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A novel approach for production of an active N-terminally truncated Ulp1 (SUMO protease 1) catalytic domain from Escherichia coli inclusion bodies.

Linova MY, Risør MW, Jørgensen SE, Mansour Z, Kaya J, Sigurdarson JJ, Enghild JJ, Karring H.

Protein Expr Purif. 2019 Oct 4;166:105507. doi: 10.1016/j.pep.2019.105507. [Epub ahead of print]


Unfolding and partial refolding of a cellulase from the SDS-denatured state: From β-sheet to α-helix and back.

Rasmussen HØ, Enghild JJ, Otzen DE, Pedersen JS.

Biochim Biophys Acta Gen Subj. 2019 Sep 13:129434. doi: 10.1016/j.bbagen.2019.129434. [Epub ahead of print]


Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and release active heavy chain 2 in synovial fluids from arthritic patients.

Scavenius C, Poulsen EC, Thøgersen IB, Roebuck M, Frosticke S, Bou-Gharios G, Yamamoto K, Deleuran B, Enghild JJ.

J Biol Chem. 2019 Sep 4. pii: jbc.RA119.008844. doi: 10.1074/jbc.RA119.008844. [Epub ahead of print]


Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain.

Richner M, Pallesen LT, Ulrichsen M, Poulsen ET, Holm TH, Login H, Castonguay A, Lorenzo LE, Gonçalves NP, Andersen OM, Lykke-Hartmann K, Enghild JJ, Rønn LCB, Malik IJ, De Koninck Y, Bjerrum OJ, Vægter CB, Nykjær A.

Sci Adv. 2019 Jun 19;5(6):eaav9946. doi: 10.1126/sciadv.aav9946. eCollection 2019 Jun.


Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis.

Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J.

Biochimie. 2019 Jun 15. pii: S0300-9084(19)30175-0. doi: 10.1016/j.biochi.2019.06.010. [Epub ahead of print]


The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation.

Poulsen ET, Nielsen NS, Scavenius C, Mogensen EH, Risør MW, Runager K, Lukassen MV, Rasmussen CB, Christiansen G, Richner M, Vorum H, Enghild JJ.

J Biol Chem. 2019 Aug 2;294(31):11817-11828. doi: 10.1074/jbc.RA119.009050. Epub 2019 Jun 13.


Staphylococcus saccharolyticus Isolated From Blood Cultures and Prosthetic Joint Infections Exhibits Excessive Genome Decay.

Brüggemann H, Poehlein A, Brzuszkiewicz E, Scavenius C, Enghild JJ, Al-Zeer MA, Brinkmann V, Jensen A, Söderquist B.

Front Microbiol. 2019 Mar 12;10:478. doi: 10.3389/fmicb.2019.00478. eCollection 2019.


Conservation of the Amyloid Interactome Across Diverse Fibrillar Structures.

Juhl DW, Risør MW, Scavenius C, Rasmussen CB, Otzen D, Nielsen NC, Enghild JJ.

Sci Rep. 2019 Mar 7;9(1):3863. doi: 10.1038/s41598-019-40483-z.


Imperfect repeats in the functional amyloid protein FapC reduce the tendency to fragment during fibrillation.

Rasmussen CB, Christiansen G, Vad BS, Lynggaard C, Enghild JJ, Andreasen M, Otzen D.

Protein Sci. 2019 Mar;28(3):633-642. doi: 10.1002/pro.3566. Epub 2019 Jan 12.


A Screening Method for the Isolation of Bacteria Capable of Degrading Toxic Steroidal Glycoalkaloids Present in Potato.

Hennessy RC, Jørgensen NOG, Scavenius C, Enghild JJ, Greve-Poulsen M, Sørensen OB, Stougaard P.

Front Microbiol. 2018 Nov 5;9:2648. doi: 10.3389/fmicb.2018.02648. eCollection 2018.


APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells.

Jacobsen KM, Villadsen NL, Tørring T, Nielsen CB, Salomón T, Nielsen MM, Tsakos M, Sibbersen C, Scavenius C, Nielsen R, Christensen EI, Guerra PF, Bross P, Pedersen JS, Enghild JJ, Johannsen M, Frøkiær J, Overgaard J, Horsman MR, Busk M, Poulsen TB.

Cell Chem Biol. 2018 Nov 15;25(11):1337-1349.e12. doi: 10.1016/j.chembiol.2018.07.010. Epub 2018 Aug 16.


Small-Molecule Probes for Affinity-Guided Introduction of Biocompatible Handles on Metal-Binding Proteins.

Mortensen MR, Skovsgaard MB, Okholm AH, Scavenius C, Dupont DM, Rosen CB, Enghild JJ, Kjems J, Gothelf KV.

Bioconjug Chem. 2018 Sep 19;29(9):3016-3025. doi: 10.1021/acs.bioconjchem.8b00424. Epub 2018 Aug 23.


α-Synucleins from Animal Species Show Low Fibrillation Propensities and Weak Oligomer Membrane Disruption.

Sahin C, Kjær L, Christensen MS, N Pedersen J, Christiansen G, Pérez AW, Møller IM, Enghild JJ, Pedersen JS, Larsen K, Otzen DE.

Biochemistry. 2018 Aug 28;57(34):5145-5158. doi: 10.1021/acs.biochem.8b00627. Epub 2018 Aug 15.


Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

Andersen LL, Terczyńska-Dyla E, Mørk N, Scavenius C, Enghild JJ, Höning K, Hornung V, Christiansen M, Mogensen TH, Hartmann R.

Genes Immun. 2019 Jan;20(1):10-22. doi: 10.1038/s41435-017-0002-z. Epub 2017 Dec 4.


Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein.

Nielsen NS, Juhl DW, Poulsen ET, Lukassen MV, Poulsen EC, Risør MW, Scavenius C, Enghild JJ.

Biochemistry. 2017 Dec 12;56(49):6470-6480. doi: 10.1021/acs.biochem.7b00668. Epub 2017 Nov 22.


Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies.

Poulsen ET, Runager K, Nielsen NS, Lukassen MV, Thomsen K, Snider P, Simmons O, Vorum H, Conway SJ, Enghild JJ.

FEBS J. 2018 Jan;285(1):101-114. doi: 10.1111/febs.14321. Epub 2017 Nov 23.


Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies.

García-Castellanos R, Nielsen NS, Runager K, Thøgersen IB, Lukassen MV, Poulsen ET, Goulas T, Enghild JJ, Gomis-Rüth FX.

Structure. 2017 Nov 7;25(11):1740-1750.e2. doi: 10.1016/j.str.2017.09.001. Epub 2017 Oct 5.


How glycosaminoglycans promote fibrillation of salmon calcitonin.

Malmos KG, Bjerring M, Jessen CM, Nielsen EHT, Poulsen ET, Christiansen G, Vosegaard T, Skrydstrup T, Enghild JJ, Pedersen JS, Otzen DE.

J Biol Chem. 2017 Sep 22;292(38):15992. doi: 10.1074/jbc.A116.715466. No abstract available.


Transcriptome analysis of the response of Burmese python to digestion.

Duan J, Sanggaard KW, Schauser L, Lauridsen SE, Enghild JJ, Schierup MH, Wang T.

Gigascience. 2017 Aug 1;6(8):1-18. doi: 10.1093/gigascience/gix057.


Characterisation of protein families in spider digestive fluids and their role in extra-oral digestion.

Walter A, Bechsgaard J, Scavenius C, Dyrlund TS, Sanggaard KW, Enghild JJ, Bilde T.

BMC Genomics. 2017 Aug 10;18(1):600. doi: 10.1186/s12864-017-3987-9.


Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.

Pihl R, Jensen L, Hansen AG, Thøgersen IB, Andres S, Dagnæs-Hansen F, Oexle K, Enghild JJ, Thiel S.

J Immunol. 2017 Aug 9. pii: ji1700518. doi: 10.4049/jimmunol.1700518. [Epub ahead of print]


Critical Influence of Cosolutes and Surfaces on the Assembly of Serpin-Derived Amyloid Fibrils.

Risør MW, Juhl DW, Bjerring M, Mathiesen J, Enghild JJ, Nielsen NC, Otzen DE.

Biophys J. 2017 Aug 8;113(3):580-596. doi: 10.1016/j.bpj.2017.06.030.


Activation of Complement by Pigment Epithelium-Derived Factor in Rheumatoid Arthritis.

Vogt LM, Talens S, Kwasniewicz E, Scavenius C, Struglics A, Enghild JJ, Saxne T, Blom AM.

J Immunol. 2017 Aug 1;199(3):1113-1121. doi: 10.4049/jimmunol.1700018. Epub 2017 Jun 21.


An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients.

Poulsen ET, Iannuzzi F, Rasmussen HF, Maier TJ, Enghild JJ, Jørgensen AL, Matrone C.

Front Mol Neurosci. 2017 Mar 15;10:59. doi: 10.3389/fnmol.2017.00059. eCollection 2017.


Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels.

Poulsen ET, Pedersen KW, Marzeda AM, Enghild JJ.

Biochemistry. 2017 Feb 14;56(6):896-902. doi: 10.1021/acs.biochem.6b01027. Epub 2017 Feb 1.


Mirolysin, a LysargiNase from Tannerella forsythia, proteolytically inactivates the human cathelicidin, LL-37.

Koneru L, Ksiazek M, Waligorska I, Straczek A, Lukasik M, Madej M, Thøgersen IB, Enghild JJ, Potempa J.

Biol Chem. 2017 Mar;398(3):395-409. doi: 10.1515/hsz-2016-0267.


Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation.

Andersen OJ, Risør MW, Poulsen EC, Nielsen NC, Miao Y, Enghild JJ, Schiøtt B.

Biochemistry. 2017 Jan 31;56(4):634-646. doi: 10.1021/acs.biochem.6b00839. Epub 2017 Jan 17.


Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.

Andersen KK, Vad BS, Scavenius C, Enghild JJ, Otzen DE.

Biochemistry. 2017 Jan 10;56(1):260-270. doi: 10.1021/acs.biochem.6b01009. Epub 2016 Dec 20.


Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

Lasica AM, Goulas T, Mizgalska D, Zhou X, de Diego I, Ksiazek M, Madej M, Guo Y, Guevara T, Nowak M, Potempa B, Goel A, Sztukowska M, Prabhakar AT, Bzowska M, Widziolek M, Thøgersen IB, Enghild JJ, Simonian M, Kulczyk AW, Nguyen KA, Potempa J, Gomis-Rüth FX.

Sci Rep. 2016 Nov 24;6:37708. doi: 10.1038/srep37708.


"Ant-egg" cataract revisited.

Clemmensen K, Enghild JJ, Ivarsen A, Riise R, Vorum H, Heegaard S.

Graefes Arch Clin Exp Ophthalmol. 2017 Jan;255(1):119-125. doi: 10.1007/s00417-016-3539-z. Epub 2016 Nov 5.


Disulfide Bond Pattern of Transforming Growth Factor β-Induced Protein.

Lukassen MV, Scavenius C, Thøgersen IB, Enghild JJ.

Biochemistry. 2016 Oct 4;55(39):5610-5621. Epub 2016 Sep 23.


SILAC-MS Based Characterization of LPS and Resveratrol Induced Changes in Adipocyte Proteomics - Resveratrol as Ameliorating Factor on LPS Induced Changes.

Nøhr MK, Kroager TP, Sanggaard KW, Knudsen AD, Stensballe A, Enghild JJ, Ølholm J, Richelsen B, Pedersen SB.

PLoS One. 2016 Jul 20;11(7):e0159747. doi: 10.1371/journal.pone.0159747. eCollection 2016.


Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation.

Iversen MB, Gottfredsen RH, Larsen UG, Enghild JJ, Praetorius J, Borregaard N, Petersen SV.

Free Radic Biol Med. 2016 Aug;97:478-488. doi: 10.1016/j.freeradbiomed.2016.07.004. Epub 2016 Jul 6.


How Glycosaminoglycans Promote Fibrillation of Salmon Calcitonin.

Malmos KG, Bjerring M, Jessen CM, Nielsen EH, Poulsen ET, Christiansen G, Vosegaard T, Skrydstrup T, Enghild JJ, Pedersen JS, Otzen DE.

J Biol Chem. 2016 Aug 5;291(32):16849-62. doi: 10.1074/jbc.M116.715466. Epub 2016 Jun 8. Erratum in: J Biol Chem. 2017 Sep 22;292(38):15992.


Dynamic protein coronas revealed as a modulator of silver nanoparticle sulphidation in vitro.

Miclăuş T, Beer C, Chevallier J, Scavenius C, Bochenkov VE, Enghild JJ, Sutherland DS.

Nat Commun. 2016 Jun 9;7:11770. doi: 10.1038/ncomms11770.


The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.

de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J.

Sci Rep. 2016 Mar 23;6:23123. doi: 10.1038/srep23123.


Carbamylated LL-37 as a modulator of the immune response.

Koro C, Hellvard A, Delaleu N, Binder V, Scavenius C, Bergum B, Główczyk I, Roberts HM, Chapple IL, Grant MM, Rapala-Kozik M, Klaga K, Enghild JJ, Potempa J, Mydel P.

Innate Immun. 2016 Apr;22(3):218-29. doi: 10.1177/1753425916631404. Epub 2016 Feb 15.


LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).

Poulsen ET, Nielsen NS, Jensen MM, Nielsen E, Hjortdal J, Kim EK, Enghild JJ.

Proteomics. 2016 Feb;16(3):539-43. doi: 10.1002/pmic.201500287. Epub 2016 Jan 3.


Genomic and exoproteomic analyses of cold- and alkaline-adapted bacteria reveal an abundance of secreted subtilisin-like proteases.

Lylloff JE, Hansen LB, Jepsen M, Sanggaard KW, Vester JK, Enghild JJ, Sørensen SJ, Stougaard P, Glaring MA.

Microb Biotechnol. 2016 Mar;9(2):245-56. doi: 10.1111/1751-7915.12343. Epub 2016 Feb 1.


Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.

Allen EH, Courtney DG, Atkinson SD, Moore JE, Mairs L, Poulsen ET, Schiroli D, Maurizi E, Cole C, Hickerson RP, James J, Murgatroyd H, Smith FJ, MacEwen C, Enghild JJ, Nesbit MA, Leslie Pedrioli DM, McLean WH, Moore CB.

Hum Mol Genet. 2016 Mar 15;25(6):1176-91. doi: 10.1093/hmg/ddw001. Epub 2016 Jan 11.


The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.

Scavenius C, Nikolajsen CL, Stenvang M, Thøgersen IB, Wyrożemski Ł, Wisniewski HG, Otzen DE, Sanggaard KW, Enghild JJ.

J Biol Chem. 2016 Feb 26;291(9):4658-70. doi: 10.1074/jbc.M115.678748. Epub 2016 Jan 4.


New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies.

Poulsen ET, Larsen A, Zollo A, Jørgensen AL, Sanggaard KW, Enghild JJ, Matrone C.

Int J Mol Sci. 2015 Dec 10;16(12):29446-53. doi: 10.3390/ijms161226181.


Transglutaminase 2-Catalyzed Intramolecular Cross-Linking of Osteopontin.

Christensen B, Zachariae ED, Scavenius C, Kløverpris S, Oxvig C, Petersen SV, Enghild JJ, Sørensen ES.

Biochemistry. 2016 Jan 19;55(2):294-303. doi: 10.1021/acs.biochem.5b01153. Epub 2016 Jan 4.


Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior.

Amin YY, Runager K, Simoes F, Celiz A, Taresco V, Rossi R, Enghild JJ, Abildtrup LA, Kraft DC, Sutherland DS, Alexander MR, Foss M, Ogaki R.

Adv Mater. 2016 Feb 17;28(7):1472-6. doi: 10.1002/adma.201504995. Epub 2015 Dec 9.


Hepatocytes respond differently to major dietary trans fatty acid isomers, elaidic acid and trans-vaccenic acid.

Krogager TP, Nielsen LV, Kahveci D, Dyrlund TF, Scavenius C, Sanggaard KW, Enghild JJ.

Proteome Sci. 2015 Dec 1;13:31. doi: 10.1186/s12953-015-0084-3. eCollection 2015.


Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.

Risør MW, Thomsen LR, Sanggaard KW, Nielsen TA, Thøgersen IB, Lukassen MV, Rossen L, Garcia-Ferrer I, Guevara T, Scavenius C, Meinjohanns E, Gomis-Rüth FX, Enghild JJ.

J Biol Chem. 2016 Jan 29;291(5):2271-87. doi: 10.1074/jbc.M115.672550. Epub 2015 Dec 1.


The spider hemolymph clot proteome reveals high concentrations of hemocyanin and von Willebrand factor-like proteins.

Sanggaard KW, Dyrlund TF, Bechsgaard JS, Scavenius C, Wang T, Bilde T, Enghild JJ.

Biochim Biophys Acta. 2016 Feb;1864(2):233-41. doi: 10.1016/j.bbapap.2015.11.004. Epub 2015 Nov 24.


Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway.

Bechsgaard J, Vanthournout B, Funch P, Vestbo S, Gibbs RA, Richards S, Sanggaard KW, Enghild JJ, Bilde T.

J Evol Biol. 2016 Feb;29(2):277-91. doi: 10.1111/jeb.12780. Epub 2015 Nov 22.


Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix.

Briggs DC, Birchenough HL, Ali T, Rugg MS, Waltho JP, Ievoli E, Jowitt TA, Enghild JJ, Richter RP, Salustri A, Milner CM, Day AJ.

J Biol Chem. 2015 Nov 27;290(48):28708-23. doi: 10.1074/jbc.M115.669838. Epub 2015 Oct 14.


Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase.

Staniec D, Ksiazek M, Thøgersen IB, Enghild JJ, Sroka A, Bryzek D, Bogyo M, Abrahamson M, Potempa J.

J Biol Chem. 2015 Nov 6;290(45):27248-60. doi: 10.1074/jbc.M115.648782. Epub 2015 Sep 18.

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