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Ancestry-specific polygenic scores and SNP heritability of 25(OH)D in African- and European-ancestry populations.

Hatchell KE, Lu Q, Hebbring SJ, Michos ED, Wood AC, Engelman CD.

Hum Genet. 2019 Oct;138(10):1155-1169. doi: 10.1007/s00439-019-02049-x. Epub 2019 Jul 24.


Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participants.

Darst BF, Lu Q, Johnson SC, Engelman CD.

Genet Epidemiol. 2019 Sep;43(6):657-674. doi: 10.1002/gepi.22211. Epub 2019 May 18.


KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD.

Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.

Neurology. 2019 Apr 16;92(16):e1878-e1889. doi: 10.1212/WNL.0000000000007323. Epub 2019 Mar 13.


Carrier frequency estimation of Zellweger spectrum disorder using ExAC database and bioinformatics tools.

Vasiljevic E, Ye Z, Pavelec DM, Darst BF, Engelman CD, Baker MW.

Genet Med. 2019 Sep;21(9):1969-1976. doi: 10.1038/s41436-019-0468-3. Epub 2019 Mar 8.


Longitudinal plasma metabolomics of aging and sex.

Darst BF, Koscik RL, Hogan KJ, Johnson SC, Engelman CD.

Aging (Albany NY). 2019 Feb 24;11(4):1262-1282. doi: 10.18632/aging.101837.


The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.

Vogt NM, Romano KA, Darst BF, Engelman CD, Johnson SC, Carlsson CM, Asthana S, Blennow K, Zetterberg H, Bendlin BB, Rey FE.

Alzheimers Res Ther. 2018 Dec 22;10(1):124. doi: 10.1186/s13195-018-0451-2.


Characterizing the Effects of Sex, APOE ɛ4, and Literacy on Mid-life Cognitive Trajectories: Application of Information-Theoretic Model Averaging and Multi-model Inference Techniques to the Wisconsin Registry for Alzheimer's Prevention Study.

Koscik RL, Norton DL, Allison SL, Jonaitis EM, Clark LR, Mueller KD, Hermann BP, Engelman CD, Gleason CE, Sager MA, Chappell RJ, Johnson SC.

J Int Neuropsychol Soc. 2019 Feb;25(2):119-133. doi: 10.1017/S1355617718000954. Epub 2018 Dec 7.


Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20.

Darst B, Engelman CD, Tian Y, Lorenzo Bermejo J.

BMC Genet. 2018 Sep 17;19(Suppl 1):76. doi: 10.1186/s12863-018-0646-3.


Using recursive feature elimination in random forest to account for correlated variables in high dimensional data.

Darst BF, Malecki KC, Engelman CD.

BMC Genet. 2018 Sep 17;19(Suppl 1):65. doi: 10.1186/s12863-018-0633-8.


The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Engelman CD, Darst BF, Bilgel M, Vasiljevic E, Koscik RL, Jedynak BM, Johnson SC.

Neurobiol Aging. 2018 Jun;66:177.e1-177.e5. doi: 10.1016/j.neurobiolaging.2017.12.025. Epub 2017 Dec 29.


Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.

Hong J, Hatchell KE, Bradfield JP, Bjonnes A, Chesi A, Lai CQ, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanghera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1380-1392. doi: 10.1210/jc.2017-01802.


The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions.

Johnson SC, Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Berman SE, Bendlin BB, Engelman CD, Okonkwo OC, Hogan KJ, Asthana S, Carlsson CM, Hermann BP, Sager MA.

Alzheimers Dement (Amst). 2017 Dec 8;10:130-142. doi: 10.1016/j.dadm.2017.11.007. eCollection 2018. Review.


Social support and verbal interaction are differentially associated with cognitive function in midlife and older age.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD.

Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019 Mar;26(2):144-160. doi: 10.1080/13825585.2017.1414769. Epub 2017 Dec 15.


Reliability of a Novel Social Activity Questionnaire: Perceived Social Support and Verbal Interaction in the Wisconsin Registry for Alzheimer's Prevention.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD.

J Aging Health. 2018 Feb;30(2):305-320. doi: 10.1177/0898264316674812. Epub 2016 Oct 24.


BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC.

Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980. Epub 2017 May 3.


Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Schultz SA, Boots EA, Darst BF, Zetterberg H, Blennow K, Edwards DF, Koscik RL, Carlsson CM, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hogan KJ, Hermann BP, Cook DB, Johnson SC, Engelman CD, Okonkwo OC.

Neurology. 2017 Apr 25;88(17):1650-1658. doi: 10.1212/WNL.0000000000003862. Epub 2017 Mar 24.


Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease.

Clark LR, Berman SE, Rivera-Rivera LA, Hoscheidt SM, Darst BF, Engelman CD, Rowley HA, Carlsson CM, Asthana S, Turski P, Wieben O, Johnson SC.

Alzheimers Dement (Amst). 2017 Jan 23;7:48-55. doi: 10.1016/j.dadm.2017.01.002. eCollection 2017.


Prioritization of family member sequencing for the detection of rare variants.

Sippy R, Kolesar JM, Darst BF, Engelman CD.

BMC Proc. 2016 Oct 18;10(Suppl 7):227-231. eCollection 2016.


Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals.

Darst BF, Engelman CD.

BMC Proc. 2016 Oct 18;10(Suppl 7):203-207. eCollection 2016.


Genetic Analysis Workshop 19: methods and strategies for analyzing human sequence and gene expression data in extended families and unrelated individuals.

Engelman CD, Greenwood CM, Bailey JN, Cantor RM, Kent JW Jr, König IR, Bermejo JL, Melton PE, Santorico SA, Schillert A, Wijsman EM, MacCluer JW, Almasy L.

BMC Proc. 2016 Oct 18;10(Suppl 7):67-70. eCollection 2016.


Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD.

J Alzheimers Dis. 2017;55(2):473-484.


Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data.

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC.

Arch Clin Neuropsychol. 2016 May 8. pii: acw024. [Epub ahead of print]


Shiftwork, Sleep Habits, and Metabolic Disparities: Results from the Survey of the Health of Wisconsin.

Givens ML, Malecki KC, Peppard PE, Palta M, Said A, Engelman CD, Walsh MC, Nieto FJ.

Sleep Health. 2015 Jun;1(2):115-120.


Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC.

Alzheimers Dement. 2016 Jul;12(7):805-14. doi: 10.1016/j.jalz.2015.12.009. Epub 2016 Jan 21.


Association between vitamin D status and age-related macular degeneration by genetic risk.

Millen AE, Meyers KJ, Liu Z, Engelman CD, Wallace RB, LeBlanc ES, Tinker LF, Iyengar SK, Robinson JG, Sarto GE, Mares JA.

JAMA Ophthalmol. 2015 Oct;133(10):1171-9. doi: 10.1001/jamaophthalmol.2015.2715.


Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease.

Darst BF, Koscik RL, Hermann BP, La Rue A, Sager MA, Johnson SC, Engelman CD.

J Alzheimers Dis. 2015;45(4):1149-55. doi: 10.3233/JAD-142658.


Prediction of genetic contributions to complex traits using whole genome sequencing data.

Yao C, Leng N, Weigel KA, Lee KE, Engelman CD, Meyers KJ.

BMC Proc. 2014 Jun 17;8(Suppl 1):S68. doi: 10.1186/1753-6561-8-S1-S68. eCollection 2014.


Genetic Analysis Workshop 18: Methods and strategies for analyzing human sequence and phenotype data in members of extended pedigrees.

Bickeböller H, Bailey JN, Beyene J, Cantor RM, Cordell HJ, Culverhouse RC, Engelman CD, Fardo DW, Ghosh S, König IR, Lorenzo Bermejo J, Melton PE, Santorico SA, Satten GA, Sun L, Tintle NL, Ziegler A, MacCluer JW, Almasy L.

BMC Proc. 2014 Jun 17;8(Suppl 1):S1. doi: 10.1186/1753-6561-8-S1-S1. eCollection 2014.


The Wisconsin Assessment of the Social and Built Environment (WASABE): a multi-dimensional objective audit instrument for examining neighborhood effects on health.

Malecki KC, Engelman CD, Peppard PE, Nieto FJ, Grabow ML, Bernardinello M, Bailey E, Bersch AJ, Walsh MC, Lo JY, Martinez-Donate A.

BMC Public Health. 2014 Nov 13;14:1165. doi: 10.1186/1471-2458-14-1165.


Methods for collapsing multiple rare variants in whole-genome sequence data.

Sung YJ, Korthauer KD, Swartz MD, Engelman CD.

Genet Epidemiol. 2014 Sep;38 Suppl 1:S13-20. doi: 10.1002/gepi.21820.


Reproductive windows, genetic loci, and breast cancer risk.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Figueroa JD, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA.

Ann Epidemiol. 2014 May;24(5):376-82. doi: 10.1016/j.annepidem.2014.02.007. Epub 2014 Mar 2.


Association between informal caregiving and cellular aging in the survey of the health of wisconsin: the role of caregiving characteristics, stress, and strain.

Litzelman K, Witt WP, Gangnon RE, Nieto FJ, Engelman CD, Mailick MR, Skinner HG.

Am J Epidemiol. 2014 Jun 1;179(11):1340-52. doi: 10.1093/aje/kwu066. Epub 2014 Apr 29.


The association of telomere length with colorectal cancer differs by the age of cancer onset.

Boardman LA, Litzelman K, Seo S, Johnson RA, Vanderboom RJ, Kimmel GW, Cunningham JM, Gangnon RE, Engelman CD, Riegert-Johnson DL, Potter J, Haile R, Buchanan D, Jenkins MA, Rider DN, Thibodeau SN, Petersen GM, Skinner HG.

Clin Transl Gastroenterol. 2014 Mar 6;5:e52. doi: 10.1038/ctg.2014.3.


Predictors of discordance between perceived and objective neighborhood data.

Bailey EJ, Malecki KC, Engelman CD, Walsh MC, Bersch AJ, Martinez-Donate AP, Peppard PE, Nieto FJ.

Ann Epidemiol. 2014 Mar;24(3):214-21. doi: 10.1016/j.annepidem.2013.12.007. Epub 2013 Dec 28.


Toward personalized prevention of obesity: can vitamin D negate the FTO effect?

Engelman CD.

Diabetes. 2014 Feb;63(2):405-6. doi: 10.2337/db13-1714. No abstract available.


Investigation of triggering receptor expressed on myeloid cells 2 variant in the Wisconsin Registry for Alzheimer's Prevention.

Engelman CD, Koscik RL, Jonaitis EM, Hermann BP, La Rue A, Sager MA.

Neurobiol Aging. 2014 Jun;35(6):1252-4. doi: 10.1016/j.neurobiolaging.2013.11.013. Epub 2013 Nov 20.


Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Skinner HG, Engelman CD, Klein BE, Titus LJ, Egan KM, Newcomb PA.

Cancer Epidemiol. 2014 Feb;38(1):62-5. doi: 10.1016/j.canep.2013.12.001. Epub 2013 Dec 25.


Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS).

Meyers KJ, Mares JA, Igo RP Jr, Truitt B, Liu Z, Millen AE, Klein M, Johnson EJ, Engelman CD, Karki CK, Blodi B, Gehrs K, Tinker L, Wallace R, Robinson J, LeBlanc ES, Sarto G, Bernstein PS, SanGiovanni JP, Iyengar SK.

Invest Ophthalmol Vis Sci. 2014 Jan 29;55(1):587-99. doi: 10.1167/iovs.13-13216.


Correlation of chromosomal instability, telomere length and telomere maintenance in microsatellite stable rectal cancer: a molecular subclass of rectal cancer.

Boardman LA, Johnson RA, Viker KB, Hafner KA, Jenkins RB, Riegert-Johnson DL, Smyrk TC, Litzelman K, Seo S, Gangnon RE, Engelman CD, Rider DN, Vanderboom RJ, Thibodeau SN, Petersen GM, Skinner HG.

PLoS One. 2013 Nov 21;8(11):e80015. doi: 10.1371/journal.pone.0080015. eCollection 2013.


Telomere length varies by DNA extraction method: implications for epidemiologic research.

Cunningham JM, Johnson RA, Litzelman K, Skinner HG, Seo S, Engelman CD, Vanderboom RJ, Kimmel GW, Gangnon RE, Riegert-Johnson DL, Baron JA, Potter JD, Haile R, Buchanan DD, Jenkins MA, Rider DN, Thibodeau SN, Petersen GM, Boardman LA.

Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2047-54. doi: 10.1158/1055-9965.EPI-13-0409. Epub 2013 Sep 9.


Stressful events, social support, and cognitive function in middle-aged adults with a family history of Alzheimer's disease.

Zuelsdorff ML, Engelman CD, Friedman EM, Koscik RL, Jonaitis EM, Rue AL, Sager MA.

J Aging Health. 2013 Sep;25(6):944-59. doi: 10.1177/0898264313498416. Epub 2013 Aug 14.


The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk.

Warren Andersen S, Trentham-Dietz A, Gangnon RE, Hampton JM, Figueroa JD, Skinner HG, Engelman CD, Klein BE, Titus LJ, Newcomb PA.

Breast Cancer Res Treat. 2013 Jul;140(2):427-34. doi: 10.1007/s10549-013-2646-3. Epub 2013 Jul 27.


Epidemiologic study of the C-3 epimer of 25-hydroxyvitamin D(3) in a population-based sample.

Engelman CD, Bo R, Zuelsdorff M, Steltenpohl H, Kirby T, Nieto FJ.

Clin Nutr. 2014 Jun;33(3):421-5. doi: 10.1016/j.clnu.2013.06.005. Epub 2013 Jun 21.


Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention.

Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA.

J Alzheimers Dis. 2013;36(4):749-57. doi: 10.3233/JAD-130482.


Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study.

Meyers KJ, Johnson EJ, Bernstein PS, Iyengar SK, Engelman CD, Karki CK, Liu Z, Igo RP Jr, Truitt B, Klein ML, Snodderly DM, Blodi BA, Gehrs KM, Sarto GE, Wallace RB, Robinson J, LeBlanc ES, Hageman G, Tinker L, Mares JA.

Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):2333-45. doi: 10.1167/iovs.12-10867.


Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations.

Engelman CD, Meyers KJ, Iyengar SK, Liu Z, Karki CK, Igo RP Jr, Truitt B, Robinson J, Sarto GE, Wallace R, Blodi BA, Klein ML, Tinker L, LeBlanc ES, Jackson RD, Song Y, Manson JE, Mares JA, Millen AE.

J Nutr. 2013 Jan;143(1):17-26. doi: 10.3945/jn.112.169482. Epub 2012 Nov 28.


Perceived neighborhood quality, sleep quality, and health status: evidence from the Survey of the Health of Wisconsin.

Hale L, Hill TD, Friedman E, Nieto FJ, Galvao LW, Engelman CD, Malecki KM, Peppard PE.

Soc Sci Med. 2013 Feb;79:16-22. doi: 10.1016/j.socscimed.2012.07.021. Epub 2012 Aug 7.


Identifying rare variants from exome scans: the GAW17 experience.

Ghosh S, Bickeböller H, Bailey J, Bailey-Wilson JE, Cantor R, Culverhouse R, Daw W, Destefano AL, Engelman CD, Hinrichs A, Houwing-Duistermaat J, König IR, Kent J Jr, Laird N, Pankratz N, Paterson A, Pugh E, Suarez B, Sun Y, Thomas A, Tintle N, Zhu X, Ziegler A, Maccluer JW, Almasy L.

BMC Proc. 2011 Nov 29;5 Suppl 9:S1. doi: 10.1186/1753-6561-5-S9-S1.


Analysis of human mini-exome sequencing data from Genetic Analysis Workshop 17 using a Bayesian hierarchical mixture model.

Bueno Filho JS, Morota G, Tran Q, Maenner MJ, Vera-Cala LM, Engelman CD, Meyers KJ.

BMC Proc. 2011 Nov 29;5 Suppl 9:S93. doi: 10.1186/1753-6561-5-S9-S93.


Detecting multiple causal rare variants in exome sequence data.

Ye KQ, Engelman CD.

Genet Epidemiol. 2011;35 Suppl 1:S18-21. doi: 10.1002/gepi.20644.

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