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Items: 1 to 50 of 284

1.

Spiral ganglion cell degeneration-induced deafness as a consequence of reduced GATA factor activity.

Hoshino T, Terunuma T, Takai J, Uemura S, Nakamura Y, Hamada M, Takahashi S, Yamamoto M, Engel JD, Moriguchi T.

Genes Cells. 2019 May 29. doi: 10.1111/gtc.12705. [Epub ahead of print]

PMID:
31141264
2.

Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis.

Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg MH, Engel JD, Cui S.

Blood. 2019 May 30;133(22):2455-2459. doi: 10.1182/blood.2018892737. Epub 2019 Apr 16. No abstract available.

PMID:
30992270
3.

Transvection-like interchromosomal interaction is not observed at the transcriptional level when tested in the Rosa26 locus in mouse.

Tanimoto K, Matsuzaki H, Okamura E, Ushiki A, Fukamizu A, Engel JD.

PLoS One. 2019 Feb 14;14(2):e0203099. doi: 10.1371/journal.pone.0203099. eCollection 2019.

4.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

Yu L, Jearawiriyapaisarn N, Lee MP, Hosoya T, Wu Q, Myers G, Lim KC, Kurita R, Nakamura Y, Vojtek AB, Rual JF, Engel JD.

Genes Dev. 2018 Dec 1;32(23-24):1537-1549. doi: 10.1101/gad.318436.118. Epub 2018 Nov 21.

5.

High-Throughput Single-Cell Sequencing of both TCR-β Alleles.

Hosoya T, Li H, Ku CJ, Wu Q, Guan Y, Engel JD.

J Immunol. 2018 Dec 1;201(11):3465-3470. doi: 10.4049/jimmunol.1800774. Epub 2018 Oct 31.

PMID:
30381480
6.

Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development.

Liu J, Li Y, Tong J, Gao J, Guo Q, Zhang L, Wang B, Zhao H, Wang H, Jiang E, Kurita R, Nakamura Y, Tanabe O, Engel JD, Bresnick EH, Zhou J, Shi L.

Nat Commun. 2018 Oct 22;9(1):4386. doi: 10.1038/s41467-018-06883-x.

7.

A Gata3 3' Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression.

Moriguchi T, Hoshino T, Rao A, Yu L, Takai J, Uemura S, Ise K, Nakamura Y, Lim KC, Shimizu R, Yamamoto M, Engel JD.

Mol Cell Biol. 2018 Oct 15;38(21). pii: e00302-18. doi: 10.1128/MCB.00302-18. Print 2018 Nov 1.

8.

Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.

Rivers A, Vaitkus K, Jagadeeswaran R, Ruiz MA, Ibanez V, Ciceri F, Cavalcanti F, Molokie RE, Saunthararajah Y, Engel JD, DeSimone J, Lavelle D.

Exp Hematol. 2018 Nov;67:60-64.e2. doi: 10.1016/j.exphem.2018.08.003. Epub 2018 Aug 17.

PMID:
30125603
9.

Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.

Wang Q, Yan R, Pinnell N, McCarter AC, Oh Y, Liu Y, Sha C, Garber NF, Chen Y, Wu Q, Ku CJ, Tran I, Serna Alarcon A, Kuick R, Engel JD, Maillard I, Cierpicki T, Chiang MY.

Blood. 2018 Sep 20;132(12):1279-1292. doi: 10.1182/blood-2018-02-835850. Epub 2018 Aug 3.

PMID:
30076146
10.

Fetal Hemoglobin Induction by Epigenetic Drugs.

Lavelle D, Engel JD, Saunthararajah Y.

Semin Hematol. 2018 Apr;55(2):60-67. doi: 10.1053/j.seminhematol.2018.04.008. Epub 2018 Apr 22. Review.

11.

Global dynamics of stage-specific transcription factor binding during thymocyte development.

Hosoya T, D'Oliveira Albanus R, Hensley J, Myers G, Kyono Y, Kitzman J, Parker SCJ, Engel JD.

Sci Rep. 2018 Apr 4;8(1):5605. doi: 10.1038/s41598-018-23774-9.

12.

Mitochondrial dysfunction in obesity.

de Mello AH, Costa AB, Engel JDG, Rezin GT.

Life Sci. 2018 Jan 1;192:26-32. doi: 10.1016/j.lfs.2017.11.019. Epub 2017 Nov 16. Review.

PMID:
29155300
13.

Reactivation of Fetal Hemoglobin for Treating β-Thalassemia and Sickle Cell Disease.

Cui S, Engel JD.

Adv Exp Med Biol. 2017;1013:177-202. doi: 10.1007/978-1-4939-7299-9_7.

PMID:
29127681
14.

The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation.

Lee MP, Tanabe O, Shi L, Jearawiriyapaisarn N, Lucas D, Engel JD.

Blood. 2017 Dec 7;130(23):2537-2547. doi: 10.1182/blood-2017-05-783159. Epub 2017 Oct 10.

15.

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.

Molokie R, Lavelle D, Gowhari M, Pacini M, Krauz L, Hassan J, Ibanez V, Ruiz MA, Ng KP, Woost P, Radivoyevitch T, Pacelli D, Fada S, Rump M, Hsieh M, Tisdale JF, Jacobberger J, Phelps M, Engel JD, Saraf S, Hsu LL, Gordeuk V, DeSimone J, Saunthararajah Y.

PLoS Med. 2017 Sep 7;14(9):e1002382. doi: 10.1371/journal.pmed.1002382. eCollection 2017 Sep.

16.

GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis.

Katayama S, Suzuki M, Yamaoka A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kure S, Engel JD, Yamamoto M.

Blood. 2017 Aug 17;130(7):908-919. doi: 10.1182/blood-2016-12-756767. Epub 2017 Jun 19.

17.

A Retroperitoneal Serous Cystadenoma of Müllerian Origin Masquerading as a Massive Renal Cyst.

Sabarwal VK, Chandrasekar A, Engel J, Toubaji A, Engel JD.

Urology. 2017 Jul;105:e9-e10. doi: 10.1016/j.urology.2017.03.041. Epub 2017 Apr 10.

PMID:
28408339
18.

GATA3 Abundance Is a Critical Determinant of T Cell Receptor β Allelic Exclusion.

Ku CJ, Sekiguchi JM, Panwar B, Guan Y, Takahashi S, Yoh K, Maillard I, Hosoya T, Engel JD.

Mol Cell Biol. 2017 May 31;37(12). pii: e00052-17. doi: 10.1128/MCB.00052-17. Print 2017 Jun 15.

19.

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease.

Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A.

Exp Hematol. 2017 Jun;50:46-52. doi: 10.1016/j.exphem.2017.02.003. Epub 2017 Feb 24.

20.

Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation.

Zhang Y, Zhang J, An W, Wan Y, Ma S, Yin J, Li X, Gao J, Yuan W, Guo Y, Engel JD, Shi L, Cheng T, Zhu X.

Nucleic Acids Res. 2017 Jan 25;45(2):657-671. doi: 10.1093/nar/gkw901. Epub 2016 Oct 7.

21.

Derepression of the DNA Methylation Machinery of the Gata1 Gene Triggers the Differentiation Cue for Erythropoiesis.

Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.

Mol Cell Biol. 2017 Mar 31;37(8). pii: e00592-16. doi: 10.1128/MCB.00592-16. Print 2017 Apr 15.

22.

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.

Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D.

Blood. 2017 Jan 12;129(2):260-263. doi: 10.1182/blood-2016-10-746727. Epub 2016 Dec 1. No abstract available.

23.

Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defect.

Moriguchi T, Yu L, Otsuki A, Ainoya K, Lim KC, Yamamoto M, Engel JD.

Mol Cell Biol. 2016 Aug 12;36(17):2272-81. doi: 10.1128/MCB.00173-16. Print 2016 Sep 1.

24.

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).

Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D.

Haematologica. 2016 Jun;101(6):688-97. doi: 10.3324/haematol.2015.140749. Epub 2016 Feb 8.

25.

Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.

Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD.

J Clin Invest. 2016 Mar 1;126(3):865-78. doi: 10.1172/JCI83894. Epub 2016 Jan 25.

26.

Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.

Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MKM, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS.

Dev Biol. 2016 Jan 1;409(1):218-233. doi: 10.1016/j.ydbio.2015.10.022. Epub 2015 Nov 2.

27.

A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance.

Ku CJ, Lim KC, Kalantry S, Maillard I, Engel JD, Hosoya T.

Genes Dev. 2015 Sep 15;29(18):1930-41. doi: 10.1101/gad.265025.115.

28.

Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation.

Keleku-Lukwete N, Suzuki M, Otsuki A, Tsuchida K, Katayama S, Hayashi M, Naganuma E, Moriguchi T, Tanabe O, Engel JD, Imaizumi M, Yamamoto M.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):12169-74. doi: 10.1073/pnas.1509158112. Epub 2015 Sep 14.

29.

An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.

Blobel GA, Bodine D, Brand M, Crispino J, de Bruijn MF, Nathan D, Papayannopoulou T, Porcher C, Strouboulis J, Zon L, Higgs DR, Stamatoyannopoulos G, Engel JD.

Exp Hematol. 2015 Oct;43(10):821-37. doi: 10.1016/j.exphem.2015.06.008. Epub 2015 Jul 2. Review.

30.

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.

Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD.

Blood. 2015 Jul 16;126(3):386-96. doi: 10.1182/blood-2015-02-626259. Epub 2015 Jun 1.

31.

Regulatory network inferred using expression data of small sample size: application and validation in erythroid system.

Zhu F, Shi L, Engel JD, Guan Y.

Bioinformatics. 2015 Aug 1;31(15):2537-44. doi: 10.1093/bioinformatics/btv186. Epub 2015 Apr 2.

32.

What is your diagnosis? Seminal vesicle disease.

Hayhurst SE, Engel JD, Walsh T, Gordon S, Murray S, Boedeker N.

J Am Vet Med Assoc. 2015 Apr 15;246(8):839-41. doi: 10.2460/javma.246.8.839. No abstract available.

PMID:
25835164
33.

Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes.

Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim KC, Engel JD.

Blood. 2015 Feb 26;125(9):1477-87. doi: 10.1182/blood-2014-10-605022. Epub 2015 Jan 5.

34.

Modeling dynamic functional relationship networks and application to ex vivo human erythroid differentiation.

Zhu F, Shi L, Li H, Eksi R, Engel JD, Guan Y.

Bioinformatics. 2014 Dec 1;30(23):3325-33. doi: 10.1093/bioinformatics/btu542. Epub 2014 Aug 12.

35.

Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies.

Suzuki M, Yamamoto M, Engel JD.

Mol Cell Biol. 2014 Oct 1;34(19):3560-9. doi: 10.1128/MCB.00714-14. Epub 2014 Jul 14. Review.

36.

Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.

Shi L, Sierant MC, Gurdziel K, Zhu F, Cui S, Kolodziej KE, Strouboulis J, Guan Y, Tanabe O, Lim KC, Engel JD.

PLoS Genet. 2014 May 8;10(5):e1004339. doi: 10.1371/journal.pgen.1004339. eCollection 2014 May.

37.

Developmental transcriptome analysis of human erythropoiesis.

Shi L, Lin YH, Sierant MC, Zhu F, Cui S, Guan Y, Sartor MA, Tanabe O, Lim KC, Engel JD.

Hum Mol Genet. 2014 Sep 1;23(17):4528-42. doi: 10.1093/hmg/ddu167. Epub 2014 Apr 29.

38.

A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression.

Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.

Cancer Cell. 2014 Apr 14;25(4):415-27. doi: 10.1016/j.ccr.2014.02.008. Epub 2014 Apr 3.

39.

PGC-1 coactivator activity is required for murine erythropoiesis.

Cui S, Tanabe O, Lim KC, Xu HE, Zhou XE, Lin JD, Shi L, Schmidt L, Campbell A, Shimizu R, Yamamoto M, Engel JD.

Mol Cell Biol. 2014 Jun;34(11):1956-65. doi: 10.1128/MCB.00247-14. Epub 2014 Mar 24.

40.

GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts.

Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, Yamamoto M.

Mol Cell Biol. 2014 Jun;34(11):1929-41. doi: 10.1128/MCB.01659-13. Epub 2014 Mar 17.

41.

Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.

Udager AM, Prakash A, Saenz DA, Schinke M, Moriguchi T, Jay PY, Lim KC, Engel JD, Gumucio DL.

Gastroenterology. 2014 Jan;146(1):157-165.e10. doi: 10.1053/j.gastro.2013.10.008. Epub 2013 Oct 9.

42.

TRIM28 is essential for erythroblast differentiation in the mouse.

Hosoya T, Clifford M, Losson R, Tanabe O, Engel JD.

Blood. 2013 Nov 28;122(23):3798-807. doi: 10.1182/blood-2013-04-496166. Epub 2013 Oct 3.

43.

Seminal vesicle abscess following prostate biopsy requiring transgluteal percutaneous drainage.

Bayne CE, Davis WA, Rothstein CP, Engel JD.

Can J Urol. 2013 Jun;20(3):6811-4. Review.

44.
45.

Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.

Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe O, Engel JD, Yamamoto M.

Mol Cell Biol. 2013 Apr;33(8):1687-95. doi: 10.1128/MCB.01617-12. Epub 2013 Feb 19.

46.

Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction.

Shi L, Cui S, Engel JD, Tanabe O.

Nat Med. 2013 Mar;19(3):291-4. doi: 10.1038/nm.3101. Epub 2013 Feb 17.

47.

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning.

Lim KC, Hosoya T, Brandt W, Ku CJ, Hosoya-Ohmura S, Camper SA, Yamamoto M, Engel JD.

J Clin Invest. 2012 Oct;122(10):3705-17. doi: 10.1172/JCI61619. Epub 2012 Sep 10.

48.

Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks.

Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M.

Nucleic Acids Res. 2012 Nov 1;40(20):10228-39. doi: 10.1093/nar/gks827. Epub 2012 Sep 10.

49.

Sexual outcomes after prostatectomy: a call for uniformity.

Engel JD.

Can J Urol. 2012 Aug;19(4):6336. No abstract available.

50.

UG4 enhancer-driven GATA-2 and bone morphogenetic protein 4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice.

Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M.

Mol Cell Biol. 2012 Jun;32(12):2312-22. doi: 10.1128/MCB.06699-11. Epub 2012 Apr 9.

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