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Items: 29


Kidney transplant monitoring by urinary flow cytometry: Biomarker combination of T cells, renal tubular epithelial cells, and podocalyxin-positive cells detects rejection.

Goerlich N, Brand HA, Langhans V, Tesch S, Schachtner T, Koch B, Paliege A, Schneider W, Grützkau A, Reinke P, Enghard P.

Sci Rep. 2020 Jan 21;10(1):796. doi: 10.1038/s41598-020-57524-7.


IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis.

Rose A, von Spee-Mayer C, Kloke L, Wu K, Kühl A, Enghard P, Burmester GR, Riemekasten G, Humrich JY.

Cells. 2019 Oct 11;8(10). pii: E1234. doi: 10.3390/cells8101234.


Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial.

Nee J, Jörres A, Krannich A, Leithner C, Schroeder T, Munk AL, Enghard P, Moore C, Steppan S, Storm C.

Resuscitation. 2019 Nov;144:54-59. doi: 10.1016/j.resuscitation.2019.09.020. Epub 2019 Sep 23.


Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice.

Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck WH, Hammock BD, Riemekasten G, Enghard P.

Sci Rep. 2019 Jun 20;9(1):8993. doi: 10.1038/s41598-019-45299-5.


Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study.

Rose T, Grützkau A, Klotsche J, Enghard P, Flechsig A, Keller J, Riemekasten G, Radbruch A, Burmester GR, Dörner T, Hiepe F, Biesen R.

Rheumatology (Oxford). 2017 Sep 1;56(9):1618-1626. doi: 10.1093/rheumatology/kex220.


What is the clinical significance of anti-Sm antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3.

Flechsig A, Rose T, Barkhudarova F, Strauss R, Klotsche J, Dähnrich C, Schlumberger W, Enghard P, Burmester GR, Hiepe F, Biesen R.

Clin Exp Rheumatol. 2017 Jul-Aug;35(4):598-606. Epub 2017 Mar 3.


Mapping urinary chemokines in human lupus nephritis: Potentially redundant pathways recruit CD4+ and CD8+ T cells and macrophages.

Klocke J, Kopetschke K, Grießbach AS, Langhans V, Humrich JY, Biesen R, Dragun D, Radbruch A, Burmester GR, Riemekasten G, Enghard P.

Eur J Immunol. 2017 Jan;47(1):180-192. doi: 10.1002/eji.201646387. Epub 2016 Nov 21.


Neutropenic Sepsis in the ICU: Outcome Predictors in a Two-Phase Model and Microbiology Findings.

Kruse JM, Jenning T, Rademacher S, Arnold R, Schmitt CA, Jörres A, Enghard P, Oppert M.

Crit Care Res Pract. 2016;2016:8137850. doi: 10.1155/2016/8137850. Epub 2016 Apr 18.


Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.

von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY.

Ann Rheum Dis. 2016 Jul;75(7):1407-15. doi: 10.1136/annrheumdis-2015-207776. Epub 2015 Aug 31.


The cellular signature of urinary immune cells in Lupus nephritis: new insights into potential biomarkers.

Kopetschke K, Klocke J, Grießbach AS, Humrich JY, Biesen R, Dragun D, Burmester GR, Enghard P, Riemekasten G.

Arthritis Res Ther. 2015 Apr 3;17:94. doi: 10.1186/s13075-015-0600-y.


Simplified lung ultrasound protocol shows excellent prediction of extravascular lung water in ventilated intensive care patients.

Enghard P, Rademacher S, Nee J, Hasper D, Engert U, Jörres A, Kruse JM.

Crit Care. 2015 Feb 6;19:36. doi: 10.1186/s13054-015-0756-5.


Weak diagnostic performance of troponin, creatine kinase and creatine kinase-MB to diagnose or exclude myocardial infarction after successful resuscitation.

Kruse JM, Enghard P, Schröder T, Hasper D, Kühnle Y, Jörres A, Storm C.

Int J Cardiol. 2014 May 1;173(2):216-21. doi: 10.1016/j.ijcard.2014.02.033. Epub 2014 Feb 28.


Impaired thymic function and CD4+ T lymphopenia, but not mannose-binding lectin deficiency, are risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients.

Schürmann M, Schürmann D, Schindler R, Meisel C, Liman P, Kruse J, Enghard P, König J, Schmidt D, Reinke P, Nickel P.

Transpl Immunol. 2013 Jun;28(4):159-63. doi: 10.1016/j.trim.2013.05.003. Epub 2013 May 15.


Urinary CD4 T cells identify SLE patients with proliferative lupus nephritis and can be used to monitor treatment response.

Enghard P, Rieder C, Kopetschke K, Klocke JR, Undeutsch R, Biesen R, Dragun D, Gollasch M, Schneider U, Aupperle K, Humrich JY, Hiepe F, Backhaus M, Radbruch AH, Burmester GR, Riemekasten G.

Ann Rheum Dis. 2014 Jan;73(1):277-83. doi: 10.1136/annrheumdis-2012-202784. Epub 2013 Mar 8.


IFNα and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus.

Rose T, Grützkau A, Hirseland H, Huscher D, Dähnrich C, Dzionek A, Ozimkowski T, Schlumberger W, Enghard P, Radbruch A, Riemekasten G, Burmester GR, Hiepe F, Biesen R.

Ann Rheum Dis. 2013 Oct;72(10):1639-45. doi: 10.1136/annrheumdis-2012-201586. Epub 2012 Oct 31.


Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus.

Engler JB, Undeutsch R, Kloke L, Rosenberger S, Backhaus M, Schneider U, Egerer K, Dragun D, Hofmann J, Huscher D, Burmester GR, Humrich JY, Enghard P, Riemekasten G.

Ann Rheum Dis. 2011 Dec;70(12):2176-83. doi: 10.1136/ard.2011.153619. Epub 2011 Sep 16.


Subset size, activation threshold and distribution of autoreactive MZ and FO B cells do not differ in a sex-specific manner in the NZB/W F1 murine lupus model: an experimental mouse study.

Enghard P, Grussie E, Rieder C, Burmester GR, Riemekasten G.

Lupus. 2011 Oct;20(12):1240-9. doi: 10.1177/0961203311409611. Epub 2011 Aug 15.


Class switching and consecutive loss of dsDNA-reactive B1a B cells from the peritoneal cavity during murine lupus development.

Enghard P, Humrich JY, Chu VT, Grussie E, Hiepe F, Burmester GR, Radbruch A, Berek C, Riemekasten G.

Eur J Immunol. 2010 Jun;40(6):1809-18. doi: 10.1002/eji.200940050.


Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.

Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):204-9. doi: 10.1073/pnas.0903158107. Epub 2009 Dec 14.


Systemic activation of the immune system induces aberrant BAFF and APRIL expression in B cells in patients with systemic lupus erythematosus.

Chu VT, Enghard P, Schürer S, Steinhauser G, Rudolph B, Riemekasten G, Berek C.

Arthritis Rheum. 2009 Jul;60(7):2083-93. doi: 10.1002/art.24628.


Immunology and the diagnosis of lupus nephritis.

Enghard P, Riemekasten G.

Lupus. 2009 Apr;18(4):287-90. doi: 10.1177/0961203308099632. No abstract available.


CXCR3+CD4+ T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute nephritis flares in systemic lupus erythematosus patients.

Enghard P, Humrich JY, Rudolph B, Rosenberger S, Biesen R, Kuhn A, Manz R, Hiepe F, Radbruch A, Burmester GR, Riemekasten G.

Arthritis Rheum. 2009 Jan;60(1):199-206. doi: 10.1002/art.24136.


Autoregulation of Th1-mediated inflammation by twist1.

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A.

J Exp Med. 2008 Aug 4;205(8):1889-901. doi: 10.1084/jem.20072468. Epub 2008 Jul 28.


In vitro and in vivo activation induces BAFF and APRIL expression in B cells.

Chu VT, Enghard P, Riemekasten G, Berek C.

J Immunol. 2007 Nov 1;179(9):5947-57.


The systemic and SmD183-119-autoantigen-specific cytokine memory of Th cells in SLE patients.

Langer S, Langnickel D, Enghard P, Undeutsch R, Burmester GR, Hiepe F, Radbruch A, Riemekasten G.

Rheumatology (Oxford). 2007 Feb;46(2):238-45. Epub 2006 Jul 31.


Induction of pathogenic anti-dsDNA antibodies is controlled on the level of B cells in a non-lupus prone mouse strain.

Langnickel D, Enghard P, Klein C, Undeutsch R, Hocher B, Manz R, Burmester GR, Riemekasten G.

J Clin Immunol. 2006 Jan;26(1):86-95.


Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells.

Riemekasten G, Langnickel D, Enghard P, Undeutsch R, Humrich J, Ebling FM, Hocher B, Humaljoki T, Neumayer H, Burmester GR, Hahn BH, Radbruch A, Hiepe F.

J Immunol. 2004 Nov 1;173(9):5835-42.


[Regulatory T cells - a possible promising target in the treatment of autoimmune diseases].

Enghard P, Riemekasten G.

Z Rheumatol. 2003 Aug;62(4):355-60. Review. German.


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