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Items: 1 to 50 of 252

1.

Establishment of a High Yield rAAV/HBoV Vector Production System Independent of Bocavirus Non-structural Proteins.

Yan Z, Zou W, Feng Z, Shen W, Park SY, Deng X, Qiu J, Engelhardt JF.

Hum Gene Ther. 2018 Nov 6. doi: 10.1089/hum.2018.173. [Epub ahead of print]

PMID:
30398383
2.

Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes.

Wang Z, Cheng F, Engelhardt JF, Yan Z, Qiu J.

Mol Ther Methods Clin Dev. 2018 Oct 4;11:40-51. doi: 10.1016/j.omtm.2018.09.005. eCollection 2018 Dec 14.

3.

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.

Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J.

Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1.

PMID:
30069044
4.

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.

Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF.

Cell Stem Cell. 2018 May 3;22(5):779. doi: 10.1016/j.stem.2018.04.007. No abstract available.

5.

Validation of a radioimmunoassay of serum trypsin-like immunoreactivity in ferrets.

Bridges CS, Miller PS, Lidbury JA, Suchodolski JS, Yi Y, Engelhardt JF, Steiner JM.

J Vet Diagn Invest. 2018 Jul;30(4):517-522. doi: 10.1177/1040638718774387. Epub 2018 May 2.

PMID:
29717637
6.

Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.

Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, Mou H, Herring BP, Thorne PS, Rajagopal J, Yeaman C, Parekh KR, Engelhardt JF.

Cell Stem Cell. 2018 May 3;22(5):653-667.e5. doi: 10.1016/j.stem.2018.03.017. Epub 2018 Apr 12. Erratum in: Cell Stem Cell. 2018 May 3;22(5):779.

PMID:
29656941
7.

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.

Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI.

Nature. 2018 Apr;556(7701):370-375. doi: 10.1038/s41586-018-0035-0. Epub 2018 Apr 11.

8.

Development of a polarized pancreatic ductular cell epithelium for physiological studies.

O'Malley Y, Rotti PG, Thornell IM, Vanegas Calderón OG, Febres-Aldana C, Durham K, Yao J, Li X, Zhu Z, Norris AW, Zabner J, Engelhardt JF, Uc A.

J Appl Physiol (1985). 2018 Jul 1;125(1):97-106. doi: 10.1152/japplphysiol.00043.2018. Epub 2018 Mar 8.

PMID:
29517421
9.

Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets.

Rotti PG, Xie W, Poudel A, Yi Y, Sun X, Tyler SR, Uc A, Norris AW, Hara M, Engelhardt JF, Gibson-Corley KN.

Am J Pathol. 2018 Apr;188(4):876-890. doi: 10.1016/j.ajpath.2017.12.015. Epub 2018 Jan 31.

PMID:
29366680
10.

Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets.

Rosen BH, Evans TIA, Moll SR, Gray JS, Liang B, Sun X, Zhang Y, Jensen-Cody CW, Swatek AM, Zhou W, He N, Rotti PG, Tyler SR, Keiser NW, Anderson PJ, Brooks L, Li Y, Pope RM, Rajput M, Hoffman EA, Wang K, Harris JK, Parekh KR, Gibson-Corley KN, Engelhardt JF.

Am J Respir Crit Care Med. 2018 May 15;197(10):1308-1318. doi: 10.1164/rccm.201708-1616OC.

PMID:
29327941
11.

Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis.

Swatek AM, Lynch TJ, Crooke AK, Anderson PJ, Tyler SR, Brooks L, Ivanovic M, Klesney-Tait JA, Eberlein M, Pena T, Meyerholz DK, Engelhardt JF, Parekh KR.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1045-1057. doi: 10.1164/rccm.201707-1368OC.

PMID:
29236513
12.

Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis.

Deng X, Zou W, Xiong M, Wang Z, Engelhardt JF, Ye SQ, Yan Z, Qiu J.

J Virol. 2017 Nov 30;91(24). pii: e01533-17. doi: 10.1128/JVI.01533-17. Print 2017 Dec 15.

13.

CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors.

Sun X, Yi Y, Xie W, Liang B, Winter MC, He N, Liu X, Luo M, Yang Y, Ode KL, Uc A, Norris AW, Engelhardt JF.

Endocrinology. 2017 Oct 1;158(10):3325-3338. doi: 10.1210/en.2017-00187.

14.

Animal and model systems for studying cystic fibrosis.

Rosen BH, Chanson M, Gawenis LR, Liu J, Sofoluwe A, Zoso A, Engelhardt JF.

J Cyst Fibros. 2018 Mar;17(2S):S28-S34. doi: 10.1016/j.jcf.2017.09.001. Epub 2017 Sep 19. Review.

PMID:
28939349
15.

Real-Time Monitoring of Insulin Using a Graphene Field-Effect Transistor Aptameric Nanosensor.

Hao Z, Zhu Y, Wang X, Rotti PG, DiMarco C, Tyler SR, Zhao X, Engelhardt JF, Hone J, Lin Q.

ACS Appl Mater Interfaces. 2017 Aug 23;9(33):27504-27511. doi: 10.1021/acsami.7b07684. Epub 2017 Aug 11.

PMID:
28770993
16.

AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR.

Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE.

J Virol. 2017 Jul 5. pii: JVI.00391-17. doi: 10.1128/JVI.00391-17. [Epub ahead of print]

17.

Human Bocavirus 1 Is a Novel Helper for Adeno-Associated Virus Replication.

Wang Z, Deng X, Zou W, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2017 Jun 28. pii: JVI.00710-17. doi: 10.1128/JVI.00710-17. [Epub ahead of print]

18.

Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes.

Yan Z, Feng Z, Sun X, Zhang Y, Zou W, Wang Z, Jensen-Cody C, Liang B, Park SY, Qiu J, Engelhardt JF.

Hum Gene Ther. 2017 Aug;28(8):612-625. doi: 10.1089/hum.2017.060. Epub 2017 May 10.

19.

Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development.

Anderson PJ, Lynch TJ, Engelhardt JF.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):716-726. doi: 10.1165/rcmb.2016-0304OC.

20.

Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication.

Wang Z, Shen W, Cheng F, Deng X, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2017 Mar 29;91(8). pii: e02375-16. doi: 10.1128/JVI.02375-16. Print 2017 Apr 15.

21.

DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.

Deng X, Xu P, Zou W, Shen W, Peng J, Liu K, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2016 Dec 16;91(1). pii: e01831-16. Print 2017 Jan 1.

22.

A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma.

Hackett TL, Ferrante SC, Hoptay CE, Engelhardt JF, Ingram JL, Zhang Y, Alcala SE, Shaheen F, Matz E, Pillai DK, Freishtat RJ.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):291-299. doi: 10.1165/rcmb.2016-0065MA.

23.

Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Uc A, Andersen DK, Bellin MD, Bruce JI, Drewes AM, Engelhardt JF, Forsmark CE, Lerch MM, Lowe ME, Neuschwander-Tetri BA, OʼKeefe SJ, Palermo TM, Pasricha P, Saluja AK, Singh VK, Szigethy EM, Whitcomb DC, Yadav D, Conwell DL.

Pancreas. 2016 Nov;45(10):1365-1375.

24.

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728.

25.

Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.

Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA.

Development. 2016 Nov 15;143(22):4115-4126. Epub 2016 Sep 22.

26.

NADPH Oxidases Are Essential for Macrophage Differentiation.

Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, Engelhardt JF, Liu ZG.

J Biol Chem. 2016 Sep 16;291(38):20030-41. doi: 10.1074/jbc.M116.731216. Epub 2016 Aug 3.

27.

Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.

Yi Y, Norris AW, Wang K, Sun X, Uc A, Moran A, Engelhardt JF, Ode KL.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):974-980.

28.

Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands.

Lynch TJ, Anderson PJ, Xie W, Crooke AK, Liu X, Tyler SR, Luo M, Kusner DM, Zhang Y, Neff T, Burnette DC, Walters KS, Goodheart MJ, Parekh KR, Engelhardt JF.

Stem Cells. 2016 Nov;34(11):2758-2771. doi: 10.1002/stem.2443. Epub 2016 Jul 11.

29.

Analysis of cis and trans Requirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome.

Shen W, Deng X, Zou W, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2016 Aug 12;90(17):7761-77. doi: 10.1128/JVI.00708-16. Print 2016 Sep 1.

30.

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.

Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, Artandi S, Mense M, Rowe S, Engelhardt JF, Hsu YC, Rajagopal J.

Cell Stem Cell. 2016 Aug 4;19(2):217-231. doi: 10.1016/j.stem.2016.05.012. Epub 2016 Jun 16.

31.

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins.

Zou W, Cheng F, Shen W, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2016 Apr 14;90(9):4658-4669. doi: 10.1128/JVI.02964-15. Print 2016 May.

32.

A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling.

Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, Tyler SR, Uc A, Philipson LH, Wang K, Hara M, Ode KL, Norris AW, Engelhardt JF.

Endocrinology. 2016 May;157(5):1852-65. doi: 10.1210/en.2015-1935. Epub 2016 Feb 10.

33.

Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.

Deng X, Yan Z, Cheng F, Engelhardt JF, Qiu J.

PLoS Pathog. 2016 Jan 14;12(1):e1005399. doi: 10.1371/journal.ppat.1005399. eCollection 2016 Jan.

34.

Definitive localization of intracellular proteins: Novel approach using CRISPR-Cas9 genome editing, with glucose 6-phosphate dehydrogenase as a model.

Spencer NY, Yan Z, Cong L, Zhang Y, Engelhardt JF, Stanton RC.

Anal Biochem. 2016 Feb 1;494:55-67. doi: 10.1016/j.ab.2015.11.002. Epub 2015 Nov 11.

35.

Pancreatic pathophysiology in cystic fibrosis.

Gibson-Corley KN, Meyerholz DK, Engelhardt JF.

J Pathol. 2016 Jan;238(2):311-20. doi: 10.1002/path.4634. Epub 2015 Oct 1. Review.

36.

Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance.

Evans TI, Joo NS, Keiser NW, Yan Z, Tyler SR, Xie W, Zhang Y, Hsiao JJ, Cho HJ, Wright ME, Wine JJ, Engelhardt JF.

Am J Respir Cell Mol Biol. 2016 Apr;54(4):469-81. doi: 10.1165/rcmb.2015-0090OC.

37.

A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret.

Wisely SM, Ryder OA, Santymire RM, Engelhardt JF, Novak BJ.

J Hered. 2015 Sep-Oct;106(5):581-92. doi: 10.1093/jhered/esv041. Epub 2015 Aug 24.

38.

Identification and Functional Analysis of Novel Nonstructural Proteins of Human Bocavirus 1.

Shen W, Deng X, Zou W, Cheng F, Engelhardt JF, Yan Z, Qiu J.

J Virol. 2015 Oct;89(19):10097-109. doi: 10.1128/JVI.01374-15. Epub 2015 Jul 29.

39.

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice.

Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF.

J Clin Invest. 2015 May;125(5):2179. doi: 10.1172/JCI82138. Epub 2015 May 1. No abstract available.

40.

Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers.

Yan Z, Sun X, Feng Z, Li G, Fisher JT, Stewart ZA, Engelhardt JF.

Hum Gene Ther. 2015 Jun;26(6):334-46. doi: 10.1089/hum.2015.001. Epub 2015 Apr 20.

41.

Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins.

Joo NS, Evans IA, Cho HJ, Park IH, Engelhardt JF, Wine JJ.

PLoS One. 2015 Feb 23;10(2):e0116756. doi: 10.1371/journal.pone.0116756. eCollection 2015.

42.

Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy.

Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB Jr, Engelhardt JF.

Hum Gene Ther Clin Dev. 2015 Mar;26(1):38-49. doi: 10.1089/humc.2014.154. Epub 2015 Feb 12. Review.

43.

The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.

Peng X, Alföldi J, Gori K, Eisfeld AJ, Tyler SR, Tisoncik-Go J, Brawand D, Law GL, Skunca N, Hatta M, Gasper DJ, Kelly SM, Chang J, Thomas MJ, Johnson J, Berlin AM, Lara M, Russell P, Swofford R, Turner-Maier J, Young S, Hourlier T, Aken B, Searle S, Sun X, Yi Y, Suresh M, Tumpey TM, Siepel A, Wisely SM, Dessimoz C, Kawaoka Y, Birren BW, Lindblad-Toh K, Di Palma F, Engelhardt JF, Palermo RE, Katze MG.

Nat Biotechnol. 2014 Dec;32(12):1250-5. doi: 10.1038/nbt.3079. Epub 2014 Nov 17.

44.

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs.

Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):683-94. doi: 10.1165/rcmb.2014-0250OC.

45.

Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass.

Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, Gansemer ND, Ludwig PS, Hornick EE, Stoltz DA, Ode KL, Welsh MJ, Engelhardt JF, Norris AW.

Clin Sci (Lond). 2015 Jan;128(2):131-42. doi: 10.1042/CS20140059.

46.

Progenitor cells in proximal airway epithelial development and regeneration.

Lynch TJ, Engelhardt JF.

J Cell Biochem. 2014 Oct;115(10):1637-45. doi: 10.1002/jcb.24834. Review.

47.

Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.

Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, Tyler SR, Goeken JA, Kinyon JM, Radey MC, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Brittnacher MJ, Miller SI, Parekh K, Meyerholz DK, Hoffman LR, Frana T, Stewart ZA, Engelhardt JF.

Am J Pathol. 2014 May;184(5):1309-22. doi: 10.1016/j.ajpath.2014.01.035. Epub 2014 Mar 15.

48.

Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets.

Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW.

PLoS One. 2014 Mar 3;9(3):e90519. doi: 10.1371/journal.pone.0090519. eCollection 2014.

49.

The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies.

Spencer NY, Engelhardt JF.

Biochemistry. 2014 Mar 18;53(10):1551-64. doi: 10.1021/bi401719r. Epub 2014 Mar 4. Review.

50.

Sox2 modulates Lef-1 expression during airway submucosal gland development.

Xie W, Lynch TJ, Liu X, Tyler SR, Yu S, Zhou X, Luo M, Kusner DM, Sun X, Yi Y, Zhang Y, Goodheart MJ, Parekh KR, Wells JM, Xue HH, Pevny LH, Engelhardt JF.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L645-60. doi: 10.1152/ajplung.00157.2013. Epub 2014 Jan 31.

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