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Items: 1 to 50 of 65

1.

Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi.

Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS.

Nat Microbiol. 2019 Feb;4(2):244-250. doi: 10.1038/s41564-018-0327-z. Epub 2019 Jan 7.

2.

Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT.

Kumagai K, Elwell CA, Ando S, Engel JN, Hanada K.

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1070-1076. doi: 10.1016/j.bbrc.2018.09.168. Epub 2018 Oct 9.

3.

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.

Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS.

Elife. 2017 Mar 2;6. pii: e22709. doi: 10.7554/eLife.22709.

4.

Targeting the Mucosal Barrier: How Pathogens Modulate the Cellular Polarity Network.

Ruch TR, Engel JN.

Cold Spring Harb Perspect Biol. 2017 Jun 1;9(6). pii: a027953. doi: 10.1101/cshperspect.a027953. Review.

5.

Bacterial internalization is required to trigger NIK-dependent NF-κB activation in response to the bacterial type three secretion system.

Duncan MC, Herrera NG, Johnson KS, Engel JN, Auerbuch V.

PLoS One. 2017 Feb 6;12(2):e0171406. doi: 10.1371/journal.pone.0171406. eCollection 2017.

6.

Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity.

Ruch TR, Bryant DM, Mostov KE, Engel JN.

Mol Biol Cell. 2017 Jan 15;28(2):252-260. doi: 10.1091/mbc.E16-07-0541. Epub 2016 Nov 23.

7.

A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa.

Inclan YF, Persat A, Greninger A, Von Dollen J, Johnson J, Krogan N, Gitai Z, Engel JN.

Mol Microbiol. 2016 Aug;101(4):590-605. doi: 10.1111/mmi.13410. Epub 2016 May 27.

8.

Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa.

Persat A, Inclan YF, Engel JN, Stone HA, Gitai Z.

Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):7563-8. doi: 10.1073/pnas.1502025112. Epub 2015 Jun 3.

9.

The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier.

Tran CS, Rangel SM, Almblad H, Kierbel A, Givskov M, Tolker-Nielsen T, Hauser AR, Engel JN.

PLoS Pathog. 2014 Nov 6;10(11):e1004479. doi: 10.1371/journal.ppat.1004479. eCollection 2014 Nov.

10.

Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection.

Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov KE, Engel JN.

Cell Host Microbe. 2014 May 14;15(5):636-43. doi: 10.1016/j.chom.2014.04.007.

11.

Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia.

Bucior I, Abbott J, Song Y, Matthay MA, Engel JN.

Am J Physiol Lung Cell Mol Physiol. 2013 Sep;305(5):L352-63. doi: 10.1152/ajplung.00387.2012. Epub 2013 Jun 21.

12.

Chlamydial intracellular survival strategies.

Bastidas RJ, Elwell CA, Engel JN, Valdivia RH.

Cold Spring Harb Perspect Med. 2013 May 1;3(5):a010256. doi: 10.1101/cshperspect.a010256. Review.

13.

Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection.

Kim JH, Chan C, Elwell C, Singer MS, Dierks T, Lemjabbar-Alaoui H, Rosen SD, Engel JN.

Cell Microbiol. 2013 Sep;15(9):1560-71. doi: 10.1111/cmi.12133. Epub 2013 Apr 9.

14.

Pseudomonas aeruginosa pili and flagella mediate distinct binding and signaling events at the apical and basolateral surface of airway epithelium.

Bucior I, Pielage JF, Engel JN.

PLoS Pathog. 2012;8(4):e1002616. doi: 10.1371/journal.ppat.1002616. Epub 2012 Apr 5.

15.

Lipid acquisition by intracellular Chlamydiae.

Elwell CA, Engel JN.

Cell Microbiol. 2012 Jul;14(7):1010-8. doi: 10.1111/j.1462-5822.2012.01794.x. Epub 2012 Apr 17. Review.

16.

Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection.

Kim JH, Jiang S, Elwell CA, Engel JN.

PLoS Pathog. 2011 Oct;7(10):e1002285. doi: 10.1371/journal.ppat.1002285. Epub 2011 Oct 6.

17.

Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development.

Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, Engel JN.

PLoS Pathog. 2011 Sep;7(9):e1002198. doi: 10.1371/journal.ppat.1002198. Epub 2011 Sep 1. Erratum in: PLoS Pathog. 2013 Aug;9(8). doi: 10.1371/annotation/f8e7c7e3-c347-4243-9146-db77900cb90c.

18.

Species-specific interactions of Src family tyrosine kinases regulate Chlamydia intracellular growth and trafficking.

Elwell CA, Kierbel A, Engel JN.

MBio. 2011 May 17;2(3):e00082-11. doi: 10.1128/mBio.00082-11. Print 2011.

19.

FimL regulates cAMP synthesis in Pseudomonas aeruginosa.

Inclan YF, Huseby MJ, Engel JN.

PLoS One. 2011 Jan 11;6(1):e15867. doi: 10.1371/journal.pone.0015867.

20.

Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium.

Bucior I, Mostov K, Engel JN.

Infect Immun. 2010 Mar;78(3):939-53. doi: 10.1128/IAI.01215-09. Epub 2009 Dec 14.

21.

Genetic analysis of the regulation of type IV pilus function by the Chp chemosensory system of Pseudomonas aeruginosa.

Bertrand JJ, West JT, Engel JN.

J Bacteriol. 2010 Feb;192(4):994-1010. doi: 10.1128/JB.01390-09. Epub 2009 Dec 11.

22.

CbpA: a polarly localized novel cyclic AMP-binding protein in Pseudomonas aeruginosa.

Endoh T, Engel JN.

J Bacteriol. 2009 Dec;191(23):7193-205. doi: 10.1128/JB.00970-09. Epub 2009 Oct 2.

23.

Using the SCERTS model assessment tool to identify music therapy goals for clients with autism spectrum disorder.

Walworth DD, Register D, Engel JN.

J Music Ther. 2009 Fall;46(3):204-16.

PMID:
19757876
24.

Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.

Barken KB, Pamp SJ, Yang L, Gjermansen M, Bertrand JJ, Klausen M, Givskov M, Whitchurch CB, Engel JN, Tolker-Nielsen T.

Environ Microbiol. 2008 Sep;10(9):2331-43. doi: 10.1111/j.1462-2920.2008.01658.x. Epub 2008 May 15.

PMID:
18485000
25.

RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization.

Pielage JF, Powell KR, Kalman D, Engel JN.

PLoS Pathog. 2008 Mar 21;4(3):e1000031. doi: 10.1371/journal.ppat.1000031.

26.

RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry.

Elwell CA, Ceesay A, Kim JH, Kalman D, Engel JN.

PLoS Pathog. 2008 Mar 7;4(3):e1000021. doi: 10.1371/journal.ppat.1000021. Erratum in: PLoS Pathog. 2013 Aug;9(8). doi:10.1371/annotation/d041a126-3e08-40ab-bee4-3448404b07b3.

27.

An essential, putative MEK kinase of Leishmania major.

Agron PG, Reed SL, Engel JN.

Mol Biochem Parasitol. 2005 Jul;142(1):121-5. Epub 2005 Apr 11. No abstract available.

PMID:
15878208
28.
29.

The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization.

Kierbel A, Gassama-Diagne A, Mostov K, Engel JN.

Mol Biol Cell. 2005 May;16(5):2577-85. Epub 2005 Mar 16.

30.

Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways.

Whitchurch CB, Beatson SA, Comolli JC, Jakobsen T, Sargent JL, Bertrand JJ, West J, Klausen M, Waite LL, Kang PJ, Tolker-Nielsen T, Mattick JS, Engel JN.

Mol Microbiol. 2005 Mar;55(5):1357-78.

31.

Lipid raft-mediated entry is not required for Chlamydia trachomatis infection of cultured epithelial cells.

Gabel BR, Elwell C, van Ijzendoorn SC, Engel JN.

Infect Immun. 2004 Dec;72(12):7367-73.

32.

A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion.

Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ.

Mol Microbiol. 2004 Sep;53(6):1677-93.

33.

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.

Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.

Mol Microbiol. 2004 May;52(3):873-93.

34.

The ADP ribosyltransferase domain of Pseudomonas aeruginosa ExoT contributes to its biological activities.

Garrity-Ryan L, Shafikhani S, Balachandran P, Nguyen L, Oza J, Jakobsen T, Sargent J, Fang X, Cordwell S, Matthay MA, Engel JN.

Infect Immun. 2004 Jan;72(1):546-58.

35.

Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa.

Kazmierczak BI, Mostov K, Engel JN.

Mol Biol Cell. 2004 Feb;15(2):411-9. Epub 2003 Oct 31.

36.

Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa.

Jacob T, Lee RJ, Engel JN, Machen TE.

Infect Immun. 2002 Nov;70(11):6399-408.

37.

Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa.

Hauser AR, Cobb E, Bodi M, Mariscal D, Vallés J, Engel JN, Rello J.

Crit Care Med. 2002 Mar;30(3):521-8.

PMID:
11990909
38.
39.

Interaction of bacterial pathogens with polarized epithelium.

Kazmierczak BI, Mostov K, Engel JN.

Annu Rev Microbiol. 2001;55:407-35.

PMID:
11544362
40.

Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.

Geiser TK, Kazmierczak BI, Garrity-Ryan LK, Matthay MA, Engel JN.

Cell Microbiol. 2001 Apr;3(4):223-36.

PMID:
11298646
41.

Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells.

Kazmierczak BI, Jou TS, Mostov K, Engel JN.

Cell Microbiol. 2001 Feb;3(2):85-98.

PMID:
11207623
42.

Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis.

van Ooij C, Kalman L, van Ijzendoorn, Nishijima M, Hanada K, Mostov K, Engel JN.

Cell Microbiol. 2000 Dec;2(6):627-37.

PMID:
11207614
43.
44.

Eukaryotic cell uptake of heparin-coated microspheres: a model of host cell invasion by Chlamydia trachomatis.

Stephens RS, Fawaz FS, Kennedy KA, Koshiyama K, Nichols B, van Ooij C, Engel JN.

Infect Immun. 2000 Mar;68(3):1080-5.

45.
46.

Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia.

Comolli JC, Hauser AR, Waite L, Whitchurch CB, Mattick JS, Engel JN.

Infect Immun. 1999 Jul;67(7):3625-30.

47.
48.
49.

Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells.

Hauser AR, Fleiszig S, Kang PJ, Mostov K, Engel JN.

Infect Immun. 1998 Apr;66(4):1413-20.

50.

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