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Inhibition of Receptor Dimerization as a Novel Negative Feedback Mechanism of EGFR Signaling.

Kluba M, Engelborghs Y, Hofkens J, Mizuno H.

PLoS One. 2015 Oct 14;10(10):e0139971. doi: 10.1371/journal.pone.0139971. eCollection 2015.


In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.

Schreurs S, Gerard M, Derua R, Waelkens E, Taymans JM, Baekelandt V, Engelborghs Y.

Int J Mol Sci. 2014 Jan 15;15(1):1040-67. doi: 10.3390/ijms15011040.


Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system.

De Graeve S, Marinelli S, Stolz F, Hendrix J, Vandamme J, Engelborghs Y, Van Dijck P, Thevelein JM.

Biochem J. 2013 Nov 1;455(3):295-306. doi: 10.1042/BJ20130417.


The characterization of the nuclear dynamics of syntenin-2, a PIP2 binding PDZ protein.

Geeraerts A, Hsiu-Fang F, Zimmermann P, Engelborghs Y.

Cytometry A. 2013 Sep;83(9):866-75. doi: 10.1002/cyto.a.22246. Epub 2013 Jan 8.


An elegant way to quantitatively analyze oligomer formation in solution.

Engelborghs Y.

Biophys J. 2012 Nov 7;103(9):1811-2. doi: 10.1016/j.bpj.2012.08.064. No abstract available.


Raised calcium and oxidative stress cooperatively promote alpha-synuclein aggregate formation.

Goodwin J, Nath S, Engelborghs Y, Pountney DL.

Neurochem Int. 2013 Apr;62(5):703-11. doi: 10.1016/j.neuint.2012.11.004. Epub 2012 Nov 15. Review.


Fluorescence correlation spectroscopy to determine the diffusion coefficient of α-synuclein and follow early oligomer formation.

Nath S, Deng M, Engelborghs Y.

Methods Mol Biol. 2012;895:499-506. doi: 10.1007/978-1-61779-927-3_29.


Fluorescence lifetime measurements of intrinsically unstructured proteins: application to α-synuclein.

Schreurs S, Kluba M, Meuvis J, Engelborghs Y.

Methods Mol Biol. 2012;895:461-6. doi: 10.1007/978-1-61779-927-3_27.


Tryptophan side chain conformers monitored by NMR and time-resolved fluorescence spectroscopies.

Julien O, Wang G, Jonckheer A, Engelborghs Y, Sykes BD.

Proteins. 2012 Jan;80(1):239-45. doi: 10.1002/prot.23198. Epub 2011 Nov 9.


Rational design of photoconvertible and biphotochromic fluorescent proteins for advanced microscopy applications.

Adam V, Moeyaert B, David CC, Mizuno H, Lelimousin M, Dedecker P, Ando R, Miyawaki A, Michiels J, Engelborghs Y, Hofkens J.

Chem Biol. 2011 Oct 28;18(10):1241-51. doi: 10.1016/j.chembiol.2011.08.007.


SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction.

Verbakel W, Carmeliet G, Engelborghs Y.

Biochem Biophys Res Commun. 2011 Aug 12;411(4):732-7. doi: 10.1016/j.bbrc.2011.07.015. Epub 2011 Jul 18.


Both substrate hydrolysis and secondary substrate binding determine xylanase mobility as assessed by FRAP.

Cuyvers S, Hendrix J, Dornez E, Engelborghs Y, Delcour JA, Courtin CM.

J Phys Chem B. 2011 Apr 28;115(16):4810-7. doi: 10.1021/jp110963f. Epub 2011 Apr 5.


Raised calcium promotes α-synuclein aggregate formation.

Nath S, Goodwin J, Engelborghs Y, Pountney DL.

Mol Cell Neurosci. 2011 Feb;46(2):516-26. doi: 10.1016/j.mcn.2010.12.004. Epub 2010 Dec 9.


The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering.

Hendrix J, Gijsbers R, De Rijck J, Voet A, Hotta J, McNeely M, Hofkens J, Debyser Z, Engelborghs Y.

Nucleic Acids Res. 2011 Mar;39(4):1310-25. doi: 10.1093/nar/gkq933. Epub 2010 Oct 25.


The conformation and the aggregation kinetics of α-synuclein depend on the proline residues in its C-terminal region.

Meuvis J, Gerard M, Desender L, Baekelandt V, Engelborghs Y.

Biochemistry. 2010 Nov 2;49(43):9345-52. doi: 10.1021/bi1010927.


Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.

Nath S, Meuvis J, Hendrix J, Carl SA, Engelborghs Y.

Biophys J. 2010 Apr 7;98(7):1302-11. doi: 10.1016/j.bpj.2009.12.4290.


Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

Gerard M, Deleersnijder A, Daniëls V, Schreurs S, Munck S, Reumers V, Pottel H, Engelborghs Y, Van den Haute C, Taymans JM, Debyser Z, Baekelandt V.

J Neurosci. 2010 Feb 17;30(7):2454-63. doi: 10.1523/JNEUROSCI.5983-09.2010.


Tryptophan conformations associated with partial unfolding in ribonuclease T1.

Moors SL, Jonckheer A, De Maeyer M, Engelborghs Y, Ceulemans A.

Biophys J. 2009 Sep 16;97(6):1778-86. doi: 10.1016/j.bpj.2009.07.015.


Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB - implications for the search for novel antibiotics.

Rao S, Bockstael K, Nath S, Engelborghs Y, Anné J, Geukens N.

FEBS J. 2009 Jun;276(12):3222-34. doi: 10.1111/j.1742-4658.2009.07037.x. Epub 2009 Apr 29.


The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144.

Briers Y, Schmelcher M, Loessner MJ, Hendrix J, Engelborghs Y, Volckaert G, Lavigne R.

Biochem Biophys Res Commun. 2009 May 29;383(2):187-91. doi: 10.1016/j.bbrc.2009.03.161. Epub 2009 Apr 5.


Chemical and biological characterization of thiol SAMs for neuronal cell attachment.

Jans K, Van Meerbergen B, Reekmans G, Bonroy K, Annaert W, Maes G, Engelborghs Y, Borghs G, Bartic C.

Langmuir. 2009 Apr 21;25(8):4564-70. doi: 10.1021/la802217r.


Measuring diffusion of lipid-like probes in artificial and natural membranes by raster image correlation spectroscopy (RICS): use of a commercial laser-scanning microscope with analog detection.

Gielen E, Smisdom N, vandeVen M, De Clercq B, Gratton E, Digman M, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M.

Langmuir. 2009 May 5;25(9):5209-18. doi: 10.1021/la8040538.


Peptide-functionalized microfabricated structures for improved on-chip neuronal adhesion.

Van Meerbergen B, Jans K, Loo J, Reekmans G, Braeken D, Seon-Ah C, Bonroy K, Maes G, Borghs G, Engelborghs Y, Annaert W, Bartic C.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1833-6. doi: 10.1109/IEMBS.2008.4649536.


How do rotameric conformations influence the time-resolved fluorescence of tryptophan in proteins? A perspective based on molecular modeling and quantum chemistry.

Moors SL, Jonckheer A, De Maeyer M, Engelborghs Y, Ceulemans A.

Curr Protein Pept Sci. 2008 Oct;9(5):427-46. Review.


Exploration of the activation pathway of Deltaalpha-Chymotrypsin with molecular dynamics simulations and correlation with kinetic experiments.

Mátrai J, Jonckheer A, Joris E, Krüger P, Carpenter E, Tuszynski J, De Maeyer M, Engelborghs Y.

Eur Biophys J. 2008 Nov;38(1):13-23. doi: 10.1007/s00249-008-0348-2. Epub 2008 Aug 27.


Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein.

Brandt I, Gérard M, Sergeant K, Devreese B, Baekelandt V, Augustyns K, Scharpé S, Engelborghs Y, Lambeir AM.

Peptides. 2008 Sep;29(9):1472-8. doi: 10.1016/j.peptides.2008.05.005. Epub 2008 May 15.


Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin.

Tudor C, Lerner-Marmarosh N, Engelborghs Y, Gibbs PE, Maines MD.

Biochem J. 2008 Aug 1;413(3):405-16. doi: 10.1042/BJ20080018.


FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.

Gerard M, Debyser Z, Desender L, Baert J, Brandt I, Baekelandt V, Engelborghs Y.

J Neurochem. 2008 Jul;106(1):121-33. doi: 10.1111/j.1471-4159.2008.05342.x. Epub 2008 Jul 1.


Dark states in monomeric red fluorescent proteins studied by fluorescence correlation and single molecule spectroscopy.

Hendrix J, Flors C, Dedecker P, Hofkens J, Engelborghs Y.

Biophys J. 2008 May 15;94(10):4103-13. doi: 10.1529/biophysj.107.123596. Epub 2008 Jan 30.


Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS).

Gielen E, Smisdom N, De Clercq B, Vandeven M, Gijsbers R, Debyser Z, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M.

J Fluoresc. 2008 Sep;18(5):813-9. doi: 10.1007/s10895-007-0308-8. Epub 2008 Jan 18.


Structural characterisation of the hepatitis C envelope glycoprotein E1 ectodomain derived from a mammalian and a yeast expression system.

Lorent E, Bierau H, Engelborghs Y, Verheyden G, Bosman F.

Vaccine. 2008 Jan 17;26(3):399-410. Epub 2007 Nov 21.


A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum.

Buyens K, Lucas B, Raemdonck K, Braeckmans K, Vercammen J, Hendrix J, Engelborghs Y, De Smedt SC, Sanders NN.

J Control Release. 2008 Feb 18;126(1):67-76. Epub 2007 Nov 7.


Stability of phiKMV lysin gp36c reflects its role during bacteriophage infection.

Briers Y, Lavigne R, Hertveldt K, Hanssens I, Engelborghs Y, Volckaert G.

Commun Agric Appl Biol Sci. 2007;72(1):115-8. No abstract available.


Comparative evaluation of stable TAFIa variants: importance of alpha-helix 9 and beta-sheet 11 for TAFIa (in)stability.

Ceresa E, De Maeyer M, Jonckheer A, Peeters M, Engelborghs Y, Declerck PJ, Gils A.

J Thromb Haemost. 2007 Oct;5(10):2105-12. Epub 2007 Jul 31.


Visualization of membrane rafts using a perylene monoimide derivative and fluorescence lifetime imaging.

Margineanu A, Hotta J, Vallée RA, Van der Auweraer M, Ameloot M, Stefan A, Beljonne D, Engelborghs Y, Herrmann A, Müllen K, De Schryver FC, Hofkens J.

Biophys J. 2007 Oct 15;93(8):2877-91. Epub 2007 Jun 15. Erratum in: Biophys J. 2008 Jan 15;94(2):715. Vallée, Renaud A L [added].


Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

Hombrouck A, Hantson A, van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M.

J Antimicrob Chemother. 2007 Jun;59(6):1084-95. Epub 2007 Apr 30.


The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis.

Feige JN, Gelman L, Rossi D, Zoete V, Métivier R, Tudor C, Anghel SI, Grosdidier A, Lathion C, Engelborghs Y, Michielin O, Wahli W, Desvergne B.

J Biol Chem. 2007 Jun 29;282(26):19152-66. Epub 2007 Apr 27.


Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z.

PLoS Pathog. 2007 Mar;3(3):e47.


Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy.

Boens N, Qin W, Basarić N, Hofkens J, Ameloot M, Pouget J, Lefèvre JP, Valeur B, Gratton E, vandeVen M, Silva ND Jr, Engelborghs Y, Willaert K, Sillen A, Rumbles G, Phillips D, Visser AJ, van Hoek A, Lakowicz JR, Malak H, Gryczynski I, Szabo AG, Krajcarski DT, Tamai N, Miura A.

Anal Chem. 2007 Mar 1;79(5):2137-49. Epub 2007 Feb 1.


Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells.

Tudor C, Feige JN, Pingali H, Lohray VB, Wahli W, Desvergne B, Engelborghs Y, Gelman L.

J Biol Chem. 2007 Feb 16;282(7):4417-26. Epub 2006 Dec 12.


Role of quorum sensing and antimicrobial component production by Serratia plymuthica in formation of biofilms, including mixed biofilms with Escherichia coli.

Moons P, Van Houdt R, Aertsen A, Vanoirbeek K, Engelborghs Y, Michiels CW.

Appl Environ Microbiol. 2006 Nov;72(11):7294-300. Epub 2006 Sep 22.


Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.

De Rijck J, Vandekerckhove L, Gijsbers R, Hombrouck A, Hendrix J, Vercammen J, Engelborghs Y, Christ F, Debyser Z.

J Virol. 2006 Dec;80(23):11498-509. Epub 2006 Sep 20.


Stability analysis of the bacteriophage phiKMV lysin gp36C and its putative role during infection.

Briers Y, Lavigne R, Plessers P, Hertveldt K, Hanssens I, Engelborghs Y, Volckaert G.

Cell Mol Life Sci. 2006 Aug;63(16):1899-905.


Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk5.

Vandebroek T, Terwel D, Vanhelmont T, Gysemans M, Van Haesendonck C, Engelborghs Y, Winderickx J, Van Leuven F.

J Biol Chem. 2006 Sep 1;281(35):25388-97. Epub 2006 Jul 3.


Fast and reversible photoswitching of the fluorescent protein dronpa as evidenced by fluorescence correlation spectroscopy.

Dedecker P, Hotta J, Ando R, Miyawaki A, Engelborghs Y, Hofkens J.

Biophys J. 2006 Sep 1;91(5):L45-7. Epub 2006 Jun 23.


Probing diffusion laws within cellular membranes by Z-scan fluorescence correlation spectroscopy.

Humpolícková J, Gielen E, Benda A, Fagulova V, Vercammen J, Vandeven M, Hof M, Ameloot M, Engelborghs Y.

Biophys J. 2006 Aug 1;91(3):L23-5. Epub 2006 Jun 2.


Integrating nuclear receptor mobility in models of gene regulation.

Gelman L, Feige JN, Tudor C, Engelborghs Y, Wahli W, Desvergne B.

Nucl Recept Signal. 2006;4:e010. Epub 2006 Apr 28.


Tryptophan rotamers as evidenced by X-ray, fluorescence lifetimes, and molecular dynamics modeling.

Moors SL, Hellings M, De Maeyer M, Engelborghs Y, Ceulemans A.

Biophys J. 2006 Aug 1;91(3):816-23. Epub 2006 May 12.


Human immunoglobulin adsorption investigated by means of quartz crystal microbalance dissipation, atomic force microscopy, surface acoustic wave, and surface plasmon resonance techniques.

Zhou C, Friedt JM, Angelova A, Choi KH, Laureyn W, Frederix F, Francis LA, Campitelli A, Engelborghs Y, Borghs G.

Langmuir. 2004 Jul 6;20(14):5870-8.


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