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Items: 1 to 50 of 145

1.

Impact of Nuclear Oestrogen Receptor Beta Expression in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.

Heitz F, Kümmel S, Lederer B, Solbach C, Engels K, Ataseven B, Sinn B, Blohmer JU, Denkert C, Barinoff J, Fisseler-Eckhoff A, Loibl S.

Geburtshilfe Frauenheilkd. 2019 Oct;79(10):1110-1117. doi: 10.1055/a-0987-9898. Epub 2019 Oct 22.

2.

Prevalence and Etiology of Burnout in a Community-Based Graduate Medical Education System: A Mixed-Methods Study.

Ofei-Dodoo S, Callaway P, Engels K.

Fam Med. 2019 Oct;51(9):766-771. doi: 10.22454/FamMed.2019.431489.

3.

Age effect on thyroid hormone brain response in male mice.

Kerp H, Engels K, Kramer F, Doycheva D, Sebastian Hönes G, Zwanziger D, Christian Moeller L, Heuer H, Führer D.

Endocrine. 2019 Sep 7. doi: 10.1007/s12020-019-02078-6. [Epub ahead of print]

PMID:
31494803
4.

A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple negative breast cancer - clinical results and biomarker analysis of GeparNuevo study.

Loibl S, Untch M, Burchardi N, Huober J, Sinn BV, Blohmer JU, Grischke EM, Furlanetto J, Tesch H, Hanusch C, Engels K, Rezai M, Jackisch C, Schmitt WD, von Minckwitz G, Thomalla J, Kümmel S, Rautenberg B, Fasching PA, Weber K, Rhiem K, Denkert C, Schneeweiss A.

Ann Oncol. 2019 May 16. pii: mdz158. doi: 10.1093/annonc/mdz158. [Epub ahead of print]

PMID:
31095287
5.

Clinical and analytical validation of Ki-67 in 9069 patients from IBCSG VIII + IX, BIG1-98 and GeparTrio trial: systematic modulation of interobserver variance in a comprehensive in silico ring trial.

Denkert C, Budczies J, Regan MM, Loibl S, Dell'Orto P, von Minckwitz G, Mastropasqua MG, Solbach C, Thürlimann B, Mehta K, Blohmer JU, Colleoni M, Müller V, Klauschen F, Ataseven B, Engels K, Kammler R, Pfitzner BM, Dietel M, Fasching PA, Viale G.

Breast Cancer Res Treat. 2019 Aug;176(3):557-568. doi: 10.1007/s10549-018-05112-9. Epub 2019 May 7.

PMID:
31065870
6.

Emotions towards magnetic resonance imaging in people with multiple sclerosis.

Engels K, Schiffmann I, Weierstall R, Rahn AC, Daubmann A, Pust G, Chard D, Lukas C, Scheiderbauer J, Stellmann JP, Heesen C.

Acta Neurol Scand. 2019 Jun;139(6):497-504. doi: 10.1111/ane.13082. Epub 2019 Mar 28.

PMID:
30802931
7.

Aging alters phenotypic traits of thyroid dysfunction in male mice with divergent effects on complex systems but preserved thyroid hormone action in target organs.

Engels K, Rakov H, Hönes GS, Brix K, Köhrle J, Zwanziger D, Moeller LC, Führer D.

J Gerontol A Biol Sci Med Sci. 2019 Feb 16. pii: glz040. doi: 10.1093/gerona/glz040. [Epub ahead of print]

PMID:
30770932
8.

Intense dose-dense epirubicin, paclitaxel, cyclophosphamide versus weekly paclitaxel, liposomal doxorubicin (plus carboplatin in triple-negative breast cancer) for neoadjuvant treatment of high-risk early breast cancer (GeparOcto-GBG 84): A randomised phase III trial.

Schneeweiss A, Möbus V, Tesch H, Hanusch C, Denkert C, Lübbe K, Huober J, Klare P, Kümmel S, Untch M, Kast K, Jackisch C, Thomalla J, Ingold-Heppner B, Blohmer JU, Rezai M, Frank M, Engels K, Rhiem K, Fasching PA, Nekljudova V, von Minckwitz G, Loibl S.

Eur J Cancer. 2019 Jan;106:181-192. doi: 10.1016/j.ejca.2018.10.015. Epub 2018 Dec 5.

PMID:
30528802
9.

Claudin-1 is linked to presence of implants and micropapillary pattern in serous borderline epithelial tumours of the ovary.

El-Balat A, Schmeil I, Gasimli K, Sänger N, Karn T, Ahr A, Becker S, Arsenic R, Holtrich U, Engels K.

J Clin Pathol. 2018 Dec;71(12):1060-1064. doi: 10.1136/jclinpath-2018-205292. Epub 2018 Aug 31.

PMID:
30171086
10.

Risk Assessment after Neoadjuvant Chemotherapy in Luminal Breast Cancer Using a Clinicomolecular Predictor.

Loibl S, Weber K, Huober J, Krappmann K, Marmé F, Schem C, Engels K, Pfitzner BM, Kümmel S, Furlanetto J, Hartmann A, Darb-Esfahani S, Müller V, Staebler A, von Minckwitz G, Kronenwett R, Denkert C.

Clin Cancer Res. 2018 Jul 15;24(14):3358-3365. doi: 10.1158/1078-0432.CCR-17-2947. Epub 2018 Apr 4.

11.

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in aged mice.

Rakov H, Engels K, Hönes GS, Brix K, Köhrle J, Moeller LC, Zwanziger D, Führer D.

Biol Sex Differ. 2017 Dec 22;8(1):38. doi: 10.1186/s13293-017-0159-1.

12.

Clinical relevance and concordance of HER2 status in local and central testing-an analysis of 1581 HER2-positive breast carcinomas over 12 years.

Pfitzner BM, Lederer B, Lindner J, Solbach C, Engels K, Rezai M, Dohnal K, Tesch H, Hansmann ML, Salat C, Beer M, Schneeweiss A, Sinn P, Bankfalvi A, Darb-Esfahani S, von Minckwitz G, Sinn BV, Kronenwett R, Weber K, Denkert C, Loibl S.

Mod Pathol. 2018 Apr;31(4):607-615. doi: 10.1038/modpathol.2017.171. Epub 2017 Dec 22.

13.

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.

Denkert C, von Minckwitz G, Darb-Esfahani S, Lederer B, Heppner BI, Weber KE, Budczies J, Huober J, Klauschen F, Furlanetto J, Schmitt WD, Blohmer JU, Karn T, Pfitzner BM, Kümmel S, Engels K, Schneeweiss A, Hartmann A, Noske A, Fasching PA, Jackisch C, van Mackelenbergh M, Sinn P, Schem C, Hanusch C, Untch M, Loibl S.

Lancet Oncol. 2018 Jan;19(1):40-50. doi: 10.1016/S1470-2045(17)30904-X. Epub 2017 Dec 7.

PMID:
29233559
14.

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.

Hönes GS, Rakov H, Logan J, Liao XH, Werbenko E, Pollard AS, Præstholm SM, Siersbæk MS, Rijntjes E, Gassen J, Latteyer S, Engels K, Strucksberg KH, Kleinbongard P, Zwanziger D, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Klein-Hitpass L, Köhrle J, Armstrong DL, Grøntved L, Bassett JHD, Williams GR, Refetoff S, Führer D, Moeller LC.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11323-E11332. doi: 10.1073/pnas.1706801115. Epub 2017 Dec 11.

15.

Expression of Cyclin D1 protein in residual tumor after neoadjuvant chemotherapy for breast cancer.

Villegas SL, Darb-Esfahani S, von Minckwitz G, Huober J, Weber K, Marmé F, Furlanetto J, Schem C, Pfitzner BM, Lederer B, Engels K, Kümmel S, Müller V, Mehta K, Denkert C, Loibl S.

Breast Cancer Res Treat. 2018 Feb;168(1):179-187. doi: 10.1007/s10549-017-4581-1. Epub 2017 Nov 25.

PMID:
29177689
16.

Randomised, open-label, phase II study comparing the efficacy and the safety of cabazitaxel versus weekly paclitaxel given as neoadjuvant treatment in patients with operable triple-negative or luminal B/HER2-negative breast cancer (GENEVIEVE).

Kümmel S, Paepke S, Huober J, Schem C, Untch M, Blohmer JU, Eiermann W, Gerber B, Hanusch C, Hilfrich J, Jackisch C, Schneeweiss A, Denkert C, Engels K, Klare P, Fasching PA, von Minckwitz G, Burchardi N, Loibl S.

Eur J Cancer. 2017 Oct;84:1-8. doi: 10.1016/j.ejca.2017.06.037. Epub 2017 Jul 30.

PMID:
28768217
17.

[Perioperative management of patients on NOACs].

Kelm C, Engels K.

Med Klin Intensivmed Notfmed. 2017 Mar;112(2):125-128. doi: 10.1007/s00063-016-0244-y. Epub 2017 Jan 12. Review. German.

PMID:
28083624
18.

Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile.

Klemmt PA, Resch E, Smyrek I, Engels K, Stelzer EH, Starzinski-Powitz A.

Biol Open. 2016 Nov 15;5(11):1607-1619. doi: 10.1242/bio.019463.

19.

Dual HER2-blockade with pertuzumab and trastuzumab in HER2-positive early breast cancer: a subanalysis of data from the randomized phase III GeparSepto trial.

Loibl S, Jackisch C, Schneeweiss A, Schmatloch S, Aktas B, Denkert C, Wiebringhaus H, Kümmel S, Warm M, Paepke S, Just M, Hanusch C, Hackmann J, Blohmer JU, Clemens M, Dan Costa S, Gerber B, Engels K, Nekljudova V, von Minckwitz G, Untch M; investigators of the German Breast Group (GBG) and the Arbeitsgemeinschaft Gynäkologische Onkologie—Breast (AGO-B) study groups.

Ann Oncol. 2017 Mar 1;28(3):497-504. doi: 10.1093/annonc/mdw610.

PMID:
27831502
20.

Efficacy of protocols for induction of chronic hyperthyroidism in male and female mice.

Engels K, Rakov H, Zwanziger D, Hönes GS, Rehders M, Brix K, Köhrle J, Möller LC, Führer D.

Endocrine. 2016 Oct;54(1):47-54. Epub 2016 Jul 29.

PMID:
27473100
21.

Sex-specific phenotypes of hyperthyroidism and hypothyroidism in mice.

Rakov H, Engels K, Hönes GS, Strucksberg KH, Moeller LC, Köhrle J, Zwanziger D, Führer D.

Biol Sex Differ. 2016 Aug 24;7(1):36. doi: 10.1186/s13293-016-0089-3. eCollection 2016.

22.

Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition.

Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW.

J Toxicol Environ Health A. 2016;79(11):447-52. doi: 10.1080/15287394.2016.1164101. Epub 2016 Apr 19.

23.

Nab-paclitaxel versus solvent-based paclitaxel in neoadjuvant chemotherapy for early breast cancer (GeparSepto-GBG 69): a randomised, phase 3 trial.

Untch M, Jackisch C, Schneeweiss A, Conrad B, Aktas B, Denkert C, Eidtmann H, Wiebringhaus H, Kümmel S, Hilfrich J, Warm M, Paepke S, Just M, Hanusch C, Hackmann J, Blohmer JU, Clemens M, Darb-Esfahani S, Schmitt WD, Dan Costa S, Gerber B, Engels K, Nekljudova V, Loibl S, von Minckwitz G; German Breast Group (GBG); Arbeitsgemeinschaft Gynäkologische Onkologie—Breast (AGO-B) Investigators.

Lancet Oncol. 2016 Mar;17(3):345-56. doi: 10.1016/S1470-2045(15)00542-2. Epub 2016 Feb 8. Erratum in: Lancet Oncol. 2016 Jul;17 (7):e270.

PMID:
26869049
24.

Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism.

Engels K, Rakov H, Zwanziger D, Moeller LC, Homuth G, Köhrle J, Brix K, Führer D.

Eur Thyroid J. 2015 Sep;4(Suppl 1):81-6. doi: 10.1159/000381020. Epub 2015 May 27.

25.

Sex-Dependent Claudin-1 Expression in the Liver of Euthyroid and Hypothyroid Mice.

Zwanziger D, Rakov H, Engels K, Moeller LC, Führer D.

Eur Thyroid J. 2015 Sep;4(Suppl 1):67-73. doi: 10.1159/000431316. Epub 2015 May 30.

26.

Biopower, Normalization, and HPV: A Foucauldian Analysis of the HPV Vaccine Controversy.

Engels KS.

J Med Humanit. 2016 Sep;37(3):299-312. doi: 10.1007/s10912-015-9361-5.

PMID:
26438668
27.

Fascin-1 expression as stratification marker in borderline epithelial tumours of the ovary.

El-Balat A, Arsenic R, Sänger N, Karn T, Becker S, Holtrich U, Engels K.

J Clin Pathol. 2016 Feb;69(2):142-8. doi: 10.1136/jclinpath-2015-203224. Epub 2015 Sep 11.

PMID:
26362828
28.

Notes from the Field: Measles Transmission in an International Airport at a Domestic Terminal Gate--April-May 2014.

Banerjee E, Hickman C, Engels K, Kenyon C; Centers for Disease Control and Prevention (CDC).

MMWR Morb Mortal Wkly Rep. 2015 Jun 26;64(24):679.

29.

Dual Blockade with AFatinib and Trastuzumab as NEoadjuvant Treatment for Patients with Locally Advanced or Operable Breast Cancer Receiving Taxane-Anthracycline Containing Chemotherapy-DAFNE (GBG-70).

Hanusch C, Schneeweiss A, Loibl S, Untch M, Paepke S, Kümmel S, Jackisch C, Huober J, Hilfrich J, Gerber B, Eidtmann H, Denkert C, Costa S, Blohmer JU, Engels K, Burchardi N, von Minckwitz G.

Clin Cancer Res. 2015 Jul 1;21(13):2924-31. doi: 10.1158/1078-0432.CCR-14-2774. Epub 2015 Mar 30. Erratum in: Clin Cancer Res. 2016 Sep 1;22(17 ):4536.

30.

Molecular Markers as Prognostic Factors in DCIS and Small Invasive Breast Cancers.

Sänger N, Engels K, Graf A, Ruckhäberle E, Effenberger KE, Fehm T, Holtrich U, Becker S, Karn T.

Geburtshilfe Frauenheilkd. 2014 Nov;74(11):1016-1022.

31.

Expression of secreted protein acidic and rich in cysteine (SPARC) in breast cancer and response to neoadjuvant chemotherapy.

Lindner JL, Loibl S, Denkert C, Ataseven B, Fasching PA, Pfitzner BM, Gerber B, Gade S, Darb-Esfahani S, Sinn BV, Huober J, Engels K, Tesch H, Karn T, Pommerenke F, Liedtke C, Untch M, Müller V, Rack B, Schem C, von Minckwitz G.

Ann Oncol. 2015 Jan;26(1):95-100. doi: 10.1093/annonc/mdu487. Epub 2014 Oct 29.

PMID:
25355716
32.

Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.

Sänger N, Ruckhäberle E, Györffy B, Engels K, Heinrich T, Fehm T, Graf A, Holtrich U, Becker S, Karn T.

Mol Oncol. 2015 Jan;9(1):58-67. doi: 10.1016/j.molonc.2014.07.016. Epub 2014 Jul 31.

33.

Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial.

von Minckwitz G, Schneeweiss A, Loibl S, Salat C, Denkert C, Rezai M, Blohmer JU, Jackisch C, Paepke S, Gerber B, Zahm DM, Kümmel S, Eidtmann H, Klare P, Huober J, Costa S, Tesch H, Hanusch C, Hilfrich J, Khandan F, Fasching PA, Sinn BV, Engels K, Mehta K, Nekljudova V, Untch M.

Lancet Oncol. 2014 Jun;15(7):747-56. doi: 10.1016/S1470-2045(14)70160-3. Epub 2014 Apr 30.

PMID:
24794243
34.

Maternal engineered nanomaterial exposure and fetal microvascular function: does the Barker hypothesis apply?

Stapleton PA, Minarchick VC, Yi J, Engels K, McBride CR, Nurkiewicz TR.

Am J Obstet Gynecol. 2013 Sep;209(3):227.e1-11. doi: 10.1016/j.ajog.2013.04.036. Epub 2013 Apr 30.

35.

Acid ceramidase (AC)--a key enzyme of sphingolipid metabolism--correlates with better prognosis in epithelial ovarian cancer.

Hanker LC, Karn T, Holtrich U, Gätje R, Rody A, Heinrich T, Ruckhäberle E, Engels K.

Int J Gynecol Pathol. 2013 May;32(3):249-57. doi: 10.1097/PGP.0b013e3182673982.

PMID:
23518908
36.

HER2 and ESR1 mRNA expression levels and response to neoadjuvant trastuzumab plus chemotherapy in patients with primary breast cancer.

Denkert C, Huober J, Loibl S, Prinzler J, Kronenwett R, Darb-Esfahani S, Brase JC, Solbach C, Mehta K, Fasching PA, Sinn BV, Engels K, Reinisch M, Hansmann ML, Tesch H, von Minckwitz G, Untch M.

Breast Cancer Res. 2013 Feb 7;15(1):R11. doi: 10.1186/bcr3384.

37.

The effect of intraarterial high-dose cisplatin on lymph nodes in oral and oropharyngeal cancer.

Kovács AF, Döbert N, Engels K.

Indian J Cancer. 2012 Apr-Jun;49(2):230-5. doi: 10.4103/0019-509X.102918.

38.

Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels.

Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, Engels K, Pleli T, Benz A, Canamero M, Longerich T, Kronenberger B, Richter S, Waidmann O, Vogl TJ, Zeuzem S, Piiper A.

Neoplasia. 2012 May;14(5):410-9.

39.

High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a.

Fernández ML, Engels KK, Bender F, Gassel M, Marhöfer RJ, Mottram JC, Selzer PM.

Microbiology. 2012 Sep;158(Pt 9):2262-71. doi: 10.1099/mic.0.059428-0. Epub 2012 Jun 21.

40.

Retrospective study on the use of different protocols for repeated transarterial chemoembolization in the treatment of patients with hepatocellular carcinoma.

Vogl TJ, Naguib NN, Nour-Eldin NE, Farshid P, Lehnert T, Gruber-Rouh T, Engels KS.

Acad Radiol. 2012 Apr;19(4):434-9. doi: 10.1016/j.acra.2011.12.009. Epub 2012 Jan 23.

PMID:
22265853
41.

14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.

Andersen SD, Keijzers G, Rampakakis E, Engels K, Luhn P, El-Shemerly M, Nielsen FC, Du Y, May A, Bohr VA, Ferrari S, Zannis-Hadjopoulos M, Fu H, Rasmussen LJ.

DNA Repair (Amst). 2012 Mar 1;11(3):267-77. doi: 10.1016/j.dnarep.2011.11.007. Epub 2012 Jan 4.

42.

Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation.

Mousset S, Martin H, Berger A, Heß S, Bug G, Kriener S, Engels K, Hoelzer D, Klein SA.

Ann Hematol. 2012 May;91(5):737-742. doi: 10.1007/s00277-011-1354-5. Epub 2011 Nov 3.

PMID:
22048789
43.

Malignant fibrous histiocytoma is a rare Lynch syndrome-associated tumor in two German families.

Brieger A, Engels K, Schaefer D, Plotz G, Zeuzem S, Raedle J, Trojan J.

Fam Cancer. 2011 Sep;10(3):591-5. doi: 10.1007/s10689-011-9455-9.

PMID:
21598002
44.

14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks.

Engels K, Giannattasio M, Muzi-Falconi M, Lopes M, Ferrari S.

PLoS Genet. 2011 Apr;7(4):e1001367. doi: 10.1371/journal.pgen.1001367. Epub 2011 Apr 14.

45.

Trends in the postmortem epidemiology of invasive fungal infections at a university hospital.

Lehrnbecher T, Frank C, Engels K, Kriener S, Groll AH, Schwabe D.

J Infect. 2010 Sep;61(3):259-65. doi: 10.1016/j.jinf.2010.06.018. Epub 2010 Jul 31.

PMID:
20624423
46.

Inhibition of Eimeria tenella CDK-related kinase 2: From target identification to lead compounds.

Engels K, Beyer C, Suárez Fernández ML, Bender F, Gassel M, Unden G, Marhöfer RJ, Mottram JC, Selzer PM.

ChemMedChem. 2010 Aug 2;5(8):1259-71. doi: 10.1002/cmdc.201000157.

47.

Efficacy and safety of sorafenib in advanced hepatocellular carcinoma under daily practice conditions.

Welker MW, Lubomierski N, Gog C, Herrmann E, Engels K, Vogl TJ, Bechstein WO, Zeuzem S, Trojan J.

J Chemother. 2010 Jun;22(3):205-11.

PMID:
20566428
48.

Sonic hedgehog acts as a negative regulator of {beta}-catenin signaling in the adult tongue epithelium.

Schneider FT, Schänzer A, Czupalla CJ, Thom S, Engels K, Schmidt MHH, Plate KH, Liebner S.

Am J Pathol. 2010 Jul;177(1):404-14. doi: 10.2353/ajpath.2010.091079. Epub 2010 May 27.

49.

Contrast-enhanced ultrasound in the diagnosis of malignant mesenchymal liver tumors.

Trojan J, Hammerstingl R, Engels K, Schneider AR, Zeuzem S, Dietrich CF.

J Clin Ultrasound. 2010 Jun;38(5):227-31. doi: 10.1002/jcu.20690.

PMID:
20336772
50.

Breast Cancer Proteomics - Differences in Protein Expression between Estrogen Receptor-Positive and -Negative Tumors Identified by Tandem Mass Tag Technology.

Ruckhäberle E, Karn T, Hanker L, Schwarz J, Schulz-Knappe P, Kuhn K, Böhm G, Selzer S, Erhard N, Engels K, Holtrich U, Kaufmann M, Rody A.

Breast Care (Basel). 2010 Mar;5(1):7-10. Epub 2010 Feb 16.

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