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Items: 1 to 50 of 146

1.

Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice.

Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD.

Nat Biotechnol. 2019 Aug 19. doi: 10.1038/s41587-019-0222-z. [Epub ahead of print]

PMID:
31427820
2.

Structural basis of the atypical activation mechanism of KRAS V14I.

Bera AK, Lu J, Wales TE, Gondi S, Gurbani D, Nelson A, Engen JR, Westover KD.

J Biol Chem. 2019 Jul 24. pii: jbc.RA119.009131. doi: 10.1074/jbc.RA119.009131. [Epub ahead of print]

3.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.

4.

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding.

Twomey EC, Ji Z, Wales TE, Bodnar NO, Ficarro SB, Marto JA, Engen JR, Rapoport TA.

Science. 2019 Aug 2;365(6452). pii: eaax1033. doi: 10.1126/science.aax1033. Epub 2019 Jun 27.

PMID:
31249135
5.

Hydrogen deuterium exchange mass spectrometry applied to chaperones and chaperone-assisted protein folding.

Georgescauld F, Wales TE, Engen JR.

Expert Rev Proteomics. 2019 Jul;16(7):613-625. doi: 10.1080/14789450.2019.1633920. Epub 2019 Jun 24.

PMID:
31215268
6.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
7.

Dynamic and structural differences between heme oxygenase-1 and -2 are due to differences in their C-terminal regions.

Kochert BA, Fleischhacker AS, Wales TE, Becker DF, Engen JR, Ragsdale SW.

J Biol Chem. 2019 May 17;294(20):8259-8272. doi: 10.1074/jbc.RA119.008592. Epub 2019 Apr 3.

PMID:
30944174
8.

Remodeling of the Binding Site of Nucleoside Diphosphate Kinase Revealed by X-ray Structure and H/D Exchange.

Dautant A, Henri J, Wales TE, Meyer P, Engen JR, Georgescauld F.

Biochemistry. 2019 Mar 12;58(10):1440-1449. doi: 10.1021/acs.biochem.8b01308. Epub 2019 Mar 4.

PMID:
30785730
9.

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.

Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE.

Sci Signal. 2018 Oct 23;11(553). pii: eaat5916. doi: 10.1126/scisignal.aat5916.

PMID:
30352950
10.

Fusion surface structure, function, and dynamics of gamete fusogen HAP2.

Feng J, Dong X, Pinello J, Zhang J, Lu C, Iacob RE, Engen JR, Snell WJ, Springer TA.

Elife. 2018 Oct 3;7. pii: e39772. doi: 10.7554/eLife.39772.

11.

Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins.

Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR.

Biochemistry. 2018 Jul 31;57(30):4583-4596. doi: 10.1021/acs.biochem.8b00538. Epub 2018 Jul 13.

12.

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.

Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA.

Nat Struct Mol Biol. 2018 Jul;25(7):616-622. doi: 10.1038/s41594-018-0085-x. Epub 2018 Jul 2.

13.

Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein.

de Wispelaere M, Lian W, Potisopon S, Li PC, Jang J, Ficarro SB, Clark MJ, Zhu X, Kaplan JB, Pitts JD, Wales TE, Wang J, Engen JR, Marto JA, Gray NS, Yang PL.

Cell Chem Biol. 2018 Aug 16;25(8):1006-1016.e8. doi: 10.1016/j.chembiol.2018.05.011. Epub 2018 Jun 21.

14.

Hydrogen-Deuterium Exchange Mass Spectrometry to Study Protein Complexes.

Kochert BA, Iacob RE, Wales TE, Makriyannis A, Engen JR.

Methods Mol Biol. 2018;1764:153-171. doi: 10.1007/978-1-4939-7759-8_10.

PMID:
29605914
15.

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.

Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD.

Mol Cell. 2018 Mar 1;69(5):729-743.e7. doi: 10.1016/j.molcel.2018.02.005.

16.

Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation.

Le VQ, Iacob RE, Tian Y, McConaughy W, Jackson J, Su Y, Zhao B, Engen JR, Pirruccello-Straub M, Springer TA.

EMBO J. 2018 Feb 1;37(3):384-397. doi: 10.15252/embj.201797931. Epub 2018 Jan 17.

17.

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

Moroco JA, Alvarado JJ, Staudt RP, Shi H, Wales TE, Smithgall TE, Engen JR.

J Mol Biol. 2018 Feb 2;430(3):310-321. doi: 10.1016/j.jmb.2017.12.008. Epub 2017 Dec 16.

18.

Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Lamberto I, Liu X, Seo HS, Schauer NJ, Iacob RE, Hu W, Das D, Mikhailova T, Weisberg EL, Engen JR, Anderson KC, Chauhan D, Dhe-Paganon S, Buhrlage SJ.

Cell Chem Biol. 2017 Dec 21;24(12):1490-1500.e11. doi: 10.1016/j.chembiol.2017.09.003. Epub 2017 Oct 19.

19.

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.

Kerres N, Steurer S, Schlager S, Bader G, Berger H, Caligiuri M, Dank C, Engen JR, Ettmayer P, Fischerauer B, Flotzinger G, Gerlach D, Gerstberger T, Gmaschitz T, Greb P, Han B, Heyes E, Iacob RE, Kessler D, Kölle H, Lamarre L, Lancia DR, Lucas S, Mayer M, Mayr K, Mischerikow N, Mück K, Peinsipp C, Petermann O, Reiser U, Rudolph D, Rumpel K, Salomon C, Scharn D, Schnitzer R, Schrenk A, Schweifer N, Thompson D, Traxler E, Varecka R, Voss T, Weiss-Puxbaum A, Winkler S, Zheng X, Zoephel A, Kraut N, McConnell D, Pearson M, Koegl M.

Cell Rep. 2017 Sep 19;20(12):2860-2875. doi: 10.1016/j.celrep.2017.08.081.

20.

Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts.

Joseph RE, Wales TE, Fulton DB, Engen JR, Andreotti AH.

Structure. 2017 Oct 3;25(10):1481-1494.e4. doi: 10.1016/j.str.2017.07.014. Epub 2017 Aug 31.

21.

Mechanism of Enzyme Repair by the AAA+ Chaperone Rubisco Activase.

Bhat JY, Miličić G, Thieulin-Pardo G, Bracher A, Maxwell A, Ciniawsky S, Mueller-Cajar O, Engen JR, Hartl FU, Wendler P, Hayer-Hartl M.

Mol Cell. 2017 Sep 7;67(5):744-756.e6. doi: 10.1016/j.molcel.2017.07.004. Epub 2017 Aug 10.

22.

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.

Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD.

Structure. 2017 Sep 5;25(9):1442-1448.e3. doi: 10.1016/j.str.2017.07.003. Epub 2017 Aug 3.

23.

Engineering Aglycosylated IgG Variants with Wild-Type or Improved Binding Affinity to Human Fc Gamma RIIA and Fc Gamma RIIIAs.

Chen TF, Sazinsky SL, Houde D, DiLillo DJ, Bird J, Li KK, Cheng GT, Qiu H, Engen JR, Ravetch JV, Wittrup KD.

J Mol Biol. 2017 Aug 4;429(16):2528-2541. doi: 10.1016/j.jmb.2017.07.001. Epub 2017 Jul 8.

24.

Allosteric sensitization of proapoptotic BAX.

Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD.

Nat Chem Biol. 2017 Sep;13(9):961-967. doi: 10.1038/nchembio.2433. Epub 2017 Jul 10.

25.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.

26.

Subzero Celsius separations in three-zone temperature controlled hydrogen deuterium exchange mass spectrometry.

Wales TE, Fadgen KE, Eggertson MJ, Engen JR.

J Chromatogr A. 2017 Nov 10;1523:275-282. doi: 10.1016/j.chroma.2017.05.067. Epub 2017 Jun 3.

27.

Force interacts with macromolecular structure in activation of TGF-β.

Dong X, Zhao B, Iacob RE, Zhu J, Koksal AC, Lu C, Engen JR, Springer TA.

Nature. 2017 Feb 2;542(7639):55-59. doi: 10.1038/nature21035. Epub 2017 Jan 25.

28.

Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?

Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O.

Amyloid. 2017 Mar;24(sup1):11-12. doi: 10.1080/13506129.2016.1269737. Epub 2016 Dec 31. No abstract available.

29.

Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching.

Harrison RA, Lu J, Carrasco M, Hunter J, Manandhar A, Gondi S, Westover KD, Engen JR.

J Mol Biol. 2016 Nov 20;428(23):4723-4735. doi: 10.1016/j.jmb.2016.10.017. Epub 2016 Oct 14.

30.

Conformational insight into multi-protein signaling assemblies by hydrogen-deuterium exchange mass spectrometry.

Harrison RA, Engen JR.

Curr Opin Struct Biol. 2016 Dec;41:187-193. doi: 10.1016/j.sbi.2016.08.003. Epub 2016 Aug 20. Review.

31.

Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G.

J Am Soc Mass Spectrom. 2017 May;28(5):795-802. doi: 10.1007/s13361-016-1452-7. Epub 2016 Aug 15.

PMID:
27527097
32.

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.

Badger J, Grover P, Shi H, Panjarian SB, Engen JR, Smithgall TE, Makowski L.

Biochemistry. 2016 Jun 14;55(23):3251-60. doi: 10.1021/acs.biochem.6b00202. Epub 2016 Jun 3.

33.

Allosteric inhibition of antiapoptotic MCL-1.

Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD.

Nat Struct Mol Biol. 2016 Jun;23(6):600-7. doi: 10.1038/nsmb.3223. Epub 2016 May 9.

34.

Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.

Wales TE, Poe JA, Emert-Sedlak L, Morgan CR, Smithgall TE, Engen JR.

J Am Soc Mass Spectrom. 2016 Jun;27(6):1048-61. doi: 10.1007/s13361-016-1365-5. Epub 2016 Mar 31.

35.

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

Chopra N, Wales TE, Joseph RE, Boyken SE, Engen JR, Jernigan RL, Andreotti AH.

PLoS Comput Biol. 2016 Mar 24;12(3):e1004826. doi: 10.1371/journal.pcbi.1004826. eCollection 2016 Mar.

36.

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome.

Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ.

Science. 2016 Feb 19;351(6275). pii: aad9421. doi: 10.1126/science.aad9421.

37.

Tuning a High Transmission Ion Guide to Prevent Gas-Phase Proton Exchange During H/D Exchange MS Analysis.

Guttman M, Wales TE, Whittington D, Engen JR, Brown JM, Lee KK.

J Am Soc Mass Spectrom. 2016 Apr;27(4):662-8. doi: 10.1007/s13361-015-1330-8. Epub 2016 Jan 26.

38.

Dynamics of the Tec-family tyrosine kinase SH3 domains.

Roberts JM, Tarafdar S, Joseph RE, Andreotti AH, Smithgall TE, Engen JR, Wales TE.

Protein Sci. 2016 Apr;25(4):852-64. doi: 10.1002/pro.2887. Epub 2016 Mar 18.

39.

Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?

Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O.

J Mol Biol. 2016 Jan 29;428(2 Pt B):449-62. doi: 10.1016/j.jmb.2015.10.029. Epub 2015 Nov 10.

40.

Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.

Wales TE, Hochrein JM, Morgan CR, Emert-Sedlak LA, Smithgall TE, Engen JR.

Biochemistry. 2015 Oct 20;54(41):6382-91. doi: 10.1021/acs.biochem.5b00875. Epub 2015 Oct 6.

41.

Hydrogen Exchange Mass Spectrometry of Proteins at Langmuir Monolayers.

Pirrone GF, Vernon BC, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7022-9. doi: 10.1021/acs.analchem.5b01724. Epub 2015 Jul 2.

42.

Membrane-Associated Conformation of HIV-1 Nef Investigated with Hydrogen Exchange Mass Spectrometry at a Langmuir Monolayer.

Pirrone GF, Emert-Sedlak LA, Wales TE, Smithgall TE, Kent MS, Engen JR.

Anal Chem. 2015 Jul 21;87(14):7030-5. doi: 10.1021/acs.analchem.5b01725. Epub 2015 Jul 2.

43.

Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Engen JR, Wales TE.

Annu Rev Anal Chem (Palo Alto Calif). 2015;8:127-48. doi: 10.1146/annurev-anchem-062011-143113. Epub 2015 May 29. Review.

44.

Replication in bioanalytical studies with HDX MS: aim as high as possible.

Moroco JA, Engen JR.

Bioanalysis. 2015;7(9):1065-7. doi: 10.4155/bio.15.46. No abstract available.

45.

Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe.

Marcsisin SR, Liptak C, Marineau J, Bradner JE, Engen JR.

Anal Chem. 2015 Jun 16;87(12):6349-56. doi: 10.1021/acs.analchem.5b01220. Epub 2015 May 29.

46.

Utilizing Microchip Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry.

Black WA, Stocks BB, Mellors JS, Engen JR, Ramsey JM.

Anal Chem. 2015 Jun 16;87(12):6280-7. doi: 10.1021/acs.analchem.5b01179. Epub 2015 Jun 2.

47.

Noncognate DNA damage prevents the formation of the active conformation of the Y-family DNA polymerases DinB and DNA polymerase κ.

Nevin P, Lu X, Zhang K, Engen JR, Beuning PJ.

FEBS J. 2015 Jul;282(14):2646-60. doi: 10.1111/febs.13304. Epub 2015 May 11.

48.

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.

Iacob RE, Krystek SR, Huang RY, Wei H, Tao L, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR, Chen G.

Expert Rev Proteomics. 2015 Apr;12(2):159-69. doi: 10.1586/14789450.2015.1018897. Epub 2015 Feb 24. Review.

49.

Steric gate residues of Y-family DNA polymerases DinB and pol kappa are crucial for dNTP-induced conformational change.

Nevin P, Engen JR, Beuning PJ.

DNA Repair (Amst). 2015 May;29:65-73. doi: 10.1016/j.dnarep.2015.01.012. Epub 2015 Feb 4.

50.

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-886. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.

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