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Time from first symptom onset to the final diagnosis of multiple myeloma (MM) - possible risks and future solutions: retrospective and prospective 'Deutsche Studiengruppe MM' (DSMM) and 'European Myeloma Network' (EMN) analysis.

Graziani G, Herget GW, Ihorst G, Zeissig M, Chaidos A, Auner HW, Duyster J, Wäsch R, Engelhardt M.

Leuk Lymphoma. 2019 Nov 28:1-12. doi: 10.1080/10428194.2019.1695051. [Epub ahead of print]


The Prevalence of Legal Performance-Enhancing Substance Use and Potential Cognitive and or Physical Doping in German Recreational Triathletes, Assessed via the Randomised Response Technique.

Seifarth S, Dietz P, Disch AC, Engelhardt M, Zwingenberger S.

Sports (Basel). 2019 Nov 26;7(12). pii: E241. doi: 10.3390/sports7120241.


Different Effects of Foam Rolling on Passive Tissue Stiffness in Experienced and Nonexperienced Athletes.

Mayer I, Hoppe MW, Freiwald J, Heiss R, Engelhardt M, Grim C, Lutter C, Huettel M, Forst R, Hotfiel T.

J Sport Rehabil. 2019 Nov 27:1-8. doi: 10.1123/jsr.2019-0172. [Epub ahead of print]


Carfilzomib combination treatment as first-line therapy in multiple myeloma: where do we go from the Carthadex (KTd)-trial update?

Engelhardt M, Yong K, Bringhen S, Wäsch R.

Haematologica. 2019 Nov;104(11):2128-2131. doi: 10.3324/haematol.2019.228684. No abstract available.


Functional Integration of Neuronal Precursors in the Adult Murine Piriform Cortex.

Benedetti B, Dannehl D, König R, Coviello S, Kreutzer C, Zaunmair P, Jakubecova D, Weiger TM, Aigner L, Nacher J, Engelhardt M, Couillard-Després S.

Cereb Cortex. 2019 Oct 22. pii: bhz181. doi: 10.1093/cercor/bhz181. [Epub ahead of print]


A Phase 1 study of BAL101553, a novel tumor checkpoint controller targeting microtubules, administered as 48-h infusion in adult patients with advanced solid tumors.

Joerger M, Stathis A, Metaxas Y, Hess D, Mantiero M, Mark M, Volden M, Kaindl T, Engelhardt M, Larger P, Lane H, Hafner P, Levy N, Stuedeli S, Sessa C, von Moos R.

Invest New Drugs. 2019 Aug 30. doi: 10.1007/s10637-019-00850-z. [Epub ahead of print]


Venetoclax in combination with carfilzomib, doxorubicin and dexamethasone restores responsiveness in an otherwise treatment-refractory multiple myeloma patient.

Bojtine Kovacs S, Luan J, Dold SM, Weis A, Pantic M, Duyster J, Wäsch R, Engelhardt M.

Haematologica. 2019 Aug 29. pii: haematol.2019.232330. doi: 10.3324/haematol.2019.232330. [Epub ahead of print]


Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis.

Knop S, Engelhardt M, Liebisch P, Meisner C, Holler E, Metzner B, Peest D, Kaufmann M, Bunjes D, Straka C, Fischer T, Sezer O, Hentrich M, Ostermann H, Bassermann F, Hess G, Hertenstein B, Freund M, Kropff M, Schmidt CA, Wolf HH, Jung W, Frickhofen N, Mielke S, Bargou RC, Maschmeyer G, Svaldi M, Langer CH, Gramatzki M, Hebart H, Kanz L, Einsele H; Deutsche Studiengruppe Multiples Myelom.

Leukemia. 2019 Nov;33(11):2710-2719. doi: 10.1038/s41375-019-0537-2. Epub 2019 Aug 28.


Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

Chari A, Vogl DT, Gavriatopoulou M, Nooka AK, Yee AJ, Huff CA, Moreau P, Dingli D, Cole C, Lonial S, Dimopoulos M, Stewart AK, Richter J, Vij R, Tuchman S, Raab MS, Weisel KC, Delforge M, Cornell RF, Kaminetzky D, Hoffman JE, Costa LJ, Parker TL, Levy M, Schreder M, Meuleman N, Frenzel L, Mohty M, Choquet S, Schiller G, Comenzo RL, Engelhardt M, Illmer T, Vlummens P, Doyen C, Facon T, Karlin L, Perrot A, Podar K, Kauffman MG, Shacham S, Li L, Tang S, Picklesimer C, Saint-Martin JR, Crochiere M, Chang H, Parekh S, Landesman Y, Shah J, Richardson PG, Jagannath S.

N Engl J Med. 2019 Aug 22;381(8):727-738. doi: 10.1056/NEJMoa1903455.


The inner clock-Blue light sets the human rhythm.

Wahl S, Engelhardt M, Schaupp P, Lappe C, Ivanov IV.

J Biophotonics. 2019 Dec;12(12):e201900102. doi: 10.1002/jbio.201900102. Epub 2019 Sep 2. Review.


Dynamic Regulation of Synaptopodin and the Axon Initial Segment in Retinal Ganglion Cells During Postnatal Development.

Schlüter A, Rossberger S, Dannehl D, Janssen JM, Vorwald S, Hanne J, Schultz C, Mauceri D, Engelhardt M.

Front Cell Neurosci. 2019 Jul 30;13:318. doi: 10.3389/fncel.2019.00318. eCollection 2019.


Term Delivery in an Infertile Patient after Transcervical Radiofrequency Fibroid Ablation and Assisted Reproductive Technology.

Pschadka G, Engelhardt M, Niehoff C, Toub D.

J Gynecol Surg. 2019 Aug 1;35(4):253-255. doi: 10.1089/gyn.2019.0001.


Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia.

Yu C, Gorantla SP, Müller-Rudorf A, Müller TA, Kreutmair S, Albers C, Jakob L, Lippert LJ, Yue Z, Engelhardt M, Follo M, Zeiser R, Huber TB, Duyster J, Illert AL.

Haematologica. 2019 Aug 8. pii: haematol.2018.212027. doi: 10.3324/haematol.2018.212027. [Epub ahead of print]


Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation.

Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke J.

JCI Insight. 2019 Jul 23;5. pii: 128336. doi: 10.1172/jci.insight.128336.


Effects of Pre- and Post-Exercise Cold-Water Immersion Therapy on Passive Muscle Stiffness.

Hüttel M, Golditz T, Mayer I, Heiss R, Lutter C, Hoppe MW, Engelhardt M, Grim C, Seehaus F, Forst R, Hotfiel T.

Sportverletz Sportschaden. 2019 Jul 18. doi: 10.1055/a-0854-8302. [Epub ahead of print]


[Effectiveness of Upper Body Compression Garments Under Competitive Conditions: A Randomised Crossover Study with Elite Canoeists with an Additional Case Study].

Grim C, Hotfiel T, Engelhardt M, Drieschner DB, Willscheid G, Hoppe MW.

Sportverletz Sportschaden. 2019 Jul 18. doi: 10.1055/a-0895-2317. [Epub ahead of print] German.


Estimation of the resting motor threshold (RMT) in transcranial magnetic stimulation using relative-frequency and threshold-hunting methods in brain tumor patients.

Engelhardt M, Schneider H, Gast T, Picht T.

Acta Neurochir (Wien). 2019 Sep;161(9):1845-1851. doi: 10.1007/s00701-019-03997-z. Epub 2019 Jul 8.


[Adequate Perioperative Use of Antibiotics in Thoracic Surgery].

Engelhardt MJ, Bornemann S, Pfannschmidt J, Rüssmann H, Schönfeld N, Tiedt N, Tönnies M, Bauer TT.

Zentralbl Chir. 2019 Jul 3. doi: 10.1055/a-0915-2618. [Epub ahead of print] German.


Bortezomib consolidation following autologous transplant in younger and older patients with newly diagnosed multiple myeloma in two phase III trials.

Straka C, Knop S, Vogel M, Müller J, Kropff M, Metzner B, Langer C, Sayer H, Jung W, Dürk HA, Salwender H, Wandt H, Bassermann F, Gramatzki M, Rösler W, Wolf HH, Brugger W, Fischer T, Liebisch P, Engelhardt M, Einsele H.

Eur J Haematol. 2019 Sep;103(3):255-267. doi: 10.1111/ejh.13281. Epub 2019 Jul 19.


Accelerating Recovery from Exercise-Induced Muscle Injuries in Triathletes: Considerations for Olympic Distance Races.

Hotfiel T, Mayer I, Huettel M, Hoppe MW, Engelhardt M, Lutter C, Pöttgen K, Heiss R, Kastner T, Grim C.

Sports (Basel). 2019 Jun 13;7(6). pii: E143. doi: 10.3390/sports7060143. Review.


Mucormycosis in South America: A review of 143 reported cases.

Nucci M, Engelhardt M, Hamed K.

Mycoses. 2019 Sep;62(9):730-738. doi: 10.1111/myc.12958. Epub 2019 Jul 11. Review.


Effectiveness of Manual Therapy, Customised Foot Orthoses and Combined Therapy in the Management of Plantar Fasciitis-a RCT.

Grim C, Kramer R, Engelhardt M, John SM, Hotfiel T, Hoppe MW.

Sports (Basel). 2019 May 28;7(6). pii: E128. doi: 10.3390/sports7060128.


Cross-Sectional Investigation of Stress Fractures in German Elite Triathletes.

Neidel P, Wolfram P, Hotfiel T, Engelhardt M, Koch R, Lee G, Zwingenberger S.

Sports (Basel). 2019 Apr 15;7(4). pii: E88. doi: 10.3390/sports7040088.


Dynamic prediction: A challenge for biostatisticians, but greatly needed by patients, physicians and the public.

Schumacher M, Hieke S, Ihorst G, Engelhardt M.

Biom J. 2019 Mar 25. doi: 10.1002/bimj.201800248. [Epub ahead of print]


Early improvement in severely ill patients with pneumonia treated with ceftobiprole: a retrospective analysis of two major trials.

Scheeren TWL, Welte T, Saulay M, Engelhardt M, Santerre-Henriksen A, Hamed K.

BMC Infect Dis. 2019 Feb 26;19(1):195. doi: 10.1186/s12879-019-3820-y.


Critical mercury concentration in tropical soils: Impact on plants and soil biological attributes.

Lima FRD, Martins GC, Silva AO, Vasques ICF, Engelhardt MM, Cândido GS, Pereira P, Reis RHCL, Carvalho GS, Windmöller CC, Moreira FMS, Guilherme LRG, Marques JJ.

Sci Total Environ. 2019 May 20;666:472-479. doi: 10.1016/j.scitotenv.2019.02.216. Epub 2019 Feb 14.


A mind-brain-body dataset of MRI, EEG, cognition, emotion, and peripheral physiology in young and old adults.

Babayan A, Erbey M, Kumral D, Reinelt JD, Reiter AMF, Röbbig J, Schaare HL, Uhlig M, Anwander A, Bazin PL, Horstmann A, Lampe L, Nikulin VV, Okon-Singer H, Preusser S, Pampel A, Rohr CS, Sacher J, Thöne-Otto A, Trapp S, Nierhaus T, Altmann D, Arelin K, Blöchl M, Bongartz E, Breig P, Cesnaite E, Chen S, Cozatl R, Czerwonatis S, Dambrauskaite G, Dreyer M, Enders J, Engelhardt M, Fischer MM, Forschack N, Golchert J, Golz L, Guran CA, Hedrich S, Hentschel N, Hoffmann DI, Huntenburg JM, Jost R, Kosatschek A, Kunzendorf S, Lammers H, Lauckner ME, Mahjoory K, Kanaan AS, Mendes N, Menger R, Morino E, Näthe K, Neubauer J, Noyan H, Oligschläger S, Panczyszyn-Trzewik P, Poehlchen D, Putzke N, Roski S, Schaller MC, Schieferbein A, Schlaak B, Schmidt R, Gorgolewski KJ, Schmidt HM, Schrimpf A, Stasch S, Voss M, Wiedemann A, Margulies DS, Gaebler M, Villringer A.

Sci Data. 2019 Feb 12;6:180308. doi: 10.1038/sdata.2018.308.


Plantar pressure changes in hindfoot relief devices of different designs.

Mazur F, Swoboda B, Carl HD, Lutter C, Engelhardt M, Hoppe MW, Hotfiel T, Grim C.

J Exp Orthop. 2019 Feb 7;6(1):7. doi: 10.1186/s40634-019-0173-9.


Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A consensus paper by the European Myeloma Network and the Italian Society of Arterial Hypertension.

Bringhen S, Milan A, D'Agostino M, Ferri C, Wäsch R, Gay F, Larocca A, Offidani M, Zweegman S, Terpos E, Goldschmidt H, Cavo M, Ludwig H, Driessen C, Auner HW, Caers J, Gramatzki M, Dimopoulos MA, Boccadoro M, Einsele H, Sonneveld P, Engelhardt M.

J Intern Med. 2019 Jul;286(1):63-74. doi: 10.1111/joim.12882. Epub 2019 Apr 8.


Elaboration of Consensus Clinical Endpoints to Evaluate Antimicrobial Treatment Efficacy in Future Hospital-acquired/Ventilator-associated Bacterial Pneumonia Clinical Trials.

Weiss E, Zahar JR, Alder J, Asehnoune K, Bassetti M, Bonten MJM, Chastre J, De Waele J, Dimopoulos G, Eggimann P, Engelhardt M, Ewig S, Kollef M, Lipman J, Luna C, Martin-Loeches I, Pagani L, Palmer LB, Papazian L, Poulakou G, Prokocimer P, Rello J, Rex JH, Shorr AF, Talbot GH, Thamlikitkul V, Torres A, Wunderink RG, Timsit JF.

Clin Infect Dis. 2019 Nov 13;69(11):1912-1918. doi: 10.1093/cid/ciz093.


Avoiding chemotherapy prescribing errors: Analysis and innovative strategies.

Reinhardt H, Otte P, Eggleton AG, Ruch M, Wöhrl S, Ajayi S, Duyster J, Jung M, Hug MJ, Engelhardt M.

Cancer. 2019 May 1;125(9):1547-1557. doi: 10.1002/cncr.31950. Epub 2019 Jan 29.


Kidney embolization induces prompt organ response in a 86-year-old patient with MGRS-related AL-amyloidosis.

Küchlin S, Duffner J, Scheubeck S, Schoeller K, Maruschke L, Seidl M, Engelhardt M, Walz G, Prager EP, Waldschmidt JM.

Hemodial Int. 2019 Apr;23(2):E59-E64. doi: 10.1111/hdi.12707. Epub 2018 Dec 13.


Variability and exposure-response relationships of isavuconazole plasma concentrations in the Phase 3 SECURE trial of patients with invasive mould diseases.

Kaindl T, Andes D, Engelhardt M, Saulay M, Larger P, Groll AH.

J Antimicrob Chemother. 2019 Mar 1;74(3):761-767. doi: 10.1093/jac/dky463.


Response to letter.

Engelhardt MI, Fonseca ACG, Huang ZJ, Jiang ZY, Yuksel S, Roy S.

Am J Otolaryngol. 2019 Mar - Apr;40(2):340. doi: 10.1016/j.amjoto.2018.09.019. Epub 2018 Oct 2. No abstract available.


Risk of venous thromboembolism after endoprosthetic surgeries: lower versus upper extremity endoprosthetic surgeries.

Keller K, Hobohm L, Engelhardt M.

Heart Vessels. 2019 May;34(5):815-823. doi: 10.1007/s00380-018-1305-3. Epub 2018 Nov 15.


Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4.

Villar-Prados A, Wu SY, Court KA, Ma S, LaFargue C, Chowdhury MA, Engelhardt MI, Ivan C, Ram PT, Wang Y, Baggerly K, Rodriguez-Aguayo C, Lopez-Berestein G, Ming-Yang S, Maloney DJ, Yoshioka M, Strovel JW, Roszik J, Sood AK.

Mol Cancer Ther. 2019 Feb;18(2):421-436. doi: 10.1158/1535-7163.MCT-18-0365. Epub 2018 Nov 12.


Evaluation of mercury phytoavailability in Oxisols.

Lima FRD, Engelhardt MM, Vasques ICF, Martins GC, Cândido GS, Pereira P, Reis RHCL, Silva AO, Guilherme LRG, Marques JJ.

Environ Sci Pollut Res Int. 2019 Jan;26(1):483-491. doi: 10.1007/s11356-018-3623-5. Epub 2018 Nov 7.


Anatomy of proximal attachment, course, and innervation of hamstring muscles: a pictorial essay.

Stępień K, Śmigielski R, Mouton C, Ciszek B, Engelhardt M, Seil R.

Knee Surg Sports Traumatol Arthrosc. 2019 Mar;27(3):673-684. doi: 10.1007/s00167-018-5265-z. Epub 2018 Oct 29.


[Management of Vascular Trauma in Military Conflicts and Terrorist Attacks].

Engelhardt M, Elias K, Debus S, Zischek C.

Zentralbl Chir. 2018 Oct;143(5):466-474. doi: 10.1055/a-0713-0833. Epub 2018 Oct 24. German.


APC/CCdh1 regulates the balance between maintenance and differentiation of hematopoietic stem and progenitor cells.

Ewerth D, Kreutmair S, Schmidts A, Ihorst G, Follo M, Wider D, Felthaus J, Schüler J, Duyster J, Illert AL, Engelhardt M, Wäsch R.

Cell Mol Life Sci. 2019 Jan;76(2):369-380. doi: 10.1007/s00018-018-2952-3. Epub 2018 Oct 24.


Isavuconazole Versus Caspofungin in the Treatment of Candidemia and Other Invasive Candida Infections: The ACTIVE Trial.

Kullberg BJ, Viscoli C, Pappas PG, Vazquez J, Ostrosky-Zeichner L, Rotstein C, Sobel JD, Herbrecht R, Rahav G, Jaruratanasirikul S, Chetchotisakd P, Van Wijngaerden E, De Waele J, Lademacher C, Engelhardt M, Kovanda L, Croos-Dabrera R, Fredericks C, Thompson GR.

Clin Infect Dis. 2019 May 30;68(12):1981-1989. doi: 10.1093/cid/ciy827.


Allogeneic transplantation of multiple myeloma patients may allow long-term survival in carefully selected patients with acceptable toxicity and preserved quality of life.

Greil C, Engelhardt M, Ihorst G, Schoeller K, Bertz H, Marks R, Zeiser R, Duyster J, Einsele H, Finke J, Wäsch R.

Haematologica. 2019 Feb;104(2):370-379. doi: 10.3324/haematol.2018.200881. Epub 2018 Sep 20.


European Myeloma Network recommendations on tools for the diagnosis and monitoring of multiple myeloma: what to use and when.

Caers J, Garderet L, Kortüm KM, O'Dwyer ME, van de Donk NWCJ, Binder M, Dold SM, Gay F, Corre J, Beguin Y, Ludwig H, Larocca A, Driessen C, Dimopoulos MA, Boccadoro M, Gramatzki M, Zweegman S, Einsele H, Cavo M, Goldschmidt H, Sonneveld P, Delforge M, Auner HW, Terpos E, Engelhardt M.

Haematologica. 2018 Nov;103(11):1772-1784. doi: 10.3324/haematol.2018.189159. Epub 2018 Aug 31. Review.


GFR estimation in lenalidomide treatment of multiple myeloma patients: a prospective cohort study.

Schmidts A, Grünewald J, Kleber M, Terpos E, Ihorst G, Reinhardt H, Walz G, Wäsch R, Engelhardt M, Zschiedrich S.

Clin Exp Nephrol. 2019 Feb;23(2):199-206. doi: 10.1007/s10157-018-1626-7. Epub 2018 Aug 20.


IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells.

Plaumann J, Engelhardt M, Awwad MHS, Echchannaoui H, Amman E, Raab MS, Hillengass J, Halama N, Neuber B, Müller-Tidow C, Goldschmidt H, Hundemer M.

Cancer Immunol Immunother. 2018 Nov;67(11):1695-1707. doi: 10.1007/s00262-018-2230-0. Epub 2018 Aug 20.


Fast prenatal development of the NPY neuron system in the neocortex of the European wild boar, Sus scrofa.

Ernst L, Darschnik S, Roos J, González-Gómez M, Beemelmans C, Beemelmans C, Engelhardt M, Meyer G, Wahle P.

Brain Struct Funct. 2018 Nov;223(8):3855-3873. doi: 10.1007/s00429-018-1725-y. Epub 2018 Aug 9.



Engelhardt M, Szymaniak-Vits M, Ajayi S, Dold SM, Müller SJ, Scheubeck S, Wäsch R.

Recent Results Cancer Res. 2018;212:265-283. doi: 10.1007/978-3-319-91439-8_13.



Engelhardt M, Ajayi S, Reinhardt H, Müller SJ, Dold SM, Wäsch R.

Recent Results Cancer Res. 2018;212:169-185. doi: 10.1007/978-3-319-91439-8_8.



Ajayi S, Becker H, Reinhardt H, Engelhardt M, Zeiser R, von Bubnoff N, Wäsch R.

Recent Results Cancer Res. 2018;212:119-132. doi: 10.1007/978-3-319-91439-8_6.


Organization of the German Army Medical Service 1914-1918 and the role of academic surgeons.

Zischek C, Grunwald E, Engelhardt M.

Can J Surg. 2018 Aug;61(4):223-225.

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