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Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.

Engelman AN.

J Biol Chem. 2019 Oct 11;294(41):15137-15157. doi: 10.1074/jbc.REV119.006901. Epub 2019 Aug 29. Review.


Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration.

Achuthan V, Perreira JM, Ahn JJ, Brass AL, Engelman AN.

J Life Sci (Westlake Village). 2019 Jun;1(1):39-45. doi: 10.36069/jols/20190604.


Auer rod-like inclusions in a monoclonal B lymphocytosis.

Engelman A, Manzoni D, Bordet JC, Vila L.

Ann Biol Clin (Paris). 2019 Aug 1;77(4):461-463. doi: 10.1684/abc.2019.1467. No abstract available.


Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes.

Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C.

J Virol. 2019 Oct 15;93(21). pii: e01118-19. doi: 10.1128/JVI.01118-19. Print 2019 Nov 1.


Deaf Women's Health: Adherence to Breast and Cervical Cancer Screening Recommendations.

Kushalnagar P, Engelman A, Simons AN.

Am J Prev Med. 2019 Sep;57(3):346-354. doi: 10.1016/j.amepre.2019.04.017. Epub 2019 Aug 1.


A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid.

Zhang DW, Luo RH, Xu L, Yang LM, Xu XS, Bedwell GJ, Engelman AN, Zheng YT, Chang S.

Antiviral Res. 2019 Sep;169:104544. doi: 10.1016/j.antiviral.2019.104544. Epub 2019 Jun 27.


HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.

Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M.

Elife. 2019 May 23;8. pii: e46344. doi: 10.7554/eLife.46344.


Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.

Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN.

Nucleic Acids Res. 2019 May 21;47(9):4663-4683. doi: 10.1093/nar/gkz206.


State of the Profession: The Landscape of Disability Justice, Health Inequities, and Access for Patients With Disabilities.

Engelman A, Valderama-Wallace C, Nouredini S.

ANS Adv Nurs Sci. 2019 Jul/Sep;42(3):231-242. doi: 10.1097/ANS.0000000000000261.


Deaf and Hard-of-Hearing Learners in Emergency Medicine.

Meeks LM, Engelman A, Booth A, Argenyi M.

West J Emerg Med. 2018 Nov;19(6):1014-1018. doi: 10.5811/westjem.2018.8.38550. Epub 2018 Oct 10.


Peer support and food security in deaf college students.

Keogh B, Kushalnagar P, Engelman A.

J Am Coll Health. 2018 Oct 26:1-5. doi: 10.1080/07448481.2018.1515750. [Epub ahead of print]


Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.

Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN.

Cell Host Microbe. 2018 Sep 12;24(3):392-404.e8. doi: 10.1016/j.chom.2018.08.002. Epub 2018 Aug 30.


Deaf patient-provider communication and lung cancer screening: Health Information National Trends survey in American Sign Language (HINTS-ASL).

Kushalnagar P, Engelman A, Sadler G.

Patient Educ Couns. 2018 Jul;101(7):1232-1239. doi: 10.1016/j.pec.2018.03.003. Epub 2018 Mar 5.


Cellular and molecular mechanisms of HIV-1 integration targeting.

Engelman AN, Singh PK.

Cell Mol Life Sci. 2018 Jul;75(14):2491-2507. doi: 10.1007/s00018-018-2772-5. Epub 2018 Feb 7. Review.


Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation.

Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y.

Mol Cell. 2018 Jan 4;69(1):62-74.e4. doi: 10.1016/j.molcel.2017.11.031. Epub 2017 Dec 21.


Multiplex single-cell visualization of nucleic acids and protein during HIV infection.

Puray-Chavez M, Tedbury PR, Huber AD, Ukah OB, Yapo V, Liu D, Ji J, Wolf JJ, Engelman AN, Sarafianos SG.

Nat Commun. 2017 Dec 1;8(1):1882. doi: 10.1038/s41467-017-01693-z.


LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J.

Blood. 2018 Jan 4;131(1):95-107. doi: 10.1182/blood-2017-05-786962. Epub 2017 Oct 30.


Epidemiology, diagnosis, and optimal management of glioma in adolescents and young adults.

Diwanji TP, Engelman A, Snider JW, Mohindra P.

Adolesc Health Med Ther. 2017 Sep 22;8:99-113. doi: 10.2147/AHMT.S53391. eCollection 2017. Review.


Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.

Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M.

J Biol Chem. 2017 Dec 1;292(48):19814-19825. doi: 10.1074/jbc.M117.816645. Epub 2017 Sep 28.


CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.

Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P.

Sci Adv. 2017 Sep 15;3(9):e1701264. doi: 10.1126/sciadv.1701264. eCollection 2017 Sep.


Risk perception and perceived self-efficacy of deaf and hard-of-hearing seniors and young adults in emergencies.

Engelman A, Ivey SL, Tseng W, Neuhauser L.

Am J Disaster Med. 2017 Winter;12(1):43-60. doi: 10.5055/ajdm.2017.0257.


Capsid-Dependent Host Factors in HIV-1 Infection.

Yamashita M, Engelman AN.

Trends Microbiol. 2017 Sep;25(9):741-755. doi: 10.1016/j.tim.2017.04.004. Epub 2017 May 18. Review.


Haematopoietic stem and progenitor cells from human pluripotent stem cells.

Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ.

Nature. 2017 May 25;545(7655):432-438. doi: 10.1038/nature22370. Epub 2017 May 17.


Structural basis for spumavirus GAG tethering to chromatin.

Lesbats P, Serrao E, Maskell DP, Pye VE, O'Reilly N, Lindemann D, Engelman AN, Cherepanov P.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5509-5514. doi: 10.1073/pnas.1621159114. Epub 2017 May 10.


Retroviral intasomes arising.

Engelman AN, Cherepanov P.

Curr Opin Struct Biol. 2017 Dec;47:23-29. doi: 10.1016/ Epub 2017 Apr 28. Review.


Risk perception and perceived self-efficacy of deaf and hard-of-hearing seniors and young adults in emergencies.

Engelman A, Ivey SL, Tseng W, Neuhauser L.

J Emerg Manag. 2017 Jan/Feb;15(1):7-15. doi: 10.5055/jem.2017.0309.


Retroviral integrase protein and intasome nucleoprotein complex structures.

Grawenhoff J, Engelman AN.

World J Biol Chem. 2017 Feb 26;8(1):32-44. doi: 10.4331/wjbc.v8.i1.32. Review.


Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein.

Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C.

J Virol. 2017 Apr 13;91(9). pii: e02155-16. doi: 10.1128/JVI.02155-16. Print 2017 May 1.


A supramolecular assembly mediates lentiviral DNA integration.

Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov P.

Science. 2017 Jan 6;355(6320):93-95. doi: 10.1126/science.aah7002.


Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.

Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQ.

Cell Rep. 2016 Dec 20;17(12):3178-3192. doi: 10.1016/j.celrep.2016.11.077.


Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA).

Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP.

JAMA Oncol. 2017 Jun 1;3(6):827-831. doi: 10.1001/jamaoncol.2016.3834.


Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.

Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R.

Protein Sci. 2016 Nov;25(11):1911-1917. doi: 10.1002/pro.2997. Epub 2016 Aug 17.


Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Zurnic I, Hütter S, Rzeha U, Helbig R, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D.

PLoS Pathog. 2016 Oct 10;12(10):e1005956. doi: 10.1371/journal.ppat.1005956. eCollection 2016 Oct.


A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.

Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E.

J Biol Chem. 2016 Nov 4;291(45):23569-23577. Epub 2016 Sep 19.


The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients With Adenocarcinoma of the Lung and Brain Metastases.

Sperduto PW, Yang TJ, Beal K, Pan H, Brown PD, Bangdiwala A, Shanley R, Yeh N, Gaspar LE, Braunstein S, Sneed P, Boyle J, Kirkpatrick JP, Mak KS, Shih HA, Engelman A, Roberge D, Arvold ND, Alexander B, Awad MM, Contessa J, Chiang V, Hardie J, Ma D, Lou E, Sperduto W, Mehta MP.

Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):406-413. doi: 10.1016/j.ijrobp.2016.06.006. Epub 2016 Jun 14.


Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.

Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D.

PLoS Pathog. 2016 Aug 31;12(8):e1005860. doi: 10.1371/journal.ppat.1005860. eCollection 2016 Aug. Erratum in: PLoS Pathog. 2016 Oct 10;12 (10 ):e1005956.


Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.

Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N.

J Virol. 2016 Aug 26;90(18):8059-73. doi: 10.1128/JVI.00553-16. Print 2016 Sep 15.


Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo.

Saito A, Henning MS, Serrao E, Dubose BN, Teng S, Huang J, Li X, Saito N, Roy SP, Siddiqui MA, Ahn J, Tsuji M, Hatziioannou T, Engelman AN, Yamashita M.

J Virol. 2016 Jul 11;90(15):6918-6935. doi: 10.1128/JVI.00019-16. Print 2016 Aug 1.


Retroviral DNA Integration.

Lesbats P, Engelman AN, Cherepanov P.

Chem Rev. 2016 Oct 26;116(20):12730-12757. doi: 10.1021/acs.chemrev.6b00125. Epub 2016 May 20. Review.


Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.

Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M.

J Virol. 2016 May 27;90(12):5808-5823. doi: 10.1128/JVI.03116-15. Print 2016 Jun 15.


Prognostic significance of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients treated with selective internal radiation therapy.

D'Emic N, Engelman A, Molitoris J, Hanlon A, Sharma NK, Moeslein FM, Chuong MD.

J Gastrointest Oncol. 2016 Apr;7(2):269-77. doi: 10.3978/j.issn.2078-6891.2015.108.


Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites.

Serrao E, Cherepanov P, Engelman AN.

J Vis Exp. 2016 Mar 22;(109). doi: 10.3791/53840.


The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes.

Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J.

J Biol Chem. 2016 May 27;291(22):11809-19. doi: 10.1074/jbc.M116.721647. Epub 2016 Mar 18.


The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.

Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M.

ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2.


Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.

Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN.

Nature. 2016 Feb 18;530(7590):358-61. doi: 10.1038/nature16955.


A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.

Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1054-63. doi: 10.1073/pnas.1524213113. Epub 2016 Feb 8.


Cultural Competence Training for Law Enforcement Responding to Domestic Violence Emergencies With the Deaf and Hard of Hearing: A Mixed-Methods Evaluation.

Engelman A, Deardorff J.

Health Promot Pract. 2016 Mar;17(2):177-85. doi: 10.1177/1524839915621538. Epub 2015 Dec 28.


Sites of retroviral DNA integration: From basic research to clinical applications.

Serrao E, Engelman AN.

Crit Rev Biochem Mol Biol. 2016;51(1):26-42. doi: 10.3109/10409238.2015.1102859. Epub 2015 Oct 28. Review.


Foreign DNA capture during CRISPR-Cas adaptive immunity.

Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA.

Nature. 2015 Nov 26;527(7579):535-8. doi: 10.1038/nature15760. Epub 2015 Oct 21.


Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.

Wang H, Shun MC, Dickson AK, Engelman AN.

PLoS One. 2015 Sep 14;10(9):e0137797. doi: 10.1371/journal.pone.0137797. eCollection 2015.

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