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Items: 30

1.

Modeling Spatial Correlation of Transcripts with Application to Developing Pancreas.

Liu R, Mignardi M, Jones R, Enge M, Kim SK, Quake SR, Zou J.

Sci Rep. 2019 Apr 3;9(1):5592. doi: 10.1038/s41598-019-41951-2.

2.

Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.

Enge M, Arda HE, Mignardi M, Beausang J, Bottino R, Kim SK, Quake SR.

Cell. 2017 Oct 5;171(2):321-330.e14. doi: 10.1016/j.cell.2017.09.004. Epub 2017 Sep 28.

3.

Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis.

Grinkevich VV, Nikulenkov F, Shi Y, Enge M, Bao W, Maljukova A, Gluch A, Kel A, Sangfelt O, Selivanova G.

Cancer Cell. 2017 May 8;31(5):724-726. doi: 10.1016/j.ccell.2017.04.014. No abstract available.

4.

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK.

Cell Metab. 2017 Mar 7;25(3):622-634. doi: 10.1016/j.cmet.2017.01.009. Epub 2017 Feb 16.

5.

DNA-dependent formation of transcription factor pairs alters their binding specificity.

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J.

Nature. 2015 Nov 19;527(7578):384-8. doi: 10.1038/nature15518. Epub 2015 Nov 9.

PMID:
26550823
6.

A survey of human brain transcriptome diversity at the single cell level.

Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7285-90. doi: 10.1073/pnas.1507125112. Epub 2015 May 18.

7.

CTCF/cohesin-binding sites are frequently mutated in cancer.

Katainen R, Dave K, Pitkänen E, Palin K, Kivioja T, Välimäki N, Gylfe AE, Ristolainen H, Hänninen UA, Cajuso T, Kondelin J, Tanskanen T, Mecklin JP, Järvinen H, Renkonen-Sinisalo L, Lepistö A, Kaasinen E, Kilpivaara O, Tuupanen S, Enge M, Taipale J, Aaltonen LA.

Nat Genet. 2015 Jul;47(7):818-21. doi: 10.1038/ng.3335. Epub 2015 Jun 8.

PMID:
26053496
8.

Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.

Jäger R, Migliorini G, Henrion M, Kandaswamy R, Speedy HE, Heindl A, Whiffin N, Carnicer MJ, Broome L, Dryden N, Nagano T, Schoenfelder S, Enge M, Yuan Y, Taipale J, Fraser P, Fletcher O, Houlston RS.

Nat Commun. 2015 Feb 19;6:6178. doi: 10.1038/ncomms7178.

9.

Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites.

Yan J, Enge M, Whitington T, Dave K, Liu J, Sur I, Schmierer B, Jolma A, Kivioja T, Taipale M, Taipale J.

Cell. 2013 Aug 15;154(4):801-13. doi: 10.1016/j.cell.2013.07.034.

10.

DNA-binding specificities of human transcription factors.

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J.

Cell. 2013 Jan 17;152(1-2):327-39. doi: 10.1016/j.cell.2012.12.009.

11.

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Sur IK, Hallikas O, Vähärautio A, Yan J, Turunen M, Enge M, Taipale M, Karhu A, Aaltonen LA, Taipale J.

Science. 2012 Dec 7;338(6112):1360-3. doi: 10.1126/science.1228606. Epub 2012 Nov 1.

12.

Protein kinase Cα (PKCα) regulates p53 localization and melanoma cell survival downstream of integrin αv in three-dimensional collagen and in vivo.

Smith SD, Enge M, Bao W, Thullberg M, Costa TD, Olofsson H, Gashi B, Selivanova G, Strömblad S.

J Biol Chem. 2012 Aug 24;287(35):29336-47. doi: 10.1074/jbc.M112.341917. Epub 2012 Jul 6.

13.

Counting absolute numbers of molecules using unique molecular identifiers.

Kivioja T, Vähärautio A, Karlsson K, Bonke M, Enge M, Linnarsson S, Taipale J.

Nat Methods. 2011 Nov 20;9(1):72-4. doi: 10.1038/nmeth.1778.

PMID:
22101854
14.

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

Li H, Lakshmikanth T, Garofalo C, Enge M, Spinnler C, Anichini A, Szekely L, Kärre K, Carbone E, Selivanova G.

Cell Cycle. 2011 Oct 1;10(19):3346-58. doi: 10.4161/cc.10.19.17630. Epub 2011 Oct 1.

PMID:
21941086
15.

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.

Mäkinen N, Mehine M, Tolvanen J, Kaasinen E, Li Y, Lehtonen HJ, Gentile M, Yan J, Enge M, Taipale M, Aavikko M, Katainen R, Virolainen E, Böhling T, Koski TA, Launonen V, Sjöberg J, Taipale J, Vahteristo P, Aaltonen LA.

Science. 2011 Oct 14;334(6053):252-5. doi: 10.1126/science.1208930. Epub 2011 Aug 25.

16.

Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer.

Zawacka-Pankau J, Grinkevich VV, Hünten S, Nikulenkov F, Gluch A, Li H, Enge M, Kel A, Selivanova G.

J Biol Chem. 2011 Dec 2;286(48):41600-15. doi: 10.1074/jbc.M111.240812. Epub 2011 Aug 23.

17.

[Implementation of quality management in medical rehabilitation--current challenges for rehabilitation facilities].

Enge M, Koch A, Müller T, Vorländer T.

Rehabilitation (Stuttg). 2010 Dec;49(6):383-92. doi: 10.1055/s-0030-1268004. Epub 2010 Dec 7. German.

PMID:
21140322
18.

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo.

Wei GH, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J.

EMBO J. 2010 Jul 7;29(13):2147-60. doi: 10.1038/emboj.2010.106. Epub 2010 Jun 1.

19.

Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.

Jolma A, Kivioja T, Toivonen J, Cheng L, Wei G, Enge M, Taipale M, Vaquerizas JM, Yan J, Sillanpää MJ, Bonke M, Palin K, Talukder S, Hughes TR, Luscombe NM, Ukkonen E, Taipale J.

Genome Res. 2010 Jun;20(6):861-73. doi: 10.1101/gr.100552.109. Epub 2010 Apr 8.

20.

Mice chronically fed high-fat diet have increased mortality and disturbed immune response in sepsis.

Strandberg L, Verdrengh M, Enge M, Andersson N, Amu S, Onnheim K, Benrick A, Brisslert M, Bylund J, Bokarewa M, Nilsson S, Jansson JO.

PLoS One. 2009 Oct 28;4(10):e7605. doi: 10.1371/journal.pone.0007605.

21.

Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis.

Grinkevich VV, Nikulenkov F, Shi Y, Enge M, Bao W, Maljukova A, Gluch A, Kel A, Sangfelt O, Selivanova G.

Cancer Cell. 2009 May 5;15(5):441-53. doi: 10.1016/j.ccr.2009.03.021. Erratum in: Cancer Cell. 2017 May 8;31(5):724-726.

22.

MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53.

Enge M, Bao W, Hedström E, Jackson SP, Moumen A, Selivanova G.

Cancer Cell. 2009 Mar 3;15(3):171-83. doi: 10.1016/j.ccr.2009.01.019. Erratum in: Cancer Cell. 2009 Jul 7;16(1):79.

23.

Tumor-specific induction of apoptosis by a p53-reactivating compound.

Hedström E, Issaeva N, Enge M, Selivanova G.

Exp Cell Res. 2009 Feb 1;315(3):451-61. doi: 10.1016/j.yexcr.2008.11.009. Epub 2008 Dec 3.

PMID:
19071110
24.

Mature-onset obesity in interleukin-1 receptor I knockout mice.

García MC, Wernstedt I, Berndtsson A, Enge M, Bell M, Hultgren O, Horn M, Ahrén B, Enerback S, Ohlsson C, Wallenius V, Jansson JO.

Diabetes. 2006 May;55(5):1205-13.

25.

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G.

Nat Med. 2004 Dec;10(12):1321-8. Epub 2004 Nov 21.

PMID:
15558054
26.

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

Betsholtz C, Lindblom P, Bjarnegard M, Enge M, Gerhardt H, Lindahl P.

Curr Opin Nephrol Hypertens. 2004 Jan;13(1):45-52. Review.

PMID:
15090859
27.

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities.

Bjarnegård M, Enge M, Norlin J, Gustafsdottir S, Fredriksson S, Abramsson A, Takemoto M, Gustafsson E, Fässler R, Betsholtz C.

Development. 2004 Apr;131(8):1847-57.

28.

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

Lindblom P, Gerhardt H, Liebner S, Abramsson A, Enge M, Hellstrom M, Backstrom G, Fredriksson S, Landegren U, Nystrom HC, Bergstrom G, Dejana E, Ostman A, Lindahl P, Betsholtz C.

Genes Dev. 2003 Aug 1;17(15):1835-40.

29.

Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury.

Enge M, Wilhelmsson U, Abramsson A, Stakeberg J, Kühn R, Betsholtz C, Pekny M.

Neurochem Res. 2003 Feb;28(2):271-9.

PMID:
12608700
30.

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.

Enge M, Bjarnegård M, Gerhardt H, Gustafsson E, Kalén M, Asker N, Hammes HP, Shani M, Fässler R, Betsholtz C.

EMBO J. 2002 Aug 15;21(16):4307-16.

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