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Items: 10


The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis.

Numrich J, Péli-Gulli MP, Arlt H, Sardu A, Griffith J, Levine T, Engelbrecht-Vandré S, Reggiori F, De Virgilio C, Ungermann C.

J Cell Sci. 2015 Jul 1;128(13):2278-92. doi: 10.1242/jcs.164905. Epub 2015 May 21.


Function of the Mon1-Ccz1 complex on endosomes.

Cabrera M, Engelbrecht-Vandré S, Ungermann C.

Small GTPases. 2014;5(3):1-3. doi: 10.4161/sgtp.29040.


Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.

Behrmann H, Lürick A, Kuhlee A, Balderhaar HK, Bröcker C, Kümmel D, Engelbrecht-Vandré S, Gohlke U, Raunser S, Heinemann U, Ungermann C.

J Biol Chem. 2014 Nov 28;289(48):33503-12. doi: 10.1074/jbc.M114.602714. Epub 2014 Oct 16.


The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.

Cabrera M, Nordmann M, Perz A, Schmedt D, Gerondopoulos A, Barr F, Piehler J, Engelbrecht-Vandré S, Ungermann C.

J Cell Sci. 2014 Mar 1;127(Pt 5):1043-51. doi: 10.1242/jcs.140921. Epub 2014 Jan 10.


Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex.

Bröcker C, Kuhlee A, Gatsogiannis C, Balderhaar HJ, Hönscher C, Engelbrecht-Vandré S, Ungermann C, Raunser S.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1991-6. doi: 10.1073/pnas.1117797109. Epub 2012 Jan 25.


Rab GTPases and tethering in the yeast endocytic pathway.

Lachmann J, Ungermann C, Engelbrecht-Vandré S.

Small GTPases. 2011 May;2(3):182-186.


Phosphorylation of a membrane curvature-sensing motif switches function of the HOPS subunit Vps41 in membrane tethering.

Cabrera M, Langemeyer L, Mari M, Rethmeier R, Orban I, Perz A, Bröcker C, Griffith J, Klose D, Steinhoff HJ, Reggiori F, Engelbrecht-Vandré S, Ungermann C.

J Cell Biol. 2010 Nov 15;191(4):845-59. doi: 10.1083/jcb.201004092.


Multisubunit tethering complexes and their role in membrane fusion.

Bröcker C, Engelbrecht-Vandré S, Ungermann C.

Curr Biol. 2010 Nov 9;20(21):R943-52. doi: 10.1016/j.cub.2010.09.015. Review.


The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.

Nordmann M, Cabrera M, Perz A, Bröcker C, Ostrowicz C, Engelbrecht-Vandré S, Ungermann C.

Curr Biol. 2010 Sep 28;20(18):1654-9. doi: 10.1016/j.cub.2010.08.002.


Defined subunit arrangement and rab interactions are required for functionality of the HOPS tethering complex.

Ostrowicz CW, Bröcker C, Ahnert F, Nordmann M, Lachmann J, Peplowska K, Perz A, Auffarth K, Engelbrecht-Vandré S, Ungermann C.

Traffic. 2010 Oct;11(10):1334-46. doi: 10.1111/j.1600-0854.2010.01097.x.

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