ziegler CJ, Gao X, Wheeler SE.

J Org Chem. 2018 Sep 7;83(17):10025-10036. doi: 10.1021/acs.joc.8b01382. Epub 2018 Aug 1.


Evaluation of a chloride-based 89Zr isolation strategy using a tributyl phosphate (TBP)-functionalized extraction resin.

Graves SA, Kutyreff C, Barrett KE, Hernandez R, Ellison PA, Happel S, Aluicio-Sarduy E, Barnhart TE, Nickles RJ, Engle JW.

Nucl Med Biol. 2018 Sep - Oct;64-65:1-7. doi: 10.1016/j.nucmedbio.2018.06.003. Epub 2018 Jun 18.


ImmunoPET of CD146 in a Murine Hindlimb Ischemia Model.

Ferreira CA, Hernandez R, Yang Y, Valdovinos HF, Engle JW, Cai W.

Mol Pharm. 2018 Aug 6;15(8):3434-3441. doi: 10.1021/acs.molpharmaceut.8b00424. Epub 2018 Jun 25.


Intrinsically Zirconium-89-Labeled Manganese Oxide Nanoparticles for In Vivo Dual-Modality Positron Emission Tomography and Magnetic Resonance Imaging.

Zhan Y, Ehlerding EB, Shi S, Graves SA, Goel S, Engle JW, Liang J, Cai W.

J Biomed Nanotechnol. 2018 May 1;14(5):900-909. doi: 10.1166/jbn.2018.2498.


86/90Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model.

Ehlerding EB, Ferreira CA, Aluicio-Sarduy E, Jiang D, Lee HJ, Theuer CP, Engle JW, Cai W.

Mol Pharm. 2018 Jul 2;15(7):2606-2613. doi: 10.1021/acs.molpharmaceut.8b00133. Epub 2018 May 30.


The Production of Ac-225.

Engle JW.

Curr Radiopharm. 2018;11(3):173-179. doi: 10.2174/1874471011666180418141357. Review.


Large-scale impacts of sea star wasting disease (SSWD) on intertidal sea stars and implications for recovery.

Miner CM, Burnaford JL, Ambrose RF, Antrim L, Bohlmann H, Blanchette CA, Engle JM, Fradkin SC, Gaddam R, Harley CDG, Miner BG, Murray SN, Smith JR, Whitaker SG, Raimondi PT.

PLoS One. 2018 Mar 20;13(3):e0192870. doi: 10.1371/journal.pone.0192870. eCollection 2018.


Noninvasive Trafficking of Brentuximab Vedotin and PET Imaging of CD30 in Lung Cancer Murine Models.

Kang L, Jiang D, Ehlerding EB, Barnhart TE, Ni D, Engle JW, Wang R, Huang P, Xu X, Cai W.

Mol Pharm. 2018 Apr 2;15(4):1627-1634. doi: 10.1021/acs.molpharmaceut.7b01168. Epub 2018 Mar 20.


ImmunoPET imaging of CD38 in murine lymphoma models using 89Zr-labeled daratumumab.

Kang L, Jiang D, England CG, Barnhart TE, Yu B, Rosenkrans ZT, Wang R, Engle JW, Xu X, Huang P, Cai W.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1372-1381. doi: 10.1007/s00259-018-3941-3. Epub 2018 Feb 15.


Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations.

Makvandi M, Dupis E, Engle JW, Nortier FM, Fassbender ME, Simon S, Birnbaum ER, Atcher RW, John KD, Rixe O, Norenberg JP.

Target Oncol. 2018 Apr;13(2):189-203. doi: 10.1007/s11523-018-0550-9.


The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study.

Chen DL, Huang HJ, Byers DE, Shifren A, Belikoff B, Engle JT, Arentson E, Kemp D, Phillips S, Scherrer DE, Fujiwara H, Spayd KJ, Brooks FJ, Pierce RA, Castro M, Isakow W.

PLoS One. 2018 Feb 7;13(2):e0191783. doi: 10.1371/journal.pone.0191783. eCollection 2018.


PET radiometals for antibody labeling.

Aluicio-Sarduy E, Ellison PA, Barnhart TE, Cai W, Nickles RJ, Engle JW.

J Labelled Comp Radiopharm. 2018 Jul;61(9):636-651. doi: 10.1002/jlcr.3607. Epub 2018 Mar 12.


Size, growth, and density data for shallow-water sea urchins from Mexico to the Aleutian Islands, Alaska, 1956-2016.

Ebert TA, Barr LM, Bodkin JL, Burcham D, Bureau D, Carson HS, L Caruso N, Caselle JE, Claisse JT, Clemente S, Davis K, Detwiler PM, Dixon JD, Duggins DO, Engle JM, Estes JA, Groth SD, Grupe BM, Halmay P, Hebert KP, Hernández JC, Jurgens LJ, Kalvass PE, Kenner MC, Konar B, Kushner DJ, Lee LC, Leighton DL, Montaño-Moctezuma G, Eric Munk J, Olguin I, Palleiro JS, Parker DO, Pearse JS, Pondella DJ, Rogers-Bennett L, Schroeter SC, Shelton AO, Sonnenholzner J, Taniguchi IK, VanBlaricom GR, Watson JC, Weitzman BP, Williams JP, Yakimishyn J, Zhang Z.

Ecology. 2018 Mar;99(3):761. doi: 10.1002/ecy.2123. Epub 2018 Jan 23.


Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh.

Mastren T, Radchenko V, Hopkins PD, Engle JW, Weidner JW, Copping R, Brugh M, Nortier FM, Birnbaum ER, John KD, Fassbender ME.

PLoS One. 2017 Dec 22;12(12):e0190308. doi: 10.1371/journal.pone.0190308. eCollection 2017.


Intrabilayer 64Cu Labeling of Photoactivatable, Doxorubicin-Loaded Stealth Liposomes.

Luo D, Goel S, Liu HJ, Carter KA, Jiang D, Geng J, Kutyreff CJ, Engle JW, Huang WC, Shao S, Fang C, Cai W, Lovell JF.

ACS Nano. 2017 Dec 26;11(12):12482-12491. doi: 10.1021/acsnano.7b06578. Epub 2017 Dec 5.


Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix.

Mastren T, Radchenko V, Engle JW, Weidner JW, Owens A, Wyant LE, Copping R, Brugh M, Nortier FM, Birnbaum ER, John KD, Fassbender ME.

Anal Chim Acta. 2018 Jan 15;998:75-82. doi: 10.1016/j.aca.2017.10.020. Epub 2017 Oct 30.


Genetic and neuronal regulation of sleep by neuropeptide VF.

Lee DA, Andreev A, Truong TV, Chen A, Hill AJ, Oikonomou G, Pham U, Hong YK, Tran S, Glass L, Sapin V, Engle J, Fraser SE, Prober DA.

Elife. 2017 Nov 6;6. pii: e25727. doi: 10.7554/eLife.25727.


Efficient Uptake of 177 Lu-Porphyrin-PEG Nanocomplexes by Tumor Mitochondria for Multimodal-Imaging-Guided Combination Therapy.

Yu B, Wei H, He Q, Ferreira CA, Kutyreff CJ, Ni D, Rosenkrans ZT, Cheng L, Yu F, Engle JW, Lan X, Cai W.

Angew Chem Int Ed Engl. 2018 Jan 2;57(1):218-222. doi: 10.1002/anie.201710232. Epub 2017 Nov 30.


Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.

Betthauser TJ, Ellison PA, Murali D, Lao PJ, Barnhart TE, Furumoto S, Okamura N, Johnson SC, Engle JW, Nickles RJ, Christian BT.

Appl Radiat Isot. 2017 Dec;130:230-237. doi: 10.1016/j.apradiso.2017.10.002. Epub 2017 Oct 4.


Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging.

Zhan Y, Shi S, Ehlerding EB, Graves SA, Goel S, Engle JW, Liang J, Tian J, Cai W.

ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38304-38312. doi: 10.1021/acsami.7b12216. Epub 2017 Oct 24.


Evaluating the electronic structure of formal LnII ions in LnII(C5H4SiMe3)31- using XANES spectroscopy and DFT calculations.

Fieser ME, Ferrier MG, Su J, Batista E, Cary SK, Engle JW, Evans WJ, Lezama Pacheco JS, Kozimor SA, Olson AC, Ryan AJ, Stein BW, Wagner GL, Woen DH, Vitova T, Yang P.

Chem Sci. 2017 Sep 1;8(9):6076-6091. doi: 10.1039/c7sc00825b. Epub 2017 Jun 30.


Cyclotron production and radiochemical separation of 55Co and 58mCo from 54Fe, 58Ni and 57Fe targets.

Valdovinos HF, Hernandez R, Graves S, Ellison PA, Barnhart TE, Theuer CP, Engle JW, Cai W, Nickles RJ.

Appl Radiat Isot. 2017 Dec;130:90-101. doi: 10.1016/j.apradiso.2017.09.005. Epub 2017 Sep 6.


Cancer-Related Cognitive Changes.

Asher A, Van Dyk K, Patel SK, Newman R, Engle J, Hutchison N, Padgett L; Cognitive Rehabilitation Committee through the ACRM Cancer Rehabilitation Task Force.

Arch Phys Med Rehabil. 2017 Dec;98(12):2595-2596. doi: 10.1016/j.apmr.2017.05.011. Epub 2017 Sep 12. No abstract available.


Renal-Clearable Ultrasmall Coordination Polymer Nanodots for Chelator-Free 64Cu-Labeling and Imaging-Guided Enhanced Radiotherapy of Cancer.

Shen S, Jiang D, Cheng L, Chao Y, Nie K, Dong Z, Kutyreff CJ, Engle JW, Huang P, Cai W, Liu Z.

ACS Nano. 2017 Sep 26;11(9):9103-9111. doi: 10.1021/acsnano.7b03857. Epub 2017 Sep 5. Erratum in: ACS Nano. 2018 Sep 25;12(9):9633.


Radiometric evaluation of diglycolamide resins for the chromatographic separation of actinium from fission product lanthanides.

Radchenko V, Mastren T, Meyer CAL, Ivanov AS, Bryantsev VS, Copping R, Denton D, Engle JW, Griswold JR, Murphy K, Wilson JJ, Owens A, Wyant L, Birnbaum ER, Fitzsimmons J, Medvedev D, Cutler CS, Mausner LF, Nortier MF, John KD, Mirzadeh S, Fassbender ME.

Talanta. 2017 Dec 1;175:318-324. doi: 10.1016/j.talanta.2017.07.057. Epub 2017 Jul 20.


ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer.

England CG, Jiang D, Hernandez R, Sun H, Valdovinos HF, Ehlerding EB, Engle JW, Yang Y, Huang P, Cai W.

Mol Pharm. 2017 Oct 2;14(10):3239-3247. doi: 10.1021/acs.molpharmaceut.7b00216. Epub 2017 Sep 6.


Ultra-small iron-gallic acid coordination polymer nanoparticles for chelator-free labeling of 64Cu and multimodal imaging-guided photothermal therapy.

Jin Q, Zhu W, Jiang D, Zhang R, Kutyreff CJ, Engle JW, Huang P, Cai W, Liu Z, Cheng L.

Nanoscale. 2017 Aug 31;9(34):12609-12617. doi: 10.1039/c7nr03086j.


Sirolimus and mirabegron interaction in a hematopoietic cell transplant patient.

Engle JA, Fair C.

J Oncol Pharm Pract. 2018 Dec;24(8):627-631. doi: 10.1177/1078155217726161. Epub 2017 Aug 17.


Simultaneous Separation of Actinium and Radium Isotopes from a Proton Irradiated Thorium Matrix.

Mastren T, Radchenko V, Owens A, Copping R, Boll R, Griswold JR, Mirzadeh S, Wyant LE, Brugh M, Engle JW, Nortier FM, Birnbaum ER, John KD, Fassbender ME.

Sci Rep. 2017 Aug 15;7(1):8216. doi: 10.1038/s41598-017-08506-9.


The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques.

Han P, Nielsen M, Song M, Yin J, Permenter MR, Vogt JA, Engle JR, Dugger BN, Beach TG, Barnes CA, Shi J.

Front Aging Neurosci. 2017 Jun 12;9:180. doi: 10.3389/fnagi.2017.00180. eCollection 2017.


Preparation and in vivo characterization of 51MnCl2 as PET tracer of Ca2+ channel-mediated transport.

Graves SA, Hernandez R, Valdovinos HF, Ellison PA, Engle JW, Barnhart TE, Cai W, Nickles RJ.

Sci Rep. 2017 Jun 8;7(1):3033. doi: 10.1038/s41598-017-03202-0.


Assessment of adherence and relative dose intensity with oral chemotherapy in oncology clinical trials at an academic medical center.

Engle JA, Traynor AM, Campbell TC, Wisinski KB, LoConte N, Liu G, Wilding G, Kolesar JM.

J Oncol Pharm Pract. 2018 Jul;24(5):348-353. doi: 10.1177/1078155217704989. Epub 2017 Apr 29.


Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development.

Radchenko V, Engle JW, Medvedev DG, Maassen JM, Naranjo CM, Unc GA, Meyer CAL, Mastren T, Brugh M, Mausner L, Cutler CS, Birnbaum ER, John KD, Nortier FM, Fassbender ME.

Nucl Med Biol. 2017 Jul;50:25-32. doi: 10.1016/j.nucmedbio.2017.03.006. Epub 2017 Apr 7.


Synthesis and Characterization of the Actinium Aquo Ion.

Ferrier MG, Stein BW, Batista ER, Berg JM, Birnbaum ER, Engle JW, John KD, Kozimor SA, Lezama Pacheco JS, Redman LN.

ACS Cent Sci. 2017 Mar 22;3(3):176-185. doi: 10.1021/acscentsci.6b00356. Epub 2017 Feb 1.


Bulk production and evaluation of high specific activity 186gRe for cancer therapy using enriched 186WO3 targets in a proton beam.

Mastren T, Radchenko V, Bach HT, Balkin ER, Birnbaum ER, Brugh M, Engle JW, Gott MD, Guthrie J, Hennkens HM, John KD, Ketring AR, Kuchuk M, Maassen JR, Naranjo CM, Nortier FM, Phelps TE, Jurisson SS, Wilbur DS, Fassbender ME.

Nucl Med Biol. 2017 Jun;49:24-29. doi: 10.1016/j.nucmedbio.2017.02.006. Epub 2017 Mar 3.


Nuclear excitation functions of proton-induced reactions (Ep = 35 - 90 MeV) from Fe, Cu, and Al.

Graves SA, Ellison PA, Barnhart TE, Valdovinos HF, Birnbaum ER, Nortier FM, Nickles RJ, Engle JW.

Nucl Instrum Methods Phys Res B. 2016 Nov 1;386:44-53. doi: 10.1016/j.nimb.2016.09.018. Epub 2016 Sep 28.


Network Patterns Associated with Navigation Behaviors Are Altered in Aged Nonhuman Primates.

Engle JR, Machado CJ, Permenter MR, Vogt JA, Maurer AP, Bulleri AM, Barnes CA.

J Neurosci. 2016 Nov 30;36(48):12217-12227. Epub 2016 Nov 30.


Separation of 44Ti from proton irradiated scandium by using solid-phase extraction chromatography and design of 44Ti/44Sc generator system.

Radchenko V, Meyer CAL, Engle JW, Naranjo CM, Unc GA, Mastren T, Brugh M, Birnbaum ER, John KD, Nortier FM, Fassbender ME.

J Chromatogr A. 2016 Dec 16;1477:39-46. doi: 10.1016/j.chroma.2016.11.047. Epub 2016 Nov 24.


PET of Poly (ADP-Ribose) Polymerase Activity in Cancer: Preclinical Assessment and First In-Human Studies.

Michel LS, Dyroff S, Brooks FJ, Spayd KJ, Lim S, Engle JT, Phillips S, Tan B, Wang-Gillam A, Bognar C, Chu W, Zhou D, Mach RH, Laforest R, Chen DL.

Radiology. 2017 Feb;282(2):453-463. doi: 10.1148/radiol.2016161929. Epub 2016 Nov 14.


Large scale accelerator production of 225Ac: Effective cross sections for 78-192MeV protons incident on 232Th targets.

Griswold JR, Medvedev DG, Engle JW, Copping R, Fitzsimmons JM, Radchenko V, Cooley JC, Fassbender ME, Denton DL, Murphy KE, Owens AC, Birnbaum ER, John KD, Nortier FM, Stracener DW, Heilbronn LH, Mausner LF, Mirzadeh S.

Appl Radiat Isot. 2016 Dec;118:366-374. doi: 10.1016/j.apradiso.2016.09.026. Epub 2016 Sep 28.


Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle.

Rader EP, Turk R, Willer T, Beltrán D, Inamori K, Peterson TA, Engle J, Prouty S, Matsumura K, Saito F, Anderson ME, Campbell KP.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10992-7. doi: 10.1073/pnas.1605265113. Epub 2016 Sep 13.

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