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Items: 26

1.

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.

Nature. 2019 Jan;565(7738):E5-E6. doi: 10.1038/s41586-018-0722-x. No abstract available.

PMID:
30559381
2.

Chemical activation of the mechanotransduction channel Piezo1.

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.07369.

3.

A biochemical screen for GroEL/GroES inhibitors.

Johnson SM, Sharif O, Mak PA, Wang HT, Engels IH, Brinker A, Schultz PG, Horwich AL, Chapman E.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):786-9. doi: 10.1016/j.bmcl.2013.12.100. Epub 2014 Jan 2.

PMID:
24418775
4.

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction.

Breuer S, Espinola S, Morelli X, Torbett BE, Arold ST, Engels IH.

Curr Chem Genom Transl Med. 2013 Jul 26;7:16-20. doi: 10.2174/2213988501307010016. eCollection 2013.

5.

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.

Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.

6.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.

Nature. 2012 Mar 28;483(7391):603-7. doi: 10.1038/nature11003. Erratum in: Nature. 2012 Dec 13;492(7428):290. Erratum in: Nature. 2019 Jan;565(7738):E5-E6.

7.

Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.

Crowther GJ, Napuli AJ, Gilligan JH, Gagaring K, Borboa R, Francek C, Chen Z, Dagostino EF, Stockmyer JB, Wang Y, Rodenbough PP, Castaneda LJ, Leibly DJ, Bhandari J, Gelb MH, Brinker A, Engels IH, Taylor J, Chatterjee AK, Fantauzzi P, Glynne RJ, Van Voorhis WC, Kuhen KL.

Mol Biochem Parasitol. 2011 Jan;175(1):21-9. doi: 10.1016/j.molbiopara.2010.08.005. Epub 2010 Sep 15.

8.

HTS-Compatible Patient-Derived Cell-Based Assay to Identify Small Molecule Modulators of Aberrant Splicing in Myotonic Dystrophy Type 1.

O'Leary DA, Vargas L, Sharif O, Garcia ME, Sigal YJ, Chow SK, Schmedt C, Caldwell JS, Brinker A, Engels IH.

Curr Chem Genomics. 2010 Mar 19;4:9-18. doi: 10.2174/1875397301004010009.

9.

Identification of small molecule and genetic modulators of AON-induced dystrophin exon skipping by high-throughput screening.

O'Leary DA, Sharif O, Anderson P, Tu B, Welch G, Zhou Y, Caldwell JS, Engels IH, Brinker A.

PLoS One. 2009 Dec 17;4(12):e8348. doi: 10.1371/journal.pone.0008348.

10.

A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity.

Engels IH, Daguia C, Huynh T, Urbina H, Buddenkotte J, Schumacher A, Caldwell JS, Brinker A.

Anal Biochem. 2009 Jul 1;390(1):85-7. doi: 10.1016/j.ab.2009.03.035. Epub 2009 Mar 27.

PMID:
19328766
11.

Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner.

Engels IH, Totzke G, Fischer U, Schulze-Osthoff K, Jänicke RU.

Mol Cell Biol. 2005 Apr;25(7):2808-18.

12.

Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B.

Buddenkotte J, Stroh C, Engels IH, Moormann C, Shpacovitch VM, Seeliger S, Vergnolle N, Vestweber D, Luger TA, Schulze-Osthoff K, Steinhoff M.

J Invest Dermatol. 2005 Jan;124(1):38-45.

14.

Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway.

Wagner KW, Engels IH, Deveraux QL.

J Biol Chem. 2004 Aug 13;279(33):35047-52. Epub 2004 Jun 1.

15.

Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway.

Wang Y, Engels IH, Knee DA, Nasoff M, Deveraux QL, Quon KC.

Cancer Cell. 2004 May;5(5):501-12.

16.

Transcription factor AP-2alpha triggers apoptosis in cardiac myocytes.

Müller FU, Loser K, Kleideiter U, Neumann J, von Wallbrunn C, Dobner T, Scheld HH, Bantel H, Engels IH, Schulze-Osthoff K, Schmitz W.

Cell Death Differ. 2004 May;11(5):485-93.

17.

Expression of calcium-binding proteins MRP8 and MRP14 in inflammatory muscle diseases.

Seeliger S, Vogl T, Engels IH, Schröder JM, Sorg C, Sunderkötter C, Roth J.

Am J Pathol. 2003 Sep;163(3):947-56. Erratum in: Am J Pathol. 2003 Dec;163(6):2645.

18.

Staphylococcus aureus alpha-toxin-induced cell death: predominant necrosis despite apoptotic caspase activation.

Essmann F, Bantel H, Totzke G, Engels IH, Sinha B, Schulze-Osthoff K, Jänicke RU.

Cell Death Differ. 2003 Nov;10(11):1260-72.

19.

Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets.

Berg CP, Rothbart A, Lauber K, Stein GM, Engels IH, Belka C, Jänicke RU, Schulze-Osthoff K, Wesselborg S.

Oncogene. 2003 Feb 6;22(5):775-80.

PMID:
12569371
20.

Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis.

Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, Schulze-Osthoff K, Wesselborg S.

Cell Death Differ. 2001 Dec;8(12):1197-206.

21.

Ionizing radiation but not anticancer drugs causes cell cycle arrest and failure to activate the mitochondrial death pathway in MCF-7 breast carcinoma cells.

Jänicke RU, Engels IH, Dunkern T, Kaina B, Schulze-Osthoff K, Porter AG.

Oncogene. 2001 Aug 16;20(36):5043-53.

22.

Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.

Stepczynska A, Lauber K, Engels IH, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K.

Oncogene. 2001 Mar 8;20(10):1193-202.

23.

Caspases: more than just killers?

Los M, Stroh C, Jänicke RU, Engels IH, Schulze-Osthoff K.

Trends Immunol. 2001 Jan;22(1):31-4. Review.

PMID:
11286689
24.

Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis.

Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Jänicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S.

Oncogene. 2000 Sep 21;19(40):4563-73.

25.

Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.

Bantel H, Engels IH, Voelter W, Schulze-Osthoff K, Wesselborg S.

Cancer Res. 1999 May 1;59(9):2083-90.

26.

Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction.

Wesselborg S, Engels IH, Rossmann E, Los M, Schulze-Osthoff K.

Blood. 1999 May 1;93(9):3053-63.

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