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CGRP Is Critical for Hot Flushes in Ovariectomized Mice.

Wilhelms DB, Dock H, Brito HO, Pettersson E, Stojakovic A, Zajdel J, Engblom D, Theodorsson E, Hammar ML, Spetz Holm AE.

Front Pharmacol. 2019 Jan 4;9:1452. doi: 10.3389/fphar.2018.01452. eCollection 2018.


Acute maternal separation potentiates the gene expression and corticosterone response induced by inflammation.

Zajdel J, Zager A, Blomqvist A, Engblom D, Shionoya K.

Brain Behav Immun. 2019 Mar;77:141-149. doi: 10.1016/j.bbi.2018.12.016. Epub 2018 Dec 24.


Motivational valence is determined by striatal melanocortin 4 receptors.

Klawonn AM, Fritz M, Nilsson A, Bonaventura J, Shionoya K, Mirrasekhian E, Karlsson U, Jaarola M, Granseth B, Blomqvist A, Michaelides M, Engblom D.

J Clin Invest. 2018 Jul 2;128(7):3160-3170. doi: 10.1172/JCI97854. Epub 2018 Jun 18.


Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity.

Klawonn AM, Wilhelms DB, Lindström SH, Singh AK, Jaarola M, Wess J, Fritz M, Engblom D.

Front Mol Neurosci. 2018 Apr 24;11:139. doi: 10.3389/fnmol.2018.00139. eCollection 2018.


The antipyretic effect of paracetamol occurs independent of transient receptor potential ankyrin 1-mediated hypothermia and is associated with prostaglandin inhibition in the brain.

Mirrasekhian E, Nilsson JLÅ, Shionoya K, Blomgren A, Zygmunt PM, Engblom D, Högestätt ED, Blomqvist A.

FASEB J. 2018 Oct;32(10):5751-5759. doi: 10.1096/fj.201800272R. Epub 2018 May 8.


Neural Mechanisms of Inflammation-Induced Fever.

Blomqvist A, Engblom D.

Neuroscientist. 2018 Aug;24(4):381-399. doi: 10.1177/1073858418760481. Epub 2018 Mar 20. Review.


Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice.

Stojakovic A, Walczak M, Cieślak PE, Trenk A, Sköld J, Zajdel J, Mirrasekhian E, Karlsson C, Thorsell A, Heilig M, Parkitna JR, Błasiak T, Engblom D.

Neuropsychopharmacology. 2018 Jun;43(7):1548-1556. doi: 10.1038/s41386-018-0022-z. Epub 2018 Feb 5.


The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum.

Klawonn AM, Nilsson A, Rådberg CF, Lindström SH, Ericson M, Granseth B, Engblom D, Fritz M.

Front Pharmacol. 2017 Oct 10;8:714. doi: 10.3389/fphar.2017.00714. eCollection 2017.


Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion.

Fritz M, Klawonn AM, Jaarola M, Engblom D.

Brain Behav Immun. 2018 Jan;67:54-58. doi: 10.1016/j.bbi.2017.08.020. Epub 2017 Aug 30.


Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses.

Matsuwaki T, Shionoya K, Ihnatko R, Eskilsson A, Kakuta S, Dufour S, Schwaninger M, Waisman A, Müller W, Pinteaux E, Engblom D, Blomqvist A.

Brain Behav Immun. 2017 Nov;66:165-176. doi: 10.1016/j.bbi.2017.06.013. Epub 2017 Jun 24.


Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain.

Eskilsson A, Matsuwaki T, Shionoya K, Mirrasekhian E, Zajdel J, Schwaninger M, Engblom D, Blomqvist A.

J Neurosci. 2017 May 10;37(19):5035-5044. doi: 10.1523/JNEUROSCI.3846-16.2017. Epub 2017 Apr 24.


Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain.

Singh AK, Zajdel J, Mirrasekhian E, Almoosawi N, Frisch I, Klawonn AM, Jaarola M, Fritz M, Engblom D.

J Clin Invest. 2017 Apr 3;127(4):1370-1374. doi: 10.1172/JCI90678. Epub 2017 Mar 13.


Inflammation-induced anorexia and fever are elicited by distinct prostaglandin dependent mechanisms, whereas conditioned taste aversion is prostaglandin independent.

Nilsson A, Wilhelms DB, Mirrasekhian E, Jaarola M, Blomqvist A, Engblom D.

Brain Behav Immun. 2017 Mar;61:236-243. doi: 10.1016/j.bbi.2016.12.007. Epub 2016 Dec 9.


Cyclooxygenase Isoform Exchange Blocks Brain-Mediated Inflammatory Symptoms.

Björk Wilhelms D, Mirrasekhian E, Zajdel J, Kumar Singh A, Engblom D.

PLoS One. 2016 Nov 18;11(11):e0166153. doi: 10.1371/journal.pone.0166153. eCollection 2016.


Loss of NMDA receptors in dopamine neurons leads to the development of affective disorder-like symptoms in mice.

Jastrzębska K, Walczak M, Cieślak PE, Szumiec Ł, Turbasa M, Engblom D, Błasiak T, Parkitna JR.

Sci Rep. 2016 Nov 17;6:37171. doi: 10.1038/srep37171.


Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin-1β in Rats.

Brito HO, Radulski DR, Wilhelms DB, Stojakovic A, Brito LM, Engblom D, Franco CR, Zampronio AR.

J Neuroendocrinol. 2016 Oct;28(10). doi: 10.1111/jne.12414.


The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent.

Nilsson A, Elander L, Hallbeck M, Örtegren Kugelberg U, Engblom D, Blomqvist A.

Brain Behav Immun. 2017 Feb;60:27-31. doi: 10.1016/j.bbi.2016.06.014. Epub 2016 Jun 29.


NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference.

Sikora M, Tokarski K, Bobula B, Zajdel J, Jastrzębska K, Cieślak PE, Zygmunt M, Sowa J, Smutek M, Kamińska K, Gołembiowska K, Engblom D, Hess G, Przewlocki R, Rodriguez Parkitna J.

eNeuro. 2016 Jun 9;3(3). pii: ENEURO.0084-15.2016. doi: 10.1523/ENEURO.0084-15.2016. eCollection 2016 May-Jun.


Proinflammatory signaling regulates voluntary alcohol intake and stress-induced consumption after exposure to social defeat stress in mice.

Karlsson C, Schank JR, Rehman F, Stojakovic A, Björk K, Barbier E, Solomon M, Tapocik J, Engblom D, Thorsell A, Heilig M.

Addict Biol. 2017 Sep;22(5):1279-1288. doi: 10.1111/adb.12416. Epub 2016 Jun 7.


Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D.

J Clin Invest. 2016 Feb;126(2):695-705.


Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis.

Eskilsson A, Mirrasekhian E, Dufour S, Schwaninger M, Engblom D, Blomqvist A.

J Neurosci. 2014 Nov 26;34(48):15957-61. doi: 10.1523/JNEUROSCI.3520-14.2014.


Deletion of prostaglandin E2 synthesizing enzymes in brain endothelial cells attenuates inflammatory fever.

Wilhelms DB, Kirilov M, Mirrasekhian E, Eskilsson A, Kugelberg UÖ, Klar C, Ridder DA, Herschman HR, Schwaninger M, Blomqvist A, Engblom D.

J Neurosci. 2014 Aug 27;34(35):11684-90. doi: 10.1523/JNEUROSCI.1838-14.2014.


Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Rodriguez Parkitna J.

Front Behav Neurosci. 2014 Jul 9;8:239. doi: 10.3389/fnbeh.2014.00239. eCollection 2014. No abstract available.


CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.

Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Parkitna JR.

Front Behav Neurosci. 2014 Jun 11;8:212. doi: 10.3389/fnbeh.2014.00212. eCollection 2014. Erratum in: Front Behav Neurosci. 2014;8:239. Front Behav Neurosci. 2014;8:239.


Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5.

Fieblinger T, Sebastianutto I, Alcacer C, Bimpisidis Z, Maslava N, Sandberg S, Engblom D, Cenci MA.

J Neurosci. 2014 Mar 26;34(13):4728-40. doi: 10.1523/JNEUROSCI.2702-13.2014.


Acetaminophen reduces lipopolysaccharide-induced fever by inhibiting cyclooxygenase-2.

Engström Ruud L, Wilhelms DB, Eskilsson A, Vasilache AM, Elander L, Engblom D, Blomqvist A.

Neuropharmacology. 2013 Aug;71:124-9. doi: 10.1016/j.neuropharm.2013.03.012. Epub 2013 Mar 29.


Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells.

Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich T, Bäckhed F, Engblom D, Blomqvist A.

FASEB J. 2013 May;27(5):1973-80. doi: 10.1096/fj.12-225433. Epub 2013 Feb 8.


Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1.

Ruud J, Nilsson A, Engström Ruud L, Wang W, Nilsberth C, Iresjö BM, Lundholm K, Engblom D, Blomqvist A.

Brain Behav Immun. 2013 Mar;29:124-35. doi: 10.1016/j.bbi.2012.12.020. Epub 2013 Jan 7.


Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models?

Rodriguez Parkitna J, Engblom D.

Front Mol Neurosci. 2012 Aug 31;5:89. doi: 10.3389/fnmol.2012.00089. eCollection 2012.


Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors.

Parkitna JR, Sikora M, Gołda S, Gołembiowska K, Bystrowska B, Engblom D, Bilbao A, Przewlocki R.

Biol Psychiatry. 2013 Feb 1;73(3):263-70. doi: 10.1016/j.biopsych.2012.07.019. Epub 2012 Aug 16.


Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells.

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A.

Endocrinology. 2012 Oct;153(10):4849-61. Epub 2012 Aug 7.


Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1.

Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, Wotjak CT, Sillaber I, Holsboer F, Wurst W, Deussing JM.

Science. 2011 Sep 30;333(6051):1903-7. doi: 10.1126/science.1202107. Epub 2011 Sep 1.


Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting.

Hagbom M, Istrate C, Engblom D, Karlsson T, Rodriguez-Diaz J, Buesa J, Taylor JA, Loitto VM, Magnusson KE, Ahlman H, Lundgren O, Svensson L.

PLoS Pathog. 2011 Jul;7(7):e1002115. doi: 10.1371/journal.ppat.1002115. Epub 2011 Jul 14.


Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.

Mueller KM, Kornfeld JW, Friedbichler K, Blaas L, Egger G, Esterbauer H, Hasselblatt P, Schlederer M, Haindl S, Wagner KU, Engblom D, Haemmerle G, Kratky D, Sexl V, Kenner L, Kozlov AV, Terracciano L, Zechner R, Schuetz G, Casanova E, Pospisilik JA, Heim MH, Moriggl R.

Hepatology. 2011 Oct;54(4):1398-409. doi: 10.1002/hep.24509.


Tumor necrosis factor inhibits glucocorticoid receptor function in mice: a strong signal toward lethal shock.

Van Bogaert T, Vandevyver S, Dejager L, Van Hauwermeiren F, Pinheiro I, Petta I, Engblom D, Kleyman A, Schütz G, Tuckermann J, Libert C.

J Biol Chem. 2011 Jul 29;286(30):26555-67. doi: 10.1074/jbc.M110.212365. Epub 2011 Jun 6.


Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of rapamycin signaling.

Rieker C, Engblom D, Kreiner G, Domanskyi A, Schober A, Stotz S, Neumann M, Yuan X, Grummt I, Schütz G, Parlato R.

J Neurosci. 2011 Jan 12;31(2):453-60. doi: 10.1523/JNEUROSCI.0590-10.2011.


Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons.

Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D.

J Neurosci. 2010 Sep 8;30(36):11973-82. doi: 10.1523/JNEUROSCI.2550-10.2010.


Loss of the serum response factor in the dopamine system leads to hyperactivity.

Parkitna JR, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, Spanagel R, Schütz G.

FASEB J. 2010 Jul;24(7):2427-35. doi: 10.1096/fj.09-151423. Epub 2010 Mar 11.


Deletion of the gene encoding MyD88 protects from anorexia in a mouse tumor model.

Ruud J, Bäckhed F, Engblom D, Blomqvist A.

Brain Behav Immun. 2010 May;24(4):554-7. doi: 10.1016/j.bbi.2010.01.006. Epub 2010 Jan 18.


Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc.

Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C.

Nat Neurosci. 2009 Aug;12(8):1036-41. doi: 10.1038/nn.2367. Epub 2009 Jul 13.


Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes.

Parkitna JR, Engblom D, Schütz G.

Methods Mol Biol. 2009;530:325-42. doi: 10.1007/978-1-59745-471-1_17.


Inducible prostaglandin E2 synthesis interacts in a temporally supplementary sequence with constitutive prostaglandin-synthesizing enzymes in creating the hypothalamic-pituitary-adrenal axis response to immune challenge.

Elander L, Engström L, Ruud J, Mackerlova L, Jakobsson PJ, Engblom D, Nilsberth C, Blomqvist A.

J Neurosci. 2009 Feb 4;29(5):1404-13. doi: 10.1523/JNEUROSCI.5247-08.2009.


Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine.

Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, Schumann G, Schütz G, Spanagel R.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17549-54. doi: 10.1073/pnas.0803959105. Epub 2008 Nov 10.


Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.

Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R.

Neuron. 2008 Aug 14;59(3):497-508. doi: 10.1016/j.neuron.2008.07.010.


CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis.

Lemberger T, Parkitna JR, Chai M, Schütz G, Engblom D.

FASEB J. 2008 Aug;22(8):2872-9. doi: 10.1096/fj.08-107888. Epub 2008 Apr 18.


Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland.

Engström L, Rosén K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D, Blomqvist A.

Endocrinology. 2008 Apr;149(4):1436-50. doi: 10.1210/en.2007-1456. Epub 2008 Jan 3.


Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression.

Engblom D, Kornfeld JW, Schwake L, Tronche F, Reimann A, Beug H, Hennighausen L, Moriggl R, Schütz G.

Genes Dev. 2007 May 15;21(10):1157-62.


Activation of the parabrachio-amygdaloid pathway by immune challenge or spinal nociceptive input: a quantitative study in the rat using Fos immunohistochemistry and retrograde tract tracing.

Richard S, Engblom D, Paues J, Mackerlova L, Blomqvist A.

J Comp Neurol. 2005 Jan 10;481(2):210-9. Erratum in: J Comp Neurol. 2005 Mar 21;483(4):489-90.


EP3 and EP4 receptor mRNA expression in peptidergic cell groups of the rat parabrachial nucleus.

Engblom D, Ek M, Ericsson-Dahlstrand A, Blomqvist A.

Neuroscience. 2004;126(4):989-99.


Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis.

Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A.

Nat Neurosci. 2003 Nov;6(11):1137-8. Epub 2003 Oct 19.

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