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Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases-Current State of the Art.

Smorodinsky-Atias K, Soudah N, Engelberg D.

Cells. 2020 Jan 6;9(1). pii: E129. doi: 10.3390/cells9010129. Review.


An Activating Mutation in ERK Causes Hyperplastic Tumors in a scribble Mutant Tissue in Drosophila.

Kushnir T, Bar-Cohen S, Mooshayef N, Lange R, Bar-Sinai A, Rozen H, Salzberg A, Engelberg D, Paroush Z.

Genetics. 2020 Jan;214(1):109-120. doi: 10.1534/genetics.119.302794. Epub 2019 Nov 18.


Alternative Experimental Models for Studying Influenza Proteins, Host-Virus Interactions and Anti-Influenza Drugs.

Chua SCJH, Tan HQ, Engelberg D, Lim LHK.

Pharmaceuticals (Basel). 2019 Sep 30;12(4). pii: E147. doi: 10.3390/ph12040147. Review.


Cesium and Strontium Contamination of Nuclear Plant Stainless Steel: Implications for Decommissioning and Waste Minimization.

Lang AR, Engelberg DL, Walther C, Weiss M, Bosco H, Jenkins A, Livens FR, Law GTW.

ACS Omega. 2019 Aug 26;4(11):14420-14429. doi: 10.1021/acsomega.9b01311. eCollection 2019 Sep 10.


Diagnostic value of hysteroscopy in abnormal uterine bleeding.

Engelberg D, Pankratieva E, Liauchonak I.

Can Fam Physician. 2018 Jun;64(6):442-444. No abstract available.


Analysis of contaminated nuclear plant steel by laser-induced breakdown spectroscopy.

Lang A, Engelberg D, Smith NT, Trivedi D, Horsfall O, Banford A, Martin PA, Coffey P, Bower WR, Walther C, Weiß M, Bosco H, Jenkins A, Law GTW.

J Hazard Mater. 2018 Mar 5;345:114-122. doi: 10.1016/j.jhazmat.2017.10.064. Epub 2017 Nov 7.


Isolation and Characterization of Intrinsically Active (MEK-Independent) Mutants of Mpk1/Erk.

Goshen-Lago T, Melamed D, Admon A, Engelberg D.

Methods Mol Biol. 2017;1487:65-88.


How Do Protein Kinases Take a Selfie (Autophosphorylate)?

Beenstock J, Mooshayef N, Engelberg D.

Trends Biochem Sci. 2016 Nov;41(11):938-953. doi: 10.1016/j.tibs.2016.08.006. Epub 2016 Sep 1. Review.


Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.

Goshen-Lago T, Goldberg-Carp A, Melamed D, Darlyuk-Saadon I, Bai C, Ahn NG, Admon A, Engelberg D.

Mol Biol Cell. 2016 Sep 1;27(17):2771-83. doi: 10.1091/mbc.E16-03-0167. Epub 2016 Jul 13.


Tighter αC-helix-αL16-helix interactions seem to make p38α less prone to activation by autophosphorylation than Hog1.

Tesker M, Selamat SE, Beenstock J, Hayouka R, Livnah O, Engelberg D.

Biosci Rep. 2016 Apr 27;36(2). pii: e00324. doi: 10.1042/BSR20160020. Print 2016.


p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.

Beenstock J, Melamed D, Mooshayef N, Mordechay D, Garfinkel BP, Ahn NG, Admon A, Engelberg D.

Mol Cell Biol. 2016 May 2;36(10):1540-54. doi: 10.1128/MCB.01105-15. Print 2016 May 15.


Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation.

Smorodinsky-Atias K, Goshen-Lago T, Goldberg-Carp A, Melamed D, Shir A, Mooshayef N, Beenstock J, Karamansha Y, Darlyuk-Saadon I, Livnah O, Ahn NG, Admon A, Engelberg D.

Mol Biol Cell. 2016 Mar 15;27(6):1026-39. doi: 10.1091/mbc.E15-07-0521. Epub 2015 Dec 10.


Localised corrosion: general discussion.

Frankel G, Thornton G, Street S, Rayment T, Williams D, Cook A, Davenport A, Gibbon S, Engelberg D, Örnek C, Mol A, Marcus P, Shoesmith D, Wren C, Yliniemi K, Williams G, Lyon S, Lindsay R, Hughes T, Lützenkirchen J, Cheng ST, Scully J, Lee SF, Newman R, Taylor C, Springell R, Mauzeroll J, Virtanen S, Heurtault S, Sullivan J.

Faraday Discuss. 2015;180:381-414. doi: 10.1039/c5fd90046h. No abstract available.


The yeast Hot1 transcription factor is critical for activating a single target gene, STL1.

Bai C, Tesker M, Engelberg D.

Mol Biol Cell. 2015 Jun 15;26(12):2357-74. doi: 10.1091/mbc.E14-12-1626. Epub 2015 Apr 22.


Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: state of the art after 25 years.

Engelberg D, Perlman R, Levitzki A.

Cell Signal. 2014 Dec;26(12):2865-78. doi: 10.1016/j.cellsig.2014.09.003. Epub 2014 Sep 15. Review.


The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.

Beenstock J, Ben-Yehuda S, Melamed D, Admon A, Livnah O, Ahn NG, Engelberg D.

J Biol Chem. 2014 Aug 22;289(34):23546-56. doi: 10.1074/jbc.M114.578237. Epub 2014 Jul 8.


Correlative tomography.

Burnett TL, McDonald SA, Gholinia A, Geurts R, Janus M, Slater T, Haigh SJ, Ornek C, Almuaili F, Engelberg DL, Thompson GE, Withers PJ.

Sci Rep. 2014 Apr 16;4:4711. doi: 10.1038/srep04711.


DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation.

Tzarum N, Komornik N, Ben Chetrit D, Engelberg D, Livnah O.

J Biol Chem. 2013 Jul 5;288(27):19537-47. doi: 10.1074/jbc.M113.464511. Epub 2013 May 13.


Osmostress induces autophosphorylation of Hog1 via a C-terminal regulatory region that is conserved in p38α.

Maayan I, Beenstock J, Marbach I, Tabachnick S, Livnah O, Engelberg D.

PLoS One. 2012;7(9):e44749. doi: 10.1371/journal.pone.0044749. Epub 2012 Sep 11.


Turbidostat culture of Saccharomyces cerevisiae W303-1A under selective pressure elicited by ethanol selects for mutations in SSD1 and UTH1.

Avrahami-Moyal L, Engelberg D, Wenger JW, Sherlock G, Braun S.

FEMS Yeast Res. 2012 Aug;12(5):521-33. doi: 10.1111/j.1567-1364.2012.00803.x. Epub 2012 Apr 23.


Overexpression of PDE2 or SSD1-V in Saccharomyces cerevisiae W303-1A strain renders it ethanol-tolerant.

Avrahami-Moyal L, Braun S, Engelberg D.

FEMS Yeast Res. 2012 Jun;12(4):447-55. doi: 10.1111/j.1567-1364.2012.00795.x. Epub 2012 Mar 29.


Conformational bias imposed by source microseeds results in structural ambiguity.

Tzarum N, Engelberg D, Livnah O.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):877-84. doi: 10.1107/S1744309111017970. Epub 2011 Jul 13.


Active mutants of the TCR-mediated p38α alternative activation site show changes in the phosphorylation lip and DEF site formation.

Tzarum N, Diskin R, Engelberg D, Livnah O.

J Mol Biol. 2011 Feb 4;405(5):1154-69. doi: 10.1016/j.jmb.2010.11.023. Epub 2010 Dec 10.


A "molecular evolution" approach for isolation of intrinsically active (MEK-independent) MAP kinases.

Levin-Salomon V, Livnah O, Engelberg D.

Methods Mol Biol. 2010;661:257-72. doi: 10.1007/978-1-60761-795-2_15.


A detailed protocol for chromatin immunoprecipitation in the yeast Saccharomyces cerevisiae.

Grably M, Engelberg D.

Methods Mol Biol. 2010;638:211-24. doi: 10.1007/978-1-60761-611-5_16.


SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway.

Su B, Bu Y, Engelberg D, Gelman IH.

J Biol Chem. 2010 Feb 12;285(7):4578-86. doi: 10.1074/jbc.M109.073494. Epub 2009 Dec 15.


The yeast MAPK Hog1 is not essential for immediate survival under osmostress.

Maayan I, Engelberg D.

FEBS Lett. 2009 Jun 18;583(12):2015-20. doi: 10.1016/j.febslet.2009.05.014. Epub 2009 May 15.


In situ observation of intergranular crack nucleation in a grain boundary controlled austenitic stainless steel.

Rahimi S, Engelberg DL, Duff JA, Marrow TJ.

J Microsc. 2009 Mar;233(3):423-31. doi: 10.1111/j.1365-2818.2009.03133.x.


Five-parameter grain boundary analysis of a grain boundary-engineered austenitic stainless steel.

Jones R, Randle V, Engelberg D, Marrow TJ.

J Microsc. 2009 Mar;233(3):417-22. doi: 10.1111/j.1365-2818.2009.03129.x.


p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.

Askari N, Beenstock J, Livnah O, Engelberg D.

Biochemistry. 2009 Mar 24;48(11):2497-504. doi: 10.1021/bi900024v.


Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

Levin-Salomon V, Kogan K, Ahn NG, Livnah O, Engelberg D.

J Biol Chem. 2008 Dec 12;283(50):34500-10. doi: 10.1074/jbc.M806443200. Epub 2008 Oct 1.


When expressed in yeast, mammalian mitogen-activated protein kinases lose proper regulation and become spontaneously phosphorylated.

Levin-Salomon V, Maayan I, Avrahami-Moyal L, Marbach I, Livnah O, Engelberg D.

Biochem J. 2009 Jan 1;417(1):331-40. doi: 10.1042/BJ20081335.


Observations of intergranular stress corrosion cracking in a grain-mapped polycrystal.

King A, Johnson G, Engelberg D, Ludwig W, Marrow J.

Science. 2008 Jul 18;321(5887):382-5. doi: 10.1126/science.1156211.


The influence of low-strain thermo-mechanical processing on grain boundary network characteristics in type 304 austenitic stainless steel.

Engelberg DL, Humphreys FJ, Marrow TJ.

J Microsc. 2008 Jun;230(Pt 3):435-44. doi: 10.1111/j.1365-2818.2008.02003.x.


A novel lipid binding site formed by the MAP kinase insert in p38 alpha.

Diskin R, Engelberg D, Livnah O.

J Mol Biol. 2008 Jan 4;375(1):70-9. Epub 2007 Sep 8.


High-resolution diffracting crystals of intrinsically active p38alpha MAP kinase: a case study for low-throughput approaches.

Diskin R, Engelberg D, Livnah O.

Acta Crystallogr D Biol Crystallogr. 2007 Feb;63(Pt 2):260-5. Epub 2007 Jan 16.


Intrinsically active variants of all human p38 isoforms.

Avitzour M, Diskin R, Raboy B, Askari N, Engelberg D, Livnah O.

FEBS J. 2007 Feb;274(4):963-75. Epub 2007 Jan 22.


Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.

Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D.

J Biol Chem. 2007 Jan 5;282(1):91-9. Epub 2006 Nov 6.


Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation.

Diskin R, Lebendiker M, Engelberg D, Livnah O.

J Mol Biol. 2007 Jan 5;365(1):66-76. Epub 2006 Aug 22.


Isolation of intrinsically active mutants of MAP kinases via genetic screens in yeast.

Engelberg D, Livnah O.

Methods. 2006 Nov;40(3):255-61.


JX401, A p38alpha inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast.

Friedmann Y, Shriki A, Bennett ER, Golos S, Diskin R, Marbach I, Bengal E, Engelberg D.

Mol Pharmacol. 2006 Oct;70(4):1395-405. Epub 2006 Jul 17.


MAP-quest: could we produce constitutively active variants of MAP kinases?

Askari N, Diskin R, Avitzour M, Yaakov G, Livnah O, Engelberg D.

Mol Cell Endocrinol. 2006 Jun 27;252(1-2):231-40. Epub 2006 May 2. Review.


Ha-ras(val12) induces HSP70b transcription via the HSE/HSF1 system, but HSP70b expression is suppressed in Ha-ras(val12)-transformed cells.

Stanhill A, Levin V, Hendel A, Shachar I, Kazanov D, Arber N, Kaminski N, Engelberg D.

Oncogene. 2006 Mar 9;25(10):1485-95.


Active mutants of the human p38alpha mitogen-activated protein kinase.

Diskin R, Askari N, Capone R, Engelberg D, Livnah O.

J Biol Chem. 2004 Nov 5;279(45):47040-9. Epub 2004 Jul 28.


Stress-activated protein kinases-tumor suppressors or tumor initiators?

Engelberg D.

Semin Cancer Biol. 2004 Aug;14(4):271-82. Review.


Procedure for controlling number of repeats, orientation, and order during cloning of oligonucleotides.

Blachinsky E, Marbach I, Cohen R, Grably MR, Engelberg D.

Biotechniques. 2004 Jun;36(6):933-6. No abstract available.


Combination of two activating mutations in one HOG1 gene forms hyperactive enzymes that induce growth arrest.

Yaakov G, Bell M, Hohmann S, Engelberg D.

Mol Cell Biol. 2003 Jul;23(14):4826-40.


Phosphorylation of Tyr-176 of the yeast MAPK Hog1/p38 is not vital for Hog1 biological activity.

Bell M, Engelberg D.

J Biol Chem. 2003 Apr 25;278(17):14603-6. Epub 2003 Mar 10.


Cisplatin-induced activation of the EGF receptor.

Benhar M, Engelberg D, Levitzki A.

Oncogene. 2002 Dec 12;21(57):8723-31.

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